{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T12:09:46Z","timestamp":1776686986018,"version":"3.51.2"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T00:00:00Z","timestamp":1750204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Photodiagnosis and Photodynamic Therapy"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.pdpdt.2025.104687","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T20:09:03Z","timestamp":1750277343000},"page":"104687","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Synergistic effect of photobiomodulation and leukocyte-platelet rich fibrin on bone regeneration in rat critical defects"],"prefix":"10.1016","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6975-8758","authenticated-orcid":false,"given":"Ali","family":"Sadeghian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0050-4191","authenticated-orcid":false,"given":"Bita","family":"Rohani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9964-3182","authenticated-orcid":false,"given":"Sadegh","family":"Hasannia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3789-1727","authenticated-orcid":false,"given":"Fatemeh","family":"Mashhadiabbas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5188-8829","authenticated-orcid":false,"given":"Reza","family":"Fekrazad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"23","key":"10.1016\/j.pdpdt.2025.104687_bib0001","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232314987","article-title":"Barrier membranes for guided bone regeneration (GBR): a focus on recent advances in collagen membranes","volume":"23","author":"Ren","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.pdpdt.2025.104687_bib0002","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/prd.12502","article-title":"Membrane barriers for guided bone regeneration: An overview of available biomaterials","volume":"93","author":"Mizraji","year":"2023","journal-title":"Periodontol. 2000"},{"issue":"22","key":"10.1016\/j.pdpdt.2025.104687_bib0003","doi-asserted-by":"crossref","first-page":"6962","DOI":"10.3390\/jcm12226962","article-title":"Resorbable GBR scaffolds in oral and maxillofacial tissue engineering: design, fabrication, and applications","volume":"12","author":"Alavi","year":"2023","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.pdpdt.2025.104687_bib0004","article-title":"Effect of different membranes on vertical bone regeneration: a systematic review and network meta-analysis","volume":"2022","author":"Zhang","year":"2022","journal-title":"Biomed. Res. Int."},{"issue":"3","key":"10.1016\/j.pdpdt.2025.104687_bib0005","doi-asserted-by":"crossref","DOI":"10.1088\/1748-605X\/acc99a","article-title":"Comparison of the efficacy of different biodegradable membranes in guided bone\/tissue regeneration: a systematic review and network meta-analysis","volume":"18","author":"Zhou","year":"2023","journal-title":"Biomed. Mater."},{"issue":"3","key":"10.1016\/j.pdpdt.2025.104687_bib0006","doi-asserted-by":"crossref","first-page":"786","DOI":"10.3390\/ma13030786","article-title":"Selection of collagen membranes for bone regeneration: a literature review","volume":"13","author":"Sbricoli","year":"2020","journal-title":"Materials. (Basel)"},{"issue":"6","key":"10.1016\/j.pdpdt.2025.104687_bib0007","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1007\/s00784-017-2133-z","article-title":"Use of platelet-rich fibrin in regenerative dentistry: a systematic review","volume":"21","author":"Miron","year":"2017","journal-title":"Clin. Oral Investig."},{"issue":"8","key":"10.1016\/j.pdpdt.2025.104687_bib0008","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1007\/s00784-017-2063-9","article-title":"Injectable platelet rich fibrin (i-PRF): opportunities in regenerative dentistry?","volume":"21","author":"Miron","year":"2017","journal-title":"Clin. Oral Investig."},{"issue":"S1","key":"10.1016\/j.pdpdt.2025.104687_bib0009","doi-asserted-by":"crossref","DOI":"10.1111\/cid.12146","article-title":"Effect of leukocyte- and platelet-rich fibrin (LPRF) on bone regeneration: a study in rabbits","volume":"17","author":"Knapen","year":"2013","journal-title":"Clin. ImPlant Dent. Relat. Res."},{"issue":"3","key":"10.1016\/j.pdpdt.2025.104687_bib0010","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/jre.13116","article-title":"An in vitro study into three different PRF preparations for osteogenesis potential","volume":"58","author":"Kosmidis","year":"2023","journal-title":"J. Periodontal. Res."},{"key":"10.1016\/j.pdpdt.2025.104687_bib0011","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.1007692","article-title":"Genipin modified lyophilized platelet-rich fibrin scaffold for sustained release of growth factors to promote bone regeneration","volume":"13","author":"Liu","year":"2022","journal-title":"Front. Physiol."},{"issue":"8","key":"10.1016\/j.pdpdt.2025.104687_bib0012","doi-asserted-by":"crossref","first-page":"7094","DOI":"10.3390\/ijms24087094","article-title":"The role of low-level laser therapy in bone healing: systematic review","volume":"24","author":"Berni","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.pdpdt.2025.104687_bib0013","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.1364\/BOE.451135","article-title":"Optimization of photo-biomodulation therapy for wound healing of diabetic foot ulcers in vitro and in vivo","volume":"13","author":"Chen","year":"2022","journal-title":"Biomed. Opt. Express."},{"issue":"1","key":"10.1016\/j.pdpdt.2025.104687_bib0014","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s10103-024-04244-3","article-title":"Radiographical impact of photobiomodulation therapy on bone regeneration in clinical studies: a systematic review","volume":"40","author":"Sadeghian","year":"2025","journal-title":"Lasers. Med. Sci."},{"key":"10.1016\/j.pdpdt.2025.104687_bib0015","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.pbiomolbio.2019.04.005","article-title":"Molecular impacts of photobiomodulation on bone regeneration: a systematic review","volume":"149","author":"Hosseinpour","year":"2019","journal-title":"Prog. Biophys. Mol. Biol."},{"issue":"11","key":"10.1016\/j.pdpdt.2025.104687_bib0016","first-page":"632","article-title":"Effects of photobiomodulation therapy on hard tissue healing in rat tooth extraction sockets","volume":"41","author":"Song","year":"2023","journal-title":"Photobiomodul. Photomed. Laser. Surg."},{"issue":"1","key":"10.1016\/j.pdpdt.2025.104687_bib0017","doi-asserted-by":"crossref","DOI":"10.1002\/jbio.202000267","article-title":"Effects of photobiomodulation on bone defects grafted with bone substitutes: a systematic review of in vivo animal studies","volume":"14","author":"Hanna","year":"2021","journal-title":"J. Biophotonics."},{"issue":"5","key":"10.1016\/j.pdpdt.2025.104687_bib0018","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1007\/s10103-020-03141-9","article-title":"Evaluation of photobiomodulation therapy to accelerate bone formation in the mid palatal suture after rapid palatal expansion: a randomized clinical trial","volume":"36","author":"Matos","year":"2021","journal-title":"Lasers. Med. Sci."},{"issue":"1","key":"10.1016\/j.pdpdt.2025.104687_bib0019","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1186\/s12903-022-02275-2","article-title":"Complementarity of surgical therapy, photobiomodulation, A-PRF and L-PRF for management of medication-related osteonecrosis of the jaw (MRONJ): an animal study","volume":"22","author":"Jamalpour","year":"2022","journal-title":"BMC. Oral Health"},{"issue":"3","key":"10.1016\/j.pdpdt.2025.104687_bib0020","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s10006-022-01094-7","article-title":"Efficacy of fibrin-rich platelets and leukocytes (L-PRF) in tissue repair in surgical oral procedures in patients using zoledronic acid-case-control study","volume":"27","author":"Parise","year":"2023","journal-title":"Oral Maxillofac. Surg."},{"issue":"1","key":"10.1016\/j.pdpdt.2025.104687_bib0021","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.4102\/ajlm.v11i1.1901","article-title":"Impact of rapid centrifugation on routine coagulation assays in South Africa","volume":"11","author":"Haripersadh","year":"2022","journal-title":"Afr. J. Lab. Med."},{"issue":"2","key":"10.1016\/j.pdpdt.2025.104687_bib0022","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22020903","article-title":"Advances in growth factor delivery for bone tissue engineering","volume":"22","author":"Oliveira","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.pdpdt.2025.104687_bib0023","doi-asserted-by":"crossref","first-page":"3","DOI":"10.32098\/mltj.01.2014.02","article-title":"Classification of platelet concentrates (platelet-rich plasma-PRP, platelet-rich fibrin-PRF) for topical and infiltrative use in orthopedic and sports medicine: current consensus, clinical implications and perspectives","volume":"4","author":"Dohan Ehrenfest","year":"2014","journal-title":"Muscles. Ligaments. Tendons. J."},{"issue":"2","key":"10.1016\/j.pdpdt.2025.104687_bib0024","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1002\/JPER.19-0216","article-title":"Platelet-rich fibrin elicits an anti-inflammatory response in macrophages in vitro","volume":"91","author":"Nasirzade","year":"2020","journal-title":"J. Periodontol."},{"issue":"5","key":"10.1016\/j.pdpdt.2025.104687_bib0025","doi-asserted-by":"crossref","first-page":"400","DOI":"10.2174\/1574888X15666200204123722","article-title":"Biological responses of stem cells to photobiomodulation therapy","volume":"15","author":"Khorsandi","year":"2020","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"10.1016\/j.pdpdt.2025.104687_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.jphotobiol.2024.112973","article-title":"Efficacy of photobiomodulation following L-PRF application for recovery of mental nerve neurosensory disturbances caused by genioplasty: a randomized triple-blind clinical trial","volume":"258","author":"Behnia","year":"2024","journal-title":"J. Photochem. Photobiol. B: Biol."},{"key":"10.1016\/j.pdpdt.2025.104687_bib0027","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.jphotobiol.2015.08.002","article-title":"The effects of combined low level laser therapy and mesenchymal stem cells on bone regeneration in rabbit calvarial defects","volume":"151","author":"Fekrazad","year":"2015","journal-title":"J. Photochem. Photobiol. B"},{"key":"10.1016\/j.pdpdt.2025.104687_bib0028","doi-asserted-by":"crossref","first-page":"e31","DOI":"10.34172\/jlms.2024.31","article-title":"Bone regeneration of rat critical-sized calvarial defects by the combination of photobiomodulation and adipose-derived mesenchymal stem cells: photobiomodulation and bone regeneration","volume":"15","author":"Fekrazad","year":"2024","journal-title":"J. Lasers. Med. Sci."},{"issue":"3","key":"10.1016\/j.pdpdt.2025.104687_bib0029","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1111\/php.13365","article-title":"Effect of photobiomodulation on relapse in an experimental rapid maxillary expansion model in rat","volume":"97","author":"Pirmoradian","year":"2021","journal-title":"Photochem. Photobiol."},{"issue":"11","key":"10.1016\/j.pdpdt.2025.104687_bib0030","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1089\/pho.2015.4028","article-title":"Effects of photobiomodulation and mesenchymal stem cells on articular cartilage defects in a rabbit model","volume":"34","author":"Fekrazad","year":"2016","journal-title":"Photomed. Laser. Surg."},{"issue":"3","key":"10.1016\/j.pdpdt.2025.104687_bib0031","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1007\/s10103-013-1403-5","article-title":"Effect of low-level laser therapy irradiation and Bio-Oss graft material on the osteogenesis process in rabbit calvarium defects: a double blind experimental study","volume":"29","author":"Rasouli Ghahroudi","year":"2014","journal-title":"Lasers. Med. Sci."},{"issue":"3","key":"10.1016\/j.pdpdt.2025.104687_bib0032","doi-asserted-by":"crossref","first-page":"337","DOI":"10.3934\/biophy.2017.3.337","article-title":"Mechanisms and applications of the anti-inflammatory effects of photobiomodulation","volume":"4","author":"Hamblin","year":"2017","journal-title":"AIMS. Biophys."},{"issue":"12","key":"10.1016\/j.pdpdt.2025.104687_bib0033","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1002\/jbm.b.34885","article-title":"Effects of relative centrifugation force on L-PRF: an in vivo submandibular boney defect regeneration study","volume":"109","author":"Tovar","year":"2021","journal-title":"J. Biomed. Mater. Res. Part B: Appl. Biomater."},{"issue":"11","key":"10.1016\/j.pdpdt.2025.104687_bib0034","doi-asserted-by":"crossref","first-page":"3505","DOI":"10.3390\/jcm9113505","article-title":"Management of medication-related osteonecrosis of the jaw (MRONJ) using leukocyte- and platelet-rich fibrin (L-PRF) and photobiomodulation: a retrospective study","volume":"9","author":"Tenore","year":"2020","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.pdpdt.2025.104687_bib0035","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.pbiomolbio.2019.04.005","article-title":"Molecular impacts of photobiomodulation on bone regeneration: a systematic review","volume":"149","author":"Hosseinpour","year":"2019","journal-title":"Prog. Biophys. Mol. Biol."},{"issue":"2","key":"10.1016\/j.pdpdt.2025.104687_bib0036","doi-asserted-by":"crossref","DOI":"10.1016\/j.jebdp.2024.101983","article-title":"Is the photobiomodulation therapy effective in controlling post-surgical side effects after the extraction of mandibular third molars? a systematic review and meta-analysis","volume":"24","author":"Camolesi","year":"2024","journal-title":"J. Evid. Based. Dent. Pract."},{"key":"10.1016\/j.pdpdt.2025.104687_bib0037","doi-asserted-by":"crossref","unstructured":"Matu\u0142a A, Lizak A, Stodolak E, Bac A, Homa J, Stenka B, et al. The effect of low-level laser therapy conditions on macrophages\u2019 immunomodulatory processes as an example of regeneration process stimulation2024. 2024. doi:10.21203\/rs.3.rs-4620625\/v1.","DOI":"10.21203\/rs.3.rs-4620625\/v1"},{"issue":"15","key":"10.1016\/j.pdpdt.2025.104687_bib0038","doi-asserted-by":"crossref","first-page":"3150","DOI":"10.3390\/polym14153150","article-title":"Application of fibrin associated with photobiomodulation as a promising strategy to improve regeneration in tissue engineering: a systematic review","volume":"14","author":"Reis","year":"2022","journal-title":"Polymers. (Basel)"},{"issue":"4","key":"10.1016\/j.pdpdt.2025.104687_bib0039","first-page":"245","article-title":"The effects of photobiomodulation on leukocyte and platelet-rich fibrin as barrier membrane on bone regeneration: an experimental animal study","volume":"39","author":"Surmeli Baran","year":"2021","journal-title":"Photobiomodul. Photomed. Laser. Surg."},{"issue":"7","key":"10.1016\/j.pdpdt.2025.104687_bib0040","doi-asserted-by":"crossref","first-page":"938","DOI":"10.3390\/healthcare11070938","article-title":"Efficacy of photobiomodulation therapy in the treatment of pain and inflammation: a literature review","volume":"11","author":"Gonz\u00e1lez-Mu\u00f1oz","year":"2023","journal-title":"Healthcare (Basel)"}],"container-title":["Photodiagnosis and Photodynamic Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100025002194?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100025002194?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T08:20:40Z","timestamp":1756714840000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1572100025002194"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":40,"alternative-id":["S1572100025002194"],"URL":"https:\/\/doi.org\/10.1016\/j.pdpdt.2025.104687","relation":{},"ISSN":["1572-1000"],"issn-type":[{"value":"1572-1000","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synergistic effect of photobiomodulation and leukocyte-platelet rich fibrin on bone regeneration in rat critical defects","name":"articletitle","label":"Article Title"},{"value":"Photodiagnosis and Photodynamic Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pdpdt.2025.104687","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104687"}}