{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T16:21:56Z","timestamp":1783527716438,"version":"3.55.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T00:00:00Z","timestamp":1736121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008750","name":"Shanghai Shenkang Hospital Development Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008750","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Photodiagnosis and Photodynamic Therapy"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.pdpdt.2025.104474","type":"journal-article","created":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T08:26:23Z","timestamp":1736238383000},"page":"104474","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["A Chlorin e6 derivative-mediated photodynamic therapy versus doxycycline for moderate-to-severe rosacea: A prospective, randomized, controlled study"],"prefix":"10.1016","volume":"51","author":[{"given":"Yun","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajing","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuhe","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linglin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiru","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2302-6022","authenticated-orcid":false,"given":"Xiuli","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"18","key":"10.1016\/j.pdpdt.2025.104474_bib0001","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1056\/NEJMcp1506630","article-title":"Rosacea","volume":"377","author":"VAN ZUUREN","year":"2017","journal-title":"N. Engl. J. Med."},{"issue":"5","key":"10.1016\/j.pdpdt.2025.104474_bib0002","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.jaad.2023.12.038","article-title":"Epidemiology of acne and rosacea: a worldwide global study","volume":"90","author":"SAURAT","year":"2024","journal-title":"J. Am. Acad. Dermatol."},{"issue":"5","key":"10.1016\/j.pdpdt.2025.104474_bib0003","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/1346-8138.15301","article-title":"Epidemiological features of rosacea in Changsha, China: a population-based, cross-sectional study","volume":"47","author":"LI","year":"2020","journal-title":"J. Dermatol."},{"issue":"6","key":"10.1016\/j.pdpdt.2025.104474_bib0004","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1016\/j.jaad.2020.01.077","article-title":"Standard management options for rosacea: the 2019 update by the national rosacea society expert committee","volume":"82","author":"THIBOUTOT","year":"2020","journal-title":"J. Am. Acad. Dermatol."},{"issue":"8","key":"10.1016\/j.pdpdt.2025.104474_bib0005","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1111\/jdv.19913","article-title":"Dermatological patients with itch report more stress, stigmatization experience, anxiety and depression compared to patients without itch: results from a European multi-centre study","volume":"38","author":"ZEIDLER","year":"2024","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"issue":"4","key":"10.1016\/j.pdpdt.2025.104474_bib0006","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s40257-021-00595-7","article-title":"Rosacea: new concepts in classification and treatment","volume":"22","author":"VAN","year":"2021","journal-title":"Am. J. Clin. Dermatol."},{"issue":"1","key":"10.1016\/j.pdpdt.2025.104474_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2023.119603","article-title":"Modified 5-aminolevulinic acid photodynamic therapy induces cutaneous squamous cell carcinoma cell pyroptosis via the JNK signaling pathway","volume":"1871","author":"CHEN","year":"2024","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.pdpdt.2025.104474_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2022.102875","article-title":"Photodynamic therapy in the treatment of rosacea: a systematic review","volume":"38","author":"LI","year":"2022","journal-title":"Photodiagnosis. Photodyn. Ther."},{"issue":"4","key":"10.1016\/j.pdpdt.2025.104474_bib0009","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.jaad.2023.06.027","article-title":"5-Aminolevulinic acid photodynamic therapy versus minocycline for moderate-to-severe rosacea: a single-center, randomized, evaluator-blind controlled study","volume":"89","author":"YANG","year":"2023","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.pdpdt.2025.104474_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2019.111959","article-title":"Synthesis and evaluation of novel chlorophyll a derivatives as potent photosensitizers for photodynamic therapy","volume":"187","author":"GAO","year":"2020","journal-title":"Eur. J. Med. Chem."},{"issue":"13","key":"10.1016\/j.pdpdt.2025.104474_bib0011","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.2174\/1389557516666161004161411","article-title":"Chlorophylls and their derivatives used in food industry and medicine","volume":"17","author":"SOLYMOSI","year":"2017","journal-title":"Mini. Rev. Med. Chem."},{"issue":"6","key":"10.1016\/j.pdpdt.2025.104474_bib0012","doi-asserted-by":"crossref","first-page":"799","DOI":"10.2174\/092986712799034879","article-title":"The chlorophyll catabolite pheophorbide a as a photosensitizer for the photodynamic therapy","volume":"19","author":"XODO L E","year":"2012","journal-title":"Curr. Med. Chem."},{"issue":"10","key":"10.1016\/j.pdpdt.2025.104474_bib0013","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/S1360-1385(00)01735-0","article-title":"Degradation pathway(s) of chlorophyll: what has gene cloning revealed?","volume":"5","author":"TAKAMIYA","year":"2000","journal-title":"Trends. Plant Sci."},{"issue":"16","key":"10.1016\/j.pdpdt.2025.104474_bib0014","doi-asserted-by":"crossref","DOI":"10.3390\/molecules24162968","article-title":"Chlorophyll and chlorophyll derivatives interfere with multi-drug resistant cancer cells and bacteria","volume":"24","author":"WANG","year":"2019","journal-title":"Molecules."},{"issue":"1","key":"10.1016\/j.pdpdt.2025.104474_bib0015","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3109\/09546634.2010.514598","article-title":"Pilot study on photodynamic therapy for acne using chlorophyll: evaluator-blinded, split-face study","volume":"23","author":"KIM","year":"2012","journal-title":"J. Dermatolog. Treat."},{"issue":"4","key":"10.1016\/j.pdpdt.2025.104474_bib0016","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.jaad.2014.05.047","article-title":"Photodynamic therapy using chlorophyll-a in the treatment of acne vulgaris: a randomized, single-blind, split-face study","volume":"71","author":"SONG","year":"2014","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.pdpdt.2025.104474_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2024.104304","article-title":"A chlorin e6 derivative-mediated photodynamic therapy for mild to moderate acne: a prospective, single-blind, randomized, split-face controlled study","volume":"49","author":"ZHANG","year":"2024","journal-title":"Photodiagnosis. Photodyn. Ther."},{"issue":"5","key":"10.1016\/j.pdpdt.2025.104474_bib0018","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/j.jaad.2022.02.025","article-title":"Case\/noncase analysis of the FDA adverse events reporting system suggests higher reporting odds of photosensitivity and esophageal symptoms for sarecycline than of those for other tetracyclines","volume":"87","author":"JEDLOWSKI","year":"2022","journal-title":"J. Am. Acad. Dermatol."},{"issue":"4","key":"10.1016\/j.pdpdt.2025.104474_bib0019","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1080\/14764172.2018.1502455","article-title":"Topical photodynamic therapy with 5-aminolevulinic acid in Chinese patients with Rosacea","volume":"21","author":"SUN","year":"2019","journal-title":"J. Cosmet. Laser. Ther."},{"issue":"1","key":"10.1016\/j.pdpdt.2025.104474_bib0020","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s10103-022-03685-y","article-title":"Combined therapy of 5-aminolevulinic acid photodynamic therapy and intense pulsed light for rosacea","volume":"38","author":"BAO","year":"2022","journal-title":"Lasers. Med. Sci."},{"key":"10.1016\/j.pdpdt.2025.104474_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaad.2024.06.063","article-title":"Positive results of intense pulsed light-photodynamic therapy for moderate-to-severe rosacea: a prospective, single-arm study","author":"WU","year":"2024","journal-title":"J. Am. Acad. Dermatol."},{"issue":"2","key":"10.1016\/j.pdpdt.2025.104474_bib0022","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1159\/000086443","article-title":"Photodynamic therapy in the treatment of rosacea","volume":"211","author":"NYBAEK","year":"2005","journal-title":"Dermatology"},{"issue":"9","key":"10.1016\/j.pdpdt.2025.104474_bib0023","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1111\/j.1468-3083.2007.02219.x","article-title":"Photodynamic therapy in a series of rosacea patients","volume":"21","author":"BRYLD","year":"2007","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"issue":"2","key":"10.1016\/j.pdpdt.2025.104474_bib0024","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/j.1468-3083.2008.02781.x","article-title":"Short and limited effect of long-pulsed dye laser alone and in combination with photodynamic therapy for inflammatory rosacea","volume":"23","author":"TOGSVERD-BO","year":"2009","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"issue":"23","key":"10.1016\/j.pdpdt.2025.104474_bib0025","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26237268","article-title":"Porphyrin\/Chlorin derivatives as promising molecules for therapy of colorectal cancer","volume":"26","author":"DANDASH","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.pdpdt.2025.104474_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2023.103321","article-title":"A novel chlorin e6 derivative-mediated photodynamic therapy STBF-PDT reverses photoaging via the TGF-\u03b2 pathway","volume":"41","author":"SHI","year":"2023","journal-title":"Photodiagnosis. Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2025.104474_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2024.104022","article-title":"Successful treatment by a chlorin e6 derivative mediated photodynamic therapy combined holmium laser for cervical and vaginal giant condyloma acuminata and low-grade intraepithelial neoplasia:a case report","volume":"46","author":"WU","year":"2024","journal-title":"Photodiagnosis. Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2025.104474_bib0028","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2023.103332","article-title":"A chlorin e6 derivative-mediated photodynamic therapy inhibits cutaneous squamous cell carcinoma cell proliferation via Akt\/mTOR signaling pathway","volume":"42","author":"TAO","year":"2023","journal-title":"Photodiagnosis. Photodyn. Ther."},{"issue":"12","key":"10.1016\/j.pdpdt.2025.104474_bib0029","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1111\/jdv.19449","article-title":"Cutaneous neurogenic inflammation mediated by TRPV1-NGF-TRKA pathway activation in rosacea is exacerbated by the presence of Demodex mites","volume":"37","author":"LEE","year":"2023","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"issue":"1","key":"10.1016\/j.pdpdt.2025.104474_bib0030","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1159\/000526296","article-title":"Comparison of different anti-Demodex strategies: a systematic review and meta-analysis","volume":"239","author":"LI","year":"2023","journal-title":"Dermatology"},{"issue":"6","key":"10.1016\/j.pdpdt.2025.104474_bib0031","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1111\/j.1468-3083.2009.03171.x","article-title":"Photodynamic therapy with methyl aminolevulinate for resistant scalp folliculitis secondary to Demodex infestation","volume":"23","author":"GILABERTE","year":"2009","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"10.1016\/j.pdpdt.2025.104474_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.115403","article-title":"ALA-PDT augments intense inflammation in the treatment of acne vulgaris by COX2\/TREM1 mediated M1 macrophage polarization","volume":"208","author":"LIU","year":"2023","journal-title":"Biochem. Pharmacol."},{"issue":"1","key":"10.1016\/j.pdpdt.2025.104474_bib0033","doi-asserted-by":"crossref","first-page":"8737","DOI":"10.1038\/s41467-024-52946-7","article-title":"Single-cell transcriptomics reveals aberrant skin-resident cell populations and identifies fibroblasts as a determinant in rosacea","volume":"15","author":"CHEN","year":"2024","journal-title":"Nat. Commun."},{"issue":"10","key":"10.1016\/j.pdpdt.2025.104474_bib0034","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1016\/j.jid.2020.02.025","article-title":"Rosacea is characterized by a profoundly diminished skin barrier","volume":"140","author":"MEDGYESI","year":"2020","journal-title":"J. Invest. Dermatol."},{"issue":"8","key":"10.1016\/j.pdpdt.2025.104474_bib0035","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines11082153","article-title":"Exploring the pathogenesis and mechanism-targeted treatments of rosacea: previous understanding and updates","volume":"11","author":"CHEN","year":"2023","journal-title":"Biomedicines."},{"key":"10.1016\/j.pdpdt.2025.104474_bib0036","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/j.biopha.2018.07.049","article-title":"Photodynamic therapy - mechanisms, photosensitizers and combinations","volume":"106","author":"KWIATKOWSKI","year":"2018","journal-title":"Biomed. PharmacOther"}],"container-title":["Photodiagnosis and Photodynamic Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100025000043?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100025000043?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T01:55:36Z","timestamp":1740621336000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1572100025000043"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":36,"alternative-id":["S1572100025000043"],"URL":"https:\/\/doi.org\/10.1016\/j.pdpdt.2025.104474","relation":{},"ISSN":["1572-1000"],"issn-type":[{"value":"1572-1000","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Chlorin e6 derivative-mediated photodynamic therapy versus doxycycline for moderate-to-severe rosacea: A prospective, randomized, controlled study","name":"articletitle","label":"Article Title"},{"value":"Photodiagnosis and Photodynamic Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pdpdt.2025.104474","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104474"}}