{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:38:06Z","timestamp":1786995486718,"version":"build-2736575974"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Photodiagnosis and Photodynamic Therapy"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.pdpdt.2017.01.183","type":"journal-article","created":{"date-parts":[[2017,2,7]],"date-time":"2017-02-07T23:16:09Z","timestamp":1486509369000},"page":"119-127","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"special_numbering":"C","title":["Clinical efficacy of photodynamic therapy adjunctive to scaling and root planing in the treatment of chronic periodontitis: A systematic review and meta-analysis"],"prefix":"10.1016","volume":"18","author":[{"given":"Dong","family":"Xue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhao","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengcheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pdpdt.2017.01.183_bib0005","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/prd.12104","article-title":"Molecular aspects of the pathogenesis of periodontitis","volume":"69","author":"Meyle","year":"2015","journal-title":"Periodontol. 2000"},{"key":"10.1016\/j.pdpdt.2017.01.183_bib0010","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/j.1600-0757.2010.00370.x","article-title":"Relationship between periodontal disease and diabetes mellitus: an Asian perspective","volume":"56","author":"Taiyeb-Ali","year":"2011","journal-title":"Periodontol. 2000"},{"key":"10.1016\/j.pdpdt.2017.01.183_bib0015","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.1600-0757.2010.00368.x","article-title":"Influence of periodontal intervention therapy on risk of cardiovascular disease","volume":"56","author":"Ouyang","year":"2011","journal-title":"Periodontol. 2000"},{"key":"10.1016\/j.pdpdt.2017.01.183_bib0020","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1902\/jop.2011.100582","article-title":"Association between respiratory disease in hospitalized patients and periodontal disease: a cross-sectional study","volume":"82","author":"Sharma","year":"2011","journal-title":"J. Periodontol."},{"key":"10.1016\/j.pdpdt.2017.01.183_bib0025","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1600-051X.2009.01503.x","article-title":"Maternal periodontitis and the causes of preterm birth: the case-control Epipap study","volume":"37","author":"Nabet","year":"2010","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.pdpdt.2017.01.183_bib0030","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1177\/0022034512457373","article-title":"Prevalence of periodontitis in adults in the United States: 2009 and 2010","volume":"91","author":"Eke","year":"2012","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.pdpdt.2017.01.183_bib0035","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1111\/jcpe.12047","article-title":"Comprehensive microbiological findings in peri-implantitis and periodontitis","volume":"40","author":"Koyanagi","year":"2013","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.pdpdt.2017.01.183_bib0040","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1902\/jop.1990.61.1.3","article-title":"The effectiveness of subgingival scaling and root planing. I. Clinical detection of residual calculus","volume":"61","author":"Sherman","year":"1990","journal-title":"J. Periodontol."},{"key":"10.1016\/j.pdpdt.2017.01.183_bib0045","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/j.1600-0757.2004.03675.x","article-title":"Effects of nonsurgical periodontal therapy on the microbiota","volume":"36","author":"Umeda","year":"2004","journal-title":"Periodontol. 2000"},{"key":"10.1016\/j.pdpdt.2017.01.183_bib0050","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1902\/jop.2005.76.3.426","article-title":"Clinical response of azithromycin as an adjunct to non-surgical periodontal therapy in smokers","volume":"76","author":"Mascarenhas","year":"2005","journal-title":"J. Periodontol."},{"key":"10.1016\/j.pdpdt.2017.01.183_bib0055","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1902\/jop.2008.070493","article-title":"Moxifloxacin as an adjunctive antibiotic in the treatment of severe chronic periodontitis","volume":"79","author":"Guentsch","year":"2008","journal-title":"J. Periodontol."},{"key":"10.1016\/j.pdpdt.2017.01.183_bib0060","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1034\/j.1600-051X.29.s3.8.x","article-title":"A systematic review on the effect of systemic antimicrobials as an adjunct to scaling and root planing in periodontitis patients","volume":"29","author":"Herrera","year":"2002","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.pdpdt.2017.01.183_bib0065","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1600-0757.2010.00346.x","article-title":"Photodynamic therapy in the control of oral biofilm","volume":"55","author":"Soukos","year":"2011","journal-title":"Periodontol. 2000"},{"key":"10.1016\/j.pdpdt.2017.01.183_bib0070","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1177\/154405910708600803","article-title":"Photodynamic therapy in dentistry","volume":"86","author":"Konopka","year":"2007","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.pdpdt.2017.01.183_bib0075","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/lsm.10208","article-title":"Photodestruction of human dental plaque bacteria: Enhancement of the photodynamic effect by photomechanical waves in an oral biofilm model","volume":"33","author":"Soukos","year":"2003","journal-title":"Lasers Surg. Med."},{"key":"10.1016\/j.pdpdt.2017.01.183_bib0080","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1111\/jcpe.12249","article-title":"Efficacy of photodynamic therapy in the management of chronic periodontitis: a randomized controlled clinical trial","volume":"41","author":"Joseph","year":"2014","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.pdpdt.2017.01.183_bib0085","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1097\/01.id.0000433592.18679.91","article-title":"Photodynamic therapy to treat periimplantitis","volume":"22","author":"Bombeccari","year":"2013","journal-title":"Implant Dent."},{"key":"10.1016\/j.pdpdt.2017.01.183_bib0090","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/lsm.20415","article-title":"Antimicrobial photodynamic therapy combined with conventional endodontic treatment to eliminate root canal biofilm infection","volume":"39","author":"Garcez","year":"2007","journal-title":"Lasers Surg. Med."},{"key":"10.1016\/j.pdpdt.2017.01.183_bib0095","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/0003-9969(92)90058-G","article-title":"Sensitization of oral bacteria in biofilms to killing by light from a low-power laser","volume":"37","author":"Dobson","year":"1992","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.pdpdt.2017.01.183_bib0100","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s10103-010-0864-z","article-title":"The effect of a single episode of antimicrobial photodynamic therapy in the treatment of experimental periodontitis. Microbiological profile and cytokine pattern in the dog mandible","volume":"26","author":"Oliveira","year":"2011","journal-title":"Lasers Med. Sci."},{"key":"10.1016\/j.pdpdt.2017.01.183_bib0105","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1902\/jop.2010.090246","article-title":"Full-mouth antimicrobial photodynamic therapy in Fusobacterium nucleatum-infected periodontitis patients","volume":"81","author":"Sigusch","year":"2010","journal-title":"J. Periodontol."},{"key":"10.1016\/j.pdpdt.2017.01.183_bib0110","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/s10103-011-0942-x","article-title":"Clinical and microbiological effects of photodynamic therapy associated with nonsurgical periodontal treatment. A 6-month follow-up","volume":"27","author":"Theodoro","year":"2012","journal-title":"Lasers Med. Sci."},{"key":"10.1016\/j.pdpdt.2017.01.183_bib0115","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.adaj.2015.01.028","article-title":"Systematic review and meta-analysis on the nonsurgical treatment of chronic periodontitis by means of scaling and root planing with or without adjuncts","volume":"146","author":"Smiley","year":"2015","journal-title":"J. Am. Dent. Assoc."},{"key":"10.1016\/j.pdpdt.2017.01.183_bib0120","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1007\/s10103-009-0744-6","article-title":"Photodynamic therapy as an adjunctive treatment for chronic periodontitis: a meta-analysis","volume":"25","author":"Atieh","year":"2010","journal-title":"Lasers Med. Sci."},{"key":"10.1016\/j.pdpdt.2017.01.183_bib0125","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1902\/jop.2009.090285","article-title":"The effect of photodynamic therapy for periodontitis: a systematic review and meta-analysis","volume":"81","author":"Azarpazhooh","year":"2010","journal-title":"J. Periodontol."},{"key":"10.1016\/j.pdpdt.2017.01.183_bib0130","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/jcpe.12094","article-title":"Adjunctive photodynamic therapy to non-surgical treatment of chronic periodontitis: a systematic review and meta-analysis","volume":"40","author":"Sgolastra","year":"2013","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.pdpdt.2017.01.183_bib0135","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.ijsu.2010.02.007","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"8","author":"Moher","year":"2010","journal-title":"Int. J. Surg."},{"key":"10.1016\/j.pdpdt.2017.01.183_bib0140","article-title":"Cochrane Handbook for Systematic Reviews of Interventions, Version 5.1.0","year":"2009"},{"key":"10.1016\/j.pdpdt.2017.01.183_bib0145","doi-asserted-by":"crossref","first-page":"820","DOI":"10.7326\/0003-4819-127-9-199711010-00008","article-title":"Quantitative synthesis in systematic reviews","volume":"127","author":"Lau","year":"1997","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.pdpdt.2017.01.183_bib0150","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis","volume":"21","author":"Higgins","year":"2002","journal-title":"Stat. Med."},{"key":"10.1016\/j.pdpdt.2017.01.183_bib0155","first-page":"34","article-title":"Treatment of periodontal disease by photodisinfection compared to scaling and root planing","volume":"18","author":"Andersen","year":"2007","journal-title":"J. Clin. Dent."},{"key":"10.1016\/j.pdpdt.2017.01.183_bib0160","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1111\/j.1600-051X.2008.01303.x","article-title":"Short-term clinical effects of adjunctive antimicrobial photodynamic therapy in periodontal treatment: a randomized clinical trial","volume":"35","author":"Braun","year":"2008","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.pdpdt.2017.01.183_bib0165","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1902\/jop.2008.070652","article-title":"Photodynamic therapy as an adjunct to non-surgical periodontal treatment: a randomized, controlled clinical trial","volume":"79","author":"Christodoulides","year":"2008","journal-title":"J. Periodontol."},{"key":"10.1016\/j.pdpdt.2017.01.183_bib0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1746-160X-8-12","article-title":"Comparison between scaling-root-planing (SRP) and SRP\/photodynamic therapy: six-month study","volume":"8","author":"Berakdar","year":"2012","journal-title":"Head Face Med."},{"key":"10.1016\/j.pdpdt.2017.01.183_bib0175","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/jcpe.12024","article-title":"Photoactivated disinfection using light-emitting diode as an adjunct in the management of chronic periodontitis: a pilot double-blind split-mouth randomized clinical trial","volume":"40","author":"Bassir","year":"2013","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.pdpdt.2017.01.183_bib0180","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1007\/s10103-013-1426-y","article-title":"Long-term clinical effect of adjunctive antimicrobial photodynamic therapy in periodontal treatment: a randomized clinical trial","volume":"30","author":"Alwaeli","year":"2013","journal-title":"Lasers Med. Sci."},{"key":"10.1016\/j.pdpdt.2017.01.183_bib0185","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1902\/jop.2012.120096","article-title":"Clinical effects of potassium-titanyl-phosphate laser and photodynamic therapy on outcomes of treatment of chronic periodontitis: a randomized controlled clinical trial","volume":"84","author":"Dilsiz","year":"2013","journal-title":"J. Periodontol."},{"key":"10.1016\/j.pdpdt.2017.01.183_bib0190","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1902\/jop.2014.130464","article-title":"Effects of photodynamic therapy on clinical and gingival crevicular fluid inflammatory biomarkers in chronic periodontitis: a split-mouth randomized clinical trial","volume":"85","author":"Pourabbas","year":"2014","journal-title":"J. Periodontol."},{"key":"10.1016\/j.pdpdt.2017.01.183_bib0195","doi-asserted-by":"crossref","first-page":"112","DOI":"10.15171\/jlms.2015.04","article-title":"Effect of nonsurgical periodontal treatment combined with diode laser or photodynamic therapy on chronic periodontitis: a randomized controlled split-mouth clinical trial","volume":"6","author":"Birang","year":"2015","journal-title":"Lasers Med. Sci."},{"key":"10.1016\/j.pdpdt.2017.01.183_bib0200","doi-asserted-by":"crossref","first-page":"75","DOI":"10.4103\/0976-2868.170562","article-title":"A randomized controlled clinical trial on efficacy of photodynamic therapy as an adjunct to nonsurgical treatment of chronic periodontitis","volume":"9","author":"Malgikar","year":"2015","journal-title":"J. Dent. Lasers"},{"key":"10.1016\/j.pdpdt.2017.01.183_bib0205","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1007\/s10103-013-1379-1","article-title":"Adjunctive effect of antimicrobial photodynamic therapy to nonsurgical periodontal treatment in smokers: a randomized clinical trial","volume":"30","author":"Queiroz","year":"2015","journal-title":"Lasers Med. Sci."},{"key":"10.1016\/j.pdpdt.2017.01.183_bib0210","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1111\/j.1600-051X.2008.01245.x","article-title":"Influence of residual pockets on progression of periodontitis and tooth loss: results after 11 years of maintenance","volume":"35","author":"Matuliene","year":"2008","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.pdpdt.2017.01.183_bib0215","first-page":"87","article-title":"Antimicrobial photodynamic therapy as an adjunctive modality in the treatment of chronic periodontitis","volume":"4","author":"Moslemi","year":"2012","journal-title":"Lasers Med. Sci."},{"key":"10.1016\/j.pdpdt.2017.01.183_bib0220","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1600-051X.2008.01261.x","article-title":"The cost-effectiveness of supportive periodontal care for patients with chronic periodontitis","volume":"35","author":"Gaunt","year":"2008","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.pdpdt.2017.01.183_bib0225","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1902\/jop.2007.060292","article-title":"Longitudinal study of the association between smoking as a periodontitis risk and salivary biomarkers related to periodontitis","volume":"78","author":"Kibayashi","year":"2007","journal-title":"J. Periodontol."},{"key":"10.1016\/j.pdpdt.2017.01.183_bib0230","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1111\/j.1600-051X.2007.01118.x","article-title":"Reported methodological quality of split-mouth studies","volume":"34","author":"Lesaffre","year":"2007","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.pdpdt.2017.01.183_bib0235","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1111\/j.1600-051X.2009.01432.x","article-title":"One-year outcomes of repeated adjunctive photodynamic therapy during periodontal maintenance: a proof-of-principle randomized-controlled clinical trial","volume":"36","author":"Lulic","year":"2009","journal-title":"J. Clin. Periodontol."}],"container-title":["Photodiagnosis and Photodynamic Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100016302228?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100016302228?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:28:55Z","timestamp":1761611335000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1572100016302228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":47,"alternative-id":["S1572100016302228"],"URL":"https:\/\/doi.org\/10.1016\/j.pdpdt.2017.01.183","relation":{},"ISSN":["1572-1000"],"issn-type":[{"value":"1572-1000","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical efficacy of photodynamic therapy adjunctive to scaling and root planing in the treatment of chronic periodontitis: A systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Photodiagnosis and Photodynamic Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pdpdt.2017.01.183","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}