{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T20:10:11Z","timestamp":1779394211513,"version":"3.53.1"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004263","name":"FAPERGS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004263","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Photodiagnosis and Photodynamic Therapy"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.pdpdt.2023.103641","type":"journal-article","created":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T02:29:51Z","timestamp":1685586591000},"page":"103641","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Antileishmanial activity of tetra-cationic porphyrins with peripheral Pt(II) and Pd(II) complexes mediated by photodynamic therapy"],"prefix":"10.1016","volume":"42","author":[{"given":"Irwin A.P.","family":"Linares","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maricely S\u00e1nchez","family":"Ur\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia A.S.","family":"Graminha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernardo Almeida","family":"Iglesias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela M.A.","family":"Vel\u00e1squez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pdpdt.2023.103641_bib0001","first-page":"147","article-title":"Leishmaniasis \u2013 HIV coinfection: current challenges","volume":"8","author":"Lindoso","year":"2016","journal-title":"Dovepress"},{"key":"10.1016\/j.pdpdt.2023.103641_bib0002","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/S0140-6736(18)31204-2","article-title":"Leishmaniasis","volume":"392","author":"Burza","year":"2018","journal-title":"Lancet North Am. Ed."},{"key":"10.1016\/j.pdpdt.2023.103641_bib0003","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s40475-021-00232-7","article-title":"A review of leishmaniasis: current knowledge and future directions","volume":"8","author":"Mann","year":"2021","journal-title":"Curr. Trop. Med. Rep."},{"key":"10.1016\/j.pdpdt.2023.103641_bib0004","first-page":"9","article-title":"Current treatment of leishmaniasis: a review","volume":"1","author":"Monzote","year":"2009","journal-title":"Open Antimicrob. Agents J."},{"key":"10.1016\/j.pdpdt.2023.103641_bib0005","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1097\/MJT.0b013e3181822e90","article-title":"Current treatment for cutaneous leishmaniasis: a review","volume":"16","author":"Palumbo","year":"2009","journal-title":"Am. J. Ther."},{"key":"10.1016\/j.pdpdt.2023.103641_bib0006","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.actatropica.2017.04.029","article-title":"Application of nanotechnology in treatment of leishmaniasis\u00a0: a review","volume":"172","author":"Akbari","year":"2017","journal-title":"Acta Trop."},{"key":"10.1016\/j.pdpdt.2023.103641_bib0007","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.pdpdt.2015.08.006","article-title":"Evaluation of the efficacy of systemic miltefosine associated with photodynamic therapy with liposomal chloroaluminium phthalocyanine in the treatment of cutaneous leishmaniasis caused by Leishmania (L.) amazonensis in C57BL\/6 mice","volume":"13","author":"Ribeiro","year":"2016","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2023.103641_bib0008","series-title":"Leishmaniasis - Trends in Epidemiology, Diagnosis and Treatment","first-page":"393","article-title":"Treatment and control of leishmaniasis using photodynamic therapy","author":"Aureliano","year":"2014"},{"key":"10.1016\/j.pdpdt.2023.103641_bib0009","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1166\/jbn.2017.2349","article-title":"Nanotechnological strategies for treatment of leishmaniasis \u2014 a review","volume":"13","author":"De Almeida","year":"2017","journal-title":"J. Biomed. Nanotechnol."},{"key":"10.1016\/j.pdpdt.2023.103641_bib0010","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1002\/lsm.21080","article-title":"Photodynamic therapy for infections: clinical applications","volume":"43","author":"Kharkwal","year":"2011","journal-title":"Lasers Surg. Med."},{"key":"10.1016\/j.pdpdt.2023.103641_bib0011","doi-asserted-by":"crossref","first-page":"e11570","DOI":"10.1590\/1414-431x2021e11570","article-title":"Progress in the photodynamic therapy treatment of Leishmaniasis","volume":"54","author":"Vital-Fujii","year":"2021","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.pdpdt.2023.103641_bib0012","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.biopha.2016.07.058","article-title":"The potential of photodynamic therapy (PDT) \u2014 Experimental investigations and clinical use","volume":"83","author":"Oniszczuk","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.pdpdt.2023.103641_bib0013","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.pdpdt.2016.07.010","article-title":"Photodiagnosis and photodynamic therapy photodynamic therapy for onychomycosis\u00a0: a systematic review","volume":"15","author":"Bhatta","year":"2016","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2023.103641_bib0014","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmicb.2015.00202","article-title":"Antimicrobial photodynamic therapy\u00a0: an effective alternative approach to control fungal infections","volume":"6","author":"Baltazar","year":"2015","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.pdpdt.2023.103641_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2020.101769","article-title":"Antileishmanial activity of amphiphilic chlorin derivatives mediated by photodynamic therapy","volume":"31","author":"Linares","year":"2020","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2023.103641_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2020.104455","article-title":"Peripheral tetra-cationic Pt(II) porphyrins photo-inactivating rapidly growing mycobacteria: first application in mycobacteriology","volume":"148","author":"Rossi","year":"2020","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.pdpdt.2023.103641_bib0017","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jphotobiol.2018.04.017","article-title":"Solution-combustion synthesis of doped TiO2 compounds and its potential antileishmanial activity mediated by photodynamic therapy","volume":"183","author":"Lopera","year":"2018","journal-title":"J. Photochem. Photobiol. B"},{"key":"10.1016\/j.pdpdt.2023.103641_bib0018","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1001\/archderm.139.4.432","article-title":"Treatment of cutaneous leishmaniasis with photodynamic therapy","volume":"139","author":"Enk","year":"2003","journal-title":"Arch. Dermatol."},{"key":"10.1016\/j.pdpdt.2023.103641_bib0019","doi-asserted-by":"crossref","first-page":"3861","DOI":"10.3390\/ijms20163861","article-title":"Chlorin, phthalocyanine, and porphyrin types derivatives in phototreatment of cutaneous manifestations: a review","volume":"20","author":"de Annunzio","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.pdpdt.2023.103641_bib0020","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.pdpdt.2006.04.004","article-title":"Potential of cationic porphyrins for photodynamic treatment of cutaneous Leishmaniasis","volume":"3","author":"Bristow","year":"2006","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2023.103641_bib0021","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.3390\/molecules25092080","article-title":"Porphyrin derivative nanoformulations for therapy and antiparasitic agents","volume":"25","author":"Deda","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.pdpdt.2023.103641_bib0022","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.3390\/molecules25081887","article-title":"In vitro anti-leishmanial effect of metallic meso-substituted porphyrin derivatives against leishmania braziliensis and leishmania panamensis promastigotes properties","volume":"25","author":"Espitia-Almeida","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.pdpdt.2023.103641_bib0023","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s10534-021-00357-2","article-title":"Photophysical characterization and in vitro anti-leishmanial effect of 5,10,15,20-tetrakis(4-fluorophenyl) porphyrin and the metal (Zn(II), Sn(IV), Mn(III) and V(IV)) derivatives","volume":"35","author":"Espitia-Almeida","year":"2022","journal-title":"Biometals"},{"key":"10.1016\/j.pdpdt.2023.103641_bib0024","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.micpath.2018.12.038","article-title":"Antimicrobial activity and safety applications of meso-tetra(4-pyridyl)platinum(II) porphyrin","volume":"128","author":"Lopes","year":"2019","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.pdpdt.2023.103641_bib0025","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.tube.2019.06.001","article-title":"Preliminary evaluation of the positively and negatively charge effects of tetra-substituted porphyrins on photoinactivation of rapidly growing mycobacteria","volume":"117","author":"Guterres","year":"2019","journal-title":"Tuberculosis"},{"key":"10.1016\/j.pdpdt.2023.103641_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2020.101920","article-title":"Investigation of isomeric tetra-cationic porphyrin activity with peripheral [Pd(bpy)Cl]+ units by antimicrobial photodynamic therapy","volume":"31","author":"da Silveira","year":"2020","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2023.103641_bib0027","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.pdpdt.2016.04.014","article-title":"Chlorin E6 phototoxicity in L. major and L. braziliensis promastigotes-in vitro study","volume":"15","author":"Pinto","year":"2016","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2023.103641_bib0028","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1128\/AAC.01879-15","article-title":"Aminophthalocyanine-mediated photodynamic inactivation of leishmania tropica","volume":"60","author":"Al-Qahtani","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.pdpdt.2023.103641_bib0029","doi-asserted-by":"crossref","first-page":"4474","DOI":"10.1128\/AAC.49.11.4474-4484.2005","article-title":"Photodynamic sensitization of Leishmania amazonensis in both extracellular and intracellular stages with aluminum phthalocyanine chloride for photolysis in vitro","volume":"49","author":"Dutta","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.pdpdt.2023.103641_bib0030","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s10103-014-1665-6","article-title":"Photodynamic effects of zinc phthalocyanines on intracellular amastigotes of Leishmania amazonensis and Leishmania braziliensis","volume":"30","author":"Silva","year":"2015","journal-title":"Lasers Med. Sci."},{"key":"10.1016\/j.pdpdt.2023.103641_bib0031","doi-asserted-by":"crossref","DOI":"10.1016\/j.jphotochemrev.2020.100384","article-title":"Curcumin as a photosensitizer: from molecular structure to recent advances in antimicrobial photodynamic therapy","volume":"45","author":"Dias","year":"2020","journal-title":"J. Photochem. Photobiol. C"},{"key":"10.1016\/j.pdpdt.2023.103641_bib0032","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1007\/s10103-016-1928-5","article-title":"In vitro evaluation of photodynamic therapy using curcumin on Leishmania major and Leishmania braziliensis","volume":"31","author":"Pinto","year":"2016","journal-title":"Lasers Med. Sci."},{"key":"10.1016\/j.pdpdt.2023.103641_bib0033","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.freeradbiomed.2014.09.005","article-title":"PEGylated silver doped zinc oxide nanoparticles as novel photosensitizers for photodynamic therapy against Leishmania","volume":"77","author":"Nadhman","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.pdpdt.2023.103641_bib0034","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.chembiol.2006.06.008","article-title":"The role of photosensitizer molecular charge and structure on the efficacy of photodynamic therapy against leishmania parasites","volume":"13","author":"Akilov","year":"2006","journal-title":"Chem. Biol."},{"key":"10.1016\/j.pdpdt.2023.103641_bib0035","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.jphotobiol.2012.09.018","article-title":"In vitro phototoxicity of ultradeformable liposomes containing chloroaluminum phthalocyanine against New World Leishmania species","volume":"117","author":"Hern\u00e1ndez","year":"2012","journal-title":"J. Photochem. Photobiol. B"},{"key":"10.1016\/j.pdpdt.2023.103641_bib0036","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.pdpdt.2017.04.009","article-title":"Evaluation of methylene blue as photosensitizer in promastigotes of Leishmania major and Leishmania braziliensis","volume":"18","author":"Pinto","year":"2017","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2023.103641_bib0037","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/j.1600-0781.2011.00610.x","article-title":"Successful treatment of cutaneous leishmaniasis with intralesional aminolevulinic acid photodynamic therapy","volume":"27","author":"Evangelou","year":"2011","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"10.1016\/j.pdpdt.2023.103641_bib0038","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1089\/pho.2010.2915","article-title":"Photodynamic therapy using methylene blue to treat cutaneous leishmaniasis","volume":"29","author":"Song","year":"2011","journal-title":"Photomed. Laser Surg."},{"key":"10.1016\/j.pdpdt.2023.103641_bib0039","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.jphotobiol.2017.08.016","article-title":"The photodynamic action of pheophorbide a induces cell death through oxidative stress in Leishmania amazonensis","volume":"174","author":"Miranda","year":"2017","journal-title":"J. Photochem. Photobiol. B"},{"key":"10.1016\/j.pdpdt.2023.103641_bib0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1590\/S0100-879X2010007500141","article-title":"Photodynamic antimicrobial chemotherapy (PACT) for the treatment of malaria, leishmaniasis and trypanosomiasis","volume":"44","author":"Baptista","year":"2011","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.pdpdt.2023.103641_bib0041","doi-asserted-by":"crossref","first-page":"7033","DOI":"10.1016\/j.bmc.2008.05.037","article-title":"Carbaporphyrin ketals as potential agents for a new photodynamic therapy treatment of leishmaniasis","volume":"16","author":"Morgenthaler","year":"2008","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.pdpdt.2023.103641_bib0042","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.pdpdt.2017.11.017","article-title":"Synthesis of calcium phosphate nanostructures by combustion in solution as a potential encapsulant system of drugs with photodynamic properties for the treatment of cutaneous leishmaniasis","volume":"21","author":"Lopera","year":"2018","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2023.103641_bib0043","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1590\/S1678-91992011000300010","article-title":"Assessment of leishmania major and leishmania braziliensis promastigote viability after photodynamic treatment with aluminum phthalocyanine tetrasulfonate (AlPcS4)","volume":"17","author":"Pinto","year":"2011","journal-title":"J. Venom. Anim. Toxins incl. Trop. Dis."},{"key":"10.1016\/j.pdpdt.2023.103641_bib0044","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.exppara.2011.04.009","article-title":"Photodynamic therapy for American cutaneous leishmaniasis: the efficacy of methylene blue in hamsters experimentally infected with Leishmania (Leishmania) amazonensis","volume":"128","author":"Peloi","year":"2011","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.pdpdt.2023.103641_bib0045","doi-asserted-by":"crossref","first-page":"5804","DOI":"10.1128\/AAC.00545-15","article-title":"Development of a novel formulation with hypericin to treat cutaneous leishmaniasis based on photodynamic therapy in in vitro and in vivo studies","volume":"59","author":"Montoya","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.pdpdt.2023.103641_bib0046","doi-asserted-by":"crossref","first-page":"106","DOI":"10.15171\/jlms.2015.03","article-title":"Topical and intradermal efficacy of photodynamic therapy with methylene blue and light-emitting diode in the treatment of cutaneous leishmaniasis caused by leishmania braziliensis","volume":"6","author":"Sbeghen","year":"2015","journal-title":"J. Lasers Med. Sci."},{"key":"10.1016\/j.pdpdt.2023.103641_bib0047","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2021.102609","article-title":"Photodynamic therapy for leishmaniasis: recent advances and future trends","volume":"36","author":"Varzandeh","year":"2021","journal-title":"Photodiagnosis Photodyn Ther"},{"key":"10.1016\/j.pdpdt.2023.103641_bib0048","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/j.drudis.2010.10.005","article-title":"Metal-based drugs for malaria, trypanosomiasis and leishmaniasis: recent achievements and perspectives","volume":"15","author":"Navarro","year":"2010","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.pdpdt.2023.103641_bib0049","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jinorgbio.2008.10.005","article-title":"Probing the binding of tetraplatinum(pyridyl)porphyrin complexes to DNA by means of surface plasmon resonance","volume":"103","author":"Naue","year":"2009","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.pdpdt.2023.103641_bib0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cplett.2018.07.061","article-title":"Investigation of excited singlet state absorption and intersystem crossing mechanism of isomeric meso-tetra(pyridyl)porphyrins containing peripheral polypyridyl platinum(II) complexes","volume":"708","author":"Cocca","year":"2018","journal-title":"Chem. Phys. Lett."},{"key":"10.1016\/j.pdpdt.2023.103641_bib0051","doi-asserted-by":"crossref","first-page":"16278","DOI":"10.1039\/D0DT01063D","article-title":"Photophysical, photodynamical, redox properties and BSA interactions of novel isomeric tetracationic peripheral palladium(ii)-bipyridyl porphyrins","volume":"49","author":"Santos","year":"2020","journal-title":"Dalton Trans."},{"key":"10.1016\/j.pdpdt.2023.103641_bib0052","doi-asserted-by":"crossref","first-page":"11037","DOI":"10.1039\/C7DT01205E","article-title":"Isomeric effect on the properties of tetraplatinated porphyrins showing optimized phototoxicity for photodynamic therapy","volume":"46","author":"Tasso","year":"2017","journal-title":"Dalton Trans."},{"key":"10.1016\/j.pdpdt.2023.103641_bib0053","first-page":"191","article-title":"Sobre uma cepa de Trypanosoma cruzi altamente virulenta para o camundongo branco","volume":"20","author":"Silva","year":"1953","journal-title":"Folia Clin. Biol."},{"key":"10.1016\/j.pdpdt.2023.103641_bib0054","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid Colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assay","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.pdpdt.2023.103641_bib0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2020.101676","article-title":"Efficacy of photodynamic therapy using TiO2 nanoparticles doped with Zn and hypericin in the treatment of cutaneous Leishmaniasis caused by Leishmania amazonensis","volume":"30","author":"Sep\u00falveda","year":"2020","journal-title":"Photodiagnosis Photodyn Ther"},{"key":"10.1016\/j.pdpdt.2023.103641_bib0056","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.00688-17","article-title":"Efficacy of a binuclear cyclopalladated compound therapy for cutaneous leishmaniasis in the murine model of infection with leishmania amazonensis and its inhibitory effect on topoisomerase 1B","volume":"61","author":"Vel\u00e1squez","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.pdpdt.2023.103641_bib0057","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.dyepig.2017.06.011","article-title":"Chlorin derivatives sterically-prevented from self-aggregation with high antitumor activity for photodynamic therapy","volume":"145","author":"Linares","year":"2017","journal-title":"Dyes Pigm."},{"key":"10.1016\/j.pdpdt.2023.103641_bib0058","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.00767-21","article-title":"New Insights into the mechanism of action of the cyclopalladated complex (CP2) in Leishmania: calcium dysregulation, mitochondrial dysfunction, and cell death","volume":"66","author":"Vel\u00e1squez","year":"2022","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.pdpdt.2023.103641_bib0059","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/nrd4683","article-title":"Hit and lead criteria in drug discovery for infectious diseases of the developing world","volume":"14","author":"Katsuno","year":"2015","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.pdpdt.2023.103641_bib0060","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/php.12857","article-title":"Cell death pathways associated with photodynamic therapy: an update","volume":"94","author":"Kessel","year":"2018","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.pdpdt.2023.103641_bib0061","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S1572-1000(05)00007-4","article-title":"Mechanisms in photodynamic therapy: part one\u2014photosensitizers, photochemistry and cellular localization","volume":"1","author":"Castano","year":"2004","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2023.103641_bib0062","doi-asserted-by":"crossref","first-page":"967","DOI":"10.2741\/4629","article-title":"Leishmaniasis treatment: update of possibilities for drug repurposing","volume":"23","author":"Andrade-Neto","year":"2018","journal-title":"Front. Biosci. Landmark"},{"key":"10.1016\/j.pdpdt.2023.103641_bib0063","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1142\/S1088424619500767","article-title":"Photodynamic inactivation of selected bovine viruses by isomeric cationic tetra-platinated porphyrins","volume":"23","author":"Basso","year":"2019","journal-title":"J.Porphyr. Phthalocyanines"},{"key":"10.1016\/j.pdpdt.2023.103641_bib0064","doi-asserted-by":"crossref","unstructured":"C. Pavani, A.F. Uchoa, C.S. Oliveira, Y. Iamamoto, M.S. Baptista, Effect of zinc insertion and hydrophobicity on the membrane interactions and PDT activity of porphyrin photosensitizers, Photochemical and Photobiological Sciences. 8 (2009) 233\u2013240. 10.1039\/b810313e.","DOI":"10.1039\/b810313e"},{"key":"10.1016\/j.pdpdt.2023.103641_bib0065","doi-asserted-by":"crossref","first-page":"551","DOI":"10.3892\/ol.2014.2720","article-title":"Subcellular location and photodynamic therapeutic effect of chlorin e6 in the human tongue squamous cell cancer Tca8113 cell line","volume":"9","author":"Luo","year":"2015","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.pdpdt.2023.103641_bib0066","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1111\/php.12273","article-title":"Chlorin e6 derivative radachlorin mainly accumulates in mitochondria, lysosome and endoplasmic reticulum and shows high affinity toward tumors in nude mice in photodynamic therapy","volume":"90","author":"Biswas","year":"2014","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.pdpdt.2023.103641_bib0067","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1039\/c7pp00458c","article-title":"Photodynamic effect of zinc porphyrin on the promastigote and amastigote forms of: leishmania braziliensis","volume":"17","author":"Andrade","year":"2018","journal-title":"Photochem. Photobiol. Sci."},{"key":"10.1016\/j.pdpdt.2023.103641_bib0068","doi-asserted-by":"crossref","first-page":"9595","DOI":"10.1158\/0008-5472.CAN-08-2452","article-title":"Chemotherapy induces tumor clearance independent of apoptosis","volume":"68","author":"Guerriero","year":"2008","journal-title":"Cancer Res."}],"container-title":["Photodiagnosis and Photodynamic Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S157210002300368X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S157210002300368X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:50:37Z","timestamp":1761612637000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S157210002300368X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":68,"alternative-id":["S157210002300368X"],"URL":"https:\/\/doi.org\/10.1016\/j.pdpdt.2023.103641","relation":{},"ISSN":["1572-1000"],"issn-type":[{"value":"1572-1000","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antileishmanial activity of tetra-cationic porphyrins with peripheral Pt(II) and Pd(II) complexes mediated by photodynamic therapy","name":"articletitle","label":"Article Title"},{"value":"Photodiagnosis and Photodynamic Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pdpdt.2023.103641","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"103641"}}