{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T03:13:55Z","timestamp":1776136435975,"version":"3.50.1"},"reference-count":7,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004844","name":"National Cheng Kung University Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004844","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010002","name":"Ministry of Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Photodiagnosis and Photodynamic Therapy"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.pdpdt.2020.102149","type":"journal-article","created":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T22:25:14Z","timestamp":1608243914000},"page":"102149","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Enhancing wound healing in recalcitrant leg ulcers with aminolevulinic acid-mediated antimicrobial photodynamic therapy"],"prefix":"10.1016","volume":"33","author":[{"given":"Ming-Hsien","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia Yu-Yun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin-Chen","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0131-7339","authenticated-orcid":false,"given":"Tak-Wah","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"16","key":"10.1016\/j.pdpdt.2020.102149_bib0005","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1056\/NEJMra1615243","article-title":"Evaluation and management of lower-extremity ulcers","volume":"377","author":"Singer","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.pdpdt.2020.102149_bib0010","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.mib.2016.06.008","article-title":"Antimicrobial photodynamic inactivation: a bright new technique to kill resistant microbes","volume":"33","author":"Hamblin","year":"2016","journal-title":"Curr. Opin. Microbiol."},{"issue":"3","key":"10.1016\/j.pdpdt.2020.102149_bib0015","doi-asserted-by":"crossref","DOI":"10.3390\/jcm8030411","article-title":"Indocyanine green-mediated photodynamic therapy reduces methicillin-resistant Staphylococcus aureus drug resistance","volume":"8","author":"Wong","year":"2019","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.pdpdt.2020.102149_bib0020","doi-asserted-by":"crossref","first-page":"101682","DOI":"10.1016\/j.pdpdt.2020.101682","article-title":"Photodynamic therapy in wound healing in vivo: a systematic review","volume":"30","author":"Oyama","year":"2020","journal-title":"Photodiagn. Photodyn. Ther."},{"issue":"5","key":"10.1016\/j.pdpdt.2020.102149_bib0025","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines8050101","article-title":"The role of IL-6 in skin fibrosis and cutaneous wound healing","volume":"8","author":"Johnson","year":"2020","journal-title":"Biomedicines"},{"issue":"2","key":"10.1016\/j.pdpdt.2020.102149_bib0030","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/j.1365-2133.2006.07619.x","article-title":"Photodynamic therapy for infected leg ulcers","volume":"156","author":"Clayton","year":"2007","journal-title":"Br. J. Dermatol."},{"issue":"5","key":"10.1016\/j.pdpdt.2020.102149_bib0035","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1046\/j.1365-2133.2002.04715.x","article-title":"In vitro\/in vivo correlations between transdermal delivery of 5-aminolaevulinic acid and cutaneous protoporphyrin IX accumulation and effect of formulation","volume":"146","author":"Tsai","year":"2002","journal-title":"Br. J. Dermatol."}],"container-title":["Photodiagnosis and Photodynamic Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100020305032?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100020305032?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:43:49Z","timestamp":1761612229000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1572100020305032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":7,"alternative-id":["S1572100020305032"],"URL":"https:\/\/doi.org\/10.1016\/j.pdpdt.2020.102149","relation":{},"ISSN":["1572-1000"],"issn-type":[{"value":"1572-1000","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Enhancing wound healing in recalcitrant leg ulcers with aminolevulinic acid-mediated antimicrobial photodynamic therapy","name":"articletitle","label":"Article Title"},{"value":"Photodiagnosis and Photodynamic Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pdpdt.2020.102149","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102149"}}