{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T23:41:32Z","timestamp":1779234092294,"version":"3.51.4"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Photodiagnosis and Photodynamic Therapy"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.pdpdt.2020.101796","type":"journal-article","created":{"date-parts":[[2020,5,23]],"date-time":"2020-05-23T11:43:40Z","timestamp":1590234220000},"page":"101796","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Conventional versus daylight photodynamic therapy for acne vulgaris: A randomized and prospective clinical study in China"],"prefix":"10.1016","volume":"31","author":[{"given":"Linglin","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunfeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peiru","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiyan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongxia","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guolong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuli","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pdpdt.2020.101796_bib0005","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0140-6736(11)60321-8","article-title":"Acne vulgaris","volume":"379","author":"Williams","year":"2012","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.pdpdt.2020.101796_bib0010","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jaad.2009.09.056","article-title":"Photodynamic therapy for acne vulgaris: a critical review from basics to clinical practice: part I. Acne vulgaris: when and why consider photodynamic therapy?","volume":"63","author":"Sakamoto","year":"2010","journal-title":"J. Am. Acad. Dermatol."},{"issue":"4","key":"10.1016\/j.pdpdt.2020.101796_bib0015","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.pdpdt.2011.07.003","article-title":"Successful treatment of refractory facial acne using repeat short-cycle ALA-PDT: case study","volume":"8","author":"Ding","year":"2011","journal-title":"Photodiagnosis Photodyn. Ther."},{"issue":"1","key":"10.1016\/j.pdpdt.2020.101796_bib0020","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.pdpdt.2010.01.003","article-title":"Topical ALA PDT for the treatment of severe acne vulgaris","volume":"7","author":"Wang","year":"2010","journal-title":"Photodiagnosis Photodyn. Ther."},{"issue":"5","key":"10.1016\/j.pdpdt.2020.101796_bib0025","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1177\/120347541201600509","article-title":"Prospective study of topical 5-aminolevulinic acid photodynamic therapy for the treatment of moderate to severe acne vulgaris in Chinese patients","volume":"16","author":"Wang","year":"2012","journal-title":"J. Cutan. Med. Surg."},{"issue":"4","key":"10.1016\/j.pdpdt.2020.101796_bib0030","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.pdpdt.2013.06.007","article-title":"Low-dose topical 5-aminolevulinic acid photodynamic therapy in the treatment of different severity of acne vulgaris","volume":"10","author":"Ma","year":"2013","journal-title":"Photodiagnosis Photodyn. Ther."},{"issue":"10","key":"10.1016\/j.pdpdt.2020.101796_bib0035","first-page":"675","article-title":"Photodynamic Therapy Research Center of the Chinese Society of Dermatology and Venereology. Expert consensus on the clinical application of aminoketovalerate photodynamic therapy","volume":"48","author":"Wang","year":"2015","journal-title":"Chin. J. Dermatol."},{"key":"10.1016\/j.pdpdt.2020.101796_bib0040","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.pdpdt.2017.07.002","article-title":"Photodynamic therapy and pain: a systematic review","volume":"19","author":"Ang","year":"2017","journal-title":"Photodiagnosis Photodyn. Ther."},{"issue":"5","key":"10.1016\/j.pdpdt.2020.101796_bib0045","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1111\/bjd.13138","article-title":"Daylight photodynamic therapy with methyl aminolevulinate cream as a convenient, similarly effffective, nearly painless alternative to conventional photodynamic therapy in actinic keratosis treatment: a randomized controlled trial","volume":"171","author":"Rubel","year":"2014","journal-title":"Br. J. Dermatol."},{"issue":"10","key":"10.1016\/j.pdpdt.2020.101796_bib0050","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1111\/jdv.13076","article-title":"Conventional vs. daylight methyl aminolevulinate photodynamic therapy for actinic keratosis of the face and scalp: an intra-patient, prospective, comparison study in Italy","volume":"29","author":"Fargnoli","year":"2015","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"issue":"6","key":"10.1016\/j.pdpdt.2020.101796_bib0055","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1111\/j.1468-3083.2011.04386.x","article-title":"Daylight photodynamic therapy for actinic keratosis: an international consensus: international Society for Photodynamic Therapy in Dermatology","volume":"26","author":"Wiegell","year":"2012","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"issue":"1","key":"10.1016\/j.pdpdt.2020.101796_bib0060","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1590\/abd1806-4841.20175175","article-title":"Daylight photodynamic therapy \u2013experience and safety in treatment of actinic keratoses of the face and scalp in low latitude and high brightness region","volume":"92","author":"Galvao","year":"2017","journal-title":"An. Bras. Dermatol."},{"key":"10.1016\/j.pdpdt.2020.101796_bib0065","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.pdpdt.2018.10.010","article-title":"Conventional versus daylight photodynamic therapy for actinic keratosis: a randomized and prospective study in China","volume":"24","author":"Zhu","year":"2018","journal-title":"Photodiagnosis Photodyn. Ther."},{"issue":"5","key":"10.1016\/j.pdpdt.2020.101796_bib0070","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/1346-8138.13191","article-title":"Daylight photodynamic therapy with 1.5% 3-butenyl 5-aminolevulinate gel as a convenient, effective and safe therapy in acne treatment: a double-blind randomized controlled trial","volume":"43","author":"Kwon","year":"2016","journal-title":"J. Dermatol."},{"issue":"5","key":"10.1016\/j.pdpdt.2020.101796_bib0075","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/phpp.12312","article-title":"Nonablative fractional laser\u2010assisted daylight photodynamic therapy with topical methyl aminolevulinate for moderate to severe facial acne vulgaris: results of a randomized and comparative study","volume":"33","author":"Kim","year":"2017","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"issue":"4","key":"10.1016\/j.pdpdt.2020.101796_bib0080","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1590\/S0365-05962012000400001","article-title":"Pain in photodynamic therapy: mechanism of action and management strategies","volume":"87","author":"Chaves","year":"2012","journal-title":"An. Bras. Dermatol."},{"issue":"10","key":"10.1016\/j.pdpdt.2020.101796_bib0085","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1038\/sj.jid.5700449","article-title":"Histamine is released following aminolevulinic acid-photodynamic therapy of human skin and mediates an aminolevulinic acid dose-related immediate inflammatory response","volume":"126","author":"Brooke","year":"2006","journal-title":"J. Invest. Dermatol."},{"issue":"3","key":"10.1016\/j.pdpdt.2020.101796_bib0090","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/j.1600-0781.2010.00560.x","article-title":"Adverse effects of topical photodynamic therapy","volume":"27","author":"Sh","year":"2011","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"issue":"4","key":"10.1016\/j.pdpdt.2020.101796_bib0095","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1111\/j.1365-2133.2008.08451.x","article-title":"Pain during photodynamic therapy is associated with protoporphyrin IX fluorescence and fluence rate","volume":"158","author":"Wiegell","year":"2008","journal-title":"Br. J. Dermatol."},{"issue":"4","key":"10.1016\/j.pdpdt.2020.101796_bib0100","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1111\/j.1365-2133.2008.08450.x","article-title":"Continuous activation of PplX by daylight is as effective as and less painful than conventional photodynamic therapy for actinic keratoses-a randomized, controlled, single-blinded study","volume":"158","author":"Wiegell","year":"2008","journal-title":"Br. J. Dermatol."},{"issue":"5","key":"10.1016\/j.pdpdt.2020.101796_bib0105","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1111\/j.1365-2133.2011.10209.x","article-title":"A randomized, multicenter study of directed daylight exposure times of 1 \u00bd vs. 2 \u00bd h in daylight mediated photodynamic therapy with methyl aminolevulinate in patients with multiple thin actinic keratoses of the face and scalp","volume":"164","author":"Wiegell","year":"2011","journal-title":"Br. J. Dermatol."}],"container-title":["Photodiagnosis and Photodynamic Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100020301502?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100020301502?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:43:39Z","timestamp":1761612219000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1572100020301502"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":21,"alternative-id":["S1572100020301502"],"URL":"https:\/\/doi.org\/10.1016\/j.pdpdt.2020.101796","relation":{},"ISSN":["1572-1000"],"issn-type":[{"value":"1572-1000","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Conventional versus daylight photodynamic therapy for acne vulgaris: A randomized and prospective clinical study in China","name":"articletitle","label":"Article Title"},{"value":"Photodiagnosis and Photodynamic Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pdpdt.2020.101796","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"101796"}}