{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T01:51:08Z","timestamp":1773280268097,"version":"3.50.1"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Photodiagnosis and Photodynamic Therapy"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.pdpdt.2016.08.009","type":"journal-article","created":{"date-parts":[[2016,9,9]],"date-time":"2016-09-09T20:05:55Z","timestamp":1473451555000},"page":"76-84","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Efficacy of scaling and root planing with and without adjunct antimicrobial photodynamic therapy on the expression of cytokines in the gingival crevicular fluid of patients with periodontitis: A systematic review"],"prefix":"10.1016","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0760-841X","authenticated-orcid":false,"given":"Sergio Varela","family":"Kellesarian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa Ros","family":"Malignaggi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tariq","family":"Abduljabbar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fahim","family":"Vohra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Malmstrom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgios E.","family":"Romanos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fawad","family":"Javed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pdpdt.2016.08.009_bib0005","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1902\/jop.2008.080213","article-title":"Mapping the pathogenesis of periodontitis: a new look","volume":"79","author":"Kornman","year":"2008","journal-title":"J. Periodontol."},{"key":"10.1016\/j.pdpdt.2016.08.009_bib0010","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1600-051X.1998.tb02419.x","article-title":"Microbial complexes in subgingival plaque","volume":"25","author":"Socransky","year":"1998","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.pdpdt.2016.08.009_bib0015","doi-asserted-by":"crossref","first-page":"27327","DOI":"10.3390\/ijms161126027","article-title":"The in vitro antimicrobial efficacy of PDT against periodontopathogenic bacteria","volume":"16","author":"Haag","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.pdpdt.2016.08.009_bib0020","first-page":"766","article-title":"Understanding and treatment strategy of the pathogenesis of periodontal disease based on chronic inflammation","volume":"26","author":"Murakami","year":"2016","journal-title":"Clin. Calcium"},{"key":"10.1016\/j.pdpdt.2016.08.009_bib0025","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.archoralbio.2016.06.010","article-title":"Macrophage activating factor: a potential biomarker of periodontal health status","volume":"70","author":"Zhang","year":"2016","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.pdpdt.2016.08.009_bib0030","article-title":"The effects of tumour necrosis factor-alpha on bone cells involved in periodontal alveolar bone loss; osteoclasts, osteoblasts and osteocytes","author":"Algate","year":"2015","journal-title":"J. Periodontal Res."},{"key":"10.1016\/j.pdpdt.2016.08.009_bib0035","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1111\/jcpe.12286","article-title":"Cytokine gene expression profiles during initiation, progression and resolution of periodontitis","volume":"41","author":"Ebersole","year":"2014","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.pdpdt.2016.08.009_bib0040","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/jre.12179","article-title":"Evaluation of gingival crevicular fluid levels of tissue plasminogen activator, plasminogen activator inhibitor 2, matrix metalloproteinase-3 and interleukin 1-beta in patients with different periodontal diseases","volume":"50","author":"Toyman","year":"2015","journal-title":"J. Periodontal Res."},{"key":"10.1016\/j.pdpdt.2016.08.009_bib0045","article-title":"Interleukin-32 levels in gingival crevicular fluid and saliva of patients with chronic periodontitis after periodontal treatment","author":"Ongoz Dede","year":"2016","journal-title":"J. Periodontal Res."},{"issue":"Suppl. 2","key":"10.1016\/j.pdpdt.2016.08.009_bib0050","first-page":"6","article-title":"Clinical significance of non-surgical periodontal therapy: an evidence-based perspective of scaling and root planing","volume":"29","author":"Cobb","year":"2002","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.pdpdt.2016.08.009_bib0055","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1902\/annals.1996.1.1.443","article-title":"Non-surgical pocket therapy: mechanical","volume":"1","author":"Cobb","year":"1996","journal-title":"Ann. Periodontol."},{"key":"10.1016\/j.pdpdt.2016.08.009_bib0060","doi-asserted-by":"crossref","DOI":"10.1002\/lsm.22483","article-title":"Effect of Nd:YAG laser-assisted non-surgical periodontal therapy on clinical periodontal and serum biomarkers in patients with and without coronary artery disease: a short-term pilot study","author":"Javed","year":"2016","journal-title":"Lasers Surg. Med."},{"key":"10.1016\/j.pdpdt.2016.08.009_bib0065","doi-asserted-by":"crossref","first-page":"121","DOI":"10.4103\/0970-9290.183130","article-title":"Clinical effects of photodynamic and low-level laser therapies as an adjunct to scaling and root planing of chronic periodontitis: a split-mouth randomized controlled clinical trial","volume":"27","author":"Malgikar","year":"2016","journal-title":"Indian J. Dent. Res."},{"key":"10.1016\/j.pdpdt.2016.08.009_bib0070","first-page":"Zc08","article-title":"Efficacy of photodynamic therapy and lasers as an adjunct to scaling and root planing in the treatment of aggressive periodontitis\u2014a clinical and microbiologic short term study","volume":"10","author":"Annaji","year":"2016","journal-title":"JCDR"},{"key":"10.1016\/j.pdpdt.2016.08.009_bib0075","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1902\/jop.2014.140392","article-title":"Antimicrobial photodynamic therapy as an adjunct to non-surgical treatment of aggressive periodontitis: a split-mouth randomized controlled trial","volume":"86","author":"Moreira","year":"2015","journal-title":"J. Periodontol."},{"key":"10.1016\/j.pdpdt.2016.08.009_bib0080","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1007\/s10103-013-1379-1","article-title":"Adjunctive effect of antimicrobial photodynamic therapy to nonsurgical periodontal treatment in smokers: a randomized clinical trial","volume":"30","author":"Queiroz","year":"2015","journal-title":"Lasers Med. Sci."},{"key":"10.1016\/j.pdpdt.2016.08.009_bib0085","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1111\/jcpe.12121","article-title":"Photodynamic therapy in the treatment of class II furcation: a randomized controlled clinical trial","volume":"40","author":"Luchesi","year":"2013","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.pdpdt.2016.08.009_bib0090","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1089\/pho.2012.3328","article-title":"Effects of antimicrobial photodynamic therapy on transforming growth factor-beta1 levels in the gingival crevicular fluid","volume":"31","author":"Souza","year":"2013","journal-title":"Photomed. Laser Surg."},{"key":"10.1016\/j.pdpdt.2016.08.009_bib0095","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.1600-0765.2010.01316.x","article-title":"Combined photodynamic and low-level laser therapies as an adjunct to nonsurgical treatment of chronic periodontitis","volume":"46","author":"Lui","year":"2011","journal-title":"J. Periodontal Res."},{"key":"10.1016\/j.pdpdt.2016.08.009_bib0100","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1902\/jop.2014.130464","article-title":"Effects of photodynamic therapy on clinical and gingival crevicular fluid inflammatory biomarkers in chronic periodontitis: a split-mouth randomized clinical trial","volume":"85","author":"Pourabbas","year":"2014","journal-title":"J. Periodontol."},{"key":"10.1016\/j.pdpdt.2016.08.009_bib0105","doi-asserted-by":"crossref","first-page":"e1000097","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"6","author":"Moher","year":"2009","journal-title":"PLoS Med."},{"key":"10.1016\/j.pdpdt.2016.08.009_bib0110","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1002\/sim.2945","article-title":"Modelling patterns of agreement for nominal scales","volume":"27","author":"Roberts","year":"2008","journal-title":"Stat Med."},{"key":"10.1016\/j.pdpdt.2016.08.009_bib0115","doi-asserted-by":"crossref","first-page":"657","DOI":"10.7326\/0003-4819-134-8-200104170-00011","article-title":"The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomized trials","volume":"134","author":"Moher","year":"2001","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.pdpdt.2016.08.009_bib0120","series-title":"Cochrane Handbook for Systematic Reviews of Interventions","author":"Higgins","year":"2008"},{"key":"10.1016\/j.pdpdt.2016.08.009_bib0125","first-page":"10","article-title":"Effect of photodynamic therapy on IL-1beta and MMP-8 in gingival crevicular fluid of chronic periodontitis","volume":"17","author":"Ge","year":"2008","journal-title":"Shanghai Kou Qiang Yi Xue"},{"key":"10.1016\/j.pdpdt.2016.08.009_bib0130","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/jcpe.12094","article-title":"Adjunctive photodynamic therapy to non-surgical treatment of chronic periodontitis: a systematic review and meta-analysis","volume":"40","author":"Sgolastra","year":"2013","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.pdpdt.2016.08.009_bib0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2016.04.015","article-title":"Efficacy of periimplant mechanical debridement with and without adjunct antimicrobial photodynamic therapy in patients with type 2 diabetes mellitus","author":"Al Amri","year":"2016","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2016.08.009_bib0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2016.06.007","article-title":"Is mechanical curettage with adjunct photodynamic therapy more effective in the treatment of peri-implantitis than mechanical curettage alone?","author":"Ghanem","year":"2016","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2016.08.009_bib0145","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1562\/0031-8655(2000)072<0676:TEOPAO>2.0.CO;2","article-title":"The effect of photodynamic action on two virulence factors of gram-negative bacteria","volume":"72","author":"Komerik","year":"2000","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.pdpdt.2016.08.009_bib0150","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1007\/s10495-010-0479-7","article-title":"Photodynamic therapy: illuminating the road from cell death towards anti-tumour immunity","volume":"15","author":"Garg","year":"2010","journal-title":"Apoptosis"},{"key":"10.1016\/j.pdpdt.2016.08.009_bib0155","doi-asserted-by":"crossref","first-page":"103","DOI":"10.5978\/islsm.15-OR-09","article-title":"Lethal effect of blue light-activated hydrogen peroxide, curcumin and erythrosine as potential oral photosensitizers on the viability of Porphyromonas gingivalis and Fusobacterium nucleatum","volume":"24","author":"Mahdi","year":"2015","journal-title":"Laser Ther."},{"key":"10.1016\/j.pdpdt.2016.08.009_bib0160","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.pdpdt.2016.02.007","article-title":"Antimicrobial photodynamic therapy using diode laser activated indocyanine green as an adjunct in the treatment of chronic periodontitis: a randomized clinical trial","volume":"14","author":"Monzavi","year":"2016","journal-title":"Photodiagn. Photodyn. Ther."}],"container-title":["Photodiagnosis and Photodynamic Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100016301533?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100016301533?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:25:12Z","timestamp":1761611112000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1572100016301533"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":32,"alternative-id":["S1572100016301533"],"URL":"https:\/\/doi.org\/10.1016\/j.pdpdt.2016.08.009","relation":{},"ISSN":["1572-1000"],"issn-type":[{"value":"1572-1000","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy of scaling and root planing with and without adjunct antimicrobial photodynamic therapy on the expression of cytokines in the gingival crevicular fluid of patients with periodontitis: A systematic review","name":"articletitle","label":"Article Title"},{"value":"Photodiagnosis and Photodynamic Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pdpdt.2016.08.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}