{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T12:35:36Z","timestamp":1776688536786,"version":"3.51.2"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Photodiagnosis and Photodynamic Therapy"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.pdpdt.2022.103181","type":"journal-article","created":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T03:12:07Z","timestamp":1667272327000},"page":"103181","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Vessel density and choroidal vascularity index in patients with Bietti crystalline dystrophy and retinitis pigmentosa"],"prefix":"10.1016","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6743-1142","authenticated-orcid":false,"given":"Ferdane","family":"Ata\u015f","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"Kayaba\u015f\u0131","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Osman","family":"Saatci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.pdpdt.2022.103181_bib0001","first-page":"51","article-title":"An overview of rare and unusual clinical features of Bietti's crystalline dystrophy","volume":"3","author":"Osman Saatci","year":"2014","journal-title":"Med. Hypothesis Discov. Innov. Ophthalmol."},{"issue":"4","key":"10.1016\/j.pdpdt.2022.103181_bib0002","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1097\/APO.0000000000000209","article-title":"Genetics of Bietti crystalline dystrophy","volume":"5","author":"Ng","year":"2016","journal-title":"Asia Pac. J. Ophthalmol."},{"issue":"6","key":"10.1016\/j.pdpdt.2022.103181_bib0003","doi-asserted-by":"crossref","first-page":"e38","DOI":"10.1136\/jmg.2004.029066","article-title":"Recessive mutations in the CYP4V2 gene in East Asian and Middle Eastern patients with Bietti crystalline corneoretinal dystrophy","volume":"42","author":"Lin","year":"2005","journal-title":"J. Med. Genet."},{"issue":"4","key":"10.1016\/j.pdpdt.2022.103181_bib0004","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/ejhg.2016.184","article-title":"Identification and population history of CYP4V2 mutations in patients with Bietti crystalline corneoretinal dystrophy","volume":"25","author":"Jiao","year":"2017","journal-title":"Eur. J. Hum. Genet."},{"issue":"4","key":"10.1016\/j.pdpdt.2022.103181_bib0005","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1124\/mol.112.080085","article-title":"CYP4V2 in Bietti's crystalline dystrophy: ocular localization, metabolism of omega-3-polyunsaturated fatty acids, and functional deficit of the p.H331P variant","volume":"82","author":"Nakano","year":"2012","journal-title":"Mol. Pharmacol."},{"issue":"2","key":"10.1016\/j.pdpdt.2022.103181_bib0006","doi-asserted-by":"crossref","first-page":"106","DOI":"10.4274\/tjo.galenos.2018.90768","article-title":"Swept-source optical coherence tomography angiography in a patient with Bietti crystalline dystrophy followed for ten years","volume":"49","author":"Ipek","year":"2019","journal-title":"Turk. J. Ophthalmol."},{"key":"10.1016\/j.pdpdt.2022.103181_bib0007","article-title":"Cystoid macular Edema in Bietti's crystalline retinopathy","volume":"2014","author":"Saatci","year":"2014","journal-title":"Case Rep. Ophthalmol. Med."},{"key":"10.1016\/j.pdpdt.2022.103181_bib0008","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/739271","article-title":"Spectral domain optical coherence tomographic findings of bietti crystalline dystrophy","volume":"2014","author":"Saatci","year":"2014","journal-title":"J. Ophthalmol."},{"issue":"9","key":"10.1016\/j.pdpdt.2022.103181_bib0009","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1136\/bjophthalmol-2017-311313","article-title":"Choriocapillaris flow deficit in Bietti crystalline dystrophy detected using optical coherence tomography angiography","volume":"102","author":"Miyata","year":"2018","journal-title":"Br. J. Ophthalmol."},{"issue":"11","key":"10.1016\/j.pdpdt.2022.103181_bib0010","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1097\/IAE.0000000000003182","article-title":"Retinal and choroidal blood perfusion in patients with Bietti crystalline dystrophy","volume":"41","author":"Xu","year":"2021","journal-title":"Retina"},{"issue":"1","key":"10.1016\/j.pdpdt.2022.103181_bib0011","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1136\/bjophthalmol-2012-301917","article-title":"Evaluation of choroidal thickness in retinitis pigmentosa using enhanced depth imaging optical coherence tomography","volume":"97","author":"Dhoot","year":"2013","journal-title":"Br. J. Ophthalmol."},{"issue":"1","key":"10.1016\/j.pdpdt.2022.103181_bib0012","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3109\/13816818609058037","article-title":"Bietti's crystalline retinopathy","volume":"7","author":"Yuzawa","year":"1986","journal-title":"Ophthalmic Paediatr. Genet."},{"issue":"4","key":"10.1016\/j.pdpdt.2022.103181_bib0013","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.ajo.2008.05.032","article-title":"Enhanced depth imaging spectral-domain optical coherence tomography","volume":"146","author":"Spaide","year":"2008","journal-title":"Am. J. Ophthalmol."},{"issue":"5","key":"10.1016\/j.pdpdt.2022.103181_bib0014","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.ajo.2008.12.008","article-title":"A pilot study of enhanced depth imaging optical coherence tomography of the choroid in normal eyes","volume":"147","author":"Margolis","year":"2009","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.pdpdt.2022.103181_bib0015","series-title":"An Introduction to Digital Image Processing","first-page":"112","author":"Niblack","year":"1986"},{"issue":"6","key":"10.1016\/j.pdpdt.2022.103181_bib0016","doi-asserted-by":"crossref","first-page":"3893","DOI":"10.1167\/iovs.14-14447","article-title":"Choroidal structure in normal eyes and after photodynamic therapy determined by binarization of optical coherence tomographic images","volume":"55","author":"Sonoda","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.pdpdt.2022.103181_bib0017","doi-asserted-by":"crossref","first-page":"21090","DOI":"10.1038\/srep21090","article-title":"Choroidal vascularity index as a measure of vascular status of the choroid: measurements in healthy eyes from a population-based study","volume":"6","author":"Agrawal","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.pdpdt.2022.103181_bib0018","first-page":"164","article-title":"Bietti's tapetoretinal degeneration with marginal corneal dystrophy crystalline retinopathy","volume":"75","author":"Welch","year":"1977","journal-title":"Trans. Am. Ophthalmol. Soc."},{"issue":"2","key":"10.1016\/j.pdpdt.2022.103181_bib0019","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1136\/bjophthalmol-2012-302469","article-title":"Clinical and genetic features in Italian Bietti crystalline dystrophy patients","volume":"97","author":"Rossi","year":"2013","journal-title":"Br. J. Ophthalmol."},{"issue":"15","key":"10.1016\/j.pdpdt.2022.103181_bib0020","doi-asserted-by":"crossref","first-page":"3936","DOI":"10.1073\/pnas.1717338115","article-title":"Reduction of lipid accumulation rescues Bietti's crystalline dystrophy phenotypes","volume":"115","author":"Hata","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.pdpdt.2022.103181_bib0021","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1080\/13816810.2020.1750036","article-title":"Optical coherence tomography and optical coherence tomography angiography imaging in Bietti crystalline dystrophy","volume":"41","author":"Tiryaki Demir","year":"2020","journal-title":"Ophthalmic Genet."},{"issue":"3","key":"10.1016\/j.pdpdt.2022.103181_bib0022","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1097\/00006982-200406000-00013","article-title":"Bietti's crystalline corneoretinal dystrophy: a cross-sectional study","volume":"24","author":"Mataftsi","year":"2004","journal-title":"Retina"},{"issue":"6","key":"10.1016\/j.pdpdt.2022.103181_bib0023","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1097\/IAE.0000000000001323","article-title":"Choroidal and retinal atrophy of bietti crystalline dystrophy patients with Cyp4v2 mutations compared to retinitis pigmentosa patients with eys mutations","volume":"37","author":"Miyata","year":"2017","journal-title":"Retina"},{"issue":"10","key":"10.1016\/j.pdpdt.2022.103181_bib0024","doi-asserted-by":"crossref","first-page":"3563","DOI":"10.1167\/iovs.18-26381","article-title":"New insights on choroidal vascularity: a comprehensive topographic approach","volume":"60","author":"Goud","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"1","key":"10.1016\/j.pdpdt.2022.103181_bib0025","doi-asserted-by":"crossref","first-page":"e116","DOI":"10.1111\/aos.13836","article-title":"Choroidal structural analysis and vascularity index in retinal dystrophies","volume":"97","author":"Wei","year":"2019","journal-title":"Acta Ophthalmol."},{"issue":"12","key":"10.1016\/j.pdpdt.2022.103181_bib0026","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1097\/IAE.0000000000001879","article-title":"Choroidal structural changes and vascularity index in stargardt disease on swept source optical coherence tomography","volume":"38","author":"Ratra","year":"2018","journal-title":"Retina"},{"issue":"1","key":"10.1016\/j.pdpdt.2022.103181_bib0027","doi-asserted-by":"crossref","first-page":"10810","DOI":"10.1038\/s41598-020-67829-2","article-title":"Normal aging changes in the choroidal angioarchitecture of the macula","volume":"10","author":"Nivison-Smith","year":"2020","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.pdpdt.2022.103181_bib0028","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1007\/s00417-021-05337-3","article-title":"Choroidal vascularity index in eyes with central macular atrophy secondary to age-related macular degeneration and Stargardt disease","volume":"260","author":"Corbelli","year":"2022","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."}],"container-title":["Photodiagnosis and Photodynamic Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100022004689?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100022004689?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:52:27Z","timestamp":1761612747000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1572100022004689"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":28,"alternative-id":["S1572100022004689"],"URL":"https:\/\/doi.org\/10.1016\/j.pdpdt.2022.103181","relation":{},"ISSN":["1572-1000"],"issn-type":[{"value":"1572-1000","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vessel density and choroidal vascularity index in patients with Bietti crystalline dystrophy and retinitis pigmentosa","name":"articletitle","label":"Article Title"},{"value":"Photodiagnosis and Photodynamic Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pdpdt.2022.103181","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"103181"}}