{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T19:30:11Z","timestamp":1791747011511,"version":"4.3.4"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Photodiagnosis and Photodynamic Therapy"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.pdpdt.2021.102435","type":"journal-article","created":{"date-parts":[[2021,7,7]],"date-time":"2021-07-07T06:11:00Z","timestamp":1625638260000},"page":"102435","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Clinical efficacy of single and multiple applications of antimicrobial photodynamic therapy in periodontal maintenance: A systematic review and network meta-analysis"],"prefix":"10.1016","volume":"36","author":[{"given":"Egle","family":"Ramanauskaite","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittorio","family":"Moraschini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vita","family":"Machiulskiene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"Sculean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"22","key":"10.1016\/j.pdpdt.2021.102435_bib0001","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/jcpe.13290","article-title":"Treatment of stage I-III periodontitis-The EFP S3 level clinical practice guideline","volume":"47","author":"Sanz","year":"2020","journal-title":"J Clin Periodontol"},{"issue":"1","key":"10.1016\/j.pdpdt.2021.102435_bib0002","first-page":"S173","article-title":"Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions","volume":"89","author":"Papapanou","year":"2018","journal-title":"J Periodontol"},{"key":"10.1016\/j.pdpdt.2021.102435_bib0003","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jebdp.2014.02.007","article-title":"Periodontal debridement: still the treatment of choice","volume":"14","author":"Drisko","year":"2014","journal-title":"J Evid Based Dent Pract"},{"issue":"1","key":"10.1016\/j.pdpdt.2021.102435_bib0004","doi-asserted-by":"crossref","DOI":"10.1186\/s12903-020-01127-1","article-title":"Antiseptics as adjuncts to scaling and root planing in the treatment of periodontitis: a systematic literature review","volume":"20","author":"Ramanauskaite","year":"2020","journal-title":"BMC Oral Health"},{"issue":"8","key":"10.1016\/j.pdpdt.2021.102435_bib0005","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1902\/jop.2005.76.8.1227","article-title":"Impact of local adjuncts to scaling and root planing in periodontal disease therapy: a systematic review","volume":"76","author":"Bonito","year":"2005","journal-title":"J Periodontol"},{"issue":"1","key":"10.1016\/j.pdpdt.2021.102435_bib0006","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1902\/annals.2003.8.1.79","article-title":"Local anti-infective therapy: pharmacological agents. A systematic review","volume":"8","author":"Hanes","year":"2003","journal-title":"Ann Periodontol"},{"issue":"3","key":"10.1016\/j.pdpdt.2021.102435_bib0007","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/jcpe.12026","article-title":"A systematic review on the effects of local antimicrobials as adjuncts to subgingival debridement, compared with subgingival debridement alone, in the treatment of chronic periodontitis","volume":"40","author":"Matesanz-Perez","year":"2013","journal-title":"J Clin Periodontol"},{"issue":"1","key":"10.1016\/j.pdpdt.2021.102435_bib0008","first-page":"S74","article-title":"Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions","volume":"89","author":"Chapple","year":"2018","journal-title":"J Periodontol"},{"issue":"1","key":"10.1016\/j.pdpdt.2021.102435_bib0009","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/prd.12156","article-title":"Surgical treatment of the residual periodontal pocket","volume":"76","author":"Graziani","year":"2018","journal-title":"Periodontol 2000"},{"issue":"8","key":"10.1016\/j.pdpdt.2021.102435_bib0010","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1111\/j.1600-051X.2008.01245.x","article-title":"Influence of residual pockets on progression of periodontitis and tooth loss: results after 11 years of maintenance","volume":"35","author":"Matuliene","year":"2008","journal-title":"J Clin Periodontol"},{"issue":"1","key":"10.1016\/j.pdpdt.2021.102435_bib0011","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/idh.12288","article-title":"Periodontal maintenance following active specialist treatment: Should patients stay put or return to primary dental care for continuing care? A comparison of outcomes based on the literature","volume":"16","author":"Leavy","year":"2018","journal-title":"Int J Dent Hyg"},{"key":"10.1016\/j.pdpdt.2021.102435_bib0012","article-title":"Supportive periodontal therapy (SPT) for maintaining the dentition in adults treated for periodontitis","volume":"1","author":"Manresa","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"issue":"1","key":"10.1016\/j.pdpdt.2021.102435_bib0013","first-page":"889","article-title":"The Efficacy of Adjunctive Aids in Periodontal Maintenance Therapy: A Systematic Literature Review and Meta-analysis","volume":"18","author":"Ramanauskaite","year":"2020","journal-title":"Oral Health Prev Dent"},{"issue":"5","key":"10.1016\/j.pdpdt.2021.102435_bib0014","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1080\/1040841X.2018.1467876","article-title":"Antimicrobial photodynamic therapy - what we know and what we don't","volume":"44","author":"Cieplik","year":"2018","journal-title":"Critical Reviews in Microbiology"},{"issue":"6","key":"10.1016\/j.pdpdt.2021.102435_bib0015","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1902\/jop.2007.060494","article-title":"Antimicrobial photodynamic therapy in the non-surgical treatment of aggressive periodontitis: a preliminary randomized controlled clinical study","volume":"78","author":"de Oliveira","year":"2007","journal-title":"Journal of Periodontology"},{"issue":"2","key":"10.1016\/j.pdpdt.2021.102435_bib0016","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s10103-017-2383-7","article-title":"Efficacy of photodynamic therapy as adjunct treatment of chronic periodontitis: a systematic review and meta-analysis","volume":"33","author":"Azaripour","year":"2018","journal-title":"Lasers Med Sci"},{"issue":"7","key":"10.1016\/j.pdpdt.2021.102435_bib0017","first-page":"783","article-title":"Antimicrobial photodynamic therapy for the treatment of periodontitis and peri-implantitis: An American Academy of Periodontology best evidence review","volume":"89","author":"Chambrone","year":"2018","journal-title":"J Periodontol"},{"issue":"5","key":"10.1016\/j.pdpdt.2021.102435_bib0018","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/jcpe.12094","article-title":"Adjunctive photodynamic therapy to non-surgical treatment of chronic periodontitis: a systematic review and meta-analysis","volume":"40","author":"Sgolastra","year":"2013","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.pdpdt.2021.102435_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2020.101969","article-title":"Efficacy of adjunctive photodynamic therapy and lasers in the non-surgical periodontal treatment: A Bayesian network meta-analysis","volume":"32","author":"Zhao","year":"2020","journal-title":"Photodiagnosis Photodyn Ther"},{"issue":"5","key":"10.1016\/j.pdpdt.2021.102435_bib0020","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.ijsu.2010.02.007","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"8","author":"Moher","year":"2010","journal-title":"Int J Surg"},{"key":"10.1016\/j.pdpdt.2021.102435_bib0021","doi-asserted-by":"crossref","first-page":"d5928","DOI":"10.1136\/bmj.d5928","article-title":"The Cochrane Collaboration's tool for assessing risk of bias in randomised trials","volume":"343","author":"Higgins","year":"2011","journal-title":"BMJ"},{"issue":"11","key":"10.1016\/j.pdpdt.2021.102435_bib0022","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis","volume":"21","author":"Higgins","year":"2002","journal-title":"Stat Med"},{"issue":"9665","key":"10.1016\/j.pdpdt.2021.102435_bib0023","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/S0140-6736(09)60046-5","article-title":"Comparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments meta-analysis","volume":"373","author":"Cipriani","year":"2009","journal-title":"Lancet"},{"issue":"10","key":"10.1016\/j.pdpdt.2021.102435_bib0024","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/S0895-4356(01)00377-8","article-title":"Funnel plots for detecting bias in meta-analysis: guidelines on choice of axis","volume":"54","author":"Sterne","year":"2001","journal-title":"J Clin Epidemiol"},{"issue":"10","key":"10.1016\/j.pdpdt.2021.102435_bib0025","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1002\/lsm.22449","article-title":"Short-term microbiological effects of photodynamic therapy in non-surgical periodontal treatment of residual pockets: A split-mouth RCT","volume":"48","author":"Correa","year":"2016","journal-title":"Lasers Surg Med"},{"issue":"1","key":"10.1016\/j.pdpdt.2021.102435_bib0026","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s10103-012-1159-3","article-title":"The adjunctive effect of photodynamic therapy for residual pockets in single-rooted teeth: a randomized controlled clinical trial","volume":"28","author":"Campos","year":"2013","journal-title":"Lasers Med Sci"},{"issue":"5","key":"10.1016\/j.pdpdt.2021.102435_bib0027","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1007\/s10103-008-0565-z","article-title":"Photodynamic therapy as adjunct to non-surgical periodontal treatment in patients on periodontal maintenance: a randomized controlled clinical trial","volume":"24","author":"Chondros","year":"2009","journal-title":"Lasers Med Sci"},{"issue":"8","key":"10.1016\/j.pdpdt.2021.102435_bib0028","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1902\/jop.2011.110281","article-title":"Effect of photodynamic therapy, diode laser, and deep scaling on cytokine and acute-phase protein levels in gingival crevicular fluid of residual periodontal pockets","volume":"83","author":"Giannopoulou","year":"2012","journal-title":"J Periodontol"},{"issue":"8","key":"10.1016\/j.pdpdt.2021.102435_bib0029","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1111\/j.1600-051X.2009.01432.x","article-title":"One-year outcomes of repeated adjunctive photodynamic therapy during periodontal maintenance: a proof-of-principle randomized-controlled clinical trial","volume":"36","author":"Lulic","year":"2009","journal-title":"J Clin Periodontol"},{"issue":"1","key":"10.1016\/j.pdpdt.2021.102435_bib0030","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s10103-013-1337-y","article-title":"Single or repeated antimicrobial photodynamic therapy as adjunct to ultrasonic debridement in residual periodontal pockets: clinical, microbiological, and local biological effects","volume":"30","author":"Muller Campanile","year":"2015","journal-title":"Lasers Med Sci"},{"key":"10.1016\/j.pdpdt.2021.102435_bib0031","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.pdpdt.2019.05.028","article-title":"Clinical and microbiological effects of multiple applications of antibacterial photodynamic therapy in periodontal maintenance patients. A randomized controlled clinical study","volume":"27","author":"Grzech-Lesniak","year":"2019","journal-title":"Photodiagnosis Photodyn Ther"},{"key":"10.1016\/j.pdpdt.2021.102435_bib0032","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.pdpdt.2017.03.017","article-title":"Effects of root debridement and adjunctive photodynamic therapy in residual pockets of patients on supportive periodontal therapy: A randomized split-mouth trial","volume":"18","author":"Goh","year":"2017","journal-title":"Photodiagnosis Photodyn Ther"},{"issue":"12","key":"10.1016\/j.pdpdt.2021.102435_bib0033","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1111\/jcpe.13379","article-title":"Adjunctive local treatments for patients with residual pockets during supportive periodontal care: A systematic review and network meta-analysis","volume":"47","author":"Wang","year":"2020","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.pdpdt.2021.102435_bib0034","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.pdpdt.2016.11.011","article-title":"Clinical effectiveness of adjunctive antimicrobial photodynamic therapy for residual pockets during supportive periodontal therapy: A systematic review and meta-analysis","volume":"17","author":"Xue","year":"2017","journal-title":"Photodiagnosis Photodyn Ther"},{"issue":"5","key":"10.1016\/j.pdpdt.2021.102435_bib0035","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1007\/s10103-011-1027-6","article-title":"Treatment of residual pockets with photodynamic therapy, diode laser, or deep scaling. A randomized, split-mouth controlled clinical trial","volume":"27","author":"Cappuyns","year":"2012","journal-title":"Lasers Med Sci"},{"issue":"5","key":"10.1016\/j.pdpdt.2021.102435_bib0036","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1111\/jcpe.12393","article-title":"Antimicrobial photodynamic effect to treat residual pockets in periodontal patients: a randomized controlled clinical trial","volume":"42","author":"Carvalho","year":"2015","journal-title":"J Clin Periodontol"},{"issue":"1","key":"10.1016\/j.pdpdt.2021.102435_bib0037","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s10103-016-2076-7","article-title":"Photodynamic therapy decrease immune-inflammatory mediators levels during periodontal maintenance","volume":"32","author":"da Cruz Andrade","year":"2017","journal-title":"Lasers Med Sci"},{"issue":"2","key":"10.1016\/j.pdpdt.2021.102435_bib0038","doi-asserted-by":"crossref","first-page":"139","DOI":"10.15171\/jlms.2019.22","article-title":"Clinical and Biological Effects of Adjunctive Photodynamic Therapy in Refractory Periodontitis","volume":"10","author":"Habashneh","year":"2019","journal-title":"J Lasers Med Sci"},{"issue":"8","key":"10.1016\/j.pdpdt.2021.102435_bib0039","doi-asserted-by":"crossref","first-page":"e277","DOI":"10.1902\/jop.2014.130559","article-title":"Photodynamic therapy during supportive periodontal care: clinical, microbiologic, immunoinflammatory, and patient-centered performance in a split-mouth randomized clinical trial","volume":"85","author":"Kolbe","year":"2014","journal-title":"J Periodontol"},{"issue":"1","key":"10.1016\/j.pdpdt.2021.102435_bib0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10103-012-1225-x","article-title":"Light-activated disinfection using a light-emitting diode lamp in the red spectrum: clinical and microbiological short-term findings on periodontitis patients in maintenance. A randomized controlled split-mouth clinical trial","volume":"29","author":"Mongardini","year":"2014","journal-title":"Lasers Med Sci"},{"issue":"6","key":"10.1016\/j.pdpdt.2021.102435_bib0041","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1007\/s10103-014-1632-2","article-title":"Effect of repeated adjunctive antimicrobial photodynamic therapy on subgingival periodontal pathogens in the treatment of chronic periodontitis","volume":"30","author":"Petelin","year":"2015","journal-title":"Lasers Med Sci"},{"issue":"6","key":"10.1016\/j.pdpdt.2021.102435_bib0042","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1007\/s00784-009-0347-4","article-title":"Photodynamic therapy of persistent pockets in maintenance patients-a clinical study","volume":"14","author":"Ruhling","year":"2010","journal-title":"Clin Oral Investig"},{"issue":"4","key":"10.1016\/j.pdpdt.2021.102435_bib0043","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.cden.2015.06.008","article-title":"Is Photodynamic Therapy an Effective Treatment for Periodontal and Peri-Implant Infections?","volume":"59","author":"Sculean","year":"2015","journal-title":"Dent Clin North Am"}],"container-title":["Photodiagnosis and Photodynamic Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100021002623?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100021002623?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:40:32Z","timestamp":1761612032000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1572100021002623"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":43,"alternative-id":["S1572100021002623"],"URL":"https:\/\/doi.org\/10.1016\/j.pdpdt.2021.102435","relation":{},"ISSN":["1572-1000"],"issn-type":[{"value":"1572-1000","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical efficacy of single and multiple applications of antimicrobial photodynamic therapy in periodontal maintenance: A systematic review and network meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Photodiagnosis and Photodynamic Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pdpdt.2021.102435","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102435"}}