{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T22:34:34Z","timestamp":1774737274496,"version":"3.50.1"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"King Saud University, Riyadh, Saudi Arabia","award":["ISPP#0075"],"award-info":[{"award-number":["ISPP#0075"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Photodiagnosis and Photodynamic Therapy"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.pdpdt.2017.02.010","type":"journal-article","created":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T05:46:37Z","timestamp":1487655997000},"page":"63-77","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Effect of laser-assisted scaling and root planing on the expression of pro-inflammatory cytokines in the gingival crevicular fluid of patients with chronic periodontitis: A systematic review"],"prefix":"10.1016","volume":"18","author":[{"given":"Sergio Varela","family":"Kellesarian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa Ros","family":"Malignaggi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasham Abdullah","family":"Majoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulaziz A.","family":"Al-Kheraif","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tammy Varela","family":"Kellesarian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgios E.","family":"Romanos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fawad","family":"Javed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pdpdt.2017.02.010_bib0005","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1002\/lsm.22483","article-title":"Effect of Nd:YAG laser-assisted non-surgical periodontal therapy on clinical periodontal and serum biomarkers in patients with and without coronary artery disease: a short-term pilot study","volume":"48","author":"Javed","year":"2016","journal-title":"Lasers Surg. Med."},{"issue":"5","key":"10.1016\/j.pdpdt.2017.02.010_bib0010","article-title":"Efficacy of scaling and root planing with and without adjunct antimicrobial photodynamic therapy on the expression of cytokines in the gingival crevicular fluid of patients with periodontitis: a systematic review","author":"Kellesarian","year":"2016","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2017.02.010_bib0015","doi-asserted-by":"crossref","DOI":"10.12968\/denu.2007.34.6.326","article-title":"Periodontics 3. Non-surgical periodontal therapy in general dental practice","volume":"34","author":"Mullally","year":"2007","journal-title":"Dent. Update"},{"issue":"Suppl. 2","key":"10.1016\/j.pdpdt.2017.02.010_bib0020","first-page":"6","article-title":"Clinical significance of non-surgical periodontal therapy: an evidence-based perspective of scaling and root planing","volume":"29","author":"Cobb","year":"2002","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.pdpdt.2017.02.010_bib0025","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1111\/j.1600-051X.2005.00749.x","article-title":"The short-term effects of low-level lasers as adjunct therapy in the treatment of periodontal inflammation","volume":"32","author":"Qadri","year":"2005","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.pdpdt.2017.02.010_bib0030","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1902\/jop.2010.100195","article-title":"The effect of low-level laser therapy as an adjunct to non-surgical periodontal treatment","volume":"82","author":"Aykol","year":"2011","journal-title":"J. Periodontol."},{"key":"10.1016\/j.pdpdt.2017.02.010_bib0035","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1089\/pho.2011.3069","article-title":"Effect of adjunctive low level laser therapy (LLLT) on nonsurgical treatment of chronic periodontitis","volume":"30","author":"Makhlouf","year":"2012","journal-title":"Photomed. Laser Surg."},{"key":"10.1016\/j.pdpdt.2017.02.010_bib0040","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s10103-012-1104-5","article-title":"Short-term clinical and osteoimmunological effects of scaling and root planing complemented by simple or repeated laser phototherapy in chronic periodontitis","volume":"28","author":"Calderin","year":"2013","journal-title":"Lasers Med. Sci."},{"key":"10.1016\/j.pdpdt.2017.02.010_bib0045","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s10103-012-1230-0","article-title":"Clinical and biochemical effects of diode laser as an adjunct to nonsurgical treatment of chronic periodontitis: a randomized, controlled clinical trial","volume":"29","author":"Saglam","year":"2014","journal-title":"Lasers Med. Sci."},{"key":"10.1016\/j.pdpdt.2017.02.010_bib0050","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1089\/pho.2013.3506","article-title":"Clinical and biochemical effects of 810nm diode laser as an adjunct to periodontal therapy: a randomized split-mouth clinical trial","volume":"32","author":"Ustun","year":"2014","journal-title":"Photomed. Laser Surg."},{"key":"10.1016\/j.pdpdt.2017.02.010_bib0055","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1902\/jop.2015.150152","article-title":"Adjunctive non-surgical therapy of inflamed periodontal pockets during maintenance therapy using diode laser: a randomized clinical trial","volume":"86","author":"Nguyen","year":"2015","journal-title":"J. Periodontol."},{"key":"10.1016\/j.pdpdt.2017.02.010_bib0060","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1007\/s10103-016-2047-z","article-title":"The effect of low-level laser therapy on non-surgical periodontal treatment: a randomized controlled, single-blind, split-mouth clinical trial","volume":"31","author":"Gundogar","year":"2016","journal-title":"Lasers Med. Sci."},{"key":"10.1016\/j.pdpdt.2017.02.010_bib0065","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s10103-016-1868-0","article-title":"Nonsurgical periodontal therapy with\/without diode laser modulates metabolic control of type 2 diabetics with periodontitis: a randomized clinical trial","volume":"31","author":"Kocak","year":"2016","journal-title":"Lasers Med. Sci."},{"key":"10.1016\/j.pdpdt.2017.02.010_bib0070","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1902\/jop.1999.70.11.1276","article-title":"Comparison of Nd:YAG laser versus scaling and root planing in periodontal therapy","volume":"70","author":"Liu","year":"1999","journal-title":"J. Periodontol."},{"key":"10.1016\/j.pdpdt.2017.02.010_bib0075","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1902\/jop.2008.070600","article-title":"Short-term clinical and immunologic effects of scaling and root planing with Er:YAG laser in chronic periodontitis","volume":"79","author":"Lopes","year":"2008","journal-title":"J. Periodontol."},{"key":"10.1016\/j.pdpdt.2017.02.010_bib0080","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/lsm.20873","article-title":"IL-1beta, TNF-alpha, total antioxidative status and microbiological findings in chronic periodontitis treated with fluorescence-controlled Er:YAG laser radiation","volume":"42","author":"Dominguez","year":"2010","journal-title":"Lasers Surg. Med."},{"key":"10.1016\/j.pdpdt.2017.02.010_bib0085","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1902\/jop.2010.090700","article-title":"A short-term evaluation of Nd:YAG laser as an adjunct to scaling and root planing in the treatment of periodontal inflammation","volume":"81","author":"Qadri","year":"2010","journal-title":"J. Periodontol."},{"key":"10.1016\/j.pdpdt.2017.02.010_bib0090","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s10103-010-0795-8","article-title":"Adjunctive Nd YAG laser application in chronic periodontitis: clinical, immunological, and microbiological aspects","volume":"26","author":"Gomez","year":"2011","journal-title":"Lasers Med. Sci."},{"key":"10.1016\/j.pdpdt.2017.02.010_bib0095","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s10103-011-0939-5","article-title":"Effect of 1,064-nm Nd:YAG laser therapy on GCF IL-1beta and MMP-8 levels in patients with chronic periodontitis","volume":"27","author":"Eltas","year":"2012","journal-title":"Lasers Med. Sci."},{"key":"10.1016\/j.pdpdt.2017.02.010_bib0100","first-page":"10","article-title":"Effect of photodynamic therapy on IL-1beta and MMP-8 in gingival crevicular fluid of chronic periodontitis","volume":"17","author":"Ge","year":"2008","journal-title":"Shanghai Kou Qiang Yi Xue"},{"key":"10.1016\/j.pdpdt.2017.02.010_bib0105","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.1600-0765.2010.01316.x","article-title":"Combined photodynamic and low-level laser therapies as an adjunct to nonsurgical treatment of chronic periodontitis","volume":"46","author":"Lui","year":"2011","journal-title":"J. Periodontal Res."},{"key":"10.1016\/j.pdpdt.2017.02.010_bib0110","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1089\/pho.2012.3328","article-title":"Effects of antimicrobial photodynamic therapy on transforming growth factor-beta1 levels in the gingival crevicular fluid","volume":"31","author":"Souza","year":"2013","journal-title":"Photomed. Laser Surg."},{"key":"10.1016\/j.pdpdt.2017.02.010_bib0115","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1902\/jop.2014.130464","article-title":"Effects of photodynamic therapy on clinical and gingival crevicular fluid inflammatory biomarkers in chronic periodontitis: a split-mouth randomized clinical trial","volume":"85","author":"Pourabbas","year":"2014","journal-title":"J. Periodontol."},{"key":"10.1016\/j.pdpdt.2017.02.010_bib0120","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1007\/s10103-013-1379-1","article-title":"Adjunctive effect of antimicrobial photodynamic therapy to nonsurgical periodontal treatment in smokers: a randomized clinical trial","volume":"30","author":"Queiroz","year":"2015","journal-title":"Lasers Med. Sci."},{"key":"10.1016\/j.pdpdt.2017.02.010_bib0125","first-page":"226","article-title":"The effect of photodynamic therapy and diode laser as adjunctive periodontal therapy on the inflammatory mediators levels in gingival crevicular fluid and clinical periodontal status","volume":"17","author":"Teymouri","year":"2016","journal-title":"J. Dent. (Shiraz, Iran)"},{"key":"10.1016\/j.pdpdt.2017.02.010_bib0130","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s10103-016-2076-7","article-title":"Photodynamic therapy decrease immune-inflammatory mediators levels during periodontal maintenance","volume":"32","author":"da Cruz Andrade","year":"2017","journal-title":"Lasers Med. Sci."},{"key":"10.1016\/j.pdpdt.2017.02.010_bib0135","series-title":"Clinical Laser Therapy: Low Level Laser Therapy: Scandinavian Medical Laser Technology","author":"Kert","year":"1989"},{"key":"10.1016\/j.pdpdt.2017.02.010_bib0140","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.cden.2004.05.004","article-title":"Low-level laser therapy in dentistry","volume":"48","author":"Sun","year":"2004","journal-title":"Dent. Clin. North Am."},{"key":"10.1016\/j.pdpdt.2017.02.010_bib0145","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0014-5793(84)80577-3","article-title":"Increase of proton electrochemical potential and ATP synthesis in rat liver mitochondria irradiated in vitro by helium-neon laser","volume":"175","author":"Passarella","year":"1984","journal-title":"FEBS Lett."},{"key":"10.1016\/j.pdpdt.2017.02.010_bib0150","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/jemt.22632","article-title":"Comparative effects of two different doses of low-level laser therapy on wound healing third-degree burns in rats","volume":"79","author":"Brassolatti","year":"2016","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.pdpdt.2017.02.010_bib0155","doi-asserted-by":"crossref","first-page":"3197","DOI":"10.1589\/jpts.28.3197","article-title":"The effects of high intensity laser therapy on pain and function in patients with knee osteoarthritis","volume":"28","author":"Kim","year":"2016","journal-title":"J. Phys. Ther. Sci."},{"key":"10.1016\/j.pdpdt.2017.02.010_bib0160","first-page":"87","article-title":"Oxygen high level laser therapy is efficient in treatment of chronic periodontitis: a clinical and microbiological study using PCR analysis","volume":"30","author":"Caccianiga","year":"2016","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"10.1016\/j.pdpdt.2017.02.010_bib0165","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1002\/(SICI)1096-9101(1996)19:2<190::AID-LSM11>3.0.CO;2-B","article-title":"Bactericidal effect of erbium YAG laser on periodontopathic bacteria","volume":"19","author":"Ando","year":"1996","journal-title":"Lasers Surg. Med."},{"issue":"67","key":"10.1016\/j.pdpdt.2017.02.010_bib0170","first-page":"268","article-title":"Lasers in periodontal therapy","volume":"2015","author":"Passanezi","year":"2000","journal-title":"J. Periodontol."},{"key":"10.1016\/j.pdpdt.2017.02.010_bib0175","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/jcpe.12094","article-title":"Adjunctive photodynamic therapy to non-surgical treatment of chronic periodontitis: a systematic review and meta-analysis","volume":"40","author":"Sgolastra","year":"2013","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.pdpdt.2017.02.010_bib0180","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.pdpdt.2016.04.015","article-title":"Efficacy of periimplant mechanical debridement with and without adjunct antimicrobial photodynamic therapy in patients with type 2 diabetes mellitus","volume":"14","author":"Al Amri","year":"2016","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2017.02.010_bib0185","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.pdpdt.2016.06.007","article-title":"Is mechanical curettage with adjunct photodynamic therapy more effective in the treatment of peri-implantitis than mechanical curettage alone?","volume":"15","author":"Ghanem","year":"2016","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2017.02.010_bib0190","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1562\/0031-8655(2000)072<0676:TEOPAO>2.0.CO;2","article-title":"The effect of photodynamic action on two virulence factors of gram-negative bacteria","volume":"72","author":"Komerik","year":"2000","journal-title":"Photochem. Photobiol."},{"issue":"34","key":"10.1016\/j.pdpdt.2017.02.010_bib0195","first-page":"9","article-title":"Periodontal diagnoses and classification of periodontal diseases","volume":"2004","author":"Armitage","year":"2000","journal-title":"J. Periodontol."},{"key":"10.1016\/j.pdpdt.2017.02.010_bib0200","doi-asserted-by":"crossref","first-page":"4801418","DOI":"10.1155\/2016\/4801418","article-title":"Cytokine profile in chronic periodontitis patients with and without obesity: a systematic review and meta-analysis","volume":"2016","author":"Akram","year":"2016","journal-title":"Dis. Markers"},{"key":"10.1016\/j.pdpdt.2017.02.010_bib0205","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1111\/jcpe.12557","article-title":"Gingival crevicular fluid levels of cytokines\/chemokines in chronic periodontitis: a meta-analysis","volume":"43","author":"Stadler","year":"2016","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.pdpdt.2017.02.010_bib0210","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.archoralbio.2012.11.012","article-title":"Profiling biomarkers in gingival crevicular fluid using multiplex bead immunoassay","volume":"58","author":"Shimada","year":"2013","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.pdpdt.2017.02.010_bib0215","doi-asserted-by":"crossref","first-page":"e1000097","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"6","author":"Moher","year":"2009","journal-title":"PLoS Med."},{"key":"10.1016\/j.pdpdt.2017.02.010_bib0220","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1002\/sim.2945","article-title":"Modelling patterns of agreement for nominal scales","volume":"27","author":"Roberts","year":"2008","journal-title":"Stat. Med."},{"key":"10.1016\/j.pdpdt.2017.02.010_bib0225","doi-asserted-by":"crossref","first-page":"657","DOI":"10.7326\/0003-4819-134-8-200104170-00011","article-title":"The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomized trials","volume":"134","author":"Moher","year":"2001","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.pdpdt.2017.02.010_bib0230","series-title":"Cochrane Handbook for Systematic Reviews of Interventions","author":"Higgins","year":"2008"},{"key":"10.1016\/j.pdpdt.2017.02.010_bib0235","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1902\/jop.2014.140392","article-title":"Antimicrobial photodynamic therapy as an adjunct to non-surgical treatment of aggressive periodontitis: a split-mouth randomized controlled trial","volume":"86","author":"Moreira","year":"2015","journal-title":"J. Periodontol."},{"key":"10.1016\/j.pdpdt.2017.02.010_bib0240","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1089\/pho.2006.24.169","article-title":"Photoengineering of bone repair processes","volume":"24","author":"Pinheiro","year":"2006","journal-title":"Photomed. Laser Surg."},{"key":"10.1016\/j.pdpdt.2017.02.010_bib0245","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/j.1600-051X.2010.01538.x","article-title":"Short-term benefits of the adjunctive use of metronidazole plus amoxicillin in the microbial profile and in the clinical parameters of subjects with generalized aggressive periodontitis","volume":"37","author":"Mestnik","year":"2010","journal-title":"J. Clin. Periodontol."}],"container-title":["Photodiagnosis and Photodynamic Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S157210001730203X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S157210001730203X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:29:51Z","timestamp":1761611391000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S157210001730203X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":49,"alternative-id":["S157210001730203X"],"URL":"https:\/\/doi.org\/10.1016\/j.pdpdt.2017.02.010","relation":{},"ISSN":["1572-1000"],"issn-type":[{"value":"1572-1000","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of laser-assisted scaling and root planing on the expression of pro-inflammatory cytokines in the gingival crevicular fluid of patients with chronic periodontitis: A systematic review","name":"articletitle","label":"Article Title"},{"value":"Photodiagnosis and Photodynamic Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pdpdt.2017.02.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}