{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:48:24Z","timestamp":1792799304173,"version":"4.5.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["88882.435595\/2019\\u221201"],"award-info":[{"award-number":["88882.435595\/2019\\u221201"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["88882.435595\/2019"],"award-info":[{"award-number":["88882.435595\/2019"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Photodiagnosis and Photodynamic Therapy"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.pdpdt.2020.102003","type":"journal-article","created":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T03:09:48Z","timestamp":1599620988000},"page":"102003","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Fluorescence-guided surgical management of medication-related osteonecrosis of the jaws"],"prefix":"10.1016","volume":"32","author":[{"given":"Saygo","family":"Tomo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago Moreira","family":"da Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9ssica Ara\u00fajo","family":"Figueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Lennon Silva","family":"Cunha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glauco Issamu","family":"Miyahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana Estevam","family":"Simonato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pdpdt.2020.102003_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.oooo.2020.03.051","article-title":"Which symptoms negatively affect the oral health\u2013related quality of life in patients with osteonecrosis of the jaw?","author":"Sato","year":"2020","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"issue":"1","key":"10.1016\/j.pdpdt.2020.102003_bib0010","first-page":"e71","article-title":"Review and update on drugs related to the development of osteonecrosis of the jaw","volume":"25","author":"Eguia","year":"2002","journal-title":"Med. Oral Patol. Oral Cir. Bucal"},{"issue":"7","key":"10.1016\/j.pdpdt.2020.102003_bib0015","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1111\/odi.13160","article-title":"Workshop of European task force on medication\u2010related osteonecrosis of the jaw\u2014current challenges","volume":"25","author":"Schiodt","year":"2019","journal-title":"Oral Dis."},{"key":"10.1016\/j.pdpdt.2020.102003_bib0020","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.job.2019.03.005","article-title":"Medication-related osteonecrosis of the jaw: a literature review","volume":"61","author":"Kuroshima","year":"2019","journal-title":"J. Oral Biosci."},{"issue":"2","key":"10.1016\/j.pdpdt.2020.102003_bib0025","doi-asserted-by":"crossref","first-page":"92","DOI":"10.15171\/jlms.2018.19","article-title":"Combined approach to treat medication-related osteonecrosis of the jaws","volume":"9","author":"Merigo","year":"2018","journal-title":"J Lasers Medical Sci."},{"issue":"1","key":"10.1016\/j.pdpdt.2020.102003_bib0030","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jdsr.2018.09.002","article-title":"Novel insight into the management of bisphosphonate-related osteonecrosis of the jaw (BRONJ)","volume":"55","author":"Kishimoto","year":"2019","journal-title":"Jap Dent Sci Rev."},{"key":"10.1016\/j.pdpdt.2020.102003_bib0035","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.oooo.2019.02.014","article-title":"Association between biomarkers and medication-related osteonecrosis of the jaws: a systematic review","volume":"127","author":"Moraschini","year":"2019","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"issue":"5","key":"10.1016\/j.pdpdt.2020.102003_bib0040","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.joms.2017.10.024","article-title":"Can autofluorescence guide surgeons in the treatment of medication-related osteonecrosis of the jaw? A prospective feasibility study","volume":"76","author":"Giudice","year":"2018","journal-title":"J. Oral Maxillofac. Surg."},{"issue":"25","key":"10.1016\/j.pdpdt.2020.102003_bib0045","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1200\/JCO.19.01186","article-title":"Medication-related osteonecrosis of the jaw: MASCC\/ISOO\/ASCO clinical practice guideline","volume":"37","author":"Yarom","year":"2019","journal-title":"J. Clin. Oncol."},{"issue":"9","key":"10.1016\/j.pdpdt.2020.102003_bib0050","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.3390\/molecules25092095","article-title":"Recent advances and the potential for clinical use of autofluorescence detection of extra-ophthalmic tissues","volume":"25","author":"Wizenty","year":"2020","journal-title":"Molec."},{"key":"10.1016\/j.pdpdt.2020.102003_bib0055","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.pdpdt.2019.10.005","article-title":"History and future perspectives for the use of fluorescence visualization to detect oral squamous cell carcinoma and oral potentially malignant disorders","volume":"28","author":"Tomo","year":"2019","journal-title":"Photodiag Photod Ther."},{"key":"10.1016\/j.pdpdt.2020.102003_bib0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pdpdt.2016.10.010","article-title":"Fluorescence visualization efficacy for detecting oral lesions more prone to be dysplastic and potentially malignant disorders: a pilot study","volume":"17","author":"Simonato","year":"2017","journal-title":"Photodiag Photodyn Ther."},{"key":"10.1016\/j.pdpdt.2020.102003_bib0065","first-page":"1","article-title":"The applicability of fluorescence guided detection to epithelial dysplasia and oral cancer","volume":"181","author":"Tomo","year":"2018","journal-title":"Photodiag Photodyn Ther."},{"key":"10.1016\/j.pdpdt.2020.102003_bib0070","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.pdpdt.2019.05.017","article-title":"Fluorescence visualization improves the detection of oral, potentially malignant, disorders in population screening","volume":"27","author":"Simonato","year":"2019","journal-title":"Photodiag Photodyn Ther"},{"issue":"3","key":"10.1016\/j.pdpdt.2020.102003_bib0075","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1111\/odi.13071","article-title":"Optical fluorescence imaging in oral cancer and potentially malignant disorders: a systematic review","volume":"26","author":"Tiwari","year":"2020","journal-title":"Oral Dis."},{"issue":"1","key":"10.1016\/j.pdpdt.2020.102003_bib0080","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1159\/000501257","article-title":"Occlusal caries detection and diagnosis using visual ICDAS criteria, laser fluorescence measurements, and near-infrared light transillumination images","volume":"29","author":"Tassoker","year":"2020","journal-title":"Med. Princ. Pract."},{"issue":"4","key":"10.1016\/j.pdpdt.2020.102003_bib0085","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1097\/SCS.0000000000004705","article-title":"Auto-fluorescence and histopathologic evaluation of medication-related osteonecrosis of the jaws: perspectives for treatment","volume":"30","author":"Giovannacci","year":"2019","journal-title":"J. Craniofac. Surg."},{"issue":"12","key":"10.1016\/j.pdpdt.2020.102003_bib0090","doi-asserted-by":"crossref","first-page":"2646","DOI":"10.1016\/j.joms.2008.07.021","article-title":"Tetracycline-guided debridement and cone beam computed tomography for the treatment of bisphosphonate-related osteonecrosis of the jaw: a technical note","volume":"66","author":"Fleisher","year":"2008","journal-title":"J. Oral Maxillofac. Surg."},{"issue":"10","key":"10.1016\/j.pdpdt.2020.102003_bib0095","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1016\/j.jcms.2019.07.012","article-title":"Fluorescence-guided bone resection: a histological analysis in medication-related osteonecrosis of the jaw","volume":"47","author":"Wehrhan","year":"2019","journal-title":"J. Craniomaxillofac. Surg."},{"issue":"3","key":"10.1016\/j.pdpdt.2020.102003_bib0100","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.joms.2008.09.037","article-title":"Fluorescence-guided bone resection in bisphosphonate-associated osteonecrosis of the jaws","volume":"67","author":"Pautke","year":"2009","journal-title":"J. Oral Maxillofac. Surg."},{"issue":"1","key":"10.1016\/j.pdpdt.2020.102003_bib0105","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.joms.2009.05.442","article-title":"Tetracycline bone fluorescence: a valuable marker for osteonecrosis characterization and therapy","volume":"68","author":"Pautke","year":"2010","journal-title":"J. Oral Maxillofac. Surg."},{"issue":"1","key":"10.1016\/j.pdpdt.2020.102003_bib0110","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.joms.2010.07.014","article-title":"Fluorescence-guided bone resection in bisphosphonate-related osteonecrosis of the jaws: first clinical results of a prospective pilot study","volume":"69","author":"Pautke","year":"2011","journal-title":"J. Oral Maxillofac. Surg."},{"issue":"8","key":"10.1016\/j.pdpdt.2020.102003_bib0115","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1158\/1078-0432.CCR-07-1609","article-title":"Understanding the biological basis of autofluorescence imaging for oral cancer detection: high-resolution fluorescence microscopy in viable tissue","volume":"14","author":"Pavlova","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.pdpdt.2020.102003_bib0120","series-title":"Principles of Fluorescence Spectroscopy","first-page":"938","author":"Lakowicz","year":"2006"},{"issue":"7","key":"10.1016\/j.pdpdt.2020.102003_bib0125","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.jcms.2013.05.038","article-title":"Successful surgical management of osteonecrosis of the jaw due to RANK-ligand inhibitor treatment using fluorescence guided bone resection","volume":"41","author":"Otto","year":"2013","journal-title":"J. Craniomaxillofac. Surg."},{"issue":"5","key":"10.1016\/j.pdpdt.2020.102003_bib0130","doi-asserted-by":"crossref","first-page":"e157","DOI":"10.1016\/j.jcms.2013.07.014","article-title":"Intraoperative efficiency of fluorescence imaging by visually enhanced Lesion Scope (VELscope\u00ae) in patients with bisphosphonate related osteonecrosis of the jaw (BRONJ)","volume":"42","author":"Assaf","year":"2014","journal-title":"J. Craniomaxillofac. Surg."},{"issue":"1","key":"10.1016\/j.pdpdt.2020.102003_bib0135","doi-asserted-by":"crossref","first-page":"e6","DOI":"10.1016\/j.oooo.2014.04.014","article-title":"Doxycycline fluorescence-guided Er: YAG laser ablation combined with Nd: YAG\/diode laser biostimulation for treating bisphosphonate-related osteonecrosis of the jaw","volume":"119","author":"Porcaro","year":"2015","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"issue":"8","key":"10.1016\/j.pdpdt.2020.102003_bib0140","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.jcms.2016.05.018","article-title":"Fluorescence-guided surgery for the treatment of medication-related osteonecrosis of the jaw: a prospective cohort study","volume":"44","author":"Otto","year":"2016","journal-title":"J. Craniomaxillofac. Surg."},{"issue":"4","key":"10.1016\/j.pdpdt.2020.102003_bib0145","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s10006-018-0718-6","article-title":"Use of a generic violet light in the surgical management of medication-related osteonecrosis of the jaws: a technical note","volume":"22","author":"Ballardin","year":"2018","journal-title":"Oral Maxillofac. Surg."},{"issue":"2","key":"10.1016\/j.pdpdt.2020.102003_bib0150","doi-asserted-by":"crossref","first-page":"e203","DOI":"10.4317\/jced.55151","article-title":"Extensive osteonecrosis of the maxilla caused by bisphosphonates: report of a rare case","volume":"11","author":"Santos","year":"2019","journal-title":"J. Clin. Exp. Dent."},{"issue":"7","key":"10.1016\/j.pdpdt.2020.102003_bib0155","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1007\/s00198-015-3096-z","article-title":"Intraoperative detection of viable bone with fluorescence imaging using visually enhanced Lesion Scope in patients with bisphosphonate-related osteonecrosis of the jaw: clinical and pathological evaluation","volume":"26","author":"Yoshiga","year":"2015","journal-title":"Osteoporos. Int."},{"issue":"2","key":"10.1016\/j.pdpdt.2020.102003_bib0160","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.ijom.2016.10.008","article-title":"Comparison of auto-fluorescence and tetracycline fluorescence for guided bone surgery of medication-related osteonecrosis of the jaw: a randomized controlled feasibility study","volume":"46","author":"Ristow","year":"2017","journal-title":"Int. J. Oral Maxillofac. Surg."},{"issue":"2","key":"10.1016\/j.pdpdt.2020.102003_bib0165","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.bone.2006.09.012","article-title":"Intracortical remodeling during human bone development\u2014a histomorphometric study","volume":"40","author":"Rauch","year":"2007","journal-title":"Bone."},{"key":"10.1016\/j.pdpdt.2020.102003_bib0170","doi-asserted-by":"crossref","DOI":"10.1007\/s00784-020-03332-2","article-title":"Differences between auto-fluorescence and tetracycline-fluorescence in medication-related osteonecrosis of the jaw\u2014a preclinical proof of concept study in the mini-pig","author":"Ristow","year":"2020","journal-title":"Clin. Oral Investig."},{"issue":"8","key":"10.1016\/j.pdpdt.2020.102003_bib0175","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1089\/pho.2015.3927","article-title":"Medication-related osteonecrosis of the jaw: an autofluorescence-guided surgical approach performed with Er: YAG laser","volume":"33","author":"Vescovi","year":"2015","journal-title":"Photomed. Laser Surg."},{"issue":"6","key":"10.1016\/j.pdpdt.2020.102003_bib0180","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/j.joms.2016.12.011","article-title":"Clinical differences in autofluorescence between viable and nonvital bone: a case report with histopathologic evaluation performed on medication-related osteonecrosis of the jaws","volume":"75","author":"Giovannacci","year":"2017","journal-title":"J. Oral Maxillofac. Surg."},{"key":"10.1016\/j.pdpdt.2020.102003_bib0185","series-title":"How Much Does the VELscope Cost?","author":"Apteryx Imaging","year":"2020"},{"key":"10.1016\/j.pdpdt.2020.102003_bib0190","series-title":"VELscope Vx\u00ae Approved for Use by AppleWhite Dental Partners","author":"Apteryx Imaging","year":"2020"},{"key":"10.1016\/j.pdpdt.2020.102003_bib0195","series-title":"Department of Health, AHTA - National Horizon Scanning Unit (NHSU) Prioritising Summaries 2010","author":"Australian Government","year":"2020"},{"key":"10.1016\/j.pdpdt.2020.102003_bib0200","series-title":"LED Medical Diagnostics\u2019 VELscope\u00ae Vx Receives Regulatory Approval for Distribution in China","author":"Apteryx Imaging","year":"2020"},{"key":"10.1016\/j.pdpdt.2020.102003_bib0205","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.bjoms.2019.12.001","article-title":"Effectiveness of laser-assisted treatments for medication-related osteonecrosis of the jaw: a systematic review","volume":"58","author":"Li","year":"2020","journal-title":"Brit J Oral Maxillofac Surg."},{"issue":"11","key":"10.1016\/j.pdpdt.2020.102003_bib0210","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1016\/j.ijom.2014.07.017","article-title":"Auto-fluorescence of the bone and its use for delineation of bone necrosis","volume":"43","author":"Ristow","year":"2014","journal-title":"Int. J. Oral Maxillofac. Surg."}],"container-title":["Photodiagnosis and Photodynamic Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100020303574?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100020303574?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T21:24:08Z","timestamp":1778621048000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1572100020303574"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":42,"alternative-id":["S1572100020303574"],"URL":"https:\/\/doi.org\/10.1016\/j.pdpdt.2020.102003","relation":{},"ISSN":["1572-1000"],"issn-type":[{"value":"1572-1000","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fluorescence-guided surgical management of medication-related osteonecrosis of the jaws","name":"articletitle","label":"Article Title"},{"value":"Photodiagnosis and Photodynamic Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pdpdt.2020.102003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102003"}}