{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T17:12:51Z","timestamp":1770484371754,"version":"3.49.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Photodiagnosis and Photodynamic Therapy"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1016\/j.pdpdt.2011.04.003","type":"journal-article","created":{"date-parts":[[2011,6,3]],"date-time":"2011-06-03T16:23:46Z","timestamp":1307118226000},"page":"291-296","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"title":["Low dose hypericin-PDT induces complete tumor regression in BALB\/c mice bearing CT26 colon carcinoma"],"prefix":"10.1016","volume":"8","author":[{"given":"Renata","family":"Sanovic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Verwanger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnulf","family":"Hartl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Krammer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pdpdt.2011.04.003_bib0005","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1111\/j.1751-1097.1991.tb02133.x","article-title":"Preclinical examination of first and second generation photosensitizers used in photodynamic therapy","volume":"54","author":"Gomer","year":"1991","journal-title":"Photochem Photobiol"},{"key":"10.1016\/j.pdpdt.2011.04.003_bib0010","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S1052-3359(25)00676-3","article-title":"Photodynamic therapy. Biology and clinical application","volume":"5","author":"Keller","year":"1995","journal-title":"Chest Surg Clin N Am"},{"key":"10.1016\/j.pdpdt.2011.04.003_bib0015","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1089\/104454702753474931","article-title":"An update on photodynamic therapy applications","volume":"20","author":"Dougherty","year":"2002","journal-title":"J Clin Laser Med Surg"},{"key":"10.1016\/j.pdpdt.2011.04.003_bib0020","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1615\/JEnvironPatholToxicolOncol.v25.i1-2.300","article-title":"PDT in clinics: indications, results, and markets","volume":"25","author":"Patrice","year":"2006","journal-title":"J Environ Pathol Toxicol Oncol"},{"key":"10.1016\/j.pdpdt.2011.04.003_bib0025","first-page":"86","article-title":"Molecular effectors of multiple cell death pathways initiated by photodynamic therapy","volume":"1776","author":"Buytaert","year":"2007","journal-title":"Bba-Rev Cancer"},{"key":"10.1016\/j.pdpdt.2011.04.003_bib0030","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1751-1097.1992.tb04222.x","article-title":"How does photodynamic therapy work?","volume":"55","author":"Henderson","year":"1992","journal-title":"Photochem Photobiol"},{"key":"10.1016\/j.pdpdt.2011.04.003_bib0035","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1007\/s10354-007-0440-8","article-title":"St. John's wort: role of active compounds for its mechanism of action and efficacy","volume":"157","author":"Butterweck","year":"2007","journal-title":"Wien Med Wochenschr"},{"key":"10.1016\/j.pdpdt.2011.04.003_bib0040","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S0022-3565(24)39043-3","article-title":"Inhibition of human cytochrome P450 enzymes by constituents of St. John's wort, an herbal preparation used in the treatment of depression","volume":"294","author":"Obach","year":"2000","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pdpdt.2011.04.003_bib0045","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1016\/j.bcp.2009.12.016","article-title":"St. John's Wort reduces neuropathic pain through a hypericin-mediated inhibition of the protein kinase C gamma and epsilon activity","volume":"79","author":"Galeotti","year":"2010","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.pdpdt.2011.04.003_bib0050","doi-asserted-by":"crossref","first-page":"562","DOI":"10.3390\/ijms11020562","article-title":"Hypericins as potential leads for new therapeutics","volume":"11","author":"Karioti","year":"2010","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.pdpdt.2011.04.003_bib0055","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1039\/b9pp00144a","article-title":"Antibacterial photodynamic therapy using water-soluble formulations of hypericin or mTHPC is effective in inactivation of Staphylococcus aureus","volume":"9","author":"Engelhardt","year":"2010","journal-title":"Photochem Photobiol Sci"},{"key":"10.1016\/j.pdpdt.2011.04.003_bib0060","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1615\/JEnvironPatholToxicolOncol.v27.i1.30","article-title":"Potentiation of the photodynamic action of hypericin","volume":"27","author":"Saw","year":"2008","journal-title":"J Environ Pathol Toxicol Oncol"},{"key":"10.1016\/j.pdpdt.2011.04.003_bib0065","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3727\/096504001108747864","article-title":"Effects of photodynamic therapy with hypericin in mice bearing highly invasive solid tumors","volume":"12","author":"Blank","year":"2000","journal-title":"Oncol Res"},{"key":"10.1016\/j.pdpdt.2011.04.003_bib0070","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1002\/ijc.1324","article-title":"Efficacy of antitumoral photodynamic therapy with hypericin: relationship between biodistribution and photodynamic effects in the RIF-1 mouse tumor model","volume":"93","author":"Chen","year":"2001","journal-title":"Int J Cancer"},{"key":"10.1016\/j.pdpdt.2011.04.003_bib0075","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/s12026-009-8119-4","article-title":"Enhancement of anti-tumor immunity by photodynamic therapy","volume":"46","author":"Gollnick","year":"2010","journal-title":"Immunol Res"},{"key":"10.1016\/j.pdpdt.2011.04.003_bib0080","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/nrc1894","article-title":"Photodynamic therapy and anti-tumour immunity","volume":"6","author":"Castano","year":"2006","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.pdpdt.2011.04.003_bib0085","first-page":"1604","article-title":"Generation of effective antitumor vaccines using photodynamic therapy","volume":"62","author":"Gollnick","year":"2002","journal-title":"Cancer Res"},{"key":"10.1016\/j.pdpdt.2011.04.003_bib0090","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1007\/s00262-005-0088-4","article-title":"Photodynamic therapy-generated vaccine for cancer therapy","volume":"55","author":"Korbelik","year":"2006","journal-title":"Cancer Immunol Immunother"},{"key":"10.1016\/j.pdpdt.2011.04.003_bib0095","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1615\/CritRevEukarGeneExpr.v16.i4.10","article-title":"Vascular and cellular targeting for photodynamic therapy","volume":"16","author":"Chen","year":"2006","journal-title":"Crit Rev Eukaryot Gene Expr"},{"key":"10.1016\/j.pdpdt.2011.04.003_bib0100","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1562\/0031-8655(2002)076<0509:ATEBHM>2.0.CO;2","article-title":"Antivascular tumor eradication by hypericin-mediated photodynamic therapy","volume":"76","author":"Chen","year":"2002","journal-title":"Photochem Photobiol"},{"key":"10.1016\/j.pdpdt.2011.04.003_bib0105","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1615\/JEnvironPatholToxicolOncol.v25.i1-2.140","article-title":"Perylenequinones in photodynamic therapy: cellular versus vascular response","volume":"25","author":"Olivo","year":"2006","journal-title":"J Environ Pathol Toxicol Oncol"},{"key":"10.1016\/j.pdpdt.2011.04.003_bib0110","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1562\/0031-8655(2002)076<0335:WDPOPT>2.0.CO;2","article-title":"Wavelength-dependent properties of photodynamic therapy using hypericin in vitro and in an animal model","volume":"76","author":"Blank","year":"2002","journal-title":"Photochem Photobiol"},{"key":"10.1016\/j.pdpdt.2011.04.003_bib0115","first-page":"4271","article-title":"Vascular effects of photodynamic therapy","volume":"21","author":"Krammer","year":"2001","journal-title":"Anticancer Res"},{"key":"10.1016\/j.pdpdt.2011.04.003_bib0120","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1002\/ijc.10175","article-title":"Photodynamic therapy with hypericin induces vascular damage and apoptosis in the RIF-1 mouse tumor model","volume":"98","author":"Chen","year":"2002","journal-title":"Int J Cancer"},{"key":"10.1016\/j.pdpdt.2011.04.003_bib0125","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1211\/jpp.59.5.0011","article-title":"Topical anti-inflammatory activity of extracts and compounds from Hypericum perforatum L.","volume":"59","author":"Sosa","year":"2007","journal-title":"J Pharm Pharmacol"},{"key":"10.1016\/j.pdpdt.2011.04.003_bib0130","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1089\/clm.1996.14.329","article-title":"Induction of tumor immunity by photodynamic therapy","volume":"14","author":"Korbelik","year":"1996","journal-title":"J Clin Laser Med Surg"},{"key":"10.1016\/j.pdpdt.2011.04.003_bib0135","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1615\/JEnvironPatholToxicolOncol.v25.i1-2.180","article-title":"Photoimmunotherapy for cancer treatment","volume":"25","author":"Chen","year":"2006","journal-title":"J Environ Pathol Toxicol Oncol"},{"key":"10.1016\/j.pdpdt.2011.04.003_bib0140","doi-asserted-by":"crossref","DOI":"10.1039\/c0pp00315h","article-title":"Antitumor immunity promoted by vascular occluding therapy: lessons from vascular-targeted photodynamic therapy (VTP)","author":"Preise","year":"2011","journal-title":"Photochem Photobiol Sci"}],"container-title":["Photodiagnosis and Photodynamic Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100011003905?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100011003905?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:22:31Z","timestamp":1761610951000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1572100011003905"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["S1572100011003905"],"URL":"https:\/\/doi.org\/10.1016\/j.pdpdt.2011.04.003","relation":{},"ISSN":["1572-1000"],"issn-type":[{"value":"1572-1000","type":"print"}],"subject":[],"published":{"date-parts":[[2011,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Low dose hypericin-PDT induces complete tumor regression in BALB\/c mice bearing CT26 colon carcinoma","name":"articletitle","label":"Article Title"},{"value":"Photodiagnosis and Photodynamic Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pdpdt.2011.04.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}