{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T22:13:10Z","timestamp":1769551990945,"version":"3.49.0"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82002733"],"award-info":[{"award-number":["82002733"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Photodiagnosis and Photodynamic Therapy"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.pdpdt.2023.103695","type":"journal-article","created":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T12:56:13Z","timestamp":1688648173000},"page":"103695","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Comparison of ALA-PDT and CO2 laser treatment of low-grade vaginal intraepithelial neoplasia with high-risk HPV infection: A non-randomized controlled pilot study"],"prefix":"10.1016","volume":"43","author":[{"given":"Lili","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoli","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junhua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huamin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuye","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongli","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihua","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baoxia","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youzhong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.pdpdt.2023.103695_bib0001","doi-asserted-by":"crossref","first-page":"e13598","DOI":"10.1111\/ijcp.13598","article-title":"Management options for vaginal intraepithelial neoplasia","volume":"74","author":"Rountis","year":"2020","journal-title":"Int. J. Clin. Pract."},{"issue":"4","key":"10.1016\/j.pdpdt.2023.103695_bib0002","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1097\/LGT.0000000000000415","article-title":"5-flouorouracil is an attractive medical treatment in women with vaginal intraepithelial neoplasia: a meta-analysis","volume":"22","author":"Tranoulis","year":"2018","journal-title":"J. Low Genit. Tract. Dis."},{"issue":"3","key":"10.1016\/j.pdpdt.2023.103695_bib0003","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.ygyno.2016.03.033","article-title":"Recurrence and risk of progression to lower genital tract malignancy in women with high grade VAIN","volume":"141","author":"Hodeib","year":"2016","journal-title":"Gynecol. Oncol."},{"issue":"5","key":"10.1016\/j.pdpdt.2023.103695_bib0004","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1007\/s12094-021-02739-x","article-title":"Analysis of related factors of cervical intraepithelial neoplasia complicated with vaginal intraepithelial neoplasia","volume":"24","author":"Zhang","year":"2022","journal-title":"Clin. Transl. Oncol."},{"key":"10.1016\/j.pdpdt.2023.103695_bib0005","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ejogrb.2022.08.017","article-title":"Clinical outcomes of laser vaporization for vaginal intraepithelial neoplasia - a 20-year retrospective review","volume":"277","author":"He","year":"2022","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"issue":"2","key":"10.1016\/j.pdpdt.2023.103695_bib0006","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s00404-015-3835-6","article-title":"Clinical presentation, treatment and outcome of vaginal intraepithelial neoplasia","volume":"293","author":"Jentschke","year":"2016","journal-title":"Arch. Gynecol. Obstet."},{"issue":"1","key":"10.1016\/j.pdpdt.2023.103695_bib0007","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s10103-023-03713-5","article-title":"Efficacy of non-invasive photodynamic therapy for female lower reproductive tract diseases associated with HPV infection: a comprehensive meta-analysis","volume":"38","author":"Li","year":"2023","journal-title":"Lasers Med. Sci."},{"issue":"9","key":"10.1016\/j.pdpdt.2023.103695_bib0008","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.3390\/pharmaceutics13091332","article-title":"Photodynamic therapy review: principles, photosensitizers, applications, and future directions","volume":"13","author":"Correia","year":"2021","journal-title":"Pharmaceutics."},{"issue":"1","key":"10.1016\/j.pdpdt.2023.103695_bib0009","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jphotobiol.2009.04.001","article-title":"Photodynamic therapy (PDT): a short review on cellular mechanisms and cancer research applications for PDT","volume":"96","author":"Robertson","year":"2009","journal-title":"J. Photochem. Photobiol. B"},{"issue":"3","key":"10.1016\/j.pdpdt.2023.103695_bib0010","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.det.2014.03.009","article-title":"Photodynamic therapy","volume":"32","author":"Rkein","year":"2014","journal-title":"Dermatol. Clin."},{"issue":"1","key":"10.1016\/j.pdpdt.2023.103695_bib0011","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1159\/000332302","article-title":"The ThinPrep pap test. a review of clinical studies","volume":"41","author":"Linder","year":"1997","journal-title":"Acta Cytol."},{"issue":"4","key":"10.1016\/j.pdpdt.2023.103695_bib0012","first-page":"239","article-title":"Detection trend of vaginal intraepithelial neoplasia diagnosed by colposcopy guided biopsy from 2013 to 2015","volume":"52","author":"Cong","year":"2017","journal-title":"Zhonghua Fu Chan Ke Za Zhi"},{"issue":"4","key":"10.1016\/j.pdpdt.2023.103695_bib0013","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0889-8545(05)70229-1","article-title":"Diagnosis and management of vulvar and vaginal intraepithelial neoplasia","volume":"28","author":"Cardosi","year":"2001","journal-title":"Obstet. Gynecol. Clin. N. Am."},{"key":"10.1016\/j.pdpdt.2023.103695_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2020.101731","article-title":"Photodynamic therapy combined with carbon dioxide laser for low-grade vaginal intraepithelial neoplasia: a retrospective analysis","volume":"30","author":"Yao","year":"2020","journal-title":"Photodiagn. Photodyn. Ther."},{"issue":"6","key":"10.1016\/j.pdpdt.2023.103695_bib0015","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1097\/AOG.0000000000002311","article-title":"Topical 5-fluorouracil for women with high-grade vaginal intraepithelial neoplasia","volume":"130","author":"Fiascone","year":"2017","journal-title":"Obstet. Gynecol."},{"issue":"1","key":"10.1016\/j.pdpdt.2023.103695_bib0016","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ijgo.2007.10.023","article-title":"Imiquimod for treatment of vulvar and vaginal intraepithelial neoplasia","volume":"101","author":"Iavazzo","year":"2008","journal-title":"Int. J. Gynaecol. Obstet."},{"issue":"Suppl 2","key":"10.1016\/j.pdpdt.2023.103695_bib0017","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1007\/s13224-018-1158-9","article-title":"Proximal partial vaginectomy for vaginal intraepithelial neoplasia","volume":"69","author":"Bhati","year":"2019","journal-title":"J. Obstet. Gynaecol. India"},{"issue":"2","key":"10.1016\/j.pdpdt.2023.103695_bib0018","doi-asserted-by":"crossref","first-page":"146","DOI":"10.5114\/jcb.2019.84696","article-title":"High-dose-rate brachytherapy for high-grade vaginal intraepithelial neoplasia: a dosimetric analysis","volume":"11","author":"Barcellini","year":"2019","journal-title":"J. Contemp. Brachyther."},{"issue":"1","key":"10.1016\/j.pdpdt.2023.103695_bib0019","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S0301-2115(02)00209-9","article-title":"Vaginal intraepithelial neoplasia: treatment by carbon dioxide laser and risk factors for failure","volume":"106","author":"Yalcin","year":"2003","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.pdpdt.2023.103695_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2021.102634","article-title":"Effect and rational application of topical photodynamic therapy (PDT) with 5-aminolevulinic acid (5-ALA) for treatment of cervical intraepithelial neoplasia with vaginal intraepithelial neoplasia","volume":"37","author":"Su","year":"2022","journal-title":"Photodiagn. Photodyn. Ther."},{"issue":"1","key":"10.1016\/j.pdpdt.2023.103695_bib0021","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3390\/biomedicines6010013","article-title":"The role of photodynamic therapy in the treatment of vulvar intraepithelial neoplasia","volume":"6","author":"Tosti","year":"2018","journal-title":"Biomedicines."},{"key":"10.1016\/j.pdpdt.2023.103695_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2022.102899","article-title":"Efficacy and safety of photodynamic therapy mediatied by 5-aminolevulinic acid for the treatment of vaginal high-grade intraepithelial lesions","volume":"39","author":"Han","year":"2022","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2023.103695_bib0023","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2020.101837","article-title":"Application of 5-aminolevulinic acid photodynamic therapy for vaginal intraepithelial neoplasia, a report of six cases","volume":"31","author":"Cai","year":"2020","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2023.103695_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2022.103009","article-title":"Evaluation of 5-aminolevulinic acid-mediated photodynamic therapy in postmenopausal women with persistent HPV infection with or without cervical and vaginal low-grade squamous intraepithelial lesions (CIN1\/VaIN1)","volume":"39","author":"Wang","year":"2022","journal-title":"Photodiagn. Photodyn. Ther."},{"issue":"3","key":"10.1016\/j.pdpdt.2023.103695_bib0025","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.ygyno.2021.06.027","article-title":"Risk factors analysis of persistence, progression and recurrence in vaginal intraepithelial neoplasia","volume":"162","author":"Ao","year":"2021","journal-title":"Gynecol. Oncol."},{"issue":"2","key":"10.1016\/j.pdpdt.2023.103695_bib0026","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.ygyno.2019.05.026","article-title":"Association of age and viral factors with high-risk HPV persistence: a retrospective follow-up study","volume":"154","author":"Li","year":"2019","journal-title":"Gynecol. Oncol."},{"issue":"7","key":"10.1016\/j.pdpdt.2023.103695_bib0027","first-page":"1219","article-title":"Risk factors for the development of vaginal intraepithelial neoplasia","volume":"125","author":"Li","year":"2012","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.pdpdt.2023.103695_bib0028","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2022.103144","article-title":"Evaluation of the efficacy and safety of 5-aminolevulinic acid-mediated photodynamic therapy in women with high-risk HPV persistent infection after cervical conization","volume":"40","author":"Wang","year":"2022","journal-title":"Photodiagn. Photodyn. Ther."}],"container-title":["Photodiagnosis and Photodynamic Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100023004222?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100023004222?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:50:56Z","timestamp":1761612656000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1572100023004222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":28,"alternative-id":["S1572100023004222"],"URL":"https:\/\/doi.org\/10.1016\/j.pdpdt.2023.103695","relation":{},"ISSN":["1572-1000"],"issn-type":[{"value":"1572-1000","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparison of ALA-PDT and CO2 laser treatment of low-grade vaginal intraepithelial neoplasia with high-risk HPV infection: A non-randomized controlled pilot study","name":"articletitle","label":"Article Title"},{"value":"Photodiagnosis and Photodynamic Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pdpdt.2023.103695","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"103695"}}