{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:27:50Z","timestamp":1792686470902,"version":"4.5.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2017\/16364-2"],"award-info":[{"award-number":["2017\/16364-2"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2019\/04107-0"],"award-info":[{"award-number":["2019\/04107-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2019\/17769-1"],"award-info":[{"award-number":["2019\/17769-1"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["54170-2019"],"award-info":[{"award-number":["54170-2019"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Photodiagnosis and Photodynamic Therapy"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.pdpdt.2022.103172","type":"journal-article","created":{"date-parts":[[2022,10,23]],"date-time":"2022-10-23T19:46:02Z","timestamp":1666554362000},"page":"103172","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Effectiveness of antimicrobial photodynamic therapy mediated by butyl toluidine blue in preventing medication-related osteonecrosis of the jaws in rats"],"prefix":"10.1016","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4859-0583","authenticated-orcid":false,"given":"Edilson","family":"Ervolino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariane Bocalon","family":"Olivo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luan Felipe","family":"Toro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9ssica de Oliveira Alvarenga","family":"Freire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vin\u00edcius Franz\u00e3o","family":"Ganzaroli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella Zacarin","family":"Guiati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta Aparecida Alberton","family":"Nuernberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Paulo Soares","family":"Franciscon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano Tavares","family":"\u00c2ngelo Cintra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valdir Gouveia","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Wainwright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia Helena","family":"Theodoro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"n.4","key":"10.1016\/j.pdpdt.2022.103172_bib0001","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.coms.2015.06.001","article-title":"Pathophysiology of osteonecrosis of the jaws","volume":"27","author":"Aghaloo","year":"2015","journal-title":"Oral Maxillofac. Surg. Clin. North Am."},{"key":"10.1016\/j.pdpdt.2022.103172_bib0002","article-title":"Preclinical models of medication-related osteonecrosis of the jaw (MRONJ)","volume":"153","author":"Aguirre","year":"2021","journal-title":"Bone"},{"key":"10.1016\/j.pdpdt.2022.103172_bib0003","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.joms.2009.01.007","article-title":"The pathogenesis of bisphosphonate-related osteonecrosis of the jaw: so many hypotheses, so few data","volume":"67","author":"Allen","year":"2009","journal-title":"J. Oral Maxillofac. Surg."},{"key":"10.1016\/j.pdpdt.2022.103172_bib0004","first-page":"645","article-title":"Pathophysiology of osteonecrosis of the jaw in patients treated with bisphosphonate","volume":"37","author":"Badel","year":"2013","journal-title":"Coll. Antropol."},{"key":"10.1016\/j.pdpdt.2022.103172_bib0005","doi-asserted-by":"crossref","first-page":"e725","DOI":"10.4317\/jced.56307","article-title":"The impact of medication-related osteonecrosis of the jaws on the quality of life in cancer patients","volume":"12","author":"Caminha","year":"2020","journal-title":"J. Clin. Exp. Dent."},{"key":"10.1016\/j.pdpdt.2022.103172_bib0006","doi-asserted-by":"crossref","DOI":"10.1088\/1054-660X\/26\/12\/123001","article-title":"The application of antimicrobial photodynamic therapy (aPDT) in dentistry: a critical review","volume":"26","author":"Carrera","year":"2016","journal-title":"Laser Phys."},{"key":"10.1016\/j.pdpdt.2022.103172_bib0007","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1080\/1040841X.2018.1467876","article-title":"Antimicrobial photodynamic therapy - what we know and what we don't","volume":"44","author":"Cieplik","year":"2018","journal-title":"Crit. Rev. Microbiol."},{"key":"10.1016\/j.pdpdt.2022.103172_bib0008","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.3390\/jcm9061724","article-title":"Photo biomodulation-underlying mechanism and clinical applications","volume":"9","author":"Dompe","year":"2020","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.pdpdt.2022.103172_bib0009","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.bone.2011.03.774","article-title":"The relationship between the chemistry and biological activity of the bisphosphonates","volume":"49","author":"Ebetino","year":"2011","journal-title":"Bone"},{"key":"10.1016\/j.pdpdt.2022.103172_bib0010","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.bone.2018.10.014","article-title":"Antimicrobial photodynamic therapy improves the alveolar repair process and prevents the occurrence of osteonecrosis of the jaws after tooth extraction in senile rats treated with zoledronate","volume":"120","author":"Ervolino","year":"2019","journal-title":"Bone"},{"key":"10.1016\/j.pdpdt.2022.103172_bib0011","doi-asserted-by":"crossref","first-page":"293","DOI":"10.5978\/islsm.27_18-RA-01","article-title":"Photosensitizers in antibacterial photodynamic therapy: an overview","volume":"27","author":"Ghorbani","year":"2018","journal-title":"Laser Ther."},{"key":"10.1016\/j.pdpdt.2022.103172_bib0012","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.mib.2016.06.008","article-title":"Antimicrobial photodynamic inactivation: a bright new technique to kill resistant microbes","volume":"33","author":"Hamblin","year":"2016","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.pdpdt.2022.103172_bib0013","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.joms.2010.06.200","article-title":"Relevance of a prolonged preoperative antibiotic regime in the treatment of bisphosphonate-related osteonecrosis of the jaw","volume":"69","author":"Hoefert","year":"2011","journal-title":"J. Oral Maxillofac. Surg."},{"key":"10.1016\/j.pdpdt.2022.103172_bib0014","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jocd.2016.09.005","article-title":"Case-based review of osteonecrosis of the jaw (ONJ) and application of the international recommendations for management from the international task force on ONJ","volume":"20","author":"Khan","year":"2017","journal-title":"J. Clin. Densitom."},{"key":"10.1016\/j.pdpdt.2022.103172_bib0015","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/jbmr.2405","article-title":"Diagnosis and management of osteonecrosis of the jaw: a systematic review and international consensus","volume":"30","author":"Khan","year":"2015","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.pdpdt.2022.103172_bib0016","doi-asserted-by":"crossref","first-page":"5239","DOI":"10.3390\/molecules25225239","article-title":"Design of photosensitizing agents for targeted antimicrobial photodynamic therapy","volume":"25","author":"Klausen","year":"2020","journal-title":"Molecules."},{"key":"10.1016\/j.pdpdt.2022.103172_bib0017","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.job.2019.03.005","article-title":"Medication-related osteonecrosis of the jaw: a literature review","volume":"61","author":"Kuroshima","year":"2019","journal-title":"J. Oral Biosci."},{"key":"10.1016\/j.pdpdt.2022.103172_bib0018","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.1016\/j.joms.2011.02.059","article-title":"Perioperative antibiotic regimen in rats treated with pamidronate plus dexamethasone and subjected to dental extraction: a study of the changes in the jaws","volume":"69","author":"L\u00f3pez-Jornet","year":"2011","journal-title":"J. Oral Maxillofac. Surg."},{"key":"10.1016\/j.pdpdt.2022.103172_bib0019","volume":"2359","author":"madeira","year":"2020","journal-title":"Arch. Endocrinol. Metab."},{"key":"10.1016\/j.pdpdt.2022.103172_bib0020","doi-asserted-by":"crossref","first-page":"154","DOI":"10.15171\/jlms.2018.29","article-title":"Antimicrobial photodynamic therapy: an effective alternative approach to control bacterial infections","volume":"9","author":"Mahmoudi","year":"2018","journal-title":"J. Lasers Med. Sci."},{"key":"10.1016\/j.pdpdt.2022.103172_bib0021","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/S0278-2391(03)00720-1","article-title":"Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic","volume":"61","author":"Marx","year":"2003","journal-title":"J. Oral Maxillofac. Surg."},{"key":"10.1016\/j.pdpdt.2022.103172_bib0022","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1111\/odi.12708","article-title":"Risk factors for medication-related osteonecrosis of the jaws: a systematic review","volume":"24","author":"Mcgowan","year":"2018","journal-title":"Oral Dis."},{"key":"10.1016\/j.pdpdt.2022.103172_bib0023","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2020.101868","article-title":"Effects of butyl toluidine blue photosensitizer on antimicrobial photodynamic therapy for experimental periodontitis treatment in rats","volume":"31","author":"Nuernberg","year":"2020","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2022.103172_bib0024","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.jcms.2011.05.003","article-title":"Bisphosphonate-related osteonecrosis of the jaws - characteristics, risk factors, clinical features, localization and impact on oncological treatment","volume":"40","author":"Otto","year":"2012","journal-title":"J. Craniomaxillofac. Surg."},{"key":"10.1016\/j.pdpdt.2022.103172_bib0025","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.pdpdt.2019.05.037","article-title":"Adjunctive application of antimicrobial photodynamic therapy in the prevention of medication-related osteonecrosis of the jaw following dentoalveolar surgery: a case series","volume":"27","author":"Poli","year":"2019","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2022.103172_bib0026","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.pdpdt.2018.06.004","article-title":"Adjunctive use of antimicrobial photodynamic therapy in the treatment of medication-related osteonecrosis of the jaws: a case report","volume":"23","author":"Poli","year":"2018","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2022.103172_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2020.115493","article-title":"Molecular mechanisms of action of bisphosphonates and new insights into their effects outside the skeleton","volume":"139","author":"Rogers","year":"2020","journal-title":"Bone"},{"key":"10.1016\/j.pdpdt.2022.103172_bib0028","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.bone.2010.11.008","article-title":"Biochemical and molecular mechanisms of action of bisphosphonates","volume":".49","author":"Rogers","year":"2011","journal-title":"Bone"},{"key":"10.1016\/j.pdpdt.2022.103172_bib0029","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.joms.2022.02.008","article-title":"American association of oral and maxillofacial surgeons' position paper on medication-related osteonecrosis of the jaws-2022 update","volume":"80","author":"Ruggiero","year":"2022","journal-title":"J. Oral Maxillofac. Surg."},{"key":"10.1016\/j.pdpdt.2022.103172_bib0030","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.joms.2018.09.036","article-title":"Efficacy of photodynamic therapy in minimizing bisphosphonate-related osteonecrosis of the jaws after dental extraction: a preliminary animal study","volume":"77","author":"Sarkarat","year":"2019","journal-title":"J. Oral Maxillofac. Surg."},{"key":"10.1016\/j.pdpdt.2022.103172_bib0031","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/j.archoralbio.2015.05.015","article-title":"Effect of different doses of zoledronic acid in establishing of bisphosphonate-related osteonecrosis","volume":"60","author":"Silva","year":"2015","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.pdpdt.2022.103172_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2022.102889","article-title":"Photodynamic therapy and photobiomodulation therapy in zoledronic acid-induced osteonecrosis in rats","volume":"38","author":"Silva","year":"2022","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2022.103172_bib0033","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jphotobiol.2018.05.004","article-title":"Photomodulation multiple sessions as a promising preventive therapy for medication-related osteonecrosis of the jaws after tooth extraction in rats","volume":"184","author":"Statkievicz","year":"2018","journal-title":"J. Photochem. Photobiol. B"},{"key":"10.1016\/j.pdpdt.2022.103172_bib0034","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2020.101651","article-title":"Antimicrobial photodynamic and photobiomodulation adjuvant therapies for prevention and treatment of medication-related osteonecrosis of the jaws: case series and long-term follow-up","volume":"29","author":"Tartaroti","year":"2020","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2022.103172_bib0035","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3390\/biomedicines8040095","article-title":"Does medication-related osteonecrosis of the jaw influence the quality of life of cancer patients?","author":"Tenore","year":"2020","journal-title":"Biomedicines"},{"key":"10.1016\/j.pdpdt.2022.103172_bib0036","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2021.102198","article-title":"Comparative effects of different phenothiazine photosensitizers on experimental periodontitis treatment","volume":"34","author":"Theodoro","year":"2021","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2022.103172_bib0037","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s41598-018-37063-y","article-title":"Application of autologous platelet-rich plasma on tooth extraction site prevents occurrence of medication-related osteonecrosis of the jaws in rats","volume":"9","author":"Toro","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.pdpdt.2022.103172_bib0038","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1039\/c8pp00390d","article-title":"Photoantimicrobials and PACT: what's in an abbreviation?","volume":"18","author":"Wainwright","year":"2019","journal-title":"Photochem. Photobiol. Sci."},{"key":"10.1016\/j.pdpdt.2022.103172_bib0039","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/jac\/42.1.13","article-title":"Photodynamic antimicrobial chemotherapy (PACT)","volume":"42","author":"Wainwright","year":"1998","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.pdpdt.2022.103172_bib0040","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jphotobiol.2016.03.035","article-title":"Phenothiazinium photosensitisers XI. Improved toluidine blue photoantimicrobials","volume":"160","author":"Wainwright","year":"2016","journal-title":"J. Photochem. Photobiol. B"},{"key":"10.1016\/j.pdpdt.2022.103172_bib0041","doi-asserted-by":"crossref","first-page":"e49","DOI":"10.1016\/S1473-3099(16)30268-7","article-title":"Photoantimicrobials \u2013 are we afraid of the light?","volume":"17","author":"Wainwright","year":"2017","journal-title":"Lancet Infect. Dis."}],"container-title":["Photodiagnosis and Photodynamic Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100022004598?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100022004598?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:45:22Z","timestamp":1761612322000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1572100022004598"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":41,"alternative-id":["S1572100022004598"],"URL":"https:\/\/doi.org\/10.1016\/j.pdpdt.2022.103172","relation":{},"ISSN":["1572-1000"],"issn-type":[{"value":"1572-1000","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effectiveness of antimicrobial photodynamic therapy mediated by butyl toluidine blue in preventing medication-related osteonecrosis of the jaws in rats","name":"articletitle","label":"Article Title"},{"value":"Photodiagnosis and Photodynamic Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pdpdt.2022.103172","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"103172"}}