{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:01:57Z","timestamp":1788447717429,"version":"build-2803163510"},"reference-count":73,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Photodiagnosis and Photodynamic Therapy"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.pdpdt.2021.102265","type":"journal-article","created":{"date-parts":[[2021,3,27]],"date-time":"2021-03-27T00:17:13Z","timestamp":1616804233000},"page":"102265","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Adjuvant effects of curcumin as a photoantimicrobial or irrigant in the non-surgical treatment of periodontitis: Systematic review and meta-analysis"],"prefix":"10.1016","volume":"34","author":[{"given":"Eduardo Quint\u00e3o Manhanini","family":"Souza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago Esgalha","family":"da Rocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luan Felipe","family":"Toro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella Zacarin","family":"Guiati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5891-8637","authenticated-orcid":false,"given":"J\u00e9ssica de Oliveira Alvarenga","family":"Freire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edilson","family":"Ervolino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela Atili","family":"Brandini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valdir Gouveia","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3026-8369","authenticated-orcid":false,"given":"Let\u00edcia Helena","family":"Theodoro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pdpdt.2021.102265_bib0005","doi-asserted-by":"crossref","first-page":"3703","DOI":"10.1038\/s41598-017-03804-8","article-title":"Dysbiosis in chronic periodontitis: key microbial players and interactions with the human host","volume":"7","author":"Deng","year":"2017","journal-title":"Sci. Rep."},{"issue":"Suppl 1","key":"10.1016\/j.pdpdt.2021.102265_bib0010","first-page":"S159","article-title":"Staging and grading of periodontitis: framework and proposal of a new classification and case definition [published correction appears in J Periodontol. Dec;89(12):1475]","volume":"89","author":"Tonetti","year":"2018","journal-title":"J. Periodontol."},{"key":"10.1016\/j.pdpdt.2021.102265_bib0015","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/prd.12221","article-title":"Periodontitis: facts, fallacies and the future","volume":"75","author":"Slots","year":"2017","journal-title":"Periodontol. 2000"},{"issue":"Suppl 22","key":"10.1016\/j.pdpdt.2021.102265_bib0020","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/jcpe.13290","article-title":"Treatment of stage I-III periodontitis-The EFP S3 level clinical practice guideline","volume":"47","author":"Sanz","year":"2020","journal-title":"J. Clin. Periodontol."},{"issue":"Suppl 18","key":"10.1016\/j.pdpdt.2021.102265_bib0025","first-page":"S94","article-title":"Global epidemiology of dental caries and severe periodontitis - a comprehensive review","volume":"44","author":"Frencken","year":"2017","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.pdpdt.2021.102265_bib0030","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1177\/0022034514552491","article-title":"Global burden of severe periodontitis in 1990\u20132010: a systematic review and meta-regression","volume":"93","author":"Kassebaum","year":"2014","journal-title":"J. Dent. Res."},{"issue":"Suppl 20","key":"10.1016\/j.pdpdt.2021.102265_bib0035","first-page":"S130","article-title":"Age-dependent distribution of periodontitis in two countries: findings from NHANES 2009 to 2014 and SHIP-TREND 2008 to 2012","volume":"45","author":"Billings","year":"2018","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.pdpdt.2021.102265_bib0040","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/1914073","article-title":"Genetic factors and the risk of periodontitis development: findings from a systematic review composed of 13 studies of meta-analysis with 71,531 participants","volume":"2017","author":"da Silva","year":"2017","journal-title":"Int. J. Dent."},{"issue":"Suppl 1","key":"10.1016\/j.pdpdt.2021.102265_bib0045","first-page":"S173","article-title":"Periodontitis: consensus report of workgroup 2 of the 2017 world workshop on the classification of periodontal and peri-implant diseases and conditions","volume":"89","author":"Papapanou","year":"2018","journal-title":"J. Periodontol."},{"key":"10.1016\/j.pdpdt.2021.102265_bib0050","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/prd.12240","article-title":"Nonsurgical therapy for teeth and implants\u2014When and why?","volume":"79","author":"Lang","year":"2019","journal-title":"Periodontol. 2000"},{"issue":"Suppl 20","key":"10.1016\/j.pdpdt.2021.102265_bib0055","first-page":"S1","article-title":"A new classification scheme for periodontal and peri-implant diseases and conditions - Introduction and key changes from the 1999 classification","volume":"45","author":"Caton","year":"2018","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.pdpdt.2021.102265_bib0060","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/jcpe.13104","article-title":"Implementation of the new classification of periodontal diseases: decision-making algorithms for clinical practice and education","volume":"46","author":"Tonetti","year":"2019","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.pdpdt.2021.102265_bib0065","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1600-0757.2004.03679.x","article-title":"Lasers in nonsurgical periodontal therapy","volume":"36","author":"Aoki","year":"2004","journal-title":"Periodontol. 2000"},{"issue":"Suppl 22","key":"10.1016\/j.pdpdt.2021.102265_bib0070","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/jcpe.13264","article-title":"Adjunctive effect of systemic antimicrobials in periodontitis therapy. A systematic review and meta-analysis","volume":"47","author":"Teughels","year":"2020","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.pdpdt.2021.102265_bib0075","doi-asserted-by":"crossref","first-page":"101808","DOI":"10.1016\/j.pdpdt.2020.101808","article-title":"Antimicrobial photodynamic therapy compared to systemic antibiotic therapy in non-surgical treatment of periodontitis: Systematic review and meta-analysis [published online ahead of print, 2020 May 12]","volume":"2020","author":"Souza","year":"2020","journal-title":"Photodiagn. Photodyn. Ther."},{"issue":"34","key":"10.1016\/j.pdpdt.2021.102265_bib0080","article-title":"Adjunctive subgingival application of Chlorhexidine gel in nonsurgical periodontal treatment for chronic periodontitis: a systematic review and meta-analysis","volume":"20","author":"Zhao","year":"2020","journal-title":"BMC Oral Health"},{"key":"10.1016\/j.pdpdt.2021.102265_bib0085","doi-asserted-by":"crossref","first-page":"318","DOI":"10.5005\/jp-journals-10024-2516","article-title":"Efficacy of ozonised water and 0.2% chlorhexidine gluconate in the management of chronic periodontitis when used as an irrigant in conjugation with phase I therapy","volume":"20","author":"Kaur","year":"2019","journal-title":"J. Contemp. Dent. Pract."},{"key":"10.1016\/j.pdpdt.2021.102265_bib0090","first-page":"115","article-title":"Role of curcumin as a subgingival irrigant: a pilot study","volume":"4","author":"Suhag","year":"2007","journal-title":"PERIO."},{"key":"10.1016\/j.pdpdt.2021.102265_bib0095","doi-asserted-by":"crossref","first-page":"186","DOI":"10.4103\/0976-237X.114874","article-title":"Effectiveness of sub gingival irrigation of an indigenous 1% curcumin solution on clinical and microbiological parameters in chronic periodontitis patients: a pilot randomized clinical trial","volume":"4","author":"Gottumukkala","year":"2013","journal-title":"Contemp. Clin. Dent."},{"key":"10.1016\/j.pdpdt.2021.102265_bib0100","first-page":"ZC65","article-title":"Novel therapeutic approach for the treatment of periodontitis by curcumin","volume":"8","author":"Bhatia","year":"2014","journal-title":"J. Clin. Diagn. Res."},{"key":"10.1016\/j.pdpdt.2021.102265_bib0105","first-page":"90","article-title":"Evaluation of anti-inflammatory effects of curcumin gel as an adjunct to scaling and root planing: a clinical study","volume":"7","author":"Anuradha","year":"2015","journal-title":"J. Int. Oral Health"},{"issue":"Suppl 2","key":"10.1016\/j.pdpdt.2021.102265_bib0110","doi-asserted-by":"crossref","first-page":"S554","DOI":"10.4103\/0975-7406.163537","article-title":"Efficacy of curcumin as an adjunct to scaling and root planning in chronic periodontitis patients: a clinical and microbiological study","volume":"7","author":"Nagasri","year":"2015","journal-title":"J. Pharm. Bioallied Sci."},{"issue":"Suppl 1","key":"10.1016\/j.pdpdt.2021.102265_bib0115","doi-asserted-by":"crossref","first-page":"S102","DOI":"10.4103\/0976-9668.166100","article-title":"Comparative evaluation of the efficacy of curcumin gel with and without photo activation as an adjunct to scaling and root planing in the treatment of chronic periodontitis: a split mouth clinical and microbiological study","volume":"6","author":"Sreedhar","year":"2015","journal-title":"J. Nat. Sci. Biol. Med."},{"key":"10.1016\/j.pdpdt.2021.102265_bib0120","doi-asserted-by":"crossref","first-page":"149","DOI":"10.4103\/0976-9668.184701","article-title":"Influence of application of chlorhexidine gel and curcumin gel as an adjunct to scaling and root planing: a interventional study","volume":"7","author":"Hugar","year":"2016","journal-title":"J. Nat. Sci. Biol. Med."},{"key":"10.1016\/j.pdpdt.2021.102265_bib0125","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1080\/10717544.2016.1233591","article-title":"Formulation, in-vitro characterization and clinical evaluation of curcumin in-situ gel for treatment of periodontitis","volume":"24","author":"Nasra","year":"2017","journal-title":"Drug Deliv."},{"key":"10.1016\/j.pdpdt.2021.102265_bib0130","first-page":"53","article-title":"Comparative evaluation of the efficacy of locally delivered 0.1% curcumin irrigation, meswak irrigation and 0.2% CHX irrigation in management Chronic periodontitis patients","volume":"5","author":"Singhla","year":"2017","journal-title":"J. Indian Acad. Dent. Spec. Res."},{"key":"10.1016\/j.pdpdt.2021.102265_bib0135","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.pdpdt.2019.07.005","article-title":"Antimicrobial photodynamic therapy (aPDT) with curcumin and LED, as an enhancement to scaling and root planing in the treatment of residual pockets in diabetic patients: a randomized and controlled split-mouth clinical trial","volume":"27","author":"Ivanaga","year":"2019","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2021.102265_bib0140","doi-asserted-by":"crossref","first-page":"171","DOI":"10.2174\/1871526518666180601073422","article-title":"Evaluation of curcumin gel as adjunct to scaling & root planing in management of periodontitis- randomized clinical & biochemical investigation","volume":"19","author":"Kaur","year":"2019","journal-title":"Infect. Disord. Drug Targets"},{"key":"10.1016\/j.pdpdt.2021.102265_bib0145","doi-asserted-by":"crossref","first-page":"842","DOI":"10.5005\/jp-journals-10024-2608","article-title":"Efficacy of curcumin as an adjunct to scaling and root planing in chronic periodontitis patients: a randomized controlled clinical trial","volume":"20","author":"Raghava","year":"2019","journal-title":"J. Contemp. Dent. Pract."},{"key":"10.1016\/j.pdpdt.2021.102265_bib0150","doi-asserted-by":"crossref","first-page":"244","DOI":"10.4103\/jisp.jisp_207_19","article-title":"Comparative evaluation of turmeric extract with nanocarrier and chlorhexidine gel as an adjunct to scaling and root planing in patients with chronic periodontitis: a pilot randomized controlled clinical trial","volume":"24","author":"Guru","year":"2020","journal-title":"J. Indian Soc. Periodontol."},{"key":"10.1016\/j.pdpdt.2021.102265_bib0155","doi-asserted-by":"crossref","first-page":"32","DOI":"10.17656\/sdj.10104","article-title":"Clinical and biochemical effects of 1% curcumin solution as an adjunct to scaling and root planing, on patients with chronic periodontitis","volume":"7","author":"Mirza","year":"2020","journal-title":"Sulaimani. Dent. J."},{"key":"10.1016\/j.pdpdt.2021.102265_bib0160","doi-asserted-by":"crossref","first-page":"494","DOI":"10.5005\/jp-journals-10024-2828","article-title":"Comparative evaluation of subgingivally delivered 2% curcumin and 0.2% chlorhexidine gel adjunctive to scaling and root planing in chronic periodontitis","volume":"21","author":"Siddharth","year":"2020","journal-title":"J. Contemp. Dent. Pract."},{"key":"10.1016\/j.pdpdt.2021.102265_bib0165","doi-asserted-by":"crossref","first-page":"506","DOI":"10.4103\/ijdr.IJDR_662_17","article-title":"Efficacy of a mouthwash containing essential oils and curcumin as an adjunct to nonsurgical periodontal therapy among rheumatoid arthritis patients with chronic periodontitis: A randomized controlled trial","volume":"30","author":"Anusha","year":"2019","journal-title":"Indian J. Dent. Res."},{"key":"10.1016\/j.pdpdt.2021.102265_bib0170","doi-asserted-by":"crossref","first-page":"79","DOI":"10.4103\/AIHB.AIHB_46_17","article-title":"Comparative evaluation of efficacy of oral curcumin gel as an adjunct to scaling and root planing in the treatment of chronic periodontitis","volume":"8","author":"Dave","year":"2018","journal-title":"Adv. Hum. Biol."},{"issue":"Suppl 1","key":"10.1016\/j.pdpdt.2021.102265_bib0175","doi-asserted-by":"crossref","first-page":"48","DOI":"10.4103\/0975-7406.191967","article-title":"Evaluation of superoxide dismutase levels in local drug delivery system containing 0.2% curcumin strip as an adjunct to scaling and root planing in chronic periodontitis: a clinical and biochemical study","volume":"8","author":"Elavarasu","year":"2016","journal-title":"J. Pharm. Bioall. Sci."},{"key":"10.1016\/j.pdpdt.2021.102265_bib0180","doi-asserted-by":"crossref","first-page":"175","DOI":"10.4103\/0976-237X.132310","article-title":"Comparative evaluation of the efficacy of two controlled release devices: chlorhexidine chips and indigenous curcumin based collagen as local drug delivery systems","volume":"5","author":"Gottumukkala","year":"2014","journal-title":"Contemp. Clin. Dent."},{"key":"10.1016\/j.pdpdt.2021.102265_bib0185","doi-asserted-by":"crossref","first-page":"53","DOI":"10.4103\/0970-9290.156806","article-title":"Comparative evaluation of natural curcumin and synthetic chlorhexidine in the management of chronic periodontitis as a local drug delivery: a clinical and microbiological study","volume":"26","author":"Anitha","year":"2015","journal-title":"Indian J. Dent. Res."},{"key":"10.1016\/j.pdpdt.2021.102265_bib0190","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1002\/ptr.6482","article-title":"Stem cell therapy: curcumin does the trick","volume":"33","author":"Sharifi","year":"2019","journal-title":"Phytother. Res."},{"key":"10.1016\/j.pdpdt.2021.102265_bib0195","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13005-018-0169-1","article-title":"Protective effect and related mechanisms of curcumin in rat experimental periodontitis","volume":"14","author":"Xiao","year":"2018","journal-title":"Head Face Med."},{"key":"10.1016\/j.pdpdt.2021.102265_bib0200","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1902\/jop.2015.150260","article-title":"Antibacterial activity of curcumin against periodontopathic Bacteria","volume":"87","author":"Izui","year":"2016","journal-title":"J. Periodontol."},{"key":"10.1016\/j.pdpdt.2021.102265_bib0205","article-title":"Effect of curcumin on growth, biofilm formation and virulence factor gene expression of Porphyromonas gingivalis","author":"Kumbar","year":"2020","journal-title":"Odontology"},{"key":"10.1016\/j.pdpdt.2021.102265_bib0210","first-page":"169","article-title":"Inhibitory effects of antimicrobial photodynamic therapy with curcumin on biofilm-associated gene expression profile of Aggregatibacter actinomycetemcomitans","volume":"15","author":"Pourhajibagher","year":"2018","journal-title":"J. Dent. Tehran (Tehran)"},{"issue":"2","key":"10.1016\/j.pdpdt.2021.102265_bib0215","doi-asserted-by":"crossref","first-page":"e49","DOI":"10.1016\/S1473-3099(16)30268-7","article-title":"Photoantimicrobials\u2014are we afraid of the light?","volume":"17","author":"Wainwright","year":"2017","journal-title":"Lancet Infect. Dis."},{"issue":"2","key":"10.1016\/j.pdpdt.2021.102265_bib0220","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1039\/c9pp00375d","article-title":"Curcumin derivatives as photosensitizers in photodynamic therapy: photophysical properties and in vitro studies with prostate cancer cells","volume":"19","author":"Kazantzis","year":"2020","journal-title":"Photochem. Photobiol. Sci."},{"key":"10.1016\/j.pdpdt.2021.102265_bib0225","doi-asserted-by":"crossref","first-page":"21","DOI":"10.15171\/jlms.2016.05","article-title":"An in vitro comparison of antimicrobial effects of curcumin-based photodynamic therapy and chlorhexidine, on Aggregatibacter actinomycetemcomitans","volume":"7","author":"Najafi","year":"2016","journal-title":"J. Lasers Med. Sci."},{"key":"10.1016\/j.pdpdt.2021.102265_bib0230","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jphotobiol.2019.03.005","article-title":"Blue photosensitizers for aPDT eliminate Aggregatibacter actinomycetemcomitans in the absence of light: an in vitro study","volume":"194","author":"Valle","year":"2019","journal-title":"J. Photochem. Photobiol. B"},{"key":"10.1016\/j.pdpdt.2021.102265_bib0235","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1039\/b311900a","article-title":"Photodynamic therapy: a new antimicrobial approach to infectious disease?","volume":"3","author":"Hamblin","year":"2004","journal-title":"Photochem. Photobiol. Sci."},{"key":"10.1016\/j.pdpdt.2021.102265_bib0240","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.archoralbio.2018.04.007","article-title":"Differential effects of natural Curcumin and chemically modified curcumin on inflammation and bone resorption in model of experimental periodontitis","volume":"91","author":"Curylofo-Zotti","year":"2018","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.pdpdt.2021.102265_bib0245","doi-asserted-by":"crossref","first-page":"e183","DOI":"10.1902\/jop.2016.150722","article-title":"Effect of curcumin on systemic t helper 17 cell response; gingival expressions of Interleukin-17 and retinoic acid receptor-related orphan receptor \u03b3t; and alveolar bone loss in experimental periodontitis","volume":"87","author":"Bak\u0131r","year":"2016","journal-title":"J. Periodontol."},{"key":"10.1016\/j.pdpdt.2021.102265_bib0250","doi-asserted-by":"crossref","first-page":"6652","DOI":"10.1038\/s41598-018-24866-2","article-title":"Local administration of curcumin-loaded nanoparticles effectively inhibits inflammation and bone resorption associated with experimental periodontal disease","volume":"8","author":"Zambrano","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.pdpdt.2021.102265_bib0255","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1007\/s10103-017-2261-3","article-title":"Curcumin photodynamic effect in the treatment of the induced periodontitis in rats","volume":"32","author":"Theodoro","year":"2017","journal-title":"Lasers Med. Sci."},{"issue":"8","key":"10.1016\/j.pdpdt.2021.102265_bib0260","doi-asserted-by":"crossref","first-page":"e2000171","DOI":"10.1002\/cbdv.202000171","article-title":"Antibacterial mechanism of curcumin: a review","volume":"17","author":"Zheng","year":"2020","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.pdpdt.2021.102265_bib0265","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jphotobiol.2016.03.035","article-title":"Phenothiazinium photosensitisers XI. Improved toluidine blue photoantimicrobials","volume":"160","author":"Wainwright","year":"2016","journal-title":"J. Photochem. Photobiol. B"},{"key":"10.1016\/j.pdpdt.2021.102265_bib0270","doi-asserted-by":"crossref","first-page":"e1000097","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"6","author":"Moher","year":"2009","journal-title":"PLoS Med."},{"key":"10.1016\/j.pdpdt.2021.102265_bib0275","series-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 6.0","author":"Higgins","year":"2019"},{"key":"10.1016\/j.pdpdt.2021.102265_bib0280","doi-asserted-by":"crossref","first-page":"188","DOI":"10.4103\/jphi.JPHI_82_17","article-title":"Effect of local application of curcumin and ornidazole gel in chronic periodontitis patients","volume":"7","author":"Ravishankar","year":"2017","journal-title":"Int. J. Pharm. Investig."},{"key":"10.1016\/j.pdpdt.2021.102265_bib0285","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1089\/pho.2016.4114","article-title":"Clinical comparison of two photosensitizers for oral cavity decontamination","volume":"35","author":"Ricci Donato","year":"2017","journal-title":"Photomed. Laser Surg."},{"key":"10.1016\/j.pdpdt.2021.102265_bib0290","doi-asserted-by":"crossref","first-page":"533","DOI":"10.3109\/00016356309011240","article-title":"Periodontal disease in pregnancy I. Prevalence and severity","volume":"21","author":"L\u00f6e","year":"1963","journal-title":"Acta Odontol. Scand."},{"key":"10.1016\/j.pdpdt.2021.102265_bib0295","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0378-8741(00)00213-0","article-title":"Review on some plants of Indian traditional medicine with antioxidant activity","volume":"71","author":"Scartezzini","year":"2000","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.pdpdt.2021.102265_bib0300","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.3390\/nu11081837","article-title":"Curcumin and type 2 diabetes mellitus: prevention and treatment","volume":"11","author":"Pivari","year":"2019","journal-title":"Nutrients."},{"key":"10.1016\/j.pdpdt.2021.102265_bib0305","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1016\/j.drudis.2017.07.001","article-title":"Curcumin and its topical formulations for wound healing applications","volume":"22","author":"Mohanty","year":"2017","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.pdpdt.2021.102265_bib0310","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.biotechadv.2014.04.004","article-title":"Curcumin, a component of golden spice: from bedside to bench and back","volume":"32","author":"Prasad","year":"2014","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.pdpdt.2021.102265_bib0315","doi-asserted-by":"crossref","first-page":"2","DOI":"10.4143\/crt.2014.46.1.2","article-title":"Recent developments in delivery, bioavailability, absorption and metabolism of curcumin: the golden pigment from golden spice","volume":"46","author":"Prasad","year":"2014","journal-title":"Cancer Res. Treat."},{"key":"10.1016\/j.pdpdt.2021.102265_bib0320","doi-asserted-by":"crossref","first-page":"e0121313","DOI":"10.1371\/journal.pone.0121313","article-title":"Bactericidal activity of curcumin I is associated with damaging of bacterial membrane","volume":"10","author":"Tyagi","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.pdpdt.2021.102265_bib0325","doi-asserted-by":"crossref","first-page":"2912","DOI":"10.1021\/la304778d","article-title":"Effect of curcumin on the diffusion kinetics of a hemicyanine dye, LDS-698, across a lipid bilayer probed by second harmonic spectroscopy","volume":"29","author":"Varshney","year":"2013","journal-title":"Langmuir."},{"key":"10.1016\/j.pdpdt.2021.102265_bib0330","doi-asserted-by":"crossref","first-page":"739","DOI":"10.2217\/fmb-2019-0042","article-title":"Bacterial viability after antimicrobial photodynamic therapy with curcumin on multiresistant Staphylococcus aureus","volume":"14","author":"Freitas","year":"2019","journal-title":"Future Microbiol."},{"key":"10.1016\/j.pdpdt.2021.102265_bib0335","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1902\/jop.2006.050358","article-title":"Reevaluation of Initial Therapy: When Is the Appropriate Time?","volume":"77","author":"Segelnick","year":"2006","journal-title":"J. Periodontol."},{"key":"10.1016\/j.pdpdt.2021.102265_bib0340","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1902\/jop.1992.63.2.118","article-title":"Periodontal response to mechanical non-surgical therapy: a review","volume":"63","author":"Greenstein","year":"1992","journal-title":"J. Periodontol."},{"key":"10.1016\/j.pdpdt.2021.102265_bib0345","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1902\/jop.1971.42.11.678","article-title":"Soft tissue healing following curettage and root planing","volume":"42","author":"Stahl","year":"1971","journal-title":"J. Periodontol."},{"issue":"4","key":"10.1016\/j.pdpdt.2021.102265_bib0350","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1159\/000161127","article-title":"Anti-inflammatory activity of curcumin in macrophages stimulated by lipopolysaccharides from Porphyromonas gingivalis","volume":"82","author":"Chen","year":"2008","journal-title":"Pharmacology"},{"issue":"5","key":"10.1016\/j.pdpdt.2021.102265_bib0355","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/cbin.10050","article-title":"Curcumin attenuates cyclooxygenase-2 expression via inhibition of the NF-kB pathway in lipopolysaccharide-stimulated human gingival fibroblasts","volume":"37","author":"Hu","year":"2013","journal-title":"Cell Biol. Int."},{"issue":"3","key":"10.1016\/j.pdpdt.2021.102265_bib0360","doi-asserted-by":"crossref","first-page":"337","DOI":"10.3934\/biophy.2017.3.337","article-title":"Mechanisms and applications of the anti-inflammatory effects of photobiomodulation","volume":"4","author":"Hamblin","year":"2017","journal-title":"AIMS Biophys."},{"issue":"2","key":"10.1016\/j.pdpdt.2021.102265_bib0365","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1600-0765.2012.01511.x","article-title":"Irradiation by light-emitting diode light as an adjunct to facilitate healing of experimental periodontitis in vivo","volume":"48","author":"Chang","year":"2013","journal-title":"J. Periodont. Res."}],"container-title":["Photodiagnosis and Photodynamic Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100021000910?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100021000910?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:47:10Z","timestamp":1761612430000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1572100021000910"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":73,"alternative-id":["S1572100021000910"],"URL":"https:\/\/doi.org\/10.1016\/j.pdpdt.2021.102265","relation":{},"ISSN":["1572-1000"],"issn-type":[{"value":"1572-1000","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adjuvant effects of curcumin as a photoantimicrobial or irrigant in the non-surgical treatment of periodontitis: Systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Photodiagnosis and Photodynamic Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pdpdt.2021.102265","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102265"}}