{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T23:09:26Z","timestamp":1793660966716,"version":"4.5.1"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004484","name":"Tehran University of Medical Sciences and Health Services","doi-asserted-by":"publisher","award":["99-2-101-48394"],"award-info":[{"award-number":["99-2-101-48394"]}],"id":[{"id":"10.13039\/501100004484","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Photodiagnosis and Photodynamic Therapy"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.pdpdt.2021.102286","type":"journal-article","created":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T12:51:16Z","timestamp":1617799876000},"page":"102286","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"special_numbering":"C","title":["Robust antimicrobial photodynamic therapy with curcumin-poly (lactic-co-glycolic acid) nanoparticles against COVID-19: A preliminary in vitro study in Vero cell line as a model"],"prefix":"10.1016","volume":"34","author":[{"given":"Maryam","family":"Pourhajibagher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Azimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vahid","family":"Haddadi-Asl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanie","family":"Ahmadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehrdad","family":"Gholamzad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Ghorbanpour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas","family":"Bahador","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pdpdt.2021.102286_bib0005","first-page":"368","article-title":"Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case series","volume":"19","author":"Xu","year":"2020","journal-title":"bmj"},{"key":"10.1016\/j.pdpdt.2021.102286_bib0010","doi-asserted-by":"crossref","first-page":"164","DOI":"10.3923\/ajava.2014.164.176","article-title":"Coronavirus infection in equines: a review","volume":"9","author":"Pradesh","year":"2014","journal-title":"Asian J. Anim. Vet. Adv."},{"key":"10.1016\/j.pdpdt.2021.102286_bib0015","doi-asserted-by":"crossref","first-page":"12686","DOI":"10.18632\/oncotarget.8475","article-title":"MERS-CoV virus-like particles produced in insect cells induce specific humoural and cellular immunity in rhesus macaques","volume":"8","author":"Wang","year":"2017","journal-title":"Oncotarget."},{"key":"10.1016\/j.pdpdt.2021.102286_bib0020","first-page":"1","article-title":"The role of primary and secondary bio-molecules in optical diagnosis of pandemic COVID-19 outbreak","volume":"31","author":"ul Rehman","year":"2010","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2021.102286_bib0025","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.tips.2020.05.005","article-title":"In vitro and animal models for SARS-CoV-2 research","volume":"41","author":"Takayama","year":"2020","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.pdpdt.2021.102286_bib0030","first-page":"235","article-title":"The clinical and biological impact of new pathogen inactivation technologies on platelet concentrates","volume":"28","author":"Kaiser-Guignard","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.pdpdt.2021.102286_bib0035","doi-asserted-by":"crossref","first-page":"119","DOI":"10.2174\/187152107780361652","article-title":"Inactivation of pathogenic microorganisms by photodynamic techniques: mechanistic aspects and perspective applications","volume":"6","author":"Jori","year":"2007","journal-title":"Current. Med. Chemis. Anti-Infec. Agen."},{"key":"10.1016\/j.pdpdt.2021.102286_bib0040","first-page":"1","article-title":"Reactive-oxygen-species-mediated mechanism for photoinduced antibacterial and antiviral activities of Ag3PO4","volume":"11","author":"Seo","year":"2020","journal-title":"Anal. Sci. Technol."},{"key":"10.1016\/j.pdpdt.2021.102286_bib0045","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1177\/039463200401700304","article-title":"Photodynamic therapy targeted to pathogens","volume":"17","author":"Demidova","year":"2004","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"10.1016\/j.pdpdt.2021.102286_bib0050","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.pdpdt.2006.08.003","article-title":"Photodynamic inactivation of influenza virus with fullerene C60 suspension in allantoic fluid","volume":"4","author":"Zarubaev","year":"2007","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2021.102286_bib0055","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1097\/00005537-199807000-00002","article-title":"Efficacy of DHE photodynamic therapy for respiratory papillomatosis: immediate and long-term results","volume":"108","author":"Shikowitz","year":"1998","journal-title":"Laryngoscope."},{"key":"10.1016\/j.pdpdt.2021.102286_bib0060","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1001\/archotol.1992.01880010029011","article-title":"Clinical effects of photodynamic therapy on recurrent laryngeal papillomas","volume":"118","author":"Abramson","year":"1992","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.pdpdt.2021.102286_bib0065","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1039\/c9pp00211a","article-title":"Trends and targets in antiviral phototherapy","volume":"18","author":"Wiehe","year":"2019","journal-title":"Photochem. Photobiol. Sci."},{"key":"10.1016\/j.pdpdt.2021.102286_bib0070","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/j.1751-1097.1995.tb05256.x","article-title":"Sulfophthalocyanines for photodynamic inactivation of viruses in blood products: effect of structural modifications","volume":"62","author":"Allen","year":"1995","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.pdpdt.2021.102286_bib0075","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1089\/pho.2015.4080","article-title":"Oral decontamination of orthodontic patients using photodynamic therapy mediated by blue-light irradiation and curcumin associated with sodium dodecyl sulfate","volume":"34","author":"Panh\u00f3ca","year":"2016","journal-title":"Photomed. Laser Surg."},{"key":"10.1016\/j.pdpdt.2021.102286_bib0080","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1021\/mp700113r","article-title":"Bioavailability of curcumin: problems and promises","volume":"4","author":"Anand","year":"2007","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.pdpdt.2021.102286_bib0085","doi-asserted-by":"crossref","first-page":"9280","DOI":"10.1021\/jf202135j","article-title":"PLGA nanoparticles improve the oral bioavailability of curcumin in rats: characterizations and mechanisms","volume":"59","author":"Xie","year":"2011","journal-title":"J. Agric. Food. Chem."},{"key":"10.1016\/j.pdpdt.2021.102286_bib0090","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1039\/C9FO00901A","article-title":"Enhanced curcumin solubility and antibacterial activity by encapsulation in PLGA oily core nanocapsules","volume":"11","author":"Gao","year":"2020","journal-title":"Food Funct."},{"key":"10.1016\/j.pdpdt.2021.102286_bib0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.colsurfb.2020.110937","article-title":"Preparation and in vitro\/in vivo evaluation of doxorubicin-loaded poly [lactic-co-glycol acid] microspheres using electrospray method for sustained drug delivery and potential intratumoral injection","volume":"190","author":"Hsu","year":"2020","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.pdpdt.2021.102286_bib0100","doi-asserted-by":"crossref","first-page":"195","DOI":"10.31989\/ffhd.v10i5.707","article-title":"Mechanisms of selected functional foods against viral infections with a view on COVID-19: mini review","volume":"10","author":"Haslberger","year":"2020","journal-title":"Funct. Food. Health. dis."},{"key":"10.1016\/j.pdpdt.2021.102286_bib0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pdpdt.2020.101674","volume":"30","author":"Ahmadi","year":"2020","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2021.102286_bib0110","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1039\/b311900a","article-title":"Photodynamic therapy: a new antimicrobial approach to infectious disease?","volume":"3","author":"Hamblin","year":"2004","journal-title":"Photochem. Photobiol. Sci."},{"key":"10.1016\/j.pdpdt.2021.102286_bib0115","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/S0924-8579(03)00035-9","article-title":"Local treatment of viral disease using photodynamic therapy","volume":"21","author":"Wainwright","year":"2003","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.pdpdt.2021.102286_bib0120","first-page":"1","article-title":"Methylene blue photochemical treatment as a reliable SARS-CoV-2 plasma virus inactivation method for blood safety and convalescent plasma therapy for the COVID-19 outbreak","volume":"1","author":"Jin","year":"2020","journal-title":"Res. Square."},{"key":"10.1016\/j.pdpdt.2021.102286_bib0125","doi-asserted-by":"crossref","DOI":"10.1111\/vox.12888","article-title":"Inactivation of three emerging viruses - severe acute respiratory syndrome coronavirus, Crimean-Congo haemorrhagic fever virus and Nipah virus \u2013 in platelet concentrates by ultraviolet C light and in plasma by methylene blue plus visible light","author":"Eickmann","year":"2020","journal-title":"Vox Sang."},{"key":"10.1016\/j.pdpdt.2021.102286_bib0130","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1111\/trf.14652","article-title":"Inactivation of Ebola virus and Middle East respiratory syndrome coronavirus in platelet concentrates and plasma by ultraviolet C light and methylene blue plus visible light, respectively","volume":"58","author":"Eickmann","year":"2018","journal-title":"Transfusion."},{"key":"10.1016\/j.pdpdt.2021.102286_bib0135","doi-asserted-by":"crossref","first-page":"2948","DOI":"10.1111\/trf.13860","article-title":"Inactivation of Middle East respiratory syndrome coronavirus (MERS-CoV) in plasma products using a riboflavin-based and ultraviolet light-based photochemical treatment","volume":"56","author":"Kei","year":"2016","journal-title":"Transfusion."},{"key":"10.1016\/j.pdpdt.2021.102286_bib0140","doi-asserted-by":"crossref","first-page":"2482157","DOI":"10.1155\/2016\/2482157","article-title":"Quality and safety of blood products","volume":"2016","author":"Ramirez-Arcos","year":"2016","journal-title":"J. Blood Transfus."},{"key":"10.1016\/j.pdpdt.2021.102286_bib0145","article-title":"The quality changes in fresh frozen plasma of the blood donors at high altitude","volume":"12","author":"Wang","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.pdpdt.2021.102286_bib0150","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1067\/mai.2003.122","article-title":"Clinical and laboratory assessment of immunity","volume":"111","author":"Folds","year":"2003","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.pdpdt.2021.102286_bib0155","doi-asserted-by":"crossref","first-page":"250","DOI":"10.5581\/1516-8484.20110067","article-title":"Titers of ABO antibodies in group O blood donors: patient safety and blood product supply remain a challenge","volume":"33","author":"Denomme","year":"2011","journal-title":"Rev. Bras. Hematol. Hemoter."},{"key":"10.1016\/j.pdpdt.2021.102286_bib0160","doi-asserted-by":"crossref","first-page":"437","DOI":"10.2217\/nnm-2019-0315","article-title":"Photodisinfection effects of silver sulfadiazine nanoliposomes doped-curcumin on Acinetobacter baumannii: a mouse model","volume":"15","author":"Pourhajibagher","year":"2020","journal-title":"Nanomedicine."},{"key":"10.1016\/j.pdpdt.2021.102286_bib0165","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.pdpdt.2021.102286_bib0170","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.ijpharm.2015.08.039","article-title":"Submicron complex lipid carriers for curcumin delivery to intestinal epithelial cells: effect of different emulsifiers on bioaccessibility and cell uptake","volume":"494","author":"Yucel","year":"2015","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.pdpdt.2021.102286_bib0175","first-page":"481","article-title":"Anticoagulation and drug release behavior of Curcumin-Loaded PLGA films","volume":"342","author":"Jiaju","year":"2007","journal-title":"Key Eng. Mater."},{"key":"10.1016\/j.pdpdt.2021.102286_bib0180","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jddst.2016.01.007","article-title":"Factorial design formulation optimization and in vitro characterization of curcumin-loaded PLGA nanoparticles for colon delivery","volume":"32","author":"Akl","year":"2016","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.pdpdt.2021.102286_bib0185","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/jbm.a.36233","article-title":"Development and characterization of electrosprayed nanoparticles for encapsulation of C urcumin","volume":"106","author":"Esmaili","year":"2018","journal-title":"J. Biomed. Mater. Res. A."},{"key":"10.1016\/j.pdpdt.2021.102286_bib0190","doi-asserted-by":"crossref","first-page":"8320","DOI":"10.1016\/S1452-3981(23)12891-4","article-title":"Curcumin dye extracted from Curcuma longa L. Used as sensitizers for efficient dye-sensitized solar cells","volume":"8","author":"Kim","year":"2013","journal-title":"Int. J. Electrochem. Sci."},{"key":"10.1016\/j.pdpdt.2021.102286_bib0195","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1021\/acscentsci.0c00501","article-title":"Assay techniques and test development for COVID-19 diagnosis","volume":"6","author":"Carter","year":"2020","journal-title":"ACS Cent. Sci."},{"key":"10.1016\/j.pdpdt.2021.102286_bib0200","doi-asserted-by":"crossref","first-page":"3822","DOI":"10.1021\/acsnano.0c02624","article-title":"Diagnosing COVID-19: the disease and tools for detection","volume":"14","author":"Udugama","year":"2020","journal-title":"ACS Nano"},{"key":"10.1016\/j.pdpdt.2021.102286_bib0205","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1002\/jmv.25786","article-title":"Stability issues of RT\u2010PCR testing of SARS\u2010CoV\u20102 for hospitalized patients clinically diagnosed with COVID\u201019","volume":"92","author":"Li","year":"2020","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.pdpdt.2021.102286_bib0210","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1039\/c9pp00211a","article-title":"Trends and targets in antiviral phototherapy","volume":"18","author":"Wiehe","year":"2019","journal-title":"Photochem. Photobiol. Sci."},{"key":"10.1016\/j.pdpdt.2021.102286_bib0215","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.3390\/v4071034","article-title":"Photodynamic inactivation of mammalian viruses and bacteriophages","volume":"4","author":"Costa","year":"2012","journal-title":"Viruses."},{"key":"10.1016\/j.pdpdt.2021.102286_bib0220","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1111\/php.12716","article-title":"Type I and Type II photosensitized oxidation reactions: guidelines and mechanistic pathways","volume":"93","author":"Baptista","year":"2017","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.pdpdt.2021.102286_bib0225","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S1011-1344(01)00207-X","article-title":"Photosensitized oxidation of membrane lipids: reaction pathways, cytotoxic effects, and cytoprotective mechanisms","volume":"63","author":"Girotti","year":"2001","journal-title":"J. Photochem. Photobiol. B, Biol."},{"key":"10.1016\/j.pdpdt.2021.102286_bib0230","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2017\/9656719","article-title":"Solid lipid curcumin particles induce more DNA fragmentation and cell death in cultured human glioblastoma cells than does natural curcumin","volume":"2017","author":"Maiti","year":"2017","journal-title":"Oxid. Med. Cell. Longev."}],"container-title":["Photodiagnosis and Photodynamic Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100021001125?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100021001125?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:41:19Z","timestamp":1761612079000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1572100021001125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":46,"alternative-id":["S1572100021001125"],"URL":"https:\/\/doi.org\/10.1016\/j.pdpdt.2021.102286","relation":{},"ISSN":["1572-1000"],"issn-type":[{"value":"1572-1000","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Robust antimicrobial photodynamic therapy with curcumin-poly (lactic-co-glycolic acid) nanoparticles against COVID-19: A preliminary in vitro study in Vero cell line as a model","name":"articletitle","label":"Article Title"},{"value":"Photodiagnosis and Photodynamic Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pdpdt.2021.102286","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102286"}}