{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:39:44Z","timestamp":1786995584538,"version":"build-2736575974"},"reference-count":19,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T00:00:00Z","timestamp":1600128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"The study was supported by DUSA Pharmaceuticals, Inc"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Photodiagnosis and Photodynamic Therapy"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.pdpdt.2020.102013","type":"journal-article","created":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T11:54:23Z","timestamp":1600170863000},"page":"102013","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Efficacy of aminolevulinic acid 20 % solution photodynamic therapy in the treatment of actinic keratoses on the upper extremities: A post hoc analysis of a phase 3, randomized, vehicle-controlled trial"],"prefix":"10.1016","volume":"32","author":[{"given":"Brian","family":"Berman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neal","family":"Bhatia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Piacquadio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Houlihan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Davidson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Siegel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.pdpdt.2020.102013_bib0005","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1002\/cncr.24284","article-title":"Actinic keratoses: Natural history and risk of malignant transformation in the Veterans Affairs Topical Tretinoin Chemoprevention Trial","volume":"115","author":"Criscione","year":"2009","journal-title":"Cancer"},{"issue":"8","key":"10.1016\/j.pdpdt.2020.102013_bib0010","doi-asserted-by":"crossref","first-page":"997","DOI":"10.2340\/00015555-2692","article-title":"Actinic keratosis, a chronic, progressive disease: understanding clinical gaps to optimise patient management","volume":"97","author":"Cerio","year":"2017","journal-title":"Acta Derm. Venereol."},{"issue":"1","key":"10.1016\/j.pdpdt.2020.102013_bib0015","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/bjd.15107","article-title":"British Association of Dermatologists\u2019 guidelines for the care of patients with actinic keratosis 2017","volume":"176","author":"de Berker","year":"2017","journal-title":"Br. J. Dermatol."},{"issue":"12","key":"10.1016\/j.pdpdt.2020.102013_bib0020","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1111\/jdv.16017","article-title":"European Dermatology Forum guidelines on topical photodynamic therapy 2019 Part 1: treatment delivery and established indications - actinic keratoses, Bowen\u2019s disease and basal cell carcinomas","volume":"33","author":"Morton","year":"2019","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"issue":"7","key":"10.1016\/j.pdpdt.2020.102013_bib0025","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1097\/DSS.0000000000000800","article-title":"Photodynamic therapy: a clinical consensus guide","volume":"42","author":"Ozog","year":"2016","journal-title":"Dermatol. Surg."},{"key":"10.1016\/j.pdpdt.2020.102013_bib0030","series-title":"Levulan Kerastick (aminolevulinic Acid HCL) for Topical Solution, 20%. Full Prescribing Information","year":"2018"},{"issue":"7","key":"10.1016\/j.pdpdt.2020.102013_bib0035","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1097\/DSS.0000000000001760","article-title":"A randomized, vehicle-controlled phase 3 study of aminolevulinic acid photodynamic therapy for the treatment of actinic keratoses on the upper extremities","volume":"45","author":"Jiang","year":"2019","journal-title":"Dermatol. Surg."},{"issue":"1","key":"10.1016\/j.pdpdt.2020.102013_bib0040","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1001\/archderm.140.1.41","article-title":"Photodynamic therapy with aminolevulinic acid topical solution and visible blue light in the treatment of multiple actinic keratoses of the face and scalp: investigator-blinded, phase 3, multicenter trials","volume":"140","author":"Piacquadio","year":"2004","journal-title":"Arch. Dermatol."},{"issue":"9","key":"10.1016\/j.pdpdt.2020.102013_bib0045","first-page":"1049","article-title":"A randomized, blinded, bilateral intraindividual, vehicle-controlled trial of the use of photodynamic therapy with 5-aminolevulinic acid and blue light for the treatment of actinic keratoses of the upper extremities","volume":"10","author":"Taub","year":"2011","journal-title":"J. Drugs Dermatol."},{"issue":"12","key":"10.1016\/j.pdpdt.2020.102013_bib0050","first-page":"1483","volume":"11","author":"Schmieder","year":"2012","journal-title":"J. Drugs Dermatol."},{"issue":"3","key":"10.1016\/j.pdpdt.2020.102013_bib0055","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/jdv.14753","article-title":"Management of actinic keratosis at specific body sites in patients at high risk of carcinoma lesions: expert consensus from the AKTeam of expert clinicians","volume":"32","author":"Richard","year":"2018","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"issue":"2","key":"10.1016\/j.pdpdt.2020.102013_bib0060","doi-asserted-by":"crossref","first-page":"168","DOI":"10.3109\/09546634.2014.915004","article-title":"Methyl-aminolevulinic acid photodynamic therapy for actinic keratoses: a useful treatment or a risk factor? A retrospective study","volume":"26","author":"Bardazzi","year":"2015","journal-title":"J. Dermatolog. Treat."},{"issue":"4","key":"10.1016\/j.pdpdt.2020.102013_bib0065","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1111\/bjd.13036","article-title":"Development of squamous cell carcinoma after photodynamic therapy with methyl aminoleuvulinate","volume":"171","author":"Calista","year":"2014","journal-title":"Br. J. Dermatol."},{"issue":"3","key":"10.1016\/j.pdpdt.2020.102013_bib0070","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/sj.jid.5700098","article-title":"Photodynamic therapy does not prevent cutaneous squamous-cell carcinoma in organ-transplant recipients: results of a randomized-controlled trial","volume":"126","author":"de Graaf","year":"2006","journal-title":"J. Invest. Dermatol."},{"issue":"5","key":"10.1016\/j.pdpdt.2020.102013_bib0075","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1111\/dsu.12457","article-title":"Rapid development of squamous cell carcinoma after photodynamic therapy","volume":"40","author":"Liang","year":"2014","journal-title":"Dermatol. Surg."},{"issue":"5","key":"10.1016\/j.pdpdt.2020.102013_bib0080","doi-asserted-by":"crossref","first-page":"658","DOI":"10.2340\/00015555-2330","article-title":"Squamous cell carcinoma following photodynamic therapy for cutaneous Bowen\u2019s disease in a series of 105 patients","volume":"96","author":"Ratour-Bigot","year":"2016","journal-title":"Acta Derm. Venereol."},{"issue":"1","key":"10.1016\/j.pdpdt.2020.102013_bib0085","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines6010012","article-title":"Early and late onset side effects of photodynamic therapy","volume":"6","author":"Borgia","year":"2018","journal-title":"Biomedicines"},{"issue":"6","key":"10.1016\/j.pdpdt.2020.102013_bib0090","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1684\/ejd.2017.3131","article-title":"Comparative study of the clinical, histological, and biological characteristics of squamous cell carcinomas in areas previously treated with photodynamic therapy","volume":"27","author":"Gracia Cazana","year":"2017","journal-title":"Eur. J. Dermatol."},{"issue":"12","key":"10.1016\/j.pdpdt.2020.102013_bib0095","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1111\/exd.13804","article-title":"Photodynamic therapy with a 5-ALA patch does not increase the risk of conversion of actinic keratoses into squamous cell carcinoma: results of a multicentre non-interventional study","volume":"27","author":"Reinhold","year":"2018","journal-title":"Exp. Dermatol."}],"container-title":["Photodiagnosis and Photodynamic Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100020303677?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100020303677?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:35:24Z","timestamp":1761611724000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1572100020303677"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":19,"alternative-id":["S1572100020303677"],"URL":"https:\/\/doi.org\/10.1016\/j.pdpdt.2020.102013","relation":{},"ISSN":["1572-1000"],"issn-type":[{"value":"1572-1000","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy of aminolevulinic acid 20 % solution photodynamic therapy in the treatment of actinic keratoses on the upper extremities: A post hoc analysis of a phase 3, randomized, vehicle-controlled trial","name":"articletitle","label":"Article Title"},{"value":"Photodiagnosis and Photodynamic Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pdpdt.2020.102013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102013"}}