{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T16:44:57Z","timestamp":1776185097789,"version":"3.50.1"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100008055","name":"Fundaci\u00f3n Eugenio Rodr\u00edguez Pascual","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["MAT 2017-83856-C3"],"award-info":[{"award-number":["MAT 2017-83856-C3"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Photodiagnosis and Photodynamic Therapy"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.pdpdt.2021.102176","type":"journal-article","created":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T14:06:38Z","timestamp":1610460398000},"page":"102176","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Methyl aminolevulinate photodynamic therapy after partial debulking in the treatment of superficial and nodular basal cell carcinoma: 3-years follow-up"],"prefix":"10.1016","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5265-2233","authenticated-orcid":false,"given":"Clara","family":"G\u00f3mez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pilar","family":"Cobos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrique","family":"Alberdi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pdpdt.2021.102176_bib0005","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1111\/j.1365-2133.2012.10830.x","article-title":"A systematic review of worldwide incidence of nonmelanoma skin cancer","volume":"166","author":"Lomas","year":"2012","journal-title":"Br. J. Dermatol."},{"issue":"2","key":"10.1016\/j.pdpdt.2021.102176_bib0010","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s11864-019-0610-0","article-title":"Diagnosis and management of basal cell carcinoma","volume":"20","author":"Tanese","year":"2019","journal-title":"Curr. Treat. Options Oncol."},{"issue":"2","key":"10.1016\/j.pdpdt.2021.102176_bib0015","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1590\/S0365-05962011000200013","article-title":"Epidemiology of basal cell carcinoma","volume":"86","author":"Chinem","year":"2011","journal-title":"An. Bras. Dermatol."},{"issue":"3","key":"10.1016\/j.pdpdt.2021.102176_bib0020","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1684\/ejd.2014.2271","article-title":"Update of the European guidelines for basal cell carcinoma management","volume":"24","author":"Trakatelli","year":"2014","journal-title":"Eur. J. Dermatol."},{"issue":"1","key":"10.1016\/j.pdpdt.2021.102176_bib0025","doi-asserted-by":"crossref","first-page":"56","DOI":"10.4103\/0019-5154.123496","article-title":"Characteristics of mixed type basal cell carcinoma in comparison to other BCC subtypes","volume":"59","author":"Ghanadan","year":"2014","journal-title":"Indian J. Dermatol."},{"issue":"5","key":"10.1016\/j.pdpdt.2021.102176_bib0030","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1346-8138.1979.tb01912.x","article-title":"Computer analysis of 3531 basal cell carcinomas of the skin","volume":"6","author":"Kopf","year":"1979","journal-title":"J. Dermatol."},{"issue":"3","key":"10.1016\/j.pdpdt.2021.102176_bib0035","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s40257-014-0070-z","article-title":"Basal cell carcinoma: an evidence-based treatment update","volume":"15","author":"Clark","year":"2014","journal-title":"Am. J. Clin. Dermatol."},{"issue":"6","key":"10.1016\/j.pdpdt.2021.102176_bib0040","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1111\/j.1365-4632.2010.04826.x","article-title":"Basal cell carcinoma: evidence-based medicine and review of treatment modalities","volume":"50","author":"Kwasniak","year":"2011","journal-title":"Int. J. Dermatol."},{"issue":"5","key":"10.1016\/j.pdpdt.2021.102176_bib0045","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1111\/jdv.12031","article-title":"European guidelines for topical photodynamic therapy part 1: treatment delivery and current indications \u2013 actinic keratoses, Bowen\u2019s disease, basal cell carcinoma","volume":"27","author":"Morton","year":"2013","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"issue":"2","key":"10.1016\/j.pdpdt.2021.102176_bib0050","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.clindermatol.2017.10.009","article-title":"Nonsurgical treatment of nonmelanoma skin cancer in the mature patient","volume":"36","author":"Ceovi\u0107","year":"2018","journal-title":"Clin. Dermatol."},{"issue":"2","key":"10.1016\/j.pdpdt.2021.102176_bib0055","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1001\/archderm.134.2.248","article-title":"Photodynamic therapy for basal cell carcinoma: effect of tumor thickness and duration of photosensitizer application on response","volume":"134","author":"Morton","year":"1998","journal-title":"Arch. Dermatol."},{"issue":"10","key":"10.1016\/j.pdpdt.2021.102176_bib0060","doi-asserted-by":"crossref","first-page":"23300","DOI":"10.3390\/ijms161023300","article-title":"Uselfulness of photodynamic therapy as a possible therapeutic alternative in the treatment of basal cell carcinoma","volume":"16","author":"Savoia","year":"2015","journal-title":"Int. J. Mol. Sci."},{"issue":"22","key":"10.1016\/j.pdpdt.2021.102176_bib0065","doi-asserted-by":"crossref","first-page":"2991","DOI":"10.2217\/fon.15.208","article-title":"Photodynamic therapy for basal cell carcinoma","volume":"11","author":"Fargnoli","year":"2015","journal-title":"Future Oncol."},{"issue":"8","key":"10.1016\/j.pdpdt.2021.102176_bib0070","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1111\/dsu.12242","article-title":"Fractional carbon dioxide laser improves nodular basal cell carcinoma treatment with photodynamic therapy with methyl 5-aminolevulinate","volume":"39","author":"Lippert","year":"2013","journal-title":"Dermatol. Surg."},{"issue":"8","key":"10.1016\/j.pdpdt.2021.102176_bib0075","article-title":"Possibility for the conjugated use of photodynamic therapy and electrosurgical devices","volume":"10","author":"de A. Rego Filho","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.pdpdt.2021.102176_bib0080","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s10103-014-1609-1","article-title":"Effect of methylene blue-mediated photodynamic therapy for treatment of basal cell carcinoma","volume":"30","author":"Samy","year":"2015","journal-title":"Lasers Med. Sci."},{"issue":"9","key":"10.1016\/j.pdpdt.2021.102176_bib0085","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1001\/archderm.143.9.1131","article-title":"Five-year follow-up of a randomized, prospective trial of topical methyl aminolevulinate photodynamic therapy vs surgery for nodular basal cell carcinoma","volume":"143","author":"Rhodes","year":"2007","journal-title":"Arch. Dermatol."},{"issue":"5","key":"10.1016\/j.pdpdt.2021.102176_bib0090","first-page":"412","article-title":"Efficacy of photodynamic therapy with methyl aminolevulinate in the treatment of superficial and nodular basal cell carcinoma: an open-label trial","volume":"17","author":"Surrenti","year":"2007","journal-title":"Eur. J. Dermatol."},{"issue":"8","key":"10.1016\/j.pdpdt.2021.102176_bib0095","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1111\/j.1468-3083.2010.03877.x","article-title":"Photodynamic therapy for basal cell carcinoma: clinical and pathological determinants of response","volume":"25","author":"Fantini","year":"2011","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"issue":"1","key":"10.1016\/j.pdpdt.2021.102176_bib0100","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.pdpdt.2013.11.001","article-title":"Experience and BCC subtypes as determinants of MAL-PDT response: preliminary results of a national Brazilian project","volume":"11","author":"Ramirez","year":"2014","journal-title":"Photodiagn. Photodyn. Ther."},{"issue":"1","key":"10.1016\/j.pdpdt.2021.102176_bib0105","doi-asserted-by":"crossref","first-page":"4835","DOI":"10.1038\/s41598-019-41313-y","article-title":"Characterization of resistance mechanisms developed by basal cell carcinoma cells in response to repeated cycles of photodynamic therapy","volume":"9","author":"Lucena","year":"2019","journal-title":"Sci. Rep."},{"issue":"10","key":"10.1016\/j.pdpdt.2021.102176_bib0110","doi-asserted-by":"crossref","first-page":"25912","DOI":"10.3390\/ijms161025912","article-title":"Combined treatments with photodynamic therapy for non-melanom skin cancer","volume":"16","author":"Lucena","year":"2015","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.pdpdt.2021.102176_bib0115","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/lsm.20606","article-title":"Combination of Er:YAG laser and photodynamic therapy in the treatment of nodular basal cell carcinoma","volume":"40","author":"Smucler","year":"2008","journal-title":"Lasers Surg. Med."},{"issue":"5","key":"10.1016\/j.pdpdt.2021.102176_bib0120","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1097\/SAP.0b013e3180338536","article-title":"Combined CO(2) laser with photodynamic therapy for the treatment of nodular basal cell carcinomas","volume":"59","author":"Whitaker","year":"2007","journal-title":"Am. Plast. Surg."},{"key":"10.1016\/j.pdpdt.2021.102176_bib0125","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.pdpdt.2019.07.017","article-title":"Photodynamic therapy in superficial basal cell carcinoma treatment","volume":"27","author":"de Albuquerque","year":"2019","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2021.102176_bib0130","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.pdpdt.2019.04.016","article-title":"Single visit PDT for basal cell carcinoma \u2013 a new therapeutic protocol","volume":"26","author":"Ramirez","year":"2019","journal-title":"Photodiagn. Photodyn. Ther."},{"issue":"13","key":"10.1016\/j.pdpdt.2021.102176_bib0135","doi-asserted-by":"crossref","first-page":"2458","DOI":"10.7150\/thno.16183","article-title":"Beyond the barriers of light penetration: strategies, perspectives and possibilities for photodynamic therapy","volume":"6","author":"Mallidi","year":"2016","journal-title":"Theranostic"},{"issue":"4","key":"10.1016\/j.pdpdt.2021.102176_bib0140","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1111\/j.1365-2133.2008.08450.x","article-title":"Continuous activation of PpIX by daylight is as effective and less painful that conventional photodynamic therapy for actinic keratosis-a randomized, controlled, single-blinded study","volume":"158","author":"Wiegell","year":"2008","journal-title":"Br. J. Dermatol."},{"issue":"2","key":"10.1016\/j.pdpdt.2021.102176_bib0145","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/jdv.12076","article-title":"Daylight-mediated photodynamic therapy of basal cell carcinomas-an explorative study","volume":"28","author":"Wiegell","year":"2014","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"issue":"11","key":"10.1016\/j.pdpdt.2021.102176_bib0150","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1111\/j.1468-3083.2008.02803.x","article-title":"A clinical study comparing methyl aminolevulinate photodynamic therapy and surgery in small superficial basal cell carcinoma (8\u201320 mm), with a 12-month follow-up","volume":"22","author":"Szeimies","year":"2008","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"issue":"5","key":"10.1016\/j.pdpdt.2021.102176_bib0155","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1111\/jdv.13453","article-title":"Er:YAG ablative fractional laser-primed photodynamic therapy with methyl aminolevulinate as an alternative treatment option for patients with thin nodular basal cell carcinoma: 12-month follow-up results of a randomized, prospective, comparative trial","volume":"30","author":"Choi","year":"2016","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"issue":"4","key":"10.1016\/j.pdpdt.2021.102176_bib0160","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1111\/j.1365-2133.2005.06484.x","article-title":"Photodynamic therapy with topical methyl aminolaevulinate for \u2018difficult-to-treat\u2019 basal cell carcinoma","volume":"152","author":"Vinciullo","year":"2005","journal-title":"Br. J. Dermatol."},{"issue":"2","key":"10.1016\/j.pdpdt.2021.102176_bib0165","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1365-2133.2006.07234.x","article-title":"Basal cell carcinoma, histological classification and body-site distribution","volume":"155","author":"Raasch","year":"2006","journal-title":"Br. J. Dermatol."}],"container-title":["Photodiagnosis and Photodynamic Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100021000028?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100021000028?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:42:05Z","timestamp":1761612125000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1572100021000028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":33,"alternative-id":["S1572100021000028"],"URL":"https:\/\/doi.org\/10.1016\/j.pdpdt.2021.102176","relation":{},"ISSN":["1572-1000"],"issn-type":[{"value":"1572-1000","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Methyl aminolevulinate photodynamic therapy after partial debulking in the treatment of superficial and nodular basal cell carcinoma: 3-years follow-up","name":"articletitle","label":"Article Title"},{"value":"Photodiagnosis and Photodynamic Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pdpdt.2021.102176","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102176"}}