{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T12:31:51Z","timestamp":1781872311050,"version":"3.54.5"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Photodiagnosis and Photodynamic Therapy"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.pdpdt.2022.102823","type":"journal-article","created":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T13:44:44Z","timestamp":1647870284000},"page":"102823","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Analysis of choroidal vascularity index in multiple sclerosis patients without optic neuritis attack"],"prefix":"10.1016","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6302-9175","authenticated-orcid":false,"given":"Emine","family":"Temel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazife","family":"A\u015f\u0131kgarip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuf","family":"Ko\u00e7ak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kemal","family":"\u00d6rnek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zkan","family":"Kocam\u0131\u015f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6k\u00e7en","family":"\u00d6zcan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.pdpdt.2022.102823_bib0001","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1172\/JCI58649","article-title":"Multiple sclerosis","volume":"122","author":"Nylander","year":"2012","journal-title":"J. Clin. Invest."},{"key":"#cr-split#-10.1016\/j.pdpdt.2022.102823_bib0002.1","unstructured":"National Multiple Sclerosis Society (2020) New York: Who gest MS (epidemiology)"},{"key":"#cr-split#-10.1016\/j.pdpdt.2022.102823_bib0002.2","unstructured":"[cited 2020 March 20]. Available from: http:\/\/www.nationalmssociety.org\/What-is-MS\/Who-Gets-MS."},{"key":"10.1016\/j.pdpdt.2022.102823_bib0003","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.msard.2018.07.013","article-title":"The disease burden of multiple sclerosis from the individual and population perspective: which symptoms matter most?","volume":"25","author":"Barin","year":"2018","journal-title":"Mult. Scler. Relat. Disord."},{"key":"10.1016\/j.pdpdt.2022.102823_bib0004","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.neuron.2006.09.011","article-title":"The neurobiology of multiple sclerosis: genes, inflammation, and neurodegeneration","volume":"52","author":"Hauser","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.pdpdt.2022.102823_bib0005","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1007\/s00417-004-0948-1","article-title":"Color doppler imaging in optic neuritis with multiple sclerosis","volume":"242","author":"Akarsu","year":"2004","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.pdpdt.2022.102823_bib0006","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1159\/000069085","article-title":"Extraocular blood flow and endothelin-1 plasma levels in patients with multiple sclerosis","volume":"49","author":"Pache","year":"2003","journal-title":"Eur. Neurol."},{"key":"10.1016\/j.pdpdt.2022.102823_bib0007","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1097\/00041327-200103000-00011","article-title":"Increased endothelin-1 plasma levels in patients with multiple sclerosis","volume":"21","author":"Haufschild","year":"2001","journal-title":"J. Neuroophthalmol."},{"key":"10.1016\/j.pdpdt.2022.102823_bib0008","first-page":"183","article-title":"Assessment of blood flow velocity in eyeball arteries in multiple sclerosis patients with past retrobulbar optic neuritis in color doppler ultrasonography","volume":"109","author":"Modrzejewska","year":"2007","journal-title":"Klin. Oczna"},{"key":"10.1016\/j.pdpdt.2022.102823_bib0009","doi-asserted-by":"crossref","first-page":"7710","DOI":"10.1167\/iovs.12-10464","article-title":"Association between choroidal thickness and ocular perfusion pressure in young, healthy subjects: enhanced depth imaging optical coherence tomography study","volume":"53","author":"Kim","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.pdpdt.2022.102823_bib0010","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1007\/s00417-014-2840-y","article-title":"Enhanced depth imaging-OCT of the choroid: a review of the current literature","volume":"252","author":"Laviers","year":"2014","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.pdpdt.2022.102823_bib0011","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1159\/000441152","article-title":"Evaluation of choroidal vascular changes in patients with multiple sclerosis using enhanced depth imaging optical coherence tomography","volume":"235","author":"Esen","year":"2016","journal-title":"Ophthalmologica"},{"key":"10.1016\/j.pdpdt.2022.102823_bib0012","doi-asserted-by":"crossref","first-page":"e77","DOI":"10.1111\/aos.13807","article-title":"Changes in peripapillary choroidal thickness in patients with multiple sclerosis","volume":"97","author":"Garcia-Martin","year":"2019","journal-title":"Acta Ophthalmol."},{"key":"10.1016\/j.pdpdt.2022.102823_bib0013","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1007\/s00417-021-05143-x","article-title":"The effect of optic neuritis attacks on choroidal vascularity index in patients with multiple sclerosis","volume":"259","author":"Balci","year":"2021","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.pdpdt.2022.102823_bib0014","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/ana.22366","article-title":"Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria","volume":"69","author":"Polman","year":"2011","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.pdpdt.2022.102823_bib0015","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.ajo.2008.05.032","article-title":"Enhanced depth imaging spectral-domain optical coherence tomography","volume":"146","author":"Spaide","year":"2008","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.pdpdt.2022.102823_bib0016","doi-asserted-by":"crossref","first-page":"3893","DOI":"10.1167\/iovs.14-14447","article-title":"Choroidal structure in normal eyes and after photodynamic therapy determined by binarization of optical coherence tomographic images","volume":"55","author":"Sonoda","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.pdpdt.2022.102823_bib0017","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1159\/000069085","article-title":"Extraocular blood flow and endothelin-1 plasma levels in patients with multiple sclerosis","volume":"49","author":"Pache","year":"2003","journal-title":"Eur. Neurol."},{"key":"10.1016\/j.pdpdt.2022.102823_bib0018","first-page":"183","article-title":"Assessment of blood flow velocity in eyeball arteries in multiple sclerosis patients with past retrobulbar optic neuritis in color Doppler ultrasonography","volume":"109","author":"Modrzejewska","year":"2007","journal-title":"Klin. Oczna"},{"key":"10.1016\/j.pdpdt.2022.102823_bib0019","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1080\/00207454.2019.1576660","article-title":"Eyes are mirror of the brain: comparison of multiple sclerosis patients and healthy controls using OCT","volume":"129","author":"Do\u011fan","year":"2019","journal-title":"Int. J. Neurosci."},{"key":"10.1016\/j.pdpdt.2022.102823_bib0020","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1093\/brain\/awaa049","article-title":"Anterior visual system imaging to investigate energy failure in multiple sclerosis","volume":"143","author":"Kleerekooper","year":"2020","journal-title":"Brain"},{"key":"10.1016\/j.pdpdt.2022.102823_bib0021","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1042\/CS20170981","article-title":"Understanding a role for hypoxia in lesion formation and location in the deep and periventricular white matter in small vessel disease and multiple sclerosis","volume":"131","author":"Martinez Sosa","year":"2017","journal-title":"Clin. Sci."},{"key":"10.1016\/j.pdpdt.2022.102823_bib0023","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1038\/jcbfm.2015.131","article-title":"Cerebral hypoperfusion: a new pathophysiologic concept in multiple sclerosis?","volume":"35","author":"D'Haeseleer","year":"2015","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.pdpdt.2022.102823_bib0022","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/598093","article-title":"The evidence for hypoperfusion as a factor in multiple sclerosis lesion development","volume":"2013","author":"Juurlink","year":"2013","journal-title":"Mult. Scler. Int."},{"key":"10.1016\/j.pdpdt.2022.102823_bib0024","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1177\/1352458516631035","article-title":"Impaired retinal microcirculation in multiple sclerosis","volume":"22","author":"Jiang","year":"2016","journal-title":"Mult. Scler."},{"key":"10.1016\/j.pdpdt.2022.102823_bib0025","first-page":"183","article-title":"Assessment of blood flow velocity in eyeball arteries in multiple sclerosis patients with past retrobulbar optic neuritis in color doppler ultrasonography","volume":"109","author":"Modrzejewska","year":"2007","journal-title":"Klin. Ocz."},{"key":"10.1016\/j.pdpdt.2022.102823_bib0026","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1136\/bjophthalmol-2013-304547","article-title":"Optical coherence tomography angiography of optic nerve head and parafovea in multiple sclerosis","volume":"98","author":"Wang","year":"2014","journal-title":"Br. J. Ophtalmol."},{"key":"10.1016\/j.pdpdt.2022.102823_bib0027","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1136\/bjophthalmol-2017-310477","article-title":"Optical coherence tomography angiography enhances the detection of optic nerve damage in multiple sclerosis","volume":"102","author":"Spain","year":"2018","journal-title":"Br. J. Ophthalmol."},{"issue":"3","key":"10.1016\/j.pdpdt.2022.102823_bib0028","first-page":"B5212","article-title":"Gender differences in multiple sclerosis epidemiology and treatment response","volume":"63","author":"Magyari","year":"2016","journal-title":"Dan. Med. J."},{"key":"10.1016\/j.pdpdt.2022.102823_bib0029","doi-asserted-by":"crossref","first-page":"21090","DOI":"10.1038\/srep21090","article-title":"Choroidal vascularity index as a measure of vascular status of the choroid: measurements in healthy eyes from a population-based study","volume":"6","author":"Agrawal","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.pdpdt.2022.102823_bib0030","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.preteyeres.2012.04.004","article-title":"Cellular and physiological mechanisms underlying blood flow regulation in the retina and choroid in health and disease","volume":"31","author":"Kur","year":"2012","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.pdpdt.2022.102823_bib0031","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.mvr.2014.08.008","article-title":"Choroidal impairment and macular thinning in patients with systemic sclerosis: the acute study","volume":"97","author":"Ingegnoli","year":"2015","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.pdpdt.2022.102823_bib0032","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1167\/tvst.5.4.7","article-title":"Choroidal vascularity index in vogt-koyanagi-harada disease: an EDI-OCT derived tool for monitoring disease progression","volume":"5","author":"Agrawal","year":"2016","journal-title":"Transl. Vis. Sci. Technol."},{"key":"10.1016\/j.pdpdt.2022.102823_bib0033","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1080\/09273948.2017.1370650","article-title":"Choroidal structural changes in tubercular multifocal serpiginoid choroiditis","volume":"26","author":"Agarwal","year":"2018","journal-title":"Ocul. Immunol. Inflamm."},{"key":"10.1016\/j.pdpdt.2022.102823_bib0034","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1080\/09273948.2017.1343357","article-title":"The choroidal vascularity index decreases and choroidal thickness increases in vogt-koyanagi-harada disease patients during a recurrent anterior uveitis attack","volume":"26","author":"Liu","year":"2018","journal-title":"Ocul. Immunol. Inflamm."},{"key":"10.1016\/j.pdpdt.2022.102823_bib0035","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.jocn.2007.02.090","article-title":"Coagulation status and biochemical and infl ammatory markers in multiple sclerosis","volume":"15","author":"Aksungar","year":"2008","journal-title":"J. Clin. Neurosci."},{"key":"10.1016\/j.pdpdt.2022.102823_bib0036","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1742-2094-5-27","article-title":"Evidence of platelet activation in multiple sclerosis","volume":"5","author":"Sheremata","year":"2008","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.pdpdt.2022.102823_bib0037","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1148\/radiol.2313030996","article-title":"Microvascular abnormality in relapsing-remitting multiple sclerosis: perfusion MR imaging findings in normal-appearing white matter","volume":"231","author":"Law","year":"2004","journal-title":"Radiology"}],"container-title":["Photodiagnosis and Photodynamic Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100022001120?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100022001120?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:43:19Z","timestamp":1761612199000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1572100022001120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":38,"alternative-id":["S1572100022001120"],"URL":"https:\/\/doi.org\/10.1016\/j.pdpdt.2022.102823","relation":{},"ISSN":["1572-1000"],"issn-type":[{"value":"1572-1000","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Analysis of choroidal vascularity index in multiple sclerosis patients without optic neuritis attack","name":"articletitle","label":"Article Title"},{"value":"Photodiagnosis and Photodynamic Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pdpdt.2022.102823","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102823"}}