{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T20:21:56Z","timestamp":1781122916032,"version":"3.54.1"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T00:00:00Z","timestamp":1578614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012190","name":"Ministry of Science and Higher Education of the Russian Federation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012190","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005749","name":"African University of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005749","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Photodiagnosis and Photodynamic Therapy"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.pdpdt.2019.101623","type":"journal-article","created":{"date-parts":[[2020,1,2]],"date-time":"2020-01-02T11:49:15Z","timestamp":1577965755000},"page":"101623","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["The effect of glucose and human serum on 5-aminolevulinic acid mediated photodynamic inactivation of Candida albicans"],"prefix":"10.1016","volume":"29","author":[{"given":"Irena","family":"Maliszewska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominika","family":"Wawrzy\u0144czyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewelina","family":"Wanarska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pdpdt.2019.101623_bib0005","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3004404","article-title":"Hidden killers: human fungal infections","volume":"4","author":"Brown","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.pdpdt.2019.101623_bib0010","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.clinmicnews.2014.08.001","article-title":"Current epidemiology of Candida infection","volume":"36","author":"Lockhart","year":"2014","journal-title":"Clin. Microbiol. Newsl."},{"key":"10.1016\/j.pdpdt.2019.101623_bib0015","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s12275-011-1064-7","article-title":"P. Candida albicans, a major human fungal pathogen","volume":"49","author":"Kim","year":"2011","journal-title":"J. Microbiol."},{"key":"10.1016\/j.pdpdt.2019.101623_bib0020","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nrmicro2711","article-title":"Candida albicans morphogenesis and host defence: discriminating invasion from colonization","volume":"10","author":"Gow","year":"2012","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.pdpdt.2019.101623_bib0025","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1111\/myc.12469","article-title":"Epidemiology and molecular mechanisms of antifungal resistance in Candida and Aspergillus","volume":"4","author":"Gon\u00e7alves","year":"2016","journal-title":"Mycoses"},{"key":"10.1016\/j.pdpdt.2019.101623_bib0030","doi-asserted-by":"crossref","first-page":"S431","DOI":"10.1093\/infdis\/jix179","article-title":"Antifungal resistance: an emerging reality and a global challenge","volume":"216","author":"Kontoyiannis","year":"2017","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.pdpdt.2019.101623_bib0035","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1097\/QCO.0000000000000411","article-title":"Emerging multidrug-resistant Candida species","volume":"30","author":"Colombo","year":"2017","journal-title":"Curr. Opin. Infect. Dis"},{"key":"10.1016\/j.pdpdt.2019.101623_bib0040","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.mib.2016.06.008","article-title":"Antimicrobial photodynamic inactivation: a bright new technique to kill resistant microbes","volume":"33","author":"Hamblin","year":"2016","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.pdpdt.2019.101623_bib0045","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1002\/lsm.20361","article-title":"Photodynamic therapy in the treatment of microbial infections: basic principles and perspective applications","volume":"38","author":"Jori","year":"2006","journal-title":"Lasers Surg. Med."},{"key":"10.1016\/j.pdpdt.2019.101623_bib0050","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1080\/1040841X.2018.1467876","article-title":"Antimicrobial photodynamic therapy \u2013what we know and what we don\u2019t","volume":"5","author":"Cieplik","year":"2018","journal-title":"Crit. Rev. Microb."},{"key":"10.1016\/j.pdpdt.2019.101623_bib0055","first-page":"188","article-title":"Susceptibility of Candida albicans to photodynamic therapy using methylene blue and toluidine blue as photosensitizing dyes","volume":"2","author":"Pupo","year":"2011","journal-title":"Acta Odontol. Latinoam."},{"key":"10.1016\/j.pdpdt.2019.101623_bib0060","doi-asserted-by":"crossref","first-page":"506","DOI":"10.4103\/0255-0857.195351","article-title":"Synergism between fluconazole and methylene blue-photodynamic therapy against fluconazole-resistant Candida strains","volume":"34","author":"Lyon","year":"2016","journal-title":"Indian J. Med. Microbiol."},{"key":"10.1016\/j.pdpdt.2019.101623_bib0065","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1111\/j.1751-1097.2011.01039.x","article-title":"Miconazole induces fungistasis and increases killing of Candida albicans subjected to photodynamic therapy","volume":"88","author":"Snell","year":"2012","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.pdpdt.2019.101623_bib0070","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.pdpdt.2015.10.005","article-title":"Photodynamic inactivation of Candida albicans by a tetracationic tentacle porphyrin and its analogue without intrinsic charges in presence of fluconazole","volume":"1","author":"Quiroga","year":"2016","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2019.101623_bib0075","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/1011-1344(90)85083-9","article-title":"Photodynamic therapy with endogenous protoporphyrin IX: basic principle and clinical experience","volume":"6","author":"Kennedy","year":"1990","journal-title":"J. Photochem. Photobiol. B"},{"key":"10.1016\/j.pdpdt.2019.101623_bib0080","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1097\/MOH.0b013e328351c48b","article-title":"Heme metabolism and erythropoiesis","volume":"3","author":"Chung","year":"2012","journal-title":"Curr. Opin. Hematol."},{"key":"10.1016\/j.pdpdt.2019.101623_bib0085","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/1011-1344(92)85128-H","article-title":"Effects of photodynamic therapy with topical application of 5-aminolevulinic acid on normal skin of hairless guinea pigs","volume":"15","author":"Goff","year":"1992","journal-title":"J. Photochem. Photobiol. B"},{"key":"10.1016\/j.pdpdt.2019.101623_bib0090","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1111\/j.1751-1097.2012.01107.x","article-title":"Photodynamic antifungal chemotherapy","volume":"88","author":"Calzavara-Pinton","year":"2012","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.pdpdt.2019.101623_bib0095","first-page":"725","article-title":"Synthesis of PPIX induced by 5-aminolevulinic acid in yeast cells in the presence of 2,20-dipyridyl","volume":"63","author":"Trakhovskaya","year":"1998","journal-title":"Biochem. (Mosc.)"},{"key":"10.1016\/j.pdpdt.2019.101623_bib0100","article-title":"The antimicrobial photodynamic inactivation resistance of Candida albicans is modulated by the Hog1 pathway and the Cap1 transcription factor","author":"Chien","year":"2018","journal-title":"Med. Mycol."},{"key":"10.1016\/j.pdpdt.2019.101623_bib0105","first-page":"1481","article-title":"The use of esters of 5-aminolevulinic acid to improve photodynamic therapy on cells in culture","volume":"57","author":"Gaullier","year":"1997","journal-title":"Cancer Res."},{"key":"10.1016\/j.pdpdt.2019.101623_bib0110","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.jphotobiol.2018.04.021","article-title":"Porphyrins and flavins as endogenous acceptors of optical radiation of blue spectral region determining photoinactivation of microbial cells","volume":"183","author":"Plavskii","year":"2018","journal-title":"J. Photochem. Photobiol. B"},{"key":"10.1016\/j.pdpdt.2019.101623_bib0115","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.pdpdt.2019.101623_bib0120","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.mib.2016.06.008","article-title":"Antimicrobial photodynamic inactivation: a bright new technique to kill resistant microbes","volume":"33","author":"Hamblin","year":"2016","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.pdpdt.2019.101623_bib0125","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.jss.2013.02.002","article-title":"Aminolevulinic acid (ALA): photodynamic detection and potential therapeutic applications","volume":"181","author":"Nokes","year":"2013","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.pdpdt.2019.101623_bib0130","doi-asserted-by":"crossref","first-page":"25865","DOI":"10.3390\/ijms161025865","article-title":"Aminolevulinic acid-based tumor detection and therapy: molecular mechanisms and strategies for enhancement","volume":"16","author":"Yang","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.pdpdt.2019.101623_bib0135","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1515\/nanoph-2016-0189","article-title":"Advances in antimicrobial photodynamic inactivation at the nanoscale","volume":"5","author":"Kashef","year":"2017","journal-title":"Nanophotonics"},{"key":"10.1016\/j.pdpdt.2019.101623_bib0140","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0014-5793(98)00504-3","article-title":"Hydroxyl radicals are involved in the oxidation of isolated and cellular DNA bases by 5-aminolevulinic acid","volume":"428","author":"Douki","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1016\/j.pdpdt.2019.101623_bib0145","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0891-5849(99)00255-5","article-title":"Genotoxic potential of porphyrin type photosensitizers with particular emphasis on 5-aminolevulinic acid: implications for clinical photodynamic therapy","volume":"28","author":"Fuchs","year":"2000","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.pdpdt.2019.101623_bib0150","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/0167-4889(84)90092-2","article-title":"Effect of glucose on the induction of delta-aminolevulinic acid synthase and ferrochelatase in isolated rat hepatocytes by allylisopropylacetamide","volume":"22","author":"C\u00e1nepa","year":"1984","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.pdpdt.2019.101623_bib0155","first-page":"186","article-title":"Candida biofilms: antifungal resistance and emerging therapeutic options","volume":"5","author":"Kuhn","year":"2004","journal-title":"Curr. Opin. Investig. Drugs"},{"key":"10.1016\/j.pdpdt.2019.101623_bib0160","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1111\/j.1567-1364.2006.00117.x","article-title":"Candida biofilms on implanted biomaterials: a clinically significant problem","volume":"6","author":"Ramage","year":"2006","journal-title":"FEMS Yeast Res."},{"key":"10.1016\/j.pdpdt.2019.101623_bib0165","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.2174\/092986711795843272","article-title":"Mechanisms of resistance to photodynamic therapy","volume":"16","author":"Casas","year":"2011","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.pdpdt.2019.101623_bib0170","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1039\/b315629j","article-title":"In vitro effect of 5-aminolaevulinic acid plus visible light on Candida albicans","volume":"3","author":"Monfrecola","year":"2004","journal-title":"Photochem. Photobiol. Sci."},{"key":"10.1016\/j.pdpdt.2019.101623_bib0175","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s00284-009-9514-8","article-title":"Photoinactivation of Candida albicans by its own endogenous porphyrins","volume":"2","author":"Oriel","year":"2010","journal-title":"Curr. Microbiol."},{"key":"10.1016\/j.pdpdt.2019.101623_bib0180","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.pdpdt.2016.04.011","article-title":"Effect of 5-aminolevulinic acid photodynamic therapy on Candida albicans biofilms: an in vitro study","volume":"15","author":"Shi","year":"2016","journal-title":"Photod. Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2019.101623_bib0185","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/j.1600-0781.2004.00095.x","article-title":"Photodynamic therapy of interdigital mycoses of the feet with topical application of 5-aminolevulinic acid","volume":"20","author":"Calzavara-Pinton","year":"2004","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"10.1016\/j.pdpdt.2019.101623_bib0190","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.jconrel.2004.12.005","article-title":"Bioadhesive patch-based delivery of 5-aminolevulinic acid to the nail for photodynamic therapy of onychomycosis","volume":"103","author":"Donnelly","year":"2005","journal-title":"J. Control. Release"}],"container-title":["Photodiagnosis and Photodynamic Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S157210001930568X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S157210001930568X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:34:57Z","timestamp":1761611697000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S157210001930568X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":38,"alternative-id":["S157210001930568X"],"URL":"https:\/\/doi.org\/10.1016\/j.pdpdt.2019.101623","relation":{},"ISSN":["1572-1000"],"issn-type":[{"value":"1572-1000","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effect of glucose and human serum on 5-aminolevulinic acid mediated photodynamic inactivation of Candida albicans","name":"articletitle","label":"Article Title"},{"value":"Photodiagnosis and Photodynamic Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pdpdt.2019.101623","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"101623"}}