{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T18:00:06Z","timestamp":1792692006757,"version":"4.5.0"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T00:00:00Z","timestamp":1753833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019978","name":"Shanghai Pudong New Area Health Commission","doi-asserted-by":"publisher","award":["PW2022D-03"],"award-info":[{"award-number":["PW2022D-03"]}],"id":[{"id":"10.13039\/501100019978","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004921","name":"Shanghai Jiao Tong University","doi-asserted-by":"publisher","award":["YG2023ZD08"],"award-info":[{"award-number":["YG2023ZD08"]}],"id":[{"id":"10.13039\/501100004921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020737","name":"Renji Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020737","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008233","name":"School of Medicine, Shanghai Jiao Tong University","doi-asserted-by":"publisher","award":["RJPY-DZX-002"],"award-info":[{"award-number":["RJPY-DZX-002"]}],"id":[{"id":"10.13039\/501100008233","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003787","name":"Hebei Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["82072865"],"award-info":[{"award-number":["82072865"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Photodiagnosis and Photodynamic Therapy"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.pdpdt.2025.104749","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T23:49:43Z","timestamp":1753919383000},"page":"104749","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Efficacy of different 5-aminolevulinic acid photodynamic therapy regimens in managing HSIL\/CIN2 among reproductive-age women: A retrospective study"],"prefix":"10.1016","volume":"55","author":[{"given":"Luting","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingting","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anyue","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zubei","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liying","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3734-1741","authenticated-orcid":false,"given":"Lihua","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.pdpdt.2025.104749_bib0001","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"issue":"10","key":"10.1016\/j.pdpdt.2025.104749_bib0002","doi-asserted-by":"crossref","first-page":"267","DOI":"10.3390\/v9100267","article-title":"Natural history of HPV infection across the lifespan: role of viral latency","volume":"9","author":"Gravitt","year":"2017","journal-title":"Viruses."},{"issue":"13","key":"10.1016\/j.pdpdt.2025.104749_bib0003","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1002\/cncr.30667","article-title":"Cervical cancer: a global health crisis","volume":"123","author":"Jr","year":"2017","journal-title":"Cancer"},{"key":"10.1016\/j.pdpdt.2025.104749_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2022.102993","article-title":"Chinese expert consensus on the clinical applications of aminolevulinic acid-based photodynamic therapy in female lower genital tract diseases (2022)","volume":"39","author":"Qiu","year":"2022","journal-title":"Photodiagnosis. Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2025.104749_bib0005","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/j.biopha.2018.07.049","article-title":"Photodynamic therapy - mechanisms, photosensitizers and combinations","volume":"106","author":"Kwiatkowski","year":"2018","journal-title":"Biomed. PharmacOther"},{"key":"10.1016\/j.pdpdt.2025.104749_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2024.104044","article-title":"Comparison of 5-ALA-PDT and LEEP of cervical squamous intraepithelial neoplasia (CIN2) with high-risk human papillomavirus infection in childbearing age women: a non-randomized controlled polit study","volume":"46","author":"Wang","year":"2024","journal-title":"Photodiagnosis. Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2025.104749_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2024.103974","article-title":"Comparative study of topical 5-aminolevulinic acid photodynamic therapy and surgery for recurrent cervical high-grade squamous intraepithelial lesions following surgery","volume":"46","author":"Wang","year":"2024","journal-title":"Photodiagnosis. Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2025.104749_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2025.104496","article-title":"Comparison of photodynamic therapy and LEEP in women of reproductive age with cervical squamous intraepithelial neoplasia 2 (CIN2): a prospective observational study in China","volume":"52","author":"Li","year":"2025","journal-title":"Photodiagnosis. Photodyn. Ther."},{"issue":"1","key":"10.1016\/j.pdpdt.2025.104749_bib0009","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/s12985-019-1252-3","article-title":"HPV16 persistent infection and recurrent disease after LEEP","volume":"16","author":"Bruno","year":"2019","journal-title":"Virol. J."},{"issue":"5","key":"10.1016\/j.pdpdt.2025.104749_bib0010","doi-asserted-by":"crossref","first-page":"509","DOI":"10.3390\/diagnostics14050509","article-title":"Correlation of the HPV 16 genotype persistence in women undergoing LEEP for CIN3 with the risk of CIN2+ relapses in the first 18 months of follow-up: a multicenter retrospective study","volume":"14","author":"Bruno","year":"2024","journal-title":"Diagnostics"},{"issue":"5","key":"10.1016\/j.pdpdt.2025.104749_bib0011","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1097\/AOG.0b013e31828caa31","article-title":"Loop electrosurgical excision procedure and the risk for preterm delivery","volume":"121","author":"Heinonen","year":"2013","journal-title":"Obs. Gynecol."},{"issue":"1","key":"10.1016\/j.pdpdt.2025.104749_bib0012","doi-asserted-by":"crossref","DOI":"10.1080\/14767058.2023.2183769","article-title":"Association between loop electrosurgical excision procedure and adverse pregnancy outcomes: a meta-analysis","volume":"36","author":"Liu","year":"2023","journal-title":"J. Matern. Fetal. Neonatal. Med."},{"issue":"7","key":"10.1016\/j.pdpdt.2025.104749_bib0013","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1001\/jama.2018.10897","article-title":"Screening for cervical cancer: US preventive services task force recommendation statement","volume":"320","author":"Curry","year":"2018","journal-title":"JAMa"},{"issue":"10","key":"10.1016\/j.pdpdt.2025.104749_bib0014","doi-asserted-by":"crossref","first-page":"e1335","DOI":"10.1016\/S2214-109X(20)30277-1","article-title":"Domestic HPV vaccine price and economic returns for cervical cancer prevention in China: a costeffectiveness analysis","volume":"8","author":"Zou","year":"2020","journal-title":"Lancet Glob. Health"},{"issue":"5","key":"10.1016\/j.pdpdt.2025.104749_bib0015","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1002\/cam4.1321","article-title":"Significant variations in the cervical cancer screening rate in China by individual-level and geographical measures of socioeconomic status: a multilevel model analysis of a nationally representative survey dataset","volume":"7","author":"Bao","year":"2018","journal-title":"Cancer Med."},{"issue":"1","key":"10.1016\/j.pdpdt.2025.104749_bib0016","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1186\/s12905-024-03254-1","article-title":"Early Cervical Cancer Detection Consortium. Cervical cancer screening by cytology and the burden of epithelial abnormalities in low resource settings: a tertiary-center 42-year study","volume":"24","author":"Ezzelarab","year":"2024","journal-title":"BMC. Womens Health"},{"issue":"10","key":"10.1016\/j.pdpdt.2025.104749_bib0017","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.3390\/biomedicines12102255","article-title":"Effect of clinicopathological characteristics on the outcomes of topical 5-aminolevulinic acid photodynamic therapy in patients with cervical high-grade squamous intraepithelial lesions (HSIL\/CIN2): a retrospective cohort study","volume":"12","author":"Wei","year":"2024","journal-title":"Biomedicines"},{"key":"10.1016\/j.pdpdt.2025.104749_bib0018","article-title":"Progress and challenges in photodynamic therapy for cervical lesions in China","volume":"5","author":"Qiu","year":"2025","journal-title":"Gynecol. Obs. Clin. Med."},{"key":"10.1016\/j.pdpdt.2025.104749_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2025.104573","article-title":"Efficacy and safety of photodynamic therapy mediatied by 5-aminolevulinic acid for the treatment of cervical intraepithelial neoplasia 3(CIN 3): a single-center, prospective, cohort study","volume":"53","author":"Han","year":"2025","journal-title":"Photodiagnosis. Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2025.104749_bib0020","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1211114","article-title":"The effects of 5-aminolevulinic acid photodynamic therapy on the local immune response of women with cervical intraepithelial neoplasia grade 2","volume":"14","author":"Wu","year":"2023","journal-title":"Front. Immunol."}],"container-title":["Photodiagnosis and Photodynamic Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100025002819?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100025002819?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T20:49:56Z","timestamp":1759351796000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1572100025002819"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":20,"alternative-id":["S1572100025002819"],"URL":"https:\/\/doi.org\/10.1016\/j.pdpdt.2025.104749","relation":{},"ISSN":["1572-1000"],"issn-type":[{"value":"1572-1000","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy of different 5-aminolevulinic acid photodynamic therapy regimens in managing HSIL\/CIN2 among reproductive-age women: A retrospective study","name":"articletitle","label":"Article Title"},{"value":"Photodiagnosis and Photodynamic Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pdpdt.2025.104749","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104749"}}