{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T10:26:11Z","timestamp":1769509571378,"version":"3.49.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771071"],"award-info":[{"award-number":["81771071"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Nonprofit Industry Research Specific Fund of National Health and Family Planning Commission of China","award":["201502018"],"award-info":[{"award-number":["201502018"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Photodiagnosis and Photodynamic Therapy"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.pdpdt.2019.01.011","type":"journal-article","created":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T22:48:37Z","timestamp":1546987717000},"page":"296-299","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Plum-blossom needle assisted photodynamic therapy for the treatment of oral potentially malignant disorder in the elderly"],"prefix":"10.1016","volume":"25","author":[{"given":"Xing","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianqiu","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenwen","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongwei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pdpdt.2019.01.011_bib0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-0714.2007.00579.x","article-title":"Natural history of potentially malignant oral lesions and conditions: an overview of the literature","volume":"37","author":"Napier","year":"2008","journal-title":"J. Oral Pathol. Med."},{"key":"10.1016\/j.pdpdt.2019.01.011_bib0010","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1111\/jop.12726","article-title":"Prevalence of oral potentially malignant disorders: a systematic review and meta-analysis","volume":"47","author":"Mello","year":"2018","journal-title":"J. Oral Pathol. Med."},{"key":"10.1016\/j.pdpdt.2019.01.011_bib0015","first-page":"619","article-title":"Racial differences in the relationship between tobacco, alcohol, and the risk of head and neck cancer: pooled analysis of US studies in the INHANCE Consortium","volume":"29","author":"Voltzke","year":"2018","journal-title":"Cancer Causes Control"},{"key":"10.1016\/j.pdpdt.2019.01.011_bib0020","first-page":"e396","article-title":"Risk factors of Oral cancer- A hospital based case control study","volume":"10","author":"Azhar","year":"2018","journal-title":"J. Clin. Exp. Dent."},{"key":"10.1016\/j.pdpdt.2019.01.011_bib0025","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1007\/s00405-016-4221-0","article-title":"Will the mininvasive approach challenge the old paradigms in oral cancer surgery?","volume":"274","author":"Tirelli","year":"2017","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"10.1016\/j.pdpdt.2019.01.011_bib0030","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1177\/030089168607200312","article-title":"Excision of oral leukoplakias by CO2 laser on an out-patient basis: a useful procedure for prevention and early detection of oral carcinomas","volume":"2","author":"Chiesa","year":"1986","journal-title":"Tumori"},{"key":"10.1016\/j.pdpdt.2019.01.011_bib0035","doi-asserted-by":"crossref","DOI":"10.1002\/lary.27214","article-title":"Risk factors of cancer occurrence after surgery of oral intraepithelial neoplasia: a long-term retrospective study","author":"Ballivet de R\u00e9gloix","year":"2018","journal-title":"Laryngoscope"},{"key":"10.1016\/j.pdpdt.2019.01.011_bib0040","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1007\/s00784-012-0845-7","article-title":"Photodynamic therapy in dentistry: a literature review","volume":"17","author":"Gursoy","year":"2013","journal-title":"Clin. Oral Investig."},{"key":"10.1016\/j.pdpdt.2019.01.011_bib0045","doi-asserted-by":"crossref","first-page":"464","DOI":"10.4103\/0973-1482.147703","article-title":"Treatment of oral leukoplakia with photodynamic therapy: a pilot study","volume":"11","author":"Selvam","year":"2015","journal-title":"J. Cancer Res. Ther."},{"key":"10.1016\/j.pdpdt.2019.01.011_bib0050","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/ijc.20080","article-title":"The use of digitized endoscopic imaging of 5\u2010ALA\u2010induced PPIX fluorescence to detect and diagnose oral premalignant and malignant lesions in vivo","volume":"110","author":"Zheng","year":"2004","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.pdpdt.2019.01.011_bib0055","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.oraloncology.2013.05.011","article-title":"A phase I trial of aminolevulinic acid-photodynamic therapy for treatment of oral leukoplakia","volume":"49","author":"Wong","year":"2013","journal-title":"Oral Oncol."},{"key":"10.1016\/j.pdpdt.2019.01.011_bib0060","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1002\/(SICI)1097-0142(19961001)78:7<1374::AID-CNCR2>3.0.CO;2-L","article-title":"Photodynamic therapy using 5\u2010aminolevulinic acid for premalignant and malignant lesions of the oral cavity","volume":"78","author":"Fan","year":"2015","journal-title":"Cancer"},{"key":"10.1016\/j.pdpdt.2019.01.011_bib0065","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.oraloncology.2007.08.016","article-title":"Photodynamic therapy outcome for oral verrucous hyperplasia depends on the clinical appearance, size, color, epithelial dysplasia, and surface keratin thickness of the lesion","volume":"44","author":"Yu","year":"2008","journal-title":"Oral Oncol."},{"key":"10.1016\/j.pdpdt.2019.01.011_bib0070","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.pdpdt.2017.09.006","article-title":"Pretreatment of skin using an abrasive skin preparation pad, a microneedling device or iontophoresis improves absorption of methyl aminolevulinate in ex vivo human skin","volume":"20","author":"Osman-Ponchet","year":"2017","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2019.01.011_bib0075","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1002\/lsm.21096","article-title":"Enhanced uptake and photoactivation of topical methyl aminolevulinate after fractional CO2 laser pretreatment","volume":"43","author":"Haedersdal","year":"2011","journal-title":"Lasers Surg. Med."},{"key":"10.1016\/j.pdpdt.2019.01.011_bib0080","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.pdpdt.2016.06.012","article-title":"Plum-blossom needling promoted PpIX fluorescence intensity from 5-aminolevulinic acid in porcine skin model and patients with actnic keratosis","volume":"15","author":"Chen","year":"2016","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2019.01.011_bib0085","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.pdpdt.2017.12.010","article-title":"Successful treatment of giant invasive cutaneous squamous cell carcinoma by plum-blossom needle assisted photodynamic therapy sequential with imiquimod: case experience","volume":"21","author":"Wang","year":"2018","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2019.01.011_bib0090","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0091-679X(08)60520-8","article-title":"DNA analysis from paraffin-embedded blocks","volume":"33","author":"Hedley","year":"1990","journal-title":"Methods Cell Biol."},{"key":"10.1016\/j.pdpdt.2019.01.011_bib0095","doi-asserted-by":"crossref","first-page":"464","DOI":"10.4103\/0973-1482.147703","article-title":"Treatment of oral leukoplakia with photodynamic therapy:\u2009a pilot study","volume":"11","author":"Selvam","year":"2015","journal-title":"J. Cancer Res. Ther."},{"key":"10.1016\/j.pdpdt.2019.01.011_bib0100","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.oraloncology.2017.02.009","article-title":"The impact of time to treatment initiation on survival from head and neck cancer in north-eastern Italy","volume":"67","author":"Polesel","year":"2017","journal-title":"Oral Oncol."},{"key":"10.1016\/j.pdpdt.2019.01.011_bib0105","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1001\/jamaoncol.2018.2706","volume":"4","author":"Global Burden of Disease Cancer Collaboration","year":"2018","journal-title":"JAMA Oncol."},{"key":"10.1016\/j.pdpdt.2019.01.011_bib0110","doi-asserted-by":"crossref","first-page":"E359","DOI":"10.1002\/ijc.29210","article-title":"Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012","volume":"136","author":"Ferlay","year":"2015","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.pdpdt.2019.01.011_bib0115","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/jop.12339","article-title":"Malignant transformation of oral leukoplakia: a systematic review of observational studies","volume":"45","author":"Warnakulasuriya","year":"2016","journal-title":"J. Oral Pathol. Med."},{"key":"10.1016\/j.pdpdt.2019.01.011_bib0120","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD001829.pub3","article-title":"Interventions for treating oral leukoplakia","volume":"18","author":"Lodi","year":"2006","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.pdpdt.2019.01.011_bib0125","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.pdpdt.2013.05.008","article-title":"Clearance mechanism of protoporphyrin IX from mouse skin after application of 5-aminolevulinic acid","volume":"10","author":"Juzeniene","year":"2013","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2019.01.011_bib0130","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0304-3835(88)90211-X","article-title":"The heme biosynthetic pathway in lymphocytes of patients with malignant lymphoproliferative disorders","volume":"43","author":"Schoenfeld","year":"1988","journal-title":"Cancer Lett."},{"key":"10.1016\/j.pdpdt.2019.01.011_bib0135","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S1040-8428(84)80016-5","article-title":"Photodynamic therapy (PDT) of malignant tumors","volume":"2","author":"Dougherty","year":"1984","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.pdpdt.2019.01.011_bib0140","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.pdpdt.2015.04.009","article-title":"Photodynamic therapy (PDT) for malignant brain tumors--where do we stand?","volume":"12","author":"Quirk","year":"2015","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2019.01.011_bib0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5411\/wji.v4.i1.1","article-title":"Immune response after photodynamic therapy increases anti-cancer and anti-bacterial effects","volume":"4","author":"Reginato","year":"2014","journal-title":"World J. Immunol."},{"key":"10.1016\/j.pdpdt.2019.01.011_bib0150","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1034\/j.1600-0714.2003.00068.x","article-title":"Photodynamic therapy (PDT) using topically applied delta-aminolevulinic acid (ALA) for the treatment of oral leukoplakia","volume":"32","author":"Siero\u0144","year":"2003","journal-title":"J. Oral Pathol. Med."},{"key":"10.1016\/j.pdpdt.2019.01.011_bib0155","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1001\/archoto.2011.178","article-title":"Using 5-aminolevulinic acid and pulsed dye laser for photodynamic treatment of oral leukoplakia","volume":"137","author":"Shafirstein","year":"2011","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.pdpdt.2019.01.011_bib0160","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.pdpdt.2006.11.003","article-title":"Topical 5-aminolevulinic acid-mediated photodynamic therapy for oral verrucous hyperplasia, oral leukoplakia and oral erythroleukoplakia","volume":"4","author":"Chen","year":"2007","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2019.01.011_bib0165","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.pdpdt.2017.10.006","article-title":"Treatment of oral refractory large area mucosal leukoplakia with CO2 laser combined with photodynamic therapy: case report","volume":"20","author":"Zhang","year":"2017","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2019.01.011_bib0170","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1111\/j.1365-2133.2012.10893.x","article-title":"Intensified photodynamic therapy of actinic keratoses with fractional CO2 laser: a randomized clinical trial","volume":"166","author":"Togsverd-Bo","year":"2012","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.pdpdt.2019.01.011_bib0175","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1001\/jamadermatol.2017.0849","article-title":"Effect of expedited microneedle-assisted photodynamic therapy for field treatment of actinic keratoses: a randomized clinical trial","volume":"153","author":"Petukhova","year":"2017","journal-title":"JAMA Dermatol."},{"key":"10.1016\/j.pdpdt.2019.01.011_bib0180","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1097\/DSS.0000000000001608","article-title":"Enhancement of photodynamic therapy for Bowen\u2019s disease using plum-blossom needling to augment drug delivery","volume":"44","author":"Wu","year":"2018","journal-title":"Dermatol. Surg."},{"key":"10.1016\/j.pdpdt.2019.01.011_bib0185","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.pdpdt.2018.08.001","article-title":"Plum-blossom needling enhanced the effect of photodynamic therapy on basal cell carcinoma","author":"Mu","year":"2018","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2019.01.011_bib0190","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0304-3959(92)90147-4","article-title":"Quantitative determinations of sensory and pain thresholds on human oral mucosa by argon laser stimulation","volume":"49","author":"Svensson","year":"1992","journal-title":"Pain"},{"key":"10.1016\/j.pdpdt.2019.01.011_bib0195","first-page":"79","article-title":"Expert consensus on the detection and screening of oral Cancer and precancer","volume":"18","author":"Kao","year":"2015","journal-title":"Chin. J. Dent. Res."}],"container-title":["Photodiagnosis and Photodynamic Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100018303429?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100018303429?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:34:20Z","timestamp":1761611660000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1572100018303429"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":39,"alternative-id":["S1572100018303429"],"URL":"https:\/\/doi.org\/10.1016\/j.pdpdt.2019.01.011","relation":{},"ISSN":["1572-1000"],"issn-type":[{"value":"1572-1000","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Plum-blossom needle assisted photodynamic therapy for the treatment of oral potentially malignant disorder in the elderly","name":"articletitle","label":"Article Title"},{"value":"Photodiagnosis and Photodynamic Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pdpdt.2019.01.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}