{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:49:59Z","timestamp":1792082999834,"version":"4.4.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["12nm0501800"],"award-info":[{"award-number":["12nm0501800"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Photodiagnosis and Photodynamic Therapy"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1016\/j.pdpdt.2015.06.007","type":"journal-article","created":{"date-parts":[[2015,6,23]],"date-time":"2015-06-23T20:37:41Z","timestamp":1435091861000},"page":"188-195","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["A new LED device used for photodynamic therapy in treatment of moderate to severe acne vulgaris"],"prefix":"10.1016","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6612-1882","authenticated-orcid":false,"given":"Yiyun","family":"Dong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoyu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyue","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao","family":"Jianxin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.pdpdt.2015.06.007_bib0170","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s00105-012-2467-z","article-title":"Isotretinoin: how should it be used?","volume":"64","author":"Thielitz","year":"2013","journal-title":"Hautarzt"},{"issue":"2","key":"10.1016\/j.pdpdt.2015.06.007_bib0175","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jaad.2009.09.056","article-title":"Photodynamic therapy for acne vulgaris: a critical review from basics to clinical practice: part i. acne vulgaris: when and why consider photodynamic therapy?","volume":"63","author":"Sakamoto","year":"2010","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.pdpdt.2015.06.007_bib0180","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1159\/000017869","article-title":"Bacterial resistance in acne [G]","volume":"196","author":"Eady","year":"1998","journal-title":"Dermatology"},{"issue":"9813","key":"10.1016\/j.pdpdt.2015.06.007_bib0185","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0140-6736(11)60321-8","article-title":"Acne vulgaris","volume":"379","author":"Williams","year":"2012","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.pdpdt.2015.06.007_bib0190","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1046\/j.1523-1747.2000.00046.x","article-title":"Topical ALA-photodynamic therapy for the treatment of acne vulgaris","volume":"115","author":"Hongcharu","year":"2000","journal-title":"J. Investig. Dermatol."},{"issue":"2","key":"10.1016\/j.pdpdt.2015.06.007_bib0195","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1046\/j.1365-2133.2001.04013.x","article-title":"Killing of cutaneous microbial species by photodynamic therapy","volume":"144","author":"Zeina","year":"2001","journal-title":"Br. J. Dermatol."},{"issue":"1","key":"10.1016\/j.pdpdt.2015.06.007_bib0200","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.det.2006.09.014","article-title":"The use of photodynamic therapy for treatment of acne vulgaris","volume":"25","author":"Nestor","year":"2007","journal-title":"Dermatol. Clin."},{"issue":"10","key":"10.1016\/j.pdpdt.2015.06.007_bib0205","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1002\/1520-6017(200010)89:10<1335::AID-JPS11>3.0.CO;2-#","article-title":"Degradation mechanism and stability of 5-aminolevulinic acid","volume":"89","author":"Bunke","year":"2000","journal-title":"J. Pharm. Sci."},{"issue":"3","key":"10.1016\/j.pdpdt.2015.06.007_bib0210","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1111\/j.1365-2133.2004.06110.x","article-title":"Topical aminolaevulinic acid-photodynamic therapy for the treatment of acnevulgaris: a study of clinical efficacy and mechanism of action","volume":"151","author":"Pollock","year":"2004","journal-title":"Br. J. Dermatol."},{"issue":"3","key":"10.1016\/j.pdpdt.2015.06.007_bib0215","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1468-3083.2007.02503.x","article-title":"Evidence-based review of lasers, light sources and photodynamic therapy in the treatment of acne vulgaris","volume":"22","author":"Haedersdal","year":"2008","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"issue":"5","key":"10.1016\/j.pdpdt.2015.06.007_bib0220","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1177\/120347541201600509","article-title":"Prospective study of topical 5-aminolevulinic acid photodynamic therapy for the treatment of moderate to severe acne vulgaris in Chinese patients","volume":"16","author":"Wang","year":"2012","journal-title":"J. Cutan. Med. Surg."},{"issue":"4","key":"10.1016\/j.pdpdt.2015.06.007_bib0225","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.pdpdt.2011.07.003","article-title":"Successful treatment of refractory facial acne using repeat short-cycle ALA-PDT: case study","volume":"8","author":"Ding","year":"2011","journal-title":"Photodiagnosis Photodyn. Ther."},{"issue":"4","key":"10.1016\/j.pdpdt.2015.06.007_bib0230","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.pdpdt.2013.06.007","article-title":"Low-dose topical 5-aminolevulinic acid photodynamic therapy in the treatment of different severity of acne vulgaris","volume":"10","author":"Ma","year":"2013","journal-title":"Photodiagnosis Photodyn. Ther."},{"issue":"5\u20136","key":"10.1016\/j.pdpdt.2015.06.007_bib0235","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1600-0781.1997.tb00226.x","article-title":"Green light is effective and less painful than red light in photodynamic therapy of facial solar keratoses","volume":"13","author":"Fritsch","year":"1997","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"issue":"2","key":"10.1016\/j.pdpdt.2015.06.007_bib0240","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1046\/j.1523-1747.2000.00046.x","article-title":"Topical ALA-photodynamic therapy for the treatment of acne vulgaris","volume":"115","author":"Hongcharu","year":"2000","journal-title":"J. Invest. Dermatol."},{"issue":"1\u20132","key":"10.1016\/j.pdpdt.2015.06.007_bib0245","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1615\/JEnvironPatholToxicolOncol.v25.i1-2.270","article-title":"Fluorescence diagnosis and photodynamic therapy in dermatology from experimental state to clinic standard methods","volume":"25","author":"Fritsch","year":"2006","journal-title":"J. Environ. Pathol. Toxicol. Oncol."},{"issue":"3","key":"10.1016\/j.pdpdt.2015.06.007_bib0250","first-page":"277","article-title":"Lasers and photodynamic therapy for the treatment of acne","volume":"147","author":"Ferris","year":"2012","journal-title":"Gironale Ital. Dermatol. Venereol."},{"issue":"5","key":"10.1016\/j.pdpdt.2015.06.007_bib0255","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1111\/j.1365-4632.2012.05673.x","article-title":"Acne treatment by methyl aminolevulinate photodynamic therapy with red light vs. intense pulsed light","volume":"52","author":"Hong","year":"2013","journal-title":"Int. J. Dermatol."},{"issue":"8","key":"10.1016\/j.pdpdt.2015.06.007_bib0260","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1097\/00042728-200508000-00004","article-title":"Effectiveness of photodynamic therapy with topical 5-aminolevulinic acid and intense pulsed light versus intense pulsed light alone in the treatment of acne vulgaris: comparative study","volume":"31","author":"Santos","year":"2005","journal-title":"Dermatol. Surg."},{"issue":"3","key":"10.1016\/j.pdpdt.2015.06.007_bib0265","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.pdpdt.2014.05.004","article-title":"A commentary on the role of skin temperature on the effectiveness of ALA-PDT in dermatology","volume":"11","author":"Mordon","year":"2014","journal-title":"Photodiagnosis Photodyn. Ther."},{"issue":"5","key":"10.1016\/j.pdpdt.2015.06.007_bib0270","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/phpp.12059","article-title":"Short-term clinical effects of photodynamic therapy with topical 5-aminolevulinic acid for facial acne conglobata: an open, prospective, parallel-arm trial","volume":"29","author":"Yang","year":"2013","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"issue":"13","key":"10.1016\/j.pdpdt.2015.06.007_bib0275","first-page":"1167","article-title":"Evidence-based review of photodynamic therapy in the treatment of acne","volume":"5","author":"Zheng","year":"2014","journal-title":"Eur. J. Dermatol."},{"key":"10.1016\/j.pdpdt.2015.06.007_bib0280","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/lsm.20469","article-title":"A comparative study of intense pulsed light alone and its combination with photodynamic therapy for the treatment of facial acne in Asian skin","volume":"39","author":"Yeung","year":"2007","journal-title":"Lasers Surg. Med."},{"key":"10.1016\/j.pdpdt.2015.06.007_bib0285","first-page":"991","article-title":"Treatment of inflammatory facial acne vulgaris with intense pulsed light and short contact of topical 5-aminolevulinic acid: a pilot study","volume":"32","author":"Rojanamatin","year":"2006","journal-title":"Dermatol. Surg."},{"key":"10.1016\/j.pdpdt.2015.06.007_bib0290","first-page":"1010","article-title":"A comparison of intense pulsed light, combination radiofrequency and intense pulsed light, and blue light in photodynamic therapy for acne vulgaris","volume":"6","author":"Taub","year":"2007","journal-title":"J. Drugs Dermatol."},{"issue":"3","key":"10.1016\/j.pdpdt.2015.06.007_bib0295","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.pdpdt.2014.04.004","article-title":"Experimental use of photodynamic therapy in high grade gliomas: a review focused on 5-aminolevulinic acid","volume":"11","author":"Tetard","year":"2014","journal-title":"Photodiagnosis Photodyn. Ther."},{"issue":"5","key":"10.1016\/j.pdpdt.2015.06.007_bib0300","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1111\/j.1365-2133.2010.09860.x","article-title":"Investigation of optimal aminolaevulinic acid concentration applied in topical aminolaevulinic acid-photodynamic therapy for treatment of moderate to severe acne: a pilot study in Chinese subjects","volume":"163","author":"Yin","year":"2010","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.pdpdt.2015.06.007_bib0305","first-page":"1","article-title":"Acne vulgaris and light-based therapies","author":"Sophie","year":"2014","journal-title":"J. Cosmet. Laser Ther."},{"issue":"4","key":"10.1016\/j.pdpdt.2015.06.007_bib0310","first-page":"1477","article-title":"Photodynamic therapy in dermatology: current treatments and implications","volume":"36","author":"Kostovi\u0107","year":"2012","journal-title":"Coll. Antropol."},{"issue":"1","key":"10.1016\/j.pdpdt.2015.06.007_bib0315","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1600-0781.2009.00399.x","article-title":"Acne-photodynamic therapy with intra-lesional injection of 5-aminolevulinic acid","volume":"25","author":"Ryou","year":"2009","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"issue":"4","key":"10.1016\/j.pdpdt.2015.06.007_bib0320","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.sder.2011.08.001","article-title":"Photodynamic therapy: current evidence and applications in dermatology","volume":"30","author":"Lee","year":"2011","journal-title":"Semin. Cutan. Med. Surg."},{"key":"10.1016\/j.pdpdt.2015.06.007_bib0325","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.jaad.2009.09.057","article-title":"Photodynamic therapy for acne vulgaris: a critical review from basics to clinical practice: part II. Understanding parameters for acne treatment with photodynamic therapy","volume":"63","author":"Sakamoto","year":"2010","journal-title":"J. Am. Acad. Dermatol."},{"issue":"1","key":"10.1016\/j.pdpdt.2015.06.007_bib0330","first-page":"1","article-title":"Improve efficacy of topical ALA-PDT by calcipotriol through up-regulation of coproporphyrinogen oxidase","volume":"5","author":"Yang","year":"2014","journal-title":"Photodiagnosis Photodyn. Ther."}],"container-title":["Photodiagnosis and Photodynamic Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100015000770?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100015000770?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:27:48Z","timestamp":1761611268000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1572100015000770"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":33,"alternative-id":["S1572100015000770"],"URL":"https:\/\/doi.org\/10.1016\/j.pdpdt.2015.06.007","relation":{},"ISSN":["1572-1000"],"issn-type":[{"value":"1572-1000","type":"print"}],"subject":[],"published":{"date-parts":[[2016,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A new LED device used for photodynamic therapy in treatment of moderate to severe acne vulgaris","name":"articletitle","label":"Article Title"},{"value":"Photodiagnosis and Photodynamic Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pdpdt.2015.06.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}