{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T18:51:23Z","timestamp":1774896683881,"version":"3.50.1"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004434","name":"Universit\u00e0 degli Studi di Firenze","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004434","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007571","name":"Fondazione Cassa di Risparmio di Civitavecchia","doi-asserted-by":"publisher","award":["2017\/ 0771"],"award-info":[{"award-number":["2017\/ 0771"]}],"id":[{"id":"10.13039\/100007571","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Photodiagnosis and Photodynamic Therapy"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.pdpdt.2021.102222","type":"journal-article","created":{"date-parts":[[2021,2,16]],"date-time":"2021-02-16T04:51:20Z","timestamp":1613451080000},"page":"102222","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Single ALA-PDT irradiation induces increase in mast cells degranulation and neuropeptide acute response in chronic venous ulcers: A pilot study"],"prefix":"10.1016","volume":"34","author":[{"given":"Vieri","family":"Grandi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaia","family":"Paroli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Puliti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3651-229X","authenticated-orcid":false,"given":"Stefano","family":"Bacci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Pimpinelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pdpdt.2021.102222_bib0005","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s12325-017-0478-y","article-title":"Chronic wound healing: a review of current management and treatments","volume":"34","author":"Han","year":"2017","journal-title":"Adv. Ther."},{"key":"10.1016\/j.pdpdt.2021.102222_bib0010","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1053\/j.semvascsurg.2015.05.002","article-title":"Venous ulcers of the lower extremity: definition, epidemiology, and economic and social burdens","volume":"28","author":"Lal","year":"2015","journal-title":"Semin. Vasc. Surg."},{"key":"10.1016\/j.pdpdt.2021.102222_bib0015","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1089\/wound.2019.0946","article-title":"Human wounds and its burden: an updated compendium of estimates","volume":"8","author":"Sen","year":"2019","journal-title":"Adv. Wound. Care (New Rochelle)"},{"key":"10.1016\/j.pdpdt.2021.102222_bib0020","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1111\/bjd.13954","article-title":"Cellular and molecular mechanisms of repair in acute and chronic wounds","volume":"173","author":"Martin","year":"2015","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.pdpdt.2021.102222_bib0025","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1111\/j.1365-2133.2008.09012.x","article-title":"Induction of protoporphyrin IX by aminolaevulinic acid in actinic keratosis, psoriasis and normal skin: preferential porphyrin enrichment in differentiated cells","volume":"160","author":"Smits","year":"2009","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.pdpdt.2021.102222_bib0030","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/j.1365-2133.2006.07619.x","article-title":"Photodynamic therapy for infected leg ulcers","volume":"156","author":"Clayton","year":"2007","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.pdpdt.2021.102222_bib0035","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s00403-014-1520-4","article-title":"A clinical study of photodynamic therapy for chronic skin ulcers in lower limbs infected with Pseudomonas aeruginosa","volume":"307","author":"Lei","year":"2015","journal-title":"Arch. Dermatol. Res."},{"key":"10.1016\/j.pdpdt.2021.102222_bib0040","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1586\/eci.12.37","article-title":"Photodynamic therapy induces an immune response against a bacterial pathogen","volume":"8","author":"Huang","year":"2012","journal-title":"Expert Rev. Clin. Immunol."},{"key":"10.1016\/j.pdpdt.2021.102222_bib0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5411\/wji.v4.i1.1","article-title":"Immune response after photodynamic therapy increases anti-cancer and anti-bacterial effects","volume":"4","author":"Reginato","year":"2014","journal-title":"World J. Immunol."},{"key":"10.1016\/j.pdpdt.2021.102222_bib0050","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/ni1078","article-title":"Elaborate interactions between the immune and nervous system","volume":"5","author":"Steinmann","year":"2004","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.pdpdt.2021.102222_bib0055","article-title":"Skin acute wound healing: a comprehensive review","author":"Canedo-Dorantes","year":"2019","journal-title":"Int. J. Inflam."},{"key":"10.1016\/j.pdpdt.2021.102222_bib0060","first-page":"875","article-title":"Skin innervation: important roles during normal and pathological cutaneous repair","volume":"30","author":"Laverdet","year":"2015","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.pdpdt.2021.102222_bib0065","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1152\/physrev.00026.2005","article-title":"Neuronal control of skin function: the skin as a neuroimmunoendocrine organ","volume":"80","author":"Roosterman","year":"2006","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.pdpdt.2021.102222_bib0070","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1111\/wrr.12101","article-title":"Role of neuropeptides, neutrophins, and neurohormones in skin wound healing","volume":"21","author":"Cheret","year":"2013","journal-title":"Wound Repair Regen."},{"key":"10.1016\/j.pdpdt.2021.102222_bib0075","doi-asserted-by":"crossref","first-page":"587","DOI":"10.2340\/00015555-2321","article-title":"The role of neuromediators and innervation in cutaneous wound healing","volume":"96","author":"Ashrafi","year":"2016","journal-title":"Acta Derm. Venereol."},{"key":"10.1016\/j.pdpdt.2021.102222_bib0080","first-page":"223","article-title":"Early activation of fibroblasts during PDT treatment in leg ulcers","volume":"151","author":"Corsi","year":"2016","journal-title":"G. Ital. Dermatol. Venereol."},{"key":"10.1016\/j.pdpdt.2021.102222_bib0085","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.pdpdt.2017.12.012","article-title":"ALA-PDT exerts beneficial effects on chronic venous ulcers by inducing changes in inflammatory microenvironment, especially through increased TGF-beta release: a pilot clinical and translational study","volume":"21","author":"Grandi","year":"2017","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2021.102222_bib0090","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.forsciint.2014.08.024","article-title":"Immunohistochemical analysis of dendritic cells in skin lesions: correlations with survival time","volume":"244","author":"Bacci","year":"2014","journal-title":"Forensic Sci. Int."},{"key":"10.1016\/j.pdpdt.2021.102222_bib0095","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0065-1281(97)80024-4","article-title":"Immunohistochemical detection of human skin nerve fibers","volume":"99","author":"Schultze","year":"1997","journal-title":"Acta Histochem."},{"key":"10.1016\/j.pdpdt.2021.102222_bib0100","first-page":"422","article-title":"Mast cells and sensory nerves contribute to neurogenic inflammation and pruritus in chronic skin inflammation","volume":"13","author":"Siiskonen","year":"2019","journal-title":"Front Cell Sci."}],"container-title":["Photodiagnosis and Photodynamic Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S157210002100048X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S157210002100048X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:42:54Z","timestamp":1761612174000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S157210002100048X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":20,"alternative-id":["S157210002100048X"],"URL":"https:\/\/doi.org\/10.1016\/j.pdpdt.2021.102222","relation":{},"ISSN":["1572-1000"],"issn-type":[{"value":"1572-1000","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Single ALA-PDT irradiation induces increase in mast cells degranulation and neuropeptide acute response in chronic venous ulcers: A pilot study","name":"articletitle","label":"Article Title"},{"value":"Photodiagnosis and Photodynamic Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pdpdt.2021.102222","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102222"}}