{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T10:38:56Z","timestamp":1792406336803,"version":"4.4.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Photodiagnosis and Photodynamic Therapy"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.pdpdt.2017.07.010","type":"journal-article","created":{"date-parts":[[2017,8,2]],"date-time":"2017-08-02T13:32:42Z","timestamp":1501680762000},"page":"6-9","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Pain during topical photodynamic therapy - comparing methyl aminolevulinate (Metvix\u00ae) to aminolaevulinic acid (Ameluz\u00ae); an intra-individual clinical study"],"prefix":"10.1016","volume":"20","author":[{"given":"Shiva","family":"Yazdanyar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kian","family":"Zarchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor B.E.","family":"Jemec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pdpdt.2017.07.010_bib0005","first-page":"25","article-title":"Differences in disease-specific quality of life in patients with actinic keratosis in Australia and Denmark","volume":"24","author":"Miller","year":"2016","journal-title":"Acta Dermatovenerol. Croat."},{"key":"10.1016\/j.pdpdt.2017.07.010_bib0010","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.jaad.2015.01.036","article-title":"Ingenol mebutate gel for actinic keratosis: the link between quality of life, treatment satisfaction, and clinical outcomes","volume":"72","author":"Augustin","year":"2015","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.pdpdt.2017.07.010_bib0015","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1159\/000366530","article-title":"Patients' perspectives on actinic keratosis","volume":"46","author":"Esmann","year":"2015","journal-title":"Curr. Probl. Dermatol."},{"key":"10.1016\/j.pdpdt.2017.07.010_bib0020","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/bjd.12036","article-title":"Assessing the influence of actinic keratosis on patients' quality of life: the AKQoL questionnaire","volume":"168","author":"Esmann","year":"2013","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.pdpdt.2017.07.010_bib0025","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.jaad.2009.02.022","article-title":"Quality of life in the actinic neoplasia syndrome: the VA topical tretinoin chemoprevention (VATTC) trial","volume":"61","author":"Weinstock","year":"2009","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.pdpdt.2017.07.010_bib0030","first-page":"1","article-title":"Real-world approach to actinic keratosis management: practical treatment algorithm for office-based dermatology","volume":"13","author":"Dirschka","year":"2016","journal-title":"J. Dermatolog. Treat."},{"issue":"7","key":"10.1016\/j.pdpdt.2017.07.010_bib0035","first-page":"145","article-title":"Current evidence and applications of photodynamic therapy in dermatology","volume":"21","author":"Wan","year":"2014","journal-title":"Clin. Cosmet. Investig. Dermatol."},{"key":"10.1016\/j.pdpdt.2017.07.010_bib0040","first-page":"651","article-title":"Development of a treatment algorithm for actinic keratoses: a European Consensus","volume":"18","author":"Stockfleth","year":"2008","journal-title":"Eur. J. Dermatol."},{"key":"10.1016\/j.pdpdt.2017.07.010_bib0045","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.jaad.2009.03.048","article-title":"Pain associated with aminolevulinic acid-photodynamic therapy of skin disease","volume":"61","author":"Warren","year":"2009","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.pdpdt.2017.07.010_bib0050","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1111\/j.1365-2133.2008.08451.x","article-title":"Pain during photodynamic therapy is associated with protoporphyrin IX fluorescence and fluence rate","volume":"158","author":"Wiegell","year":"2008","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.pdpdt.2017.07.010_bib0055","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1111\/j.1468-3083.2010.03964.x","article-title":"Factors related to pain during routine photodynamic therapy: a descriptive study of 301 patients","volume":"25","author":"Miller","year":"2011","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"10.1016\/j.pdpdt.2017.07.010_bib0060","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1001\/archderm.139.9.1173","article-title":"Pain associated with photodynamic therapy using 5-aminolevulinic acid or 5-aminolevulinic acid methylester on tape-stripped normal skin","volume":"139","author":"Wiegell","year":"2003","journal-title":"Arch. Dermatol."},{"key":"10.1016\/j.pdpdt.2017.07.010_bib0065","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1111\/j.1365-2133.2005.07107.x","article-title":"Photodynamic therapy of acne vulgaris using methyl aminolaevulinate: a blinded, randomized, controlled trial","volume":"154","author":"Wiegell","year":"2006","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.pdpdt.2017.07.010_bib0070","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1111\/jdv.13558","article-title":"Aminolevulinic acid and methyl aminolevulinate equally effective in topical photodynamic therapy for non-melanoma skin cancers","volume":"30","author":"Tarstedt","year":"2016","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"10.1016\/j.pdpdt.2017.07.010_bib0075","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.det.2014.03.009","article-title":"Photodynamic therapy","volume":"32","author":"Rkein","year":"2014","journal-title":"Dermatol. Clin."},{"key":"10.1016\/j.pdpdt.2017.07.010_bib0080","first-page":"44","article-title":"Therapeutic and aesthetic uses of photodynamic therapy part five of a five-part series: ALA-PDT and MAL-PDT what makes them different","volume":"2","author":"Gold","year":"2009","journal-title":"J. Clin. Aesthet. Dermatol."},{"issue":"62","key":"10.1016\/j.pdpdt.2017.07.010_bib0085","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/S1011-1344(01)00173-7","article-title":"Selective distribution of porphyrins in skin thick basal cell carcinoma after topical application of methyl 5-aminolevulinate","volume":"15","author":"Peng","year":"2001","journal-title":"J. Photochem. Photobiol. B"},{"key":"10.1016\/j.pdpdt.2017.07.010_bib0090","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1111\/j.1365-2133.2009.09437.x","article-title":"Topical aminolaevulinic acid- and aminolaevulinic acid methyl ester-based photodynamic therapy with red and violet light: influence of wavelength on pain and erythema","volume":"161","author":"Mikolajewska","year":"2009","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.pdpdt.2017.07.010_bib0095","first-page":"353","article-title":"Photodynamic therapy induces less pain in patients treated with methyl aminolevulinate compared to aminolevulinic acid","volume":"5","author":"Kasche","year":"2006","journal-title":"J. Drugs Dermatol."},{"key":"10.1016\/j.pdpdt.2017.07.010_bib0100","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1159\/000329025","article-title":"Treatment with 5-aminolaevulinic acid methylester is less painful than treatment with 5-aminolaevulinic acid nanoemulsion in topical photodynamic therapy for actinic keratosis","volume":"222","author":"Gholam","year":"2011","journal-title":"Dermatology"},{"key":"10.1016\/j.pdpdt.2017.07.010_bib0105","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1365-2133.2007.07946.x","article-title":"double-blind, prospective study to compare topical 5-aminolaevulinic acid methylester with topical 5-aminolaevulinic acid photodynamic therapy for extensive scalp actinic keratosis","volume":"157","author":"Moloney","year":"2007","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.pdpdt.2017.07.010_bib0110","first-page":"642","article-title":"Similar effectiveness of methyl aminolevulinate and 5-aminolevulinate in topical photodynamic therapy for nodular basal cell carcinoma","volume":"5","author":"Kuijpers","year":"2006","journal-title":"J. Drugs Dermatol."},{"key":"10.1016\/j.pdpdt.2017.07.010_bib0115","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/0190-9622(91)70113-G","article-title":"A double-blind, vehicle-controlled study evaluating masoprocol cream in the treatment of actinic keratoses on the head and neck","volume":"24","author":"Olsen","year":"1991","journal-title":"J. Am. Acad. Dermatol."},{"issue":"5","key":"10.1016\/j.pdpdt.2017.07.010_bib0120","doi-asserted-by":"crossref","first-page":"404","DOI":"10.2340\/00015555-0098","article-title":"Important factors for pain during photodynamic therapy for actinic keratosis","volume":"86","author":"Sandberg","year":"2006","journal-title":"Acta Derm. Venereol."},{"key":"10.1016\/j.pdpdt.2017.07.010_bib0125","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/j.1365-2133.2004.05652.x","article-title":"A randomized, double-blind, placebo-controlled study of the efficacy of tetracaine gel (Ametop) for pain relief during topical photodynamic therapy","volume":"150","author":"Holmes","year":"2004","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.pdpdt.2017.07.010_bib0130","doi-asserted-by":"crossref","first-page":"409","DOI":"10.2340\/00015555-0128","article-title":"Morphine gel 0.3% does not relieve pain during topical photodynamic therapy: a randomized, double-blind, placebo-controlled study","volume":"86","author":"Skiveren","year":"2006","journal-title":"Acta Derm. Venereol."},{"key":"10.1016\/j.pdpdt.2017.07.010_bib0135","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/j.1365-2133.2005.06991.x","volume":"154","author":"Langan","year":"2006","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.pdpdt.2017.07.010_bib0140","first-page":"63","article-title":"Cold air analgesia in photodynamic therapy of basal cell carcinomas and Bowen's disease: an effective addition to treatment: a pilot study","volume":"30","author":"Pagliaro","year":"2004","journal-title":"Dermatol. Surg."},{"key":"10.1016\/j.pdpdt.2017.07.010_bib0145","doi-asserted-by":"crossref","first-page":"311","DOI":"10.2340\/00015555-0429","article-title":"Transcutaneous electrical nerve stimulation for pain relief during photodynamic therapy of actinic keratoses","volume":"88","author":"Halldin","year":"2008","journal-title":"Acta Derm. Venereol."},{"key":"10.1016\/j.pdpdt.2017.07.010_bib0150","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1111\/j.1365-2230.2008.02755.x","article-title":"Nerve blocks provide effective pain relief during topical photodynamic therapy for extensive facial actinic keratoses","volume":"33","author":"Paoli","year":"2008","journal-title":"Clin. Exp. Dermatol."},{"issue":"4","key":"10.1016\/j.pdpdt.2017.07.010_bib0155","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1111\/j.1365-2133.2008.09024.x","article-title":"Nerve blocks enable adequate pain relief during topical photodynamic therapy of field cancerization on the forehead and scalp","volume":"160","author":"Halldin","year":"2009","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.pdpdt.2017.07.010_bib0160","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/j.1365-2133.2009.09184.x","article-title":"Comparative study between cold air analgesia and supraorbital and supratrochlear nerve block for the management of pain during photodynamic therapy for actinic keratoses of the frontotemporal zone","volume":"161","author":"Serra-Guillen","year":"2009","journal-title":"Br. J. Dermatol."}],"container-title":["Photodiagnosis and Photodynamic Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100017302673?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100017302673?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:29:45Z","timestamp":1761611385000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1572100017302673"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":32,"alternative-id":["S1572100017302673"],"URL":"https:\/\/doi.org\/10.1016\/j.pdpdt.2017.07.010","relation":{},"ISSN":["1572-1000"],"issn-type":[{"value":"1572-1000","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pain during topical photodynamic therapy - comparing methyl aminolevulinate (Metvix\u00ae) to aminolaevulinic acid (Ameluz\u00ae); an intra-individual clinical study","name":"articletitle","label":"Article Title"},{"value":"Photodiagnosis and Photodynamic Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pdpdt.2017.07.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}