{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T22:28:26Z","timestamp":1781130506751,"version":"3.54.1"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,11,21]],"date-time":"2018-11-21T00:00:00Z","timestamp":1542758400000},"content-version":"am","delay-in-days":265,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA-129554"],"award-info":[{"award-number":["CA-129554"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA-087971"],"award-info":[{"award-number":["CA-087971"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA-085831"],"award-info":[{"award-number":["CA-085831"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32-CA-009677"],"award-info":[{"award-number":["T32-CA-009677"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Photodiagnosis and Photodynamic Therapy"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.pdpdt.2017.10.015","type":"journal-article","created":{"date-parts":[[2017,11,4]],"date-time":"2017-11-04T17:16:38Z","timestamp":1509815798000},"page":"28-35","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"special_numbering":"C","title":["Lesion oxygenation associates with clinical outcomes in premalignant and early stage head and neck tumors treated on a phase 1 trial of photodynamic therapy"],"prefix":"10.1016","volume":"21","author":[{"given":"Peter H.","family":"Ahn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarod C.","family":"Finlay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon M.","family":"Gallagher-Colombo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"Quon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Bert W.","family":"O\u2019Malley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory S.","family":"Weinstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ara","family":"Chalian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Malloy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Sollecito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Greenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"II","given":"Charles B.","family":"Simone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally","family":"McNulty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy C.","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Livolsi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Feldman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemarie","family":"Mick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith A.","family":"Cengel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa M.","family":"Busch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pdpdt.2017.10.015_bib0005","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/978-1-60761-697-9_18","article-title":"Photodynamic therapy of head and neck cancers","volume":"635","author":"Biel","year":"2010","journal-title":"Methods Mol. Biol. (Clifton, N.J.)"},{"key":"10.1016\/j.pdpdt.2017.10.015_bib0010","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1758-3284-4-16","article-title":"Photodynamic therapy in the management of potentially malignant and malignant oral disorders","volume":"4","author":"Jerjes","year":"2012","journal-title":"Head Neck Oncol."},{"issue":"8","key":"10.1016\/j.pdpdt.2017.10.015_bib0015","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1001\/archoto.2009.98","article-title":"Photodynamic therapy for head and neck dysplasia and cancer","volume":"135","author":"Rigual","year":"2009","journal-title":"Arch. Otolaryngol.\u2013Head Neck Surg."},{"issue":"5","key":"10.1016\/j.pdpdt.2017.10.015_bib0020","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1111\/j.1751-1097.2007.00153.x","article-title":"Photodynamic therapy treatment of early oral and laryngeal cancers","volume":"83","author":"Biel","year":"2007","journal-title":"Photochem. Photobiol."},{"issue":"1","key":"10.1016\/j.pdpdt.2017.10.015_bib0025","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1002\/ijc.20209","article-title":"Putnam, mTHPC-mediated photodynamic therapy for early oral squamous cell carcinoma","volume":"111","author":"Hopper","year":"2004","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.pdpdt.2017.10.015_bib0030","unstructured":"H.S. Quon, C.B. 2nd, Cengel, K.A. Finlay, J.C. Zhu, T.C. Busch, T.M., Photodynamic Therapy in the Management of Cancer., in: E.C.W. Halperin, D.E., Perez, C.A., Brady, L.W., (Ed.), Perez and Brady\u2019s Principles of Practice of Radiation Oncology, 6th Edition, Lippincott Williams & Wilkins, Philadelphia, PA, 2013, pp. 539\u2013551."},{"issue":"9","key":"10.1016\/j.pdpdt.2017.10.015_bib0035","doi-asserted-by":"crossref","first-page":"3076","DOI":"10.1245\/s10434-013-3006-6","article-title":"mTHPC-mediated photodynamic therapy of early stage oral squamous cell carcinoma: a comparison to surgical treatment","volume":"20","author":"de Visscher","year":"2013","journal-title":"Ann. Surg. Oncol."},{"key":"10.1016\/j.pdpdt.2017.10.015_bib0040","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.oraloncology.2016.01.013","article-title":"Toxicities and early outcomes in a phase 1 trial of photodynamic therapy for premalignant and early stage head and neck tumors","volume":"55","author":"Ahn","year":"2016","journal-title":"Oral Oncol."},{"issue":"9","key":"10.1016\/j.pdpdt.2017.10.015_bib0045","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.oraloncology.2013.05.011","article-title":"A phase I trial of aminolevulinic acid-photodynamic therapy for treatment of oral leukoplakia","volume":"49","author":"Wong","year":"2013","journal-title":"Oral Oncol."},{"issue":"5","key":"10.1016\/j.pdpdt.2017.10.015_bib0050","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1111\/php.12475","article-title":"Measuring the physiologic properties of oral lesions receiving fractionated photodynamic therapy","volume":"91","author":"Gallagher-Colombo","year":"2015","journal-title":"Photochem. Photobiol."},{"issue":"12","key":"10.1016\/j.pdpdt.2017.10.015_bib0055","first-page":"3110","article-title":"Relationship of tumor hypoxia and response to photodynamic treatment in an experimental mouse tumor","volume":"47","author":"Henderson","year":"1987","journal-title":"Cancer Res."},{"issue":"3","key":"10.1016\/j.pdpdt.2017.10.015_bib0060","first-page":"599","article-title":"Simple, accurate equations for human blood O2 dissociation computations","volume":"46","author":"Severinghaus","year":"1979","journal-title":"J. Appl. Physiol. Respir. Environ. Exerc. Physiol."},{"key":"10.1016\/j.pdpdt.2017.10.015_bib0065","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.freeradbiomed.2015.03.038","article-title":"Evaluation of oxygen dependence on in vitro and in vivo cytotoxicity of photoimmunotherapy using IR-700-antibody conjugates","volume":"85","author":"Kishimoto","year":"2015","journal-title":"Free Radic. Biol. Med."},{"issue":"12","key":"10.1016\/j.pdpdt.2017.10.015_bib0070","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1039\/b9pp00004f","article-title":"Fluence rate-dependent intratumor heterogeneity in physiologic and cytotoxic responses to Photofrin photodynamic therapy","volume":"8","author":"Busch","year":"2009","journal-title":"Photochem. Photobiol. Sci."},{"issue":"20","key":"10.1016\/j.pdpdt.2017.10.015_bib0075","doi-asserted-by":"crossref","first-page":"7553","DOI":"10.1158\/0008-5472.CAN-03-3632","article-title":"Treatment-induced changes in tumor oxygenation predict photodynamic therapy outcome","volume":"64","author":"Wang","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.pdpdt.2017.10.015_bib0080","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jphotobiol.2014.07.020","article-title":"Hemodynamic monitoring of Chlorin e6-mediated photodynamic therapy using diffuse optical measurements","volume":"140","author":"Dong","year":"2014","journal-title":"J. Photochem. Photobiol. B"},{"issue":"4","key":"10.1016\/j.pdpdt.2017.10.015_bib0085","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1364\/AO.36.000949","article-title":"Predictions and measurements of scattering and absorption over broad wavelength ranges in tissue phantoms","volume":"36","author":"Mourant","year":"1997","journal-title":"Appl. Opt."},{"issue":"11","key":"10.1016\/j.pdpdt.2017.10.015_bib0090","doi-asserted-by":"crossref","first-page":"3381","DOI":"10.1088\/0031-9155\/43\/11\/014","article-title":"Quantitative broadband near-infrared spectroscopy of tissue-simulating phantoms containing erythrocytes","volume":"43","author":"Hull","year":"1998","journal-title":"Phys. Med. Biol."},{"issue":"7","key":"10.1016\/j.pdpdt.2017.10.015_bib0095","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1118\/1.1760188","article-title":"Hemoglobin oxygen saturations in phantoms and in vivo from measurements of steady-state diffuse reflectance at a single, short source-detector separation","volume":"31","author":"Finlay","year":"2004","journal-title":"Med. Phys."},{"issue":"4","key":"10.1016\/j.pdpdt.2017.10.015_bib0100","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0197-2456(96)00075-X","article-title":"A note on quantifying follow-up in studies of failure time","volume":"17","author":"Schemper","year":"1996","journal-title":"Control. Clin. Trials"},{"issue":"7","key":"10.1016\/j.pdpdt.2017.10.015_bib0105","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1002\/(SICI)1097-0142(19961001)78:7<1374::AID-CNCR2>3.0.CO;2-L","article-title":"Photodynamic therapy using 5-aminolevulinic acid for premalignant and malignant lesions of the oral cavity","volume":"78","author":"Fan","year":"1996","journal-title":"Cancer"},{"issue":"6","key":"10.1016\/j.pdpdt.2017.10.015_bib0110","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1034\/j.1600-0714.2003.00068.x","article-title":"Photodynamic therapy (PDT) using topically applied delta-aminolevulinic acid (ALA) for the treatment of oral leukoplakia","volume":"32","author":"Sieron","year":"2003","journal-title":"J. Oral Pathol. Med."},{"issue":"2","key":"10.1016\/j.pdpdt.2017.10.015_bib0115","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.pdpdt.2011.12.007","article-title":"Comparison of cryotherapy and photodynamic therapy in treatment of oral leukoplakia","volume":"9","author":"Kawczyk-Krupka","year":"2012","journal-title":"Photodiagn. Photodyn. Ther."},{"issue":"3","key":"10.1016\/j.pdpdt.2017.10.015_bib0120","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1002\/lsm.21036","article-title":"Photodynamic therapy outcome for oral dysplasia","volume":"43","author":"Jerjes","year":"2011","journal-title":"Lasers Surg. Med."},{"issue":"1","key":"10.1016\/j.pdpdt.2017.10.015_bib0125","doi-asserted-by":"crossref","first-page":"18002","DOI":"10.1117\/1.JBO.21.1.018002","article-title":"Intraoperative optical assessment of photodynamic therapy response of superficial oral squamous cell carcinoma","volume":"21","author":"Rohrbach","year":"2016","journal-title":"J. Biomed. Opt."},{"issue":"6","key":"10.1016\/j.pdpdt.2017.10.015_bib0130","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1562\/0031-8655(2001)073<0669:MTRDPT>2.0.CO;2","article-title":"Monitoring tumor response during photodynamic therapy using near-infrared photon-migration spectroscopy","volume":"73","author":"Pham","year":"2001","journal-title":"Photochem. Photobiol."},{"issue":"23","key":"10.1016\/j.pdpdt.2017.10.015_bib0135","doi-asserted-by":"crossref","first-page":"9987","DOI":"10.1158\/0008-5472.CAN-08-1128","article-title":"Interstitial Doppler optical coherence tomography as a local tumor necrosis predictor in photodynamic therapy of prostatic carcinoma: an in vivo study","volume":"68","author":"Standish","year":"2008","journal-title":"Cancer Res."},{"issue":"5","key":"10.1016\/j.pdpdt.2017.10.015_bib0140","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1002\/lsm.20355","article-title":"Local physiological changes during photodynamic therapy","volume":"38","author":"Busch","year":"2006","journal-title":"Lasers Surg. Med."},{"issue":"1","key":"10.1016\/j.pdpdt.2017.10.015_bib0145","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S1095-6433(01)00545-1","article-title":"Tumor PO(2) changes during photodynamic therapy depend upon photosensitizer type and time after injection","volume":"132","author":"Pogue","year":"2002","journal-title":"Compar. Biochem. Physiol. Part A, Mol. Integrat. Physiol."},{"issue":"6","key":"10.1016\/j.pdpdt.2017.10.015_bib0150","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1111\/j.1751-1097.1997.tb07962.x","article-title":"Light-dependent oxygen consumption in bacteriochlorophyll-serine-treated melanoma tumors: on-line determination using a tissue-inserted oxygen microsensor","volume":"65","author":"Zilberstein","year":"1997","journal-title":"Photochem. Photobiol."},{"issue":"11","key":"10.1016\/j.pdpdt.2017.10.015_bib0155","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1158\/1078-0432.CCR-15-1990","article-title":"Low cancer stem cell marker expression and low hypoxia identify good prognosis subgroups in HPV(\u2212) HNSCC after postoperative radiochemotherapy: a multicenter study of the DKTK-ROG","volume":"22","author":"Linge","year":"2016","journal-title":"Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.pdpdt.2017.10.015_bib0160","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.radonc.2012.09.015","article-title":"FAZA PET\/CT hypoxia imaging in patients with squamous cell carcinoma of the head and neck treated with radiotherapy: results from the DAHANCA 24 trial","volume":"105","author":"Mortensen","year":"2012","journal-title":"Radiother. Oncol."},{"issue":"11\u201312","key":"10.1016\/j.pdpdt.2017.10.015_bib0165","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1002\/jbio.201600121","article-title":"Evaluation of the 2-(1-Hexyloxyethyl)-2-devinyl pyropheophorbide (HPPH) mediated photodynamic therapy by macroscopic singlet oxygen modeling","volume":"9","author":"Penjweini","year":"2016","journal-title":"J. Biophoton."},{"issue":"12","key":"10.1016\/j.pdpdt.2017.10.015_bib0170","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1039\/b709644e","article-title":"The role of oxygen monitoring during photodynamic therapy and its potential for treatment dosimetry","volume":"6","author":"Woodhams","year":"2007","journal-title":"Photochem. Photobiol. Sci."},{"issue":"4","key":"10.1016\/j.pdpdt.2017.10.015_bib0175","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.bjoms.2012.11.011","article-title":"Photodynamic therapy in the management of lesions of the head and neck","volume":"51","author":"Green","year":"2013","journal-title":"Br. J. Oral Maxillofacial Surg."},{"issue":"5","key":"10.1016\/j.pdpdt.2017.10.015_bib0180","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1562\/0031-8655(2003)078<0496:HETTCK>2.0.CO;2","article-title":"Hyperoxygenation enhances the tumor cell killing of photofrin-mediated photodynamic therapy","volume":"78","author":"Huang","year":"2003","journal-title":"Photochem. Photobiol."},{"issue":"11","key":"10.1016\/j.pdpdt.2017.10.015_bib0185","doi-asserted-by":"crossref","first-page":"2696","DOI":"10.1364\/BOE.4.002696","article-title":"Quantitative physiology and immunohistochemistry of oral lesions","volume":"4","author":"Lee","year":"2013","journal-title":"Biomed. Opt. Express"},{"issue":"12","key":"10.1016\/j.pdpdt.2017.10.015_bib0190","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/j.oraloncology.2011.08.014","article-title":"Non-invasive measurement of the microvascular properties of non-dysplastic and dysplastic oral leukoplakias by use of optical spectroscopy","volume":"47","author":"Amelink","year":"2011","journal-title":"Oral Oncol."},{"issue":"1","key":"10.1016\/j.pdpdt.2017.10.015_bib0195","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.oraloncology.2006.12.011","article-title":"Non-invasive measurement of the morphology and physiology of oral mucosa by use of optical spectroscopy","volume":"44","author":"Amelink","year":"2008","journal-title":"Oral Oncol."},{"issue":"9","key":"10.1016\/j.pdpdt.2017.10.015_bib0200","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1364\/BOE.3.002142","article-title":"Interlesion differences in the local photodynamic therapy response of oral cavity lesions assessed by diffuse optical spectroscopies","volume":"3","author":"Rohrbach","year":"2012","journal-title":"Biomed. Opt. Express"}],"container-title":["Photodiagnosis and Photodynamic Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S157210001730354X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S157210001730354X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:28:26Z","timestamp":1761611306000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S157210001730354X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":40,"alternative-id":["S157210001730354X"],"URL":"https:\/\/doi.org\/10.1016\/j.pdpdt.2017.10.015","relation":{},"ISSN":["1572-1000"],"issn-type":[{"value":"1572-1000","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lesion oxygenation associates with clinical outcomes in premalignant and early stage head and neck tumors treated on a phase 1 trial of photodynamic therapy","name":"articletitle","label":"Article Title"},{"value":"Photodiagnosis and Photodynamic Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pdpdt.2017.10.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}