{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T21:53:02Z","timestamp":1773957182152,"version":"3.50.1"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Photodiagnosis and Photodynamic Therapy"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.pdpdt.2020.101966","type":"journal-article","created":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T11:20:58Z","timestamp":1598008858000},"page":"101966","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Zinc phthalocyanine tetrasulfonate-loaded polyelectrolytic PLGA nanoparticles for photodynamic therapy applications"],"prefix":"10.1016","volume":"32","author":[{"given":"Maria Cristina Modesto Clementino","family":"de Toledo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandro da Silva","family":"Abreu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janicy Arantes","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0457-6624","authenticated-orcid":false,"given":"J\u00e9ssica Aparecida Ribeiro","family":"Ambr\u00f3sio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele da Silva","family":"Godoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8829-8328","authenticated-orcid":false,"given":"Bruna Cristina","family":"dos Santos Pinto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milton","family":"Beltrame Junior","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3087-7431","authenticated-orcid":false,"given":"Andreza Ribeiro","family":"Simioni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pdpdt.2020.101966_bib0005","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s12272-020-01214-5","article-title":"Photodynamic therapy with smart nanomedicine","author":"Kim","year":"2020","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.pdpdt.2020.101966_bib0010","doi-asserted-by":"crossref","first-page":"597","DOI":"10.3389\/fonc.2020.00597","article-title":"Susceptibility and resistance mechanisms during photodynamic therapy of melanoma","author":"Li","year":"2020","journal-title":"Front. Oncol."},{"key":"10.1016\/j.pdpdt.2020.101966_bib0015","doi-asserted-by":"crossref","first-page":"102","DOI":"10.4103\/jioh.jioh_204_18","article-title":"Photodynamic therapy in the treatment of periodontal diseases: a review","author":"AlAhmari","year":"2020","journal-title":"J. Int. Oral Health"},{"key":"10.1016\/j.pdpdt.2020.101966_bib0020","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/s41467-019-14199-7","article-title":"Self-assembled single-atom nanozyme for enhanced photodynamic therapy treatment of tumor","author":"Wang","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pdpdt.2020.101966_bib0025","first-page":"250","article-title":"Photodynamic therapy of cancer: an update","author":"Agostinis","year":"2011","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.pdpdt.2020.101966_bib0030","first-page":"167","article-title":"A new approach in the treatment of oral cancer","author":"Bicalho","year":"2010","journal-title":"Rev. Univ. Ind. Santander. Salud"},{"key":"10.1016\/j.pdpdt.2020.101966_bib0035","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1071\/CH08145","author":"Moreira","year":"2008","journal-title":"Aust. J. Chem."},{"key":"10.1016\/j.pdpdt.2020.101966_bib0040","doi-asserted-by":"crossref","first-page":"7987","DOI":"10.1021\/ac502103t","article-title":"Targeted bioimaging and photodynamic therapy of cancer cells with an activatable red fluorescent bioprobe","author":"Hu","year":"2014","journal-title":"Anal. Chem."},{"key":"10.1016\/j.pdpdt.2020.101966_bib0045","doi-asserted-by":"crossref","first-page":"3323","DOI":"10.21873\/anticanres.13475","article-title":"Drug delivery systems for phthalocyanines for photodynamic therapy","author":"Rak","year":"2019","journal-title":"Anticancer Res."},{"key":"10.1016\/j.pdpdt.2020.101966_bib0050","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1039\/C8TB02491J","article-title":"Stimuli-responsive bio-based polymeric systems and their applications","author":"Gao","year":"2019","journal-title":"J. Mater. Chem. B Mater. Biol. Med."},{"key":"10.1016\/j.pdpdt.2020.101966_bib0055","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1016\/j.carbpol.2016.06.066","article-title":"pH Responsive polyurethane (core) and cellulose acetate phthalate (shell) electrospun fibers for intravaginal drug delivery","author":"Hua","year":"2016","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.pdpdt.2020.101966_bib0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/3702518","article-title":"Smart nanoparticles for drug delivery application: development of versatile nanocarrier platforms in biotechnology and nanomedicine","author":"Lombardo","year":"2019","journal-title":"J. Nanomater."},{"key":"10.1016\/j.pdpdt.2020.101966_bib0065","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s40005-019-00439-x","article-title":"Biocompatibility, biodegradation and biomedical applications of poly(lactic acid)\/poly(lactic\u2011co\u2011glycolic acid) micro and nanoparticles","author":"Elmowafy","year":"2019","journal-title":"J. Pharm. Investig."},{"key":"10.1016\/j.pdpdt.2020.101966_bib0070","first-page":"51015","article-title":"PLGA nanoparticles formed by single- or double-emulsion with vitamin ETPGS","author":"McCall","year":"2013","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.pdpdt.2020.101966_bib0075","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1021\/acsomega.8b02767","article-title":"Optimization of rutin-loaded PLGA nanoparticles synthesized by single-emulsion solvent evaporation method","author":"K\u0131z\u0131lbey","year":"2019","journal-title":"ACS Omega"},{"key":"10.1016\/j.pdpdt.2020.101966_bib0080","first-page":"1","article-title":"Formulation and characterization of combretastatin A4 loaded PLGA nanoparticles","author":"Zaid","year":"2020","journal-title":"Mater. Res. Express"},{"key":"10.1016\/j.pdpdt.2020.101966_bib0085","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.ijpharm.2015.10.057","article-title":"Double emulsion solvent evaporation techniques used for drug encapsulation","author":"Iqbal","year":"2015","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.pdpdt.2020.101966_bib0090","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.pdpdt.2019.01.026","article-title":"Evaluation of mTHPC-loaded PLGA nanoparticles for in vitro photodynamic therapy on C6 glioma cell line","author":"B\u0153uf-Muraille","year":"2019","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2020.101966_bib0095","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s11094-020-02154-6","article-title":"Physicochemical and biological properties of a nanostructured IR-photosensitizer based on dipropoxybacteriopurpurinimide","author":"Sapel\u2019nikov","year":"2020","journal-title":"Pharm Chem J"},{"key":"10.1016\/j.pdpdt.2020.101966_bib0100","doi-asserted-by":"crossref","first-page":"280","DOI":"10.3390\/pharmaceutics11060280","article-title":"Recent progress in the development of poly(lactic-co-glycolic acid)-based nanostructures for cancer imaging and therapy","author":"Kim","year":"2019","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.pdpdt.2020.101966_bib0105","doi-asserted-by":"crossref","first-page":"e20181343","DOI":"10.1590\/0001-3765201920181343","article-title":"Processing of nanomaterials in layer-by-layer films: potential applications in (bio)sensing and energy storage","author":"Oliveira","year":"2019","journal-title":"Ann. Acad. Bras. Ci\u00eanc."},{"key":"10.1016\/j.pdpdt.2020.101966_bib0110","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s40824-018-0139-5","article-title":"Layer-by-layer assembled polymeric thin films as prospective drug delivery carriers: design and applications","author":"Park","year":"2018","journal-title":"Biomater. Res."},{"key":"10.1016\/j.pdpdt.2020.101966_bib0115","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.2147\/IJN.S130404","article-title":"Doxorubicin-loaded poly (lactic-co-glycolic acid) nanoparticles coated with chitosan\/alginate by layer by layer technology for antitumor applications","author":"Chai","year":"2017","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.pdpdt.2020.101966_bib0120","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s12272-013-0289-x","article-title":"Layer-by-layer assembly of multilayer films for controlled drug release","author":"Choi","year":"2014","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.pdpdt.2020.101966_bib0125","doi-asserted-by":"crossref","first-page":"40615","DOI":"10.1039\/C6RA05289D","article-title":"Polyelectrolyte coated BaTiO3 nanoparticles for second harmonic generation imaging-guided photodynamic therapy with improved stability and enhanced cellular uptake","author":"Wang","year":"2016","journal-title":"RSC Adv."},{"key":"10.1016\/j.pdpdt.2020.101966_bib0130","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1080\/09205063.2020.1760702","article-title":"Polyelectrolytic BSA nanoparticles containing silicon dihydroxide phthalocyanine as a promising candidate for drug delivery systems for anticancer photodynamic therapy","author":"Mazzilli","year":"2020","journal-title":"J. Biomater. Sci. Polym. Ed."},{"key":"10.1016\/j.pdpdt.2020.101966_bib0135","first-page":"0120041","article-title":"Silicon (IV) phthalocyanine-loaded-nanoparticles for application in photodynamic process","author":"Simioni","year":"2012","journal-title":"J. Laser Appl."},{"key":"10.1016\/j.pdpdt.2020.101966_bib0140","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.pdpdt.2018.04.011","article-title":"Layer-by-layer hollow photosensitizer microcapsule design via a manganese carbonate hard template for photodynamic therapy in cells","author":"Simioni","year":"2018","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2020.101966_bib0145","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0939-6411(02)00161-3","article-title":"Release of small water-soluble drugs from multiblock copolymer microspheres: a feasibility study","author":"Sohiera","year":"2003","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.pdpdt.2020.101966_bib0150","doi-asserted-by":"crossref","first-page":"895","DOI":"10.3144\/expresspolymlett.2016.84","article-title":"Polymeric nanoparticles: recent development in synthesis and application","author":"Mallakpour","year":"2016","journal-title":"Express Polym. Lett."},{"key":"10.1016\/j.pdpdt.2020.101966_bib0155","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1002\/biot.201000351","article-title":"Cellular uptake of poly-(D,L-lactide-co-glycolide) (PLGA) nanoparticles synthesized through solvent emulsion evaporation and nanoprecipitation method","author":"Xiong","year":"2011","journal-title":"Biotechnol. J."},{"key":"10.1016\/j.pdpdt.2020.101966_bib0160","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1557\/jmr.2019.47","article-title":"Fabrication of polyelectrolyte microspheres using porous manganese carbonate as sacrificial template for drug delivery application","author":"Abreu","year":"2019","journal-title":"J. Mater. Res."},{"key":"10.1016\/j.pdpdt.2020.101966_bib0165","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.msec.2015.09.044","article-title":"Preparation of polyelectrolyte complex nanoparticles of chitosan and poly(2-acry1amido-2-methylpropanesulfonic acid) for doxorubicin release","author":"Zhang","year":"2016","journal-title":"Mater. Sci. Eng. C-Bio. Sci."},{"key":"10.1016\/j.pdpdt.2020.101966_bib0170","first-page":"1","article-title":"Preparation and evaluation of pralidoxime-loaded PLGA nanoparticles as potential carriers of the drug across the blood brain barrier","author":"Chigumira","year":"2015","journal-title":"J. Nanomater."},{"key":"10.1016\/j.pdpdt.2020.101966_bib0175","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s12951-018-0392-8","article-title":"Nano based drug delivery systems: recent developments and future prospects","author":"Patra","year":"2018","journal-title":"Int. J. Nanobiotechnol. Pharm."},{"key":"10.1016\/j.pdpdt.2020.101966_bib0180","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/s13204-013-0268-z","article-title":"Enhanced photodynamic efficacy of PLGA-encapsulated 5-ALA nanoparticles in mice bearing Ehrlich ascites carcinoma","author":"Shaker","year":"2014","journal-title":"Appl. Nanosci."},{"key":"10.1016\/j.pdpdt.2020.101966_bib0185","first-page":"390","article-title":"Preparation and characterisation of PLGA-nanoparticles containing an anti-hypertensive agent","author":"Jawahar","year":"2009","journal-title":"Int J Pharm. Technol. Res."},{"key":"10.1016\/j.pdpdt.2020.101966_bib0190","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1477-3155-11-41","article-title":"Antitumor activity of photodynamic therapy performed with nanospheres containing zinc-phthalocyanine","author":"Portilho","year":"2013","journal-title":"Int. J. Nanobiotechnol. Pharm."},{"key":"10.1016\/j.pdpdt.2020.101966_bib0195","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1021\/ct700017b","article-title":"Optical properties of phthalocyanine and naphthalocyanine compounds","author":"Andzelm","year":"2007","journal-title":"J. Chem. Theory Comput."},{"key":"10.1016\/j.pdpdt.2020.101966_bib0200","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1002\/jbm.a.36685","article-title":"IR820\u2010loaded PLGA nanoparticles for photothermal therapy of triple\u2010negative breast cancer","author":"Valcourt","year":"2019","journal-title":"J. Biomed. Mater. Res. Part B Appl. Biomater."},{"key":"10.1016\/j.pdpdt.2020.101966_bib0205","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1166\/jbn.2012.1355","article-title":"Polyelectrolyte coated polymeric nanoparticles for controlled release of docetaxel","author":"Agrawal","year":"2012","journal-title":"J. Biomed. Nanotechnol."},{"key":"10.1016\/j.pdpdt.2020.101966_bib0210","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/aps.2012.34","article-title":"Enhancement of cellular uptake and cytotoxicity of curcumin-loaded PLGA nanoparticles by conjugation with anti-P-glycoprotein in drug resistance cancer cells","author":"Punfa","year":"2012","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.pdpdt.2020.101966_bib0215","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.ejphar.2011.09.023","article-title":"Long circulating chitosan\/PEG blended PLGA nanoparticle for tumor drug delivery","author":"Parveen","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.pdpdt.2020.101966_bib0220","doi-asserted-by":"crossref","first-page":"401","DOI":"10.3390\/app9030401","article-title":"Synthesis and encapsulation of a new zinc phthalocyanine photosensitizer into polymeric nanoparticles to enhance cell uptake and phototoxicity","author":"Mehraban","year":"2019","journal-title":"Appl. Sci."}],"container-title":["Photodiagnosis and Photodynamic Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100020303203?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100020303203?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:38:34Z","timestamp":1761611914000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1572100020303203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":44,"alternative-id":["S1572100020303203"],"URL":"https:\/\/doi.org\/10.1016\/j.pdpdt.2020.101966","relation":{},"ISSN":["1572-1000"],"issn-type":[{"value":"1572-1000","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Zinc phthalocyanine tetrasulfonate-loaded polyelectrolytic PLGA nanoparticles for photodynamic therapy applications","name":"articletitle","label":"Article Title"},{"value":"Photodiagnosis and Photodynamic Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pdpdt.2020.101966","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"101966"}}