{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T12:26:40Z","timestamp":1781094400848,"version":"3.54.1"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T00:00:00Z","timestamp":1720742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010950","name":"Department of Science and Technology of Henan Province","doi-asserted-by":"publisher","award":["232102310356"],"award-info":[{"award-number":["232102310356"]}],"id":[{"id":"10.13039\/501100010950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Photodiagnosis and Photodynamic Therapy"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.pdpdt.2024.104281","type":"journal-article","created":{"date-parts":[[2024,7,14]],"date-time":"2024-07-14T06:31:51Z","timestamp":1720938711000},"page":"104281","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Advances in two-photon absorption photodynamic therapy of glioma based on porphyrin-based metal-organicframework composites"],"prefix":"10.1016","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1367-2810","authenticated-orcid":false,"given":"Yong-Tao","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Hui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang-lei","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pdpdt.2024.104281_bib0001","series-title":"Construction of a Tumour Microenvironment-Responsive Multifunctional Nano-Delivery System and Its Use For Enhanced Tumour Photodynamic therapy[D]","author":"Liu","year":"2021"},{"issue":"5","key":"10.1016\/j.pdpdt.2024.104281_bib0002","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/nrc1071","article-title":"Photodynamic therapy for cancer","volume":"3","author":"Dolmans","year":"2003","journal-title":"Nat. Rev. Cancer"},{"issue":"3","key":"10.1016\/j.pdpdt.2024.104281_bib0003","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1007\/s12094-008-0172-2","article-title":"Photodynamic therapy of cancer. Basic principles and applications","volume":"10","author":"Juarranz","year":"2008","journal-title":"Clin. Transl. Oncol."},{"issue":"3","key":"10.1016\/j.pdpdt.2024.104281_bib0004","doi-asserted-by":"crossref","first-page":"817","DOI":"10.3390\/ma6030817","article-title":"Dye sensitizers for photodynamic therapy","volume":"6","author":"Ormond","year":"2013","journal-title":"Mater. (Basel)"},{"key":"10.1016\/j.pdpdt.2024.104281_bib0005","series-title":"Porphyrin Phthalocyanine Nanometal-Organic Framework Materials For Optical Tumour Therapy [D]","author":"Jiang","year":"2019"},{"issue":"04","key":"10.1016\/j.pdpdt.2024.104281_bib0006","first-page":"360","article-title":"Research and clinical application progress of photodynamic therapy and photosensitiser-guided surgery for glioma","volume":"43","author":"Li","year":"2018","journal-title":"J. Centr. S. Univer. (Med. Editi.)"},{"issue":"16","key":"10.1016\/j.pdpdt.2024.104281_bib0007","first-page":"1652","article-title":"Research progress of cell membrane-modified biomimetic nanodrug delivery system in tumour photodynamic therapy","volume":"32","author":"Qi","year":"2023","journal-title":"Chin. J. New Drug."},{"issue":"01","key":"10.1016\/j.pdpdt.2024.104281_bib0008","first-page":"70","article-title":"Advances in photodynamic therapy of tumours based on upconversion nanoparticles","volume":"36","author":"Wang","year":"2024","journal-title":"Cancer-Mutat.-Mutat."},{"issue":"4","key":"10.1016\/j.pdpdt.2024.104281_bib0009","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/86684","article-title":"A clearer vision for in vivo imaging","volume":"19","author":"Weissleder","year":"2001","journal-title":"Nat. Biotechnol."},{"issue":"11","key":"10.1016\/j.pdpdt.2024.104281_bib0010","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/nnano.2009.326","article-title":"Bioimaging: second window for in vivo imaging","volume":"4","author":"Smith","year":"2009","journal-title":"Nat Nanotechnol"},{"issue":"9","key":"10.1016\/j.pdpdt.2024.104281_bib0011","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1007\/s10103-020-03226-5","article-title":"Study on the mechanism of photodynamic therapy mediated by 5-aminoketovalerate in human ovarian cancer cell line","volume":"36","author":"Wang","year":"2021","journal-title":"Laser. Med. Sci."},{"key":"10.1016\/j.pdpdt.2024.104281_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111302","article-title":"The potential of photodynamic therapy in current breast cancer treatment methodologies","volume":"137","author":"Osta\u0144ska","year":"2021","journal-title":"Biomed. Pharmacother."},{"issue":"19","key":"10.1016\/j.pdpdt.2024.104281_bib0013","doi-asserted-by":"crossref","first-page":"10506","DOI":"10.3390\/ijms221910506","article-title":"Photodynamic therapy induced cell death mechanisms in breast cancer","volume":"22","author":"Mokoena","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.pdpdt.2024.104281_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2020.102091","article-title":"Features of third generation photosensitizers used in anticancer photodynamic therapy: review","volume":"34","author":"Mfouo-Tynga","year":"2021","journal-title":"Photodiagnos. Photodyn. Ther."},{"issue":"02","key":"10.1016\/j.pdpdt.2024.104281_bib0015","first-page":"60","article-title":"Research progress of gold nanoparticle-loaded photosensitiser in improving photodynamic therapy of malignant tumours","volume":"34","author":"Sun","year":"2024","journal-title":"Chin. J. Mod. Med."},{"issue":"1","key":"10.1016\/j.pdpdt.2024.104281_bib0016","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.neurol.2015.10.007","article-title":"Descriptive epidemiology and risk factors of primary central nervous system tumors: current knowledge","volume":"172","author":"Pouchieu","year":"2016","journal-title":"Rev. Neurol. (Paris)"},{"issue":"49","key":"10.1016\/j.pdpdt.2024.104281_bib0017","doi-asserted-by":"crossref","DOI":"10.1002\/smll.201903881","article-title":"Immune checkpoint blockade mediated by a small-molecule nanoinhibitor targeting the PD-1\/PD-L1 pathway synergizes with photodynamic therapy to elicit antitumor immunity and antimetastatic effects on breast cancer","volume":"15","author":"Zhang","year":"2019","journal-title":"Small"},{"key":"10.1016\/j.pdpdt.2024.104281_bib0018","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jconrel.2022.08.025","article-title":"Bioengineered immunomodulatory organelle targeted nanozymes for photodynamic immunometabolic therapy","volume":"350","author":"Sunil","year":"2022","journal-title":"J. Control Release"},{"key":"10.1016\/j.pdpdt.2024.104281_bib0019","first-page":"26","article-title":"Terapia fotodynamiczna\u2014Za\u0142o\u017cenia, mechanizm, aplikacje kliniczne","volume":"1","author":"Choroma\u0144ska","year":"2013","journal-title":"Nowa Med."},{"key":"10.1016\/j.pdpdt.2024.104281_bib0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000469675","article-title":"Photodynamic therapy of malignant gliomas","volume":"32","author":"Kaneko","year":"2018","journal-title":"Prog. Neurol. Surg."},{"issue":"4","key":"10.1016\/j.pdpdt.2024.104281_bib0021","first-page":"1596","article-title":"Sinoporphyrin sodium is a promising sensitizer for photodynamic and sonodynamic therapy in glioma","volume":"44","author":"An","year":"2020","journal-title":"Oncol. Rep."},{"issue":"20","key":"10.1016\/j.pdpdt.2024.104281_bib0022","doi-asserted-by":"crossref","first-page":"6847","DOI":"10.3390\/molecules27206847","article-title":"The use of photodynamic therapy in the treatment of brain tumors-a review of the literature","volume":"27","author":"Bartusik-Aebisher","year":"2022","journal-title":"Molecules"},{"issue":"01","key":"10.1016\/j.pdpdt.2024.104281_bib0023","first-page":"70","article-title":"Research progress of photodynamic therapy of tumours based on upconversion nanoparticles","volume":"36","author":"Wang","year":"2024","journal-title":"Cancer-Mutat.-Mutat."},{"issue":"21","key":"10.1016\/j.pdpdt.2024.104281_bib0024","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1101\/gad.1596707","article-title":"Malignant astrocytic glioma: genetics, biology, and paths to treatment","volume":"21","author":"Furnari","year":"2007","journal-title":"Gene. Dev."},{"key":"10.1016\/j.pdpdt.2024.104281_bib0025","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/B978-0-12-822198-3.00043-4","article-title":"Atypical meningiomas","volume":"170","author":"Chen","year":"2020","journal-title":"Handb. Clin. Neurol."},{"key":"10.1016\/j.pdpdt.2024.104281_bib0026","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.699301","article-title":"5-ALA in suspected low-grade gliomas: current role, limitations, and new approaches","volume":"11","author":"Kiesel","year":"2021","journal-title":"Front. Oncol."},{"issue":"11","key":"10.1016\/j.pdpdt.2024.104281_bib0027","first-page":"853","article-title":"Photodynamic therapy: applications in bladder cancer and other malignancies","volume":"96","author":"Chang","year":"1997","journal-title":"J. Formos. Med. Assoc."},{"issue":"6 Suppl 15","key":"10.1016\/j.pdpdt.2024.104281_bib0028","first-page":"15","article-title":"Photodynamic therapy of lung cancer","volume":"21","author":"Lam","year":"1994","journal-title":"Semin. Oncol."},{"issue":"4","key":"10.1016\/j.pdpdt.2024.104281_bib0029","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1055\/s-2007-1004189","article-title":"Enhanced effectiveness of photodynamic therapy with laser light fractionation in patients with esophageal cancer","volume":"29","author":"Messmann","year":"1997","journal-title":"Endoscopy"},{"issue":"8","key":"10.1016\/j.pdpdt.2024.104281_bib0030","first-page":"1731","volume":"184","author":"Etienne","year":"2000","journal-title":"Bull. Acad. Natl. Med."},{"issue":"2","key":"10.1016\/j.pdpdt.2024.104281_bib0031","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1097\/MOO.0000000000000521","article-title":"Photodynamic therapy in head and neck cancer: indications, outcomes, and future prospects","volume":"27","author":"Meulemans","year":"2019","journal-title":"Curr. Opin. Otolaryngol. Head Neck Surg."},{"issue":"4","key":"10.1016\/j.pdpdt.2024.104281_bib0032","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1177\/153303460300200405","article-title":"Clinical outcomes of photodynamic therapy for head-and-neck cancer","volume":"2","author":"Lou","year":"2003","journal-title":"Technol. Cancer Res. Treat."},{"issue":"9","key":"10.1016\/j.pdpdt.2024.104281_bib0033","doi-asserted-by":"crossref","first-page":"4432","DOI":"10.1039\/C7NR06874C","article-title":"An upconversion nanoplatform with extracellular pH-driven tumor-targeting ability for improved photodynamic therapy","volume":"10","author":"Ai","year":"2018","journal-title":"Nanoscale"},{"issue":"10","key":"10.1016\/j.pdpdt.2024.104281_bib0034","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1007\/s007010050206","article-title":"Technical principles for protoporphyrin-IX-fluorescence guided microsurgical resection of malignant glioma tissue","volume":"140","author":"Stummer","year":"1998","journal-title":"Acta Neurochir. (Wien)"},{"issue":"1","key":"10.1016\/j.pdpdt.2024.104281_bib0035","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s11060-007-9497-x","article-title":"Long-sustaining response in a patient with non-resectable, distant recurrence of glioblastoma multiforme treated by interstitial photodynamic therapy using 5-ALA: case report","volume":"87","author":"Stummer","year":"2008","journal-title":"J. Neurooncol."},{"key":"10.1016\/j.pdpdt.2024.104281_bib0036","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/978-1-60761-697-9_17","article-title":"Photodynamic diagnosis and therapy and the brain","volume":"635","author":"Kostron","year":"2010","journal-title":"Method. Mol. Biol."},{"issue":"1","key":"10.1016\/j.pdpdt.2024.104281_bib0037","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.pdpdt.2008.01.006","article-title":"Brain photodiagnosis (PD), fluorescence guided resection (FGR) and photodynamic therapy (PDT): past, present and future","volume":"5","author":"Eljamel","year":"2008","journal-title":"Photodiagnos. Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2024.104281_bib0038","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1250699","article-title":"Photodynamic therapy and associated targeting methods for treatment of brain cancer","volume":"14","author":"Bartusik-Aebisher","year":"2023","journal-title":"Front. Pharmacol."},{"issue":"4","key":"10.1016\/j.pdpdt.2024.104281_bib0039","doi-asserted-by":"crossref","first-page":"845","DOI":"10.3171\/2013.7.JNS13415","article-title":"Phase II clinical study on intraoperative photodynamic therapy with talaporfin sodium and semiconductor laser in patients with malignant brain tumors","volume":"119","author":"Muragaki","year":"2013","journal-title":"J. Neurosurg."},{"issue":"5","key":"10.1016\/j.pdpdt.2024.104281_bib0040","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/S1470-2045(06)70665-9","article-title":"Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial","volume":"7","author":"Meinel","year":"2006","journal-title":"Lancet Oncol."},{"issue":"1","key":"10.1016\/j.pdpdt.2024.104281_bib0041","doi-asserted-by":"crossref","first-page":"47","DOI":"10.5114\/ninp.2012.27212","article-title":"Fluorescence-guided resection of primary and recurrent malignant gliomas with 5-aminolevulinic acid. Preliminary results","volume":"46","author":"Tykocki","year":"2012","journal-title":"Neurol. Neurochir. Pol."},{"issue":"5","key":"10.1016\/j.pdpdt.2024.104281_bib0042","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1002\/lsm.20338","article-title":"Photodynamic therapy of brain tumors\u2013a work in progress","volume":"38","author":"Muller","year":"2006","journal-title":"Laser. Surg. Med."},{"issue":"5","key":"10.1016\/j.pdpdt.2024.104281_bib0043","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/S1470-2045(06)70665-9","article-title":"ALA-Glioma Study Group. Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial","volume":"7","author":"Stummer","year":"2006","journal-title":"Lancet Oncol."},{"issue":"4","key":"10.1016\/j.pdpdt.2024.104281_bib0044","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s10103-007-0494-2","article-title":"ALA and Photofrin fluorescence-guided resection and repetitive PDT in glioblastoma multiforme: a single centre Phase III randomised controlled trial","volume":"23","author":"Eljamel","year":"2008","journal-title":"Laser. Med. Sci."},{"issue":"4","key":"10.1016\/j.pdpdt.2024.104281_bib0045","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1093\/jpp\/rgaa018","article-title":"Hypericin-mediated photodynamic therapy for the treatment of cancer: a review","volume":"73","author":"Dong","year":"2021","journal-title":"J. Pharm. Pharmacol."},{"issue":"3","key":"10.1016\/j.pdpdt.2024.104281_bib0046","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.pdpdt.2015.04.007","article-title":"Low-fluence rate, long duration photodynamic therapy in glioma mouse model using organic light emitting diode (OLED)","volume":"12","author":"Guo","year":"2015","journal-title":"Photodiagnos. Photodyn. Ther."},{"issue":"48","key":"10.1016\/j.pdpdt.2024.104281_bib0047","doi-asserted-by":"crossref","first-page":"16712","DOI":"10.1021\/ja508679h","article-title":"Nanoscale metal-organic framework for highly effective photodynamic therapy of resistant head and neck cancer","volume":"136","author":"Lu","year":"2014","journal-title":"J. Am. Chem. Soc."},{"issue":"24","key":"10.1016\/j.pdpdt.2024.104281_bib0048","doi-asserted-by":"crossref","first-page":"7600","DOI":"10.1021\/jacs.5b04069","article-title":"A chlorin-based nanoscale metal-organic framework for photodynamic therapy of colon cancers","volume":"137","author":"Lu","year":"2015","journal-title":"J. Am. Chem. Soc."},{"issue":"38","key":"10.1016\/j.pdpdt.2024.104281_bib0049","doi-asserted-by":"crossref","first-page":"12502","DOI":"10.1021\/jacs.6b06663","article-title":"Chlorin-based nanoscale metal-organic framework systemically rejects colorectal cancers via synergistic photodynamic therapy and checkpoint blockade immunotherapy","volume":"138","author":"Lu","year":"2016","journal-title":"J. Am. Chem. Soc."},{"issue":"54","key":"10.1016\/j.pdpdt.2024.104281_bib0050","doi-asserted-by":"crossref","first-page":"10831","DOI":"10.1039\/C5CC03028E","article-title":"A porphyrin photosensitized metal-organic framework for cancer cell apoptosis and caspase responsive theranostics","volume":"51","author":"Zhang","year":"2015","journal-title":"Chem. Commun. (Camb.)"},{"issue":"10","key":"10.1016\/j.pdpdt.2024.104281_bib0051","doi-asserted-by":"crossref","first-page":"3518","DOI":"10.1021\/jacs.6b00007","article-title":"Size-controlled synthesis of porphyrinic metal-organic framework and functionalization for targeted photodynamic therapy","volume":"138","author":"Park","year":"2016","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.pdpdt.2024.104281_bib0052","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biomaterials.2016.04.034","article-title":"Nanoscale metal-organic frameworks for combined photodynamic & radiation therapy in cancer treatment","volume":"97","author":"Liu","year":"2016","journal-title":"Biomaterials"},{"issue":"44","key":"10.1016\/j.pdpdt.2024.104281_bib0053","doi-asserted-by":"crossref","first-page":"13752","DOI":"10.1002\/anie.201708005","article-title":"H2 S-activable MOF nanoparticle photosensitizer for effective photodynamic therapy against cancer with controllable singlet-oxygen release","volume":"56","author":"Ma","year":"2017","journal-title":"Angew. Chem. Int. Ed. Engl."},{"issue":"3","key":"10.1016\/j.pdpdt.2024.104281_bib0055","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.pdpdt.2015.04.009","article-title":"Photodynamic therapy (PDT) for malignant brain tumors\u2013where do we stand?","volume":"12","author":"Quirk","year":"2015","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2024.104281_bib0056","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2023.1250621","article-title":"Photodynamic therapy in brain cancer: mechanisms, clinical and preclinical studies and therapeutic challenges","volume":"11","author":"Domka","year":"2023","journal-title":"Front. Chem."}],"container-title":["Photodiagnosis and Photodynamic Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100024003181?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100024003181?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T22:16:21Z","timestamp":1762553781000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1572100024003181"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":55,"alternative-id":["S1572100024003181"],"URL":"https:\/\/doi.org\/10.1016\/j.pdpdt.2024.104281","relation":{},"ISSN":["1572-1000"],"issn-type":[{"value":"1572-1000","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Advances in two-photon absorption photodynamic therapy of glioma based on porphyrin-based metal-organicframework composites","name":"articletitle","label":"Article Title"},{"value":"Photodiagnosis and Photodynamic Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pdpdt.2024.104281","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104281"}}