{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T17:20:42Z","timestamp":1792603242841,"version":"4.5.0"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Photodiagnosis and Photodynamic Therapy"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.pdpdt.2022.102822","type":"journal-article","created":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T13:44:05Z","timestamp":1647870245000},"page":"102822","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Efficacy and safety of ALA-PDT in treatment of diabetic foot ulcer with infection"],"prefix":"10.1016","volume":"38","author":[{"given":"Xinying","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiling","family":"Kou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanqi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengjun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunchuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8042-4679","authenticated-orcid":false,"given":"Yuangang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.pdpdt.2022.102822_bib0001","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S1479-666X(07)80007-2","article-title":"Diabetic foot ulcers\u2013a comprehensive review","volume":"5","author":"Leung","year":"2007","journal-title":"Surgeon"},{"issue":"Suppl 1","key":"10.1016\/j.pdpdt.2022.102822_bib0002","doi-asserted-by":"crossref","first-page":"S31","DOI":"10.1002\/dmrr.857","article-title":"The diabetic foot in the developing world","volume":"24","author":"Unwin","year":"2008","journal-title":"Diabetes Metab. Res. Rev."},{"key":"10.1016\/j.pdpdt.2022.102822_bib0003","doi-asserted-by":"crossref","DOI":"10.3402\/dfa.v4i0.22477","article-title":"A developing world experience with distal foot amputations for diabetic limb salvage","volume":"4","author":"Salahuddin","year":"2013","journal-title":"Diabet Foot Ankle"},{"key":"10.1016\/j.pdpdt.2022.102822_bib0004","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3390\/ijms22020482","article-title":"Therapeutic Potential of Antimicrobial Peptides in Polymicrobial Biofilm-Associated Infections","volume":"22","author":"Batoni","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"11","key":"10.1016\/j.pdpdt.2022.102822_bib0005","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1111\/j.1742-1241.2007.01534.x","article-title":"Assessment and treatment of diabetic foot ulcer","volume":"61","author":"Fard","year":"2007","journal-title":"Int. J. Clin. Pract."},{"issue":"10","key":"10.1016\/j.pdpdt.2022.102822_bib0006","doi-asserted-by":"crossref","DOI":"10.3390\/cancers8100098","article-title":"Photodynamic therapy and non-melanoma skin cancer","volume":"8","author":"Griffin","year":"2016","journal-title":"Cancers"},{"key":"10.1016\/j.pdpdt.2022.102822_bib0007","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.mib.2016.06.008","article-title":"Antimicrobial photodynamic inactivation: a bright new technique to kill resistant microbes","volume":"33","author":"Hamblin","year":"2016","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.pdpdt.2022.102822_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2021.102556","article-title":"Modulation of skin microbiome in acne patients by aminolevulinic acid-photodynamic therapy","volume":"36","author":"Yang","year":"2021","journal-title":"Photodiagn. Photodyn. Ther."},{"issue":"9","key":"10.1016\/j.pdpdt.2022.102822_bib0009","article-title":"Oxidative stress and photodynamic therapy of skin cancers: mechanisms, challenges and promising developments","volume":"5","author":"Allegra","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.pdpdt.2022.102822_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2021.102484","article-title":"Open study of photodynamic therapy for skin ulcers infected with MRSA and pseudomonas aeruginosa","volume":"36","author":"Shiratori","year":"2021","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2022.102822_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2021.102480","article-title":"Efficacy of the therapy of 5-aminolevulinic acid photodynamic therapy combined with human umbilical cord mesenchymal stem cells on methicillin-resistant Staphylococcus aureus-infected wound in a diabetic mouse model","volume":"36","author":"Huang","year":"2021","journal-title":"Photodiagn. Photodyn. Ther."},{"issue":"5","key":"10.1016\/j.pdpdt.2022.102822_bib0012","doi-asserted-by":"crossref","DOI":"10.3390\/antibiotics10050506","article-title":"Photodynamic therapy for the treatment of infected leg ulcers-a pilot study","volume":"10","author":"Krupka","year":"2021","journal-title":"Antibiotics"},{"key":"10.1016\/j.pdpdt.2022.102822_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2021.102545","article-title":"A combination of preoperative or intraoperative MB-PDT and surgery in the treatment of giant cutaneous squamous cell carcinoma with infection","volume":"36","author":"Xu","year":"2021","journal-title":"Photodiagn. Photodyn. Ther."},{"issue":"3","key":"10.1016\/j.pdpdt.2022.102822_bib0014","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1111\/j.1751-1097.2011.01039.x","article-title":"Miconazole induces fungistasis and increases killing of Candida albicans subjected to photodynamic therapy","volume":"88","author":"Snell","year":"2012","journal-title":"Photochem. Photobiol."},{"issue":"5","key":"10.1016\/j.pdpdt.2022.102822_bib0015","first-page":"48","article-title":"The right way to culture a wound","volume":"93","author":"Cuzzell","year":"1993","journal-title":"Am. J. Nurs."},{"issue":"Suppl 1","key":"10.1016\/j.pdpdt.2022.102822_bib0016","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/dmrr.2695","article-title":"Prevention and management of foot problems in diabetes: a Summary Guidance for Daily Practice 2015, based on the IWGDF Guidance Documents","volume":"32","author":"Schaper","year":"2016","journal-title":"Diabetes Metab. Res. Rev."},{"issue":"3","key":"10.1016\/j.pdpdt.2022.102822_bib0017","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1111\/dme.13564","article-title":"Diabetes and chronic kidney disease: an increasingly common multi-morbid disease in need of a paradigm shift in care","volume":"35","author":"Winocour","year":"2018","journal-title":"Diabet. Med."},{"issue":"3","key":"10.1016\/j.pdpdt.2022.102822_bib0018","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.pdpdt.2014.04.007","article-title":"A clinical trial testing the efficacy of PDT in preventing amputation in diabetic patients","volume":"11","author":"Tardivo","year":"2014","journal-title":"Photodiagn. Photodyn. Ther."},{"issue":"4","key":"10.1016\/j.pdpdt.2022.102822_bib0019","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.pdpdt.2014.08.002","article-title":"Ulcerative necrobiosis lipoidica successfully treated with photodynamic therapy: case report and literature review","volume":"11","author":"Borgia","year":"2014","journal-title":"Photodiagn. Photodyn. Ther."},{"issue":"12","key":"10.1016\/j.pdpdt.2022.102822_bib0020","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s11274-019-2768-9","article-title":"Photodynamic inactivation diminishes quorum sensing-mediated virulence factor production and biofilm formation of Serratia marcescens","volume":"35","author":"Fekrirad","year":"2019","journal-title":"World J. Microbiol. Biotechnol."},{"issue":"3","key":"10.1016\/j.pdpdt.2022.102822_bib0021","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1111\/bjd.12098","article-title":"Phase IIa randomized, placebo-controlled study of antimicrobial photodynamic therapy in bacterially colonized, chronic leg ulcers and diabetic foot ulcers: a new approach to antimicrobial therapy","volume":"168","author":"Morley","year":"2013","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.pdpdt.2022.102822_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2020.102149","article-title":"Enhancing wound healing in recalcitrant leg ulcers with aminolevulinic acid-mediated antimicrobial photodynamic therapy","volume":"33","author":"Lin","year":"2021","journal-title":"Photodiagn. Photodyn. Ther."},{"issue":"3","key":"10.1016\/j.pdpdt.2022.102822_bib0023","first-page":"223","article-title":"Early activation of fibroblasts during PDT treatment in leg ulcers","volume":"151","author":"Corsi","year":"2016","journal-title":"G. Ital. Dermatol. Venereol."},{"key":"10.1016\/j.pdpdt.2022.102822_bib0024","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.pdpdt.2017.12.012","article-title":"ALA-PDT exerts beneficial effects on chronic venous ulcers by inducing changes in inflammatory microenvironment, especially through increased TGF-beta release: a pilot clinical and translational study","volume":"21","author":"Grandi","year":"2018","journal-title":"Photodiagn. Photodyn. Ther."},{"issue":"2","key":"10.1016\/j.pdpdt.2022.102822_bib0025","first-page":"129","article-title":"Photodynamic therapy for chronic venous ulcers","volume":"22","author":"Cappugi","year":"2014","journal-title":"Acta Dermatovenerol. Croat."},{"issue":"10","key":"10.1016\/j.pdpdt.2022.102822_bib0026","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.2337\/diacare.18.10.1376","article-title":"Manufactured shoes in the prevention of diabetic foot ulcers","volume":"18","author":"Uccioli","year":"1995","journal-title":"Diabetes Care"},{"issue":"232","key":"10.1016\/j.pdpdt.2022.102822_bib0027","first-page":"763","article-title":"Improved survival of the diabetic foot: the role of a specialized foot clinic","volume":"60","author":"Edmonds","year":"1986","journal-title":"Q. J. Med."},{"issue":"24","key":"10.1016\/j.pdpdt.2022.102822_bib0028","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1056\/NEJMra1615439","article-title":"Diabetic foot ulcers and their recurrence","volume":"376","author":"Armstrong","year":"2017","journal-title":"N. Engl. J. Med."}],"container-title":["Photodiagnosis and Photodynamic Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100022001119?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100022001119?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:43:46Z","timestamp":1761612226000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1572100022001119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":28,"alternative-id":["S1572100022001119"],"URL":"https:\/\/doi.org\/10.1016\/j.pdpdt.2022.102822","relation":{},"ISSN":["1572-1000"],"issn-type":[{"value":"1572-1000","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy and safety of ALA-PDT in treatment of diabetic foot ulcer with infection","name":"articletitle","label":"Article Title"},{"value":"Photodiagnosis and Photodynamic Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pdpdt.2022.102822","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102822"}}