{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:39:49Z","timestamp":1786995589154,"version":"build-2736575974"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T00:00:00Z","timestamp":1745193600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Photodiagnosis and Photodynamic Therapy"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.pdpdt.2025.104603","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T02:59:14Z","timestamp":1745290754000},"page":"104603","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Evaluating photodynamic therapy protocols for high-grade cervical neoplasia: A comparative study"],"prefix":"10.1016","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2675-8069","authenticated-orcid":false,"given":"Cynthia Aparecida","family":"de Castro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina Fernanda","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fl\u00e1via Langellotti","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura de Oliveira","family":"Marchetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Welington","family":"Lombardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanderlei Salvador","family":"Bagnato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia Mayumi","family":"Inada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pdpdt.2025.104603_bib0001","first-page":"229","article-title":"A review of cervical cancer: incidence and disparities","volume":"112","author":"Buskwofie","year":"2020","journal-title":"J. Natl. Med. Assoc."},{"key":"10.1016\/j.pdpdt.2025.104603_bib0002","doi-asserted-by":"crossref","first-page":"e161","DOI":"10.1016\/S2214-109X(20)30459-9","article-title":"Estimates of the global burden of cervical cancer associated with HIV","volume":"9","author":"Stelzle","year":"2021","journal-title":"Lancet Glob Heal"},{"key":"10.1016\/j.pdpdt.2025.104603_bib0003","series-title":"C\u00e2ncer. Controle do C\u00e2ncer do Colo do \u00datero. Rio de Janeiro: INCA","year":"2023"},{"issue":"1","key":"10.1016\/j.pdpdt.2025.104603_bib0004","first-page":"33","article-title":"Global cancer statistics: 2011","volume":"49","author":"Jemal","year":"1999","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.pdpdt.2025.104603_bib0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/CMR.16.1.1-17.2003","article-title":"Human papillomavirus and cervical cancer","volume":"16","author":"Burd","year":"2003","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.pdpdt.2025.104603_bib0006","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1080\/01443615.2019.1634030","article-title":"Human papillomavirus and cervical cancer","volume":"40","author":"Okunade","year":"2020","journal-title":"J. Obstet. Gynaecol. (Lahore)"},{"key":"10.1016\/j.pdpdt.2025.104603_bib0007","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1002\/lsm.22255","article-title":"Efficacy and safety of hexaminolevulinate photodynamic therapy in patients with low-grade cervical intraepithelial neoplasia","volume":"46","author":"Hillemanns","year":"2014","journal-title":"Lasers Surg. Med."},{"key":"10.1016\/j.pdpdt.2025.104603_bib0008","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jphotobiol.2019.03.012","article-title":"5-aminolevulinic acid photodynamic therapy reduces HPV viral load via autophagy and apoptosis by modulating Ras\/raf\/MEK\/ERK and PI3K\/AKT pathways in HeLa cells","volume":"194","author":"Xie","year":"2019","journal-title":"J. Photochem. Photobiol. B Biol."},{"key":"10.1016\/j.pdpdt.2025.104603_bib0009","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.pdpdt.2019.02.003","article-title":"Human papillomavirus DNA detection-guided ALA-photodynamic therapy for anogenital condyloma acuminata: a report of two cases","volume":"25","author":"Wang","year":"2019","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2025.104603_bib0010","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3390\/ph12030107","article-title":"Long term effectiveness of photodynamic therapy for CIN treatment","volume":"12","author":"Inada","year":"2019","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.pdpdt.2025.104603_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2020.101937","article-title":"High-risk HPV clearance and CIN 3 treated with MAL-PDT: a case report","volume":"31","author":"de Castro","year":"2020","journal-title":"Photodiagnosis Photodyn Ther"},{"key":"10.1016\/j.pdpdt.2025.104603_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2024.104145","article-title":"Comparing two photodynamic therapy protocols for high-grade cervical intraepithelial neoplasia","volume":"46","author":"Inada","year":"2024","journal-title":"Photodiagnosis Photodyn Ther"},{"key":"10.1016\/j.pdpdt.2025.104603_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2022.102958","article-title":"Comparative study of topical 5-aminolevulinic acid photodynamic therapy (5-ALA-PDT) and surgery for the treatment of high-grade vaginal intraepithelial neoplasia","volume":"39","author":"Zhang","year":"2022","journal-title":"Photodiagnosis Photodyn Ther"},{"issue":"6","key":"10.1016\/j.pdpdt.2025.104603_bib0014","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1067\/mob.2001.113123","article-title":"Fluorescence detection of cervical intraepithelial neoplasia for photodynamic therapy with the topical agents 5-aminolevulinic acid and benzoporphyrin-derivative monoacid ring","volume":"184","author":"Keefe","year":"2001","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"2","key":"10.1016\/j.pdpdt.2025.104603_bib0015","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1117\/1.1463045","article-title":"Localization and staging of cervical intraepithelial neoplasia using double ratio fluorescence imaging","volume":"7","author":"Bogaards","year":"2002","journal-title":"J. Biomed. Opt."},{"key":"10.1016\/j.pdpdt.2025.104603_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2021.102293","article-title":"Effectiveness of photodynamic therapy with 5-aminolevulinic acid on HPV clearance in women without cervical lesions","volume":"34","author":"Cang","year":"2021","journal-title":"Photodiagnosis Photodyn Ther"},{"key":"10.1016\/j.pdpdt.2025.104603_bib0017","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jphotobiol.2019.03.012","article-title":"5-aminolevulinic acid photodynamic therapy reduces HPV viral load via autophagy and apoptosis by modulating Ras\/raf\/MEK\/ERK and PI3K\/AKT pathways in HeLa cells","volume":"194","author":"Xie","year":"2019","journal-title":"J. Photochem. Photobiol. B"},{"key":"10.1016\/j.pdpdt.2025.104603_bib0018","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.pdpdt.2016.11.006","article-title":"Sensitization of immune cells following hexylaminolevulinate photodynamic therapy of cervical intraepithelial neoplasia","volume":"17","author":"Hass","year":"2017","journal-title":"Photodiagnosis Photodyn Ther"},{"key":"10.1016\/j.pdpdt.2025.104603_bib0019","article-title":"Effect and rational application of topical photodynamic therapy (PDT) with 5-aminolevulinic acid (5-ALA) for treatment of cervical intraepithelial neoplasia with vaginal intraepithelial neoplasia","volume":"37","author":"Yuehui","year":"2022","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2025.104603_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2022.102958","article-title":"Comparative study of topical 5-aminolevulinic acid photodynamic therapy (5-ALA-PDT) and surgery for the treatment of high-grade vaginal intraepithelial neoplasia","volume":"39","author":"Zhang","year":"2022","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2025.104603_bib0022","first-page":"659","article-title":"Screening for squamous cervical cancer: duration of low risk after negative results of cervical cytology and its implication for screening policies","year":"1986","journal-title":"British Med. J. (Clinical Research Edition)"},{"key":"10.1016\/j.pdpdt.2025.104603_bib0023","article-title":"Initiation of sexual activity and protected sex in adolescents","volume":"25","author":"Vieira","year":"2021","journal-title":"Anna Nery School"},{"key":"10.1016\/j.pdpdt.2025.104603_bib0024","first-page":"580","article-title":"Association between age at first sexual intercourse and subsequent human papillomavirus infection: results of a Brazilian screening program","volume":"29","author":"Roteli-Martins","year":"2007","journal-title":"Brazilian J. Gynecol. Obstetrics"}],"container-title":["Photodiagnosis and Photodynamic Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100025001310?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100025001310?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T05:28:16Z","timestamp":1760074096000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1572100025001310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":23,"alternative-id":["S1572100025001310"],"URL":"https:\/\/doi.org\/10.1016\/j.pdpdt.2025.104603","relation":{},"ISSN":["1572-1000"],"issn-type":[{"value":"1572-1000","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluating photodynamic therapy protocols for high-grade cervical neoplasia: A comparative study","name":"articletitle","label":"Article Title"},{"value":"Photodiagnosis and Photodynamic Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pdpdt.2025.104603","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104603"}}