{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:18:53Z","timestamp":1791191933596,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002081","name":"Irish Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002081","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Photodiagnosis and Photodynamic Therapy"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1016\/j.pdpdt.2014.07.003","type":"journal-article","created":{"date-parts":[[2014,8,4]],"date-time":"2014-08-04T20:30:42Z","timestamp":1407184242000},"page":"510-515","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Lead structures for applications in photodynamic therapy. 5. Synthesis and biological evaluation of water soluble phosphorus(V) 5,10,15,20-tetraalkylporphyrins for PDT"],"prefix":"10.1016","volume":"11","author":[{"given":"Aoife A.","family":"Ryan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mothi M.","family":"Ebrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosine","family":"Petitdemange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisela M.","family":"Vaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edyta","family":"Paszko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia N.","family":"Sergeeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias O.","family":"Senge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pdpdt.2014.07.003_bib0005","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1093\/jnci\/90.12.889","article-title":"Photodynamic therapy","volume":"90","author":"Dougherty","year":"1998","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.pdpdt.2014.07.003_bib0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jphotobiol.2003.10.002","article-title":"Research advances in the use of tetrapyrrolic photosensitizers for photodynamic therapy","volume":"73","author":"Nyman","year":"2004","journal-title":"J Photochem Photobiol B: Biol"},{"key":"10.1016\/j.pdpdt.2014.07.003_bib0015","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1111\/j.1751-1097.2009.00585.x","article-title":"Porphyrin and nonporphyrin photosensitizers in oncology: preclinical and clinical advances in photodynamic therapy","volume":"85","author":"O\u2019Connor","year":"2009","journal-title":"Photochem Photobiol"},{"key":"10.1016\/j.pdpdt.2014.07.003_bib0020","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1111\/j.1751-1097.1993.tb04990.x","article-title":"Photodynamic therapy","volume":"58","author":"Dougherty","year":"1993","journal-title":"Photochem Photobiol"},{"key":"10.1016\/j.pdpdt.2014.07.003_bib0025","series-title":"Chemical aspects of photodynamic therapy","author":"Bonnett","year":"2000"},{"key":"10.1016\/j.pdpdt.2014.07.003_bib0030","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S1470-2045(04)01529-3","article-title":"The present and future role of photodynamic therapy in cancer treatment","volume":"5","author":"Brown","year":"2004","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.pdpdt.2014.07.003_bib0035","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1039\/B915149B","article-title":"The role of porphyrin chemistry in tumor imaging and photodynamic therapy","volume":"40","author":"Ethirajan","year":"2011","journal-title":"Chem Soc Rev"},{"key":"10.1016\/j.pdpdt.2014.07.003_bib0040","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1039\/c0cc03984e","article-title":"Stirring the porphyrin alphabet soup \u2013 functionalization reactions for porphyrins","volume":"47","author":"Senge","year":"2011","journal-title":"Chem Commun"},{"key":"10.1016\/j.pdpdt.2014.07.003_bib0045","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1142\/S1088424611003653","article-title":"Silica nanoparticles functionalized with porphyrins and analogs for biomedical studies","volume":"15","author":"Figueira","year":"2011","journal-title":"J Porphyr Phthalocyanines"},{"key":"10.1016\/j.pdpdt.2014.07.003_bib0050","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.pdpdt.2010.12.001","article-title":"Nanodrug applications in photodynamic therapy","volume":"8","author":"Paszko","year":"2011","journal-title":"Photodiagn Photodyn Ther"},{"key":"10.1016\/j.pdpdt.2014.07.003_bib0055","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1016\/S0968-0896(03)00050-6","article-title":"Synthesis, cellular internalization and photodynamic activity of glucoconjugated derivatives of tri and tetra(meta-hydroxyphenyl)chlorins","volume":"11","author":"Laville","year":"2003","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.pdpdt.2014.07.003_bib0060","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1021\/bc5000324","article-title":"Regioselective and stoichiometrically controlled conjugation of photodynamic sensitizers to a HER2 targeting antibody fragment","volume":"25","author":"Bryden","year":"2014","journal-title":"Bioconjugate Chem"},{"key":"10.1016\/j.pdpdt.2014.07.003_bib0065","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.jconrel.2011.08.025","article-title":"Photochemical internalisation of a macromolecular protein toxin using a cell penetrating peptide\u2013photosensitiser conjugate","volume":"157","author":"Wang","year":"2012","journal-title":"J Control Release"},{"key":"10.1016\/j.pdpdt.2014.07.003_bib0070","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1016\/j.bmcl.2013.03.040","article-title":"Synthesis of Foscan\u00ae bile acid conjugates for potential use in photodynamic therapy","volume":"23","author":"Rogers","year":"2013","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.pdpdt.2014.07.003_bib0075","doi-asserted-by":"crossref","first-page":"3867","DOI":"10.1021\/jm800125a","article-title":"Improvement of meta-tetra(hydroxyphenyl)chlorin-like photosensitizer selectivity with folate-based targeted delivery. Synthesis and in vivo delivery studies","volume":"51","author":"Gravier","year":"2008","journal-title":"J Med Chem"},{"key":"10.1016\/j.pdpdt.2014.07.003_bib0080","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.pdpdt.2011.10.001","article-title":"Lead structures for applications in photodynamic therapy. Part 4. mTHPC \u2013 a drug on its way from second to third generation photosensitizer?","volume":"9","author":"Senge","year":"2012","journal-title":"Photodiagn Photodyn Ther"},{"key":"10.1016\/j.pdpdt.2014.07.003_bib0085","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1039\/b311900a","article-title":"Photodynamic therapy: a new antimicrobial approach to infectious disease?","volume":"3","author":"Hamblin","year":"2004","journal-title":"Photochem Photobiol Sci"},{"key":"10.1016\/j.pdpdt.2014.07.003_bib0090","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.jphotochem.2011.01.002","article-title":"Water-soluble phosphorus porphyrins with high activity for visible light-assisted inactivation of Saccharomyces cerevisiae","volume":"218","author":"Matsumoto","year":"2011","journal-title":"J Photochem Photobiol A: Chem"},{"key":"10.1016\/j.pdpdt.2014.07.003_bib0095","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1021\/ic00031a011","article-title":"Preparation of group-15 (phosphorous, antimony, and bismuth) complexes of meso-tetra-para-tolylporphyrin (TTP) and X-ray crystal structure of [Sb(TTP)(OCH(CH3)2)2]Cl","volume":"31","author":"Barbour","year":"1992","journal-title":"Inorg Chem"},{"key":"10.1016\/j.pdpdt.2014.07.003_bib0100","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1021\/ar00075a002","article-title":"Metalloid porphyrins and phthalocyanines","volume":"15","author":"Sayer","year":"1982","journal-title":"Acc Chem Res"},{"key":"10.1016\/j.pdpdt.2014.07.003_bib0105","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.1016\/0277-5387(95)00552-8","article-title":"Synthesis and characterization of phosphorus complexes of meso-tetraphenylporphyrin (tpp), and X-ray crystal structure of [P(tpp)(OCH(CH3)2)2](+)Cl\u2212","volume":"15","author":"Cheng","year":"1996","journal-title":"Polyhedron"},{"key":"10.1016\/j.pdpdt.2014.07.003_bib0110","doi-asserted-by":"crossref","first-page":"3961","DOI":"10.1021\/ic00192a024","article-title":"Mechanism of electrochemical reduction of the (5,10,5,20-tetraphenylporphinato)dihydroxophosphorous(V) cation","volume":"23","author":"Marrese","year":"1984","journal-title":"Inorg Chem"},{"key":"10.1016\/j.pdpdt.2014.07.003_bib0115","doi-asserted-by":"crossref","first-page":"5553","DOI":"10.1021\/ic010595e","article-title":"Synthesis, structure, electrochemistry, and spectroelectrochemistry of hypervalent phosphorus(V) octaethylporphyrins and theoretical analysis of the nature of the PO bond in P(OEP)(CH2CH3)(O)","volume":"40","author":"Akiba","year":"2001","journal-title":"Inorg Chem"},{"key":"10.1016\/j.pdpdt.2014.07.003_bib0120","doi-asserted-by":"crossref","first-page":"8287","DOI":"10.1021\/ja00136a034","volume":"117","author":"Yamamoto","year":"1995","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.pdpdt.2014.07.003_bib0125","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S1572-1000(05)00065-7","article-title":"Lipophilic cationic porphyrins as photodynamic sensitisers \u2013 synthesis and structure\u2013activity relationships","volume":"2","author":"Hudson","year":"2005","journal-title":"Photodiagn Photodyn Ther"},{"key":"10.1016\/j.pdpdt.2014.07.003_bib0130","doi-asserted-by":"crossref","first-page":"e70653","DOI":"10.1371\/journal.pone.0070653","article-title":"High content screening as high quality assay for biological evaluation of photosensitizers in vitro","volume":"8","author":"Vaz","year":"2013","journal-title":"PLOS ONE"},{"key":"10.1016\/j.pdpdt.2014.07.003_bib0135","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1039\/b311164b","article-title":"Photodynamic therapy in oesophageal carcinoma: an overview","volume":"3","author":"Mitton","year":"2004","journal-title":"Photochem Photobiol Sci"},{"key":"10.1016\/j.pdpdt.2014.07.003_bib0140","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1002\/1097-0142(19930801)72:3<649::AID-CNCR2820720305>3.0.CO;2-L","article-title":"Characterization of cell lines established from human gastric esophageal adenocarcinomas \u2013 biological phenotype and invasion potential","volume":"72","author":"Altorki","year":"1993","journal-title":"Cancer"},{"key":"10.1016\/j.pdpdt.2014.07.003_bib0145","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/bjc.1997.42","article-title":"Five newly established oesophageal carcinoma cell lines: phenotypic and immunological characterization","volume":"75","author":"Rockett","year":"1997","journal-title":"Br J Cancer"}],"container-title":["Photodiagnosis and Photodynamic Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100014000945?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100014000945?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:24:17Z","timestamp":1761611057000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1572100014000945"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["S1572100014000945"],"URL":"https:\/\/doi.org\/10.1016\/j.pdpdt.2014.07.003","relation":{},"ISSN":["1572-1000"],"issn-type":[{"value":"1572-1000","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lead structures for applications in photodynamic therapy. 5. Synthesis and biological evaluation of water soluble phosphorus(V) 5,10,15,20-tetraalkylporphyrins for PDT","name":"articletitle","label":"Article Title"},{"value":"Photodiagnosis and Photodynamic Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pdpdt.2014.07.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}