{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T14:54:59Z","timestamp":1774104899440,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"National Research Center (NRC), Children Cancer Hospital","award":["57357"],"award-info":[{"award-number":["57357"]}]},{"name":"National Institute of Laser Enhanced Sciences (NILES), Cairo University, Egypt"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Photodiagnosis and Photodynamic Therapy"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.pdpdt.2018.06.003","type":"journal-article","created":{"date-parts":[[2018,6,2]],"date-time":"2018-06-02T12:10:07Z","timestamp":1527941407000},"page":"25-31","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Improved photodynamic efficacy of thiophenyl sulfonated zinc phthalocyanine loaded in lipid nano-carriers for hepatocellular carcinoma cancer cells"],"prefix":"10.1016","volume":"23","author":[{"given":"Doaa","family":"Abdel Fadeel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghada M.","family":"Al-Toukhy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asma M.","family":"Elsharif","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suhailah S.","family":"Al-Jameel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanan H.","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamer E.","family":"Youssef","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pdpdt.2018.06.003_bib0005","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.1021\/cr900300p","article-title":"Imaging and photodynamic therapy: mechanisms, monitoring, and optimization","volume":"110","author":"Celli","year":"2017","journal-title":"Chem. Rev."},{"key":"10.1016\/j.pdpdt.2018.06.003_bib0010","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/nrc1894","article-title":"Photodynamic therapy and anti-tumour immunity","volume":"6","author":"Castano","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.pdpdt.2018.06.003_bib0015","doi-asserted-by":"crossref","first-page":"845","DOI":"10.3390\/molecules22050845","article-title":"Preparation and in vitro photodynamic activity of glucosylated zinc(II) phthalocyanines as underlying targeting photosensitizers","volume":"22","author":"Jian-Yong","year":"2017","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.pdpdt.2018.06.003_bib0020","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1134\/S1990750810010129","article-title":"Photodynamic therapy of cancer: search for ideal photosensitizer","volume":"4","author":"Kudinovaa","year":"2010","journal-title":"Biochem. (Mosc.) Suppl. Ser. B: Biomed. Chem."},{"key":"10.1016\/j.pdpdt.2018.06.003_bib0025","first-page":"250","article-title":"Photodynamic therapy of cancer: an update","volume":"61","author":"Agostinis","year":"2011","journal-title":"CA. Cancer J. Clin."},{"key":"10.1016\/j.pdpdt.2018.06.003_bib0030","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1021\/cr5004198","article-title":"Nanoparticles in photodynamic therapy","volume":"115","author":"Lucky","year":"2015","journal-title":"Chem. Rev."},{"key":"10.1016\/j.pdpdt.2018.06.003_bib0035","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/jpp.324","article-title":"Current status of phthalocyanines in the photodynamic therapy of cancer","volume":"5","author":"Allen","year":"2001","journal-title":"J. Porphyr. Phthalocyan."},{"key":"10.1016\/j.pdpdt.2018.06.003_bib0040","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1142\/S1088424606000466","article-title":"Development of phthalocyanines for photodynamic therapy","volume":"10","author":"Ogura","year":"2006","journal-title":"J. Porphyr. Phthalocyan."},{"key":"10.1016\/j.pdpdt.2018.06.003_bib0045","doi-asserted-by":"crossref","first-page":"4152","DOI":"10.1016\/j.bmc.2016.07.003","article-title":"Synthesis of asymmetric zinc(II) phthalocyanines with two different functional groups & spectroscopic properties and photodynamic activity for photodynamic therapy","volume":"24","author":"Goksel","year":"2016","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.pdpdt.2018.06.003_bib0050","doi-asserted-by":"crossref","first-page":"9570","DOI":"10.1039\/c3cc45487h","article-title":"A novel strategy for targeting photodynamic therapy. Molecular combo of photodynamic agent zinc(II) phthalocyanine and small molecule target-based anticancer drug erlotinib","volume":"49","author":"Zhang","year":"2013","journal-title":"Chem. Commun."},{"key":"10.1016\/j.pdpdt.2018.06.003_bib0055","first-page":"560","article-title":"Antitumor activity of tetra-substituted zinc phthalocyanines containing 4(3H)-quinazolinone derivatives","volume":"65","author":"Youssef","year":"2014","journal-title":"Rev. Chim. (Buchar.)"},{"key":"10.1016\/j.pdpdt.2018.06.003_bib0060","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/s11274-018-2422-y","article-title":"Investigations on the antitumor activity of classical trifluorosubstituted zinc phthalocyanines derivatives","volume":"34","author":"Al Jameel","year":"2018","journal-title":"World J. Microbiol. Biotechnnol."},{"key":"10.1016\/j.pdpdt.2018.06.003_bib0065","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1016\/j.bbamem.2007.05.018","article-title":"Photodynamic activity and binding of sulfonated metallophthalocyanines to phospholipid membranes: contribution of metal-phosphate coordination","volume":"1768","author":"Pashkovskaya","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.pdpdt.2018.06.003_bib0070","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jphotochem.2011.05.006","article-title":"Tetra-2-[2-(dimethylamino)ethoxy]ethoxy substituted zinc phthalocyanines and their quaternized analoques: synthesis, characterization, photophysical and photochemical properties","volume":"222","author":"B\u0131y\u0131kl\u0131oglu","year":"2011","journal-title":"J. Photochem. Photobiol. A: Chem."},{"key":"10.1016\/j.pdpdt.2018.06.003_bib0075","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.colsurfb.2014.09.029","article-title":"Liposomes as carriers of hydrophilic small molecule drugs: strategies to enhance encapsulation and delivery","volume":"123","author":"Eloy","year":"2014","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.pdpdt.2018.06.003_bib0080","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/1556-276X-8-102","article-title":"Liposome: classification, preparation, and applications","volume":"8","author":"Akbarzadeh","year":"2013","journal-title":"Nanoscale Res. Lett."},{"key":"10.1016\/j.pdpdt.2018.06.003_bib0085","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.xphs.2016.10.001","article-title":"Recent advances in lipid-based vesicles and particulate carriers for topical and transdermal application","volume":"106","author":"Jain","year":"2017","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.pdpdt.2018.06.003_bib0090","first-page":"25","article-title":"Lipid vesicles for the skin delivery of diclofenac: cerosomes vs. other lipid suspensions","volume":"5","author":"Fathi-Azarbayjani","year":"2015","journal-title":"Adv. Pharm. Bull."},{"key":"10.1016\/j.pdpdt.2018.06.003_bib0095","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1021\/cr5004198","article-title":"Nanoparticles in photodynamic therapy","volume":"115","author":"Lucky","year":"2015","journal-title":"Chem. Rev."},{"key":"10.1016\/j.pdpdt.2018.06.003_bib0100","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/978-1-4939-6591-5_2","article-title":"Thin-film hydration followed by extrusion method for liposome preparation","volume":"1522","author":"Zhang","year":"2017","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.pdpdt.2018.06.003_bib0105","doi-asserted-by":"crossref","first-page":"545","DOI":"10.3109\/10837450.2016.1146294","article-title":"Topical colloidal indocyanine green-mediated photodynamic therapy for treatment of basal cell carcinoma","volume":"22","author":"Fadel","year":"2017","journal-title":"Pharm. Dev. Technol."},{"key":"10.1016\/j.pdpdt.2018.06.003_bib0110","doi-asserted-by":"crossref","first-page":"418316","DOI":"10.1155\/2011\/418316","article-title":"Characterization and in vitro skin permeation of meloxicam-loaded liposomes versus transfersomes","volume":"2011","author":"Duangjit","year":"2011","journal-title":"J. Drug Deliv."},{"key":"10.1016\/j.pdpdt.2018.06.003_bib0115","doi-asserted-by":"crossref","first-page":"354","DOI":"10.3109\/10717544.2012.724472","article-title":"Comparative study of liposomes, transfersomes and ethosomes as carriers for improving topical delivery of celecoxib","volume":"19","author":"Bragagni","year":"2012","journal-title":"Drug Deliv."},{"key":"10.1016\/j.pdpdt.2018.06.003_bib0120","first-page":"467","article-title":"Preparation, optimization and evaluation of transferosomal formulation for enhanced transdermal delivery of a cox-2 inhibitor","volume":"6","author":"Shaji","year":"2014","journal-title":"Int. J. Pharm. Sci."},{"key":"10.1016\/j.pdpdt.2018.06.003_bib0125","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jphotobiol.2017.07.007","article-title":"Development and in vitro assessment of psoralen and resveratrol co-loaded ultradeformable liposomes for the treatment of vitiligo","volume":"174","author":"Doppalapudi","year":"2017","journal-title":"J. Photochem. Photobiol. B"},{"key":"10.1016\/j.pdpdt.2018.06.003_bib0130","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.pdpdt.2017.05.013","article-title":"Ultradeformable liposome loaded with zinc phthalocyanine and [Ru(NH.NHq)(tpy)NO]3+ for photodynamic therapy by topical application","volume":"19","author":"de Lima","year":"2017","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2018.06.003_bib0135","doi-asserted-by":"crossref","first-page":"281068","DOI":"10.1155\/2012\/281068","article-title":"Assessment of DNA damage after photodynamic therapy using a metallophthalocyanine photosensitizer","volume":"2012","author":"El-Hussein","year":"2012","journal-title":"Int. J. Photoenergy"},{"key":"10.1016\/j.pdpdt.2018.06.003_bib0140","doi-asserted-by":"crossref","first-page":"845","DOI":"10.3390\/molecules22050845","article-title":"Preparation and in vitro photodynamic activity of glucosylated zinc(II) phthalocyanines as underlying targeting photosensitizers","volume":"22","author":"Liu","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.pdpdt.2018.06.003_bib0145","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1007\/s10103-012-1256-3","article-title":"Topical photodynamic therapy using transfersomal aluminum phthalocyanine tetrasulfonate: in vitro and in vivo study","volume":"28","author":"Kassab","year":"2013","journal-title":"Lasers Med. Sci."},{"key":"10.1016\/j.pdpdt.2018.06.003_bib0150","doi-asserted-by":"crossref","first-page":"5972","DOI":"10.3390\/molecules17055972","article-title":"Preparation of curcumin-loaded liposomes and evaluation of their skin permeation and pharmacodynamics","volume":"17","author":"Chen","year":"2012","journal-title":"Molecules"}],"container-title":["Photodiagnosis and Photodynamic Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100018300917?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100018300917?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:32:51Z","timestamp":1761611571000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1572100018300917"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":30,"alternative-id":["S1572100018300917"],"URL":"https:\/\/doi.org\/10.1016\/j.pdpdt.2018.06.003","relation":{},"ISSN":["1572-1000"],"issn-type":[{"value":"1572-1000","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Improved photodynamic efficacy of thiophenyl sulfonated zinc phthalocyanine loaded in lipid nano-carriers for hepatocellular carcinoma cancer cells","name":"articletitle","label":"Article Title"},{"value":"Photodiagnosis and Photodynamic Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pdpdt.2018.06.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}