{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T21:44:09Z","timestamp":1794001449145,"version":"4.8.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Photodiagnosis and Photodynamic Therapy"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.pdpdt.2022.103200","type":"journal-article","created":{"date-parts":[[2022,11,13]],"date-time":"2022-11-13T15:23:29Z","timestamp":1668353009000},"page":"103200","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["A systematic review and meta-analysis of randomized clinical trials of fire needle combined with ALA-PDT for the treatment of moderate-to- severe acne"],"prefix":"10.1016","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1086-844X","authenticated-orcid":false,"given":"Lei","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-wenyan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengya","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fujun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3488-4564","authenticated-orcid":false,"given":"Xun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.pdpdt.2022.103200_bib0001","doi-asserted-by":"crossref","first-page":"40","DOI":"10.2340\/00015555-1164","article-title":"Prevalence of acne vulgaris in Chinese adolescents and adults: a community-based study of 17,345 subjects in six cities","volume":"92","author":"Shen","year":"2012","journal-title":"Acta Derm. Venereol."},{"issue":"9","key":"10.1016\/j.pdpdt.2022.103200_bib0002","first-page":"583","article-title":"Chinese acne treatment guidelines","volume":"48","author":"Ju","year":"2019","journal-title":"J. Clin. Dermatol."},{"issue":"10","key":"10.1016\/j.pdpdt.2022.103200_bib0003","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1111\/j.1600-0625.2009.00890.x","article-title":"New developments in our understanding of acne pathogenesis and treatment","volume":"18","author":"Kurokawa","year":"2009","journal-title":"Exp. Dermatol."},{"issue":"3","key":"10.1016\/j.pdpdt.2022.103200_bib0004","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1159\/000363288","article-title":"Genotype-phenotype correlations in severe acne in a han Chinese population","volume":"229","author":"Yang","year":"2014","journal-title":"Dermatology"},{"issue":"2","key":"10.1016\/j.pdpdt.2022.103200_bib0005","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.clindermatol.2016.10.004","article-title":"Sex hormones and acne","volume":"35","author":"Ju","year":"2017","journal-title":"Clin. Dermatol."},{"key":"10.1016\/j.pdpdt.2022.103200_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2021.102340","article-title":"Chinese guidelines on the clinical application of 5-aminolevulinic acid-based photodynamic therapy in dermatology (2021 edition)","volume":"35","author":"Shi","year":"2021","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2022.103200_bib0007","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.ctim.2019.04.009","article-title":"Fire needle therapy for moderate-severe acne: A PRISMA systematic review and meta-analysis of randomized controlled trials","volume":"44","author":"Xing","year":"2019","journal-title":"Complement. Ther. Med."},{"key":"10.1016\/j.pdpdt.2022.103200_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2021.102680","article-title":"Efficacy and therapeutic reactions of tri-needle-pretreatment combined with painless ALA-PDT for the treatment of moderate-to-severe acne vulgaris: a randomized controlled trial","volume":"37","author":"Shi","year":"2022","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2022.103200_bib0009","doi-asserted-by":"crossref","first-page":"c332","DOI":"10.1136\/bmj.c332","article-title":"CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials","volume":"340","author":"Schulz","year":"2010","journal-title":"BMJ"},{"key":"10.1016\/j.pdpdt.2022.103200_bib0010","article-title":"Updated guidance for trusted systematic reviews: a new edition of the cochrane handbook for systematic reviews of interventions","volume":"10","author":"Cumpston","year":"2019","journal-title":"Cochrane Database Syst. Rev."},{"issue":"03","key":"10.1016\/j.pdpdt.2022.103200_bib0011","first-page":"392","article-title":"Efficacy observation on the treatment of cystic acne by zhe combination of ALA-PDT and fire needle","volume":"41","author":"Feng","year":"2019","journal-title":"J. Dermatol. Venereol."},{"issue":"03","key":"10.1016\/j.pdpdt.2022.103200_bib0012","first-page":"233","article-title":"Efficacy observation on the treatment of severe acne by zhe combination of ALA-PDT and fire needle","volume":"44","author":"Li","year":"2021","journal-title":"BMU J."},{"issue":"03","key":"10.1016\/j.pdpdt.2022.103200_bib0013","first-page":"282","article-title":"Clinical efficacy on the treatment of polymerized acne by zhe combination of ALA-PDT and fire needle","volume":"20","author":"Li","year":"2021","journal-title":"Chin. J. Derm. Venerol. Integ. Trad. W Med."},{"issue":"05","key":"10.1016\/j.pdpdt.2022.103200_bib0014","first-page":"1","article-title":"Efficacy analysis on the treatment of moderate- to-severe acne by zhe combination of ALA-PDT and fire needle","volume":"31","author":"Liu","year":"2022","journal-title":"Chin. J. Aesthet. Med."},{"issue":"18","key":"10.1016\/j.pdpdt.2022.103200_bib0015","first-page":"92","article-title":"Clinical observation on the treatment of moderate- to-severe acne by zhe combination of 5%-10% ALA-PDT and fire needle","author":"Pu","year":"2021","journal-title":"J. Med. Aesthet. Cosmetol."},{"issue":"A02","key":"10.1016\/j.pdpdt.2022.103200_bib0016","first-page":"1","article-title":"Clinical research on the treatment of moderate- to-severe acne by zhe combination of ALA-PDT and fire needle or lattice CO2 laser","volume":"27","author":"Sun","year":"2018","journal-title":"China Pharm."},{"issue":"01","key":"10.1016\/j.pdpdt.2022.103200_bib0017","first-page":"145","article-title":"Treatment of refractory acne by the combination of ALA-PDT and fire needle","volume":"29","author":"Wang","year":"2020","journal-title":"Chin. J. Aesthet. Med."},{"issue":"03","key":"10.1016\/j.pdpdt.2022.103200_bib0018","first-page":"234","article-title":"Clinical observation on the treatment of severe acne by zhe combination of 3.6%ALA-PDT and fire needle","volume":"18","author":"Xu","year":"2019","journal-title":"Chin J. Derm. Venerol. Integ. Trad. W Med."},{"issue":"1","key":"10.1016\/j.pdpdt.2022.103200_bib0019","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1186\/s40168-018-0558-5","article-title":"Host-microbiome interactions and recent progress into understanding the biology of acne vulgaris","volume":"6","author":"O'Neill","year":"2018","journal-title":"Microbiome"},{"issue":"5931","key":"10.1016\/j.pdpdt.2022.103200_bib0020","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1126\/science.1171700","article-title":"Topographical and temporal diversity of the human skin microbiome","volume":"324","author":"Grice","year":"2009","journal-title":"Science"},{"issue":"9","key":"10.1016\/j.pdpdt.2022.103200_bib0021","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1038\/jid.2013.21","article-title":"Propionibacterium acnes strain populations in the human skin microbiome associated with acne","volume":"133","author":"Fitz-Gibbon","year":"2013","journal-title":"J. Investig. Dermatol."},{"issue":"9","key":"10.1016\/j.pdpdt.2022.103200_bib0022","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1016\/j.jid.2018.02.038","article-title":"Isolation and identification of the follicular microbiome: implications for acne research","volume":"138","author":"Hall","year":"2018","journal-title":"J. Investig. Dermatol."},{"issue":"5684","key":"10.1016\/j.pdpdt.2022.103200_bib0023","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1126\/science.1100330","article-title":"The complete genome sequence of Propionibacterium acnes, a commensal of human skin","volume":"305","author":"Br\u00fcggemann","year":"2004","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.pdpdt.2022.103200_bib0024","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.sder.2005.03.001","article-title":"Insights in the pathogenic potential of Propionibacterium acnes from its complete genome","volume":"24","author":"Br\u00fcggemann","year":"2005","journal-title":"Semin. Cutan. Med. Surg."},{"issue":"2","key":"10.1016\/j.pdpdt.2022.103200_bib0025","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1111\/jdv.14475","article-title":"Acne prevalence and associations with lifestyle: a cross-sectional online survey of adolescents\/young adults in 7 European countries","volume":"32","author":"Wolkenstein","year":"2018","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"issue":"6","key":"10.1016\/j.pdpdt.2022.103200_bib0026","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/j.jaad.2012.02.018","article-title":"Family history, body mass index, selected dietary factors, menstrual history, and risk of moderate to severe acne in adolescents and young adults","volume":"67","author":"Di Landro","year":"2012","journal-title":"J. Am. Acad. Dermatol."},{"issue":"2","key":"10.1016\/j.pdpdt.2022.103200_bib0027","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1159\/000090655","article-title":"Heredity: a prognostic factor for acne","volume":"212","author":"Ballanger","year":"2006","journal-title":"Dermatology"},{"issue":"5","key":"10.1016\/j.pdpdt.2022.103200_bib0028","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1111\/j.1468-3083.2006.02022.x","article-title":"The familial risk of acne vulgaris in Chinese Hans - a case-control study","volume":"21","author":"Xu","year":"2007","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"issue":"2","key":"10.1016\/j.pdpdt.2022.103200_bib0029","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1046\/j.1365-2133.1999.02979.x","article-title":"The familial risk of adult acne: a comparison between first-degree relatives of affected and unaffected individuals","volume":"141","author":"Goulden","year":"1999","journal-title":"Br. J. Dermatol."},{"issue":"6","key":"10.1016\/j.pdpdt.2022.103200_bib0030","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1046\/j.1523-1747.2002.19621.x","article-title":"The influence of genetics and environmental factors in the pathogenesis of acne: a twin study of acne in women","volume":"119","author":"Bataille","year":"2002","journal-title":"J. Investig. Dermatol."},{"issue":"12","key":"10.1016\/j.pdpdt.2022.103200_bib0031","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1001\/archderm.138.12.1584","article-title":"Acne vulgaris: a disease of Western civilization","volume":"138","author":"Cordain","year":"2002","journal-title":"Arch. Dermatol."},{"issue":"12","key":"10.1016\/j.pdpdt.2022.103200_bib0032","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1001\/archderm.138.12.1591","article-title":"Diet and acne revisited","volume":"138","author":"Thiboutot","year":"2002","journal-title":"Arch. Dermatol."},{"issue":"7","key":"10.1016\/j.pdpdt.2022.103200_bib0033","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1001\/archderm.139.7.940-b","article-title":"The unwelcome return of the acne diet","volume":"139","author":"Bershad","year":"2003","journal-title":"Arch. Dermatol."},{"issue":"4","key":"10.1016\/j.pdpdt.2022.103200_bib0034","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/j.1365-4632.2009.04002.x","article-title":"Diet and acne: a review of the evidence","volume":"48","author":"Spencer","year":"2009","journal-title":"Int. J. Dermatol."},{"issue":"1","key":"10.1016\/j.pdpdt.2022.103200_bib0035","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/jdv.12878","article-title":"The constellation of dietary factors in adolescent acne: a semantic connectivity map approach","volume":"30","author":"Grossi","year":"2016","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"issue":"1","key":"10.1016\/j.pdpdt.2022.103200_bib0036","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/phpp.12413","article-title":"Comparison of efficacy of aminolaevulinic acid photodynamic therapy vs. adapalene gel plus oral doxycycline for treatment of moderate acne vulgaris-A simple, blind, randomized, and controlled trial","volume":"35","author":"Nicklas","year":"2019","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"10.1016\/j.pdpdt.2022.103200_bib0037","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.pdpdt.2016.04.005","article-title":"Photodynamic therapy for the treatment of different severity of acne: a systematic review","volume":"14","author":"Keyal","year":"2016","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2022.103200_bib0038","doi-asserted-by":"crossref","DOI":"10.1111\/bjd.21739","article-title":"A systematic review and network meta-analysis of topical pharmacological, oral pharmacological, physical and combined treatments for acne vulgaris","author":"Mavranezouli","year":"2022","journal-title":"Br. J. Dermatol."},{"issue":"4","key":"10.1016\/j.pdpdt.2022.103200_bib0039","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.pdpdt.2011.07.003","article-title":"Successful treatment of refractory facial acne using repeat short-cycle ALA-PDT: Case study","volume":"8","author":"Ding","year":"2011","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2022.103200_bib0040","first-page":"318","article-title":"Effect of fire on expression of IL-1beta and caspase-3 protein in rat model of spinal cord injury","volume":"29","author":"Zhou","year":"2010","journal-title":"Shanghai J. Acupunct Moxibust."},{"issue":"1","key":"10.1016\/j.pdpdt.2022.103200_bib0041","first-page":"31","article-title":"Experimental study on the treatment of chronic soft tissue injury by fire needle","volume":"22","author":"Wu","year":"2002","journal-title":"Chin. Acupunct. Moxibust."}],"container-title":["Photodiagnosis and Photodynamic Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100022004860?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100022004860?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:47:39Z","timestamp":1761612459000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1572100022004860"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":41,"alternative-id":["S1572100022004860"],"URL":"https:\/\/doi.org\/10.1016\/j.pdpdt.2022.103200","relation":{},"ISSN":["1572-1000"],"issn-type":[{"value":"1572-1000","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A systematic review and meta-analysis of randomized clinical trials of fire needle combined with ALA-PDT for the treatment of moderate-to- severe acne","name":"articletitle","label":"Article Title"},{"value":"Photodiagnosis and Photodynamic Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pdpdt.2022.103200","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103200"}}