{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T19:51:05Z","timestamp":1769802665391,"version":"3.49.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:00:00Z","timestamp":1755216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81860170"],"award-info":[{"award-number":["81860170"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Photodiagnosis and Photodynamic Therapy"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.pdpdt.2025.104766","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T08:26:20Z","timestamp":1755505580000},"page":"104766","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Quantitative analysis of microvasculature in macular and optic disc regions in keratoconus patients: A systematic review and meta-analysis"],"prefix":"10.1016","volume":"55","author":[{"given":"Ling","family":"Ling","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaichao","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiqiao","family":"Xing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7704-8438","authenticated-orcid":false,"given":"Kaibao","family":"Ji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.pdpdt.2025.104766_bib0001","doi-asserted-by":"crossref","first-page":"270","DOI":"10.3928\/1081597X-20200212-03","article-title":"A systematic review of subclinical keratoconus and Forme Fruste keratoconus","volume":"36","author":"Henriquez","year":"2020","journal-title":"J. Refract. Surg."},{"issue":"2","key":"10.1016\/j.pdpdt.2025.104766_bib0002","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1097\/ICO.0000000000002150","article-title":"The prevalence and risk factors for keratoconus: a systematic review and meta-analysis","volume":"39","author":"Hashemi","year":"2020","journal-title":"Cornea"},{"issue":"5","key":"10.1016\/j.pdpdt.2025.104766_bib0003","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1097\/01.ico.0000208820.32614.00","article-title":"Collagenolytic proteinases in keratoconus","volume":"25","author":"Mackiewicz","year":"2006","journal-title":"Cornea"},{"issue":"6","key":"10.1016\/j.pdpdt.2025.104766_bib0004","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.3390\/life13061363","article-title":"Systemic associations with keratoconus","volume":"13","author":"Unni","year":"2023","journal-title":"Life"},{"key":"10.1016\/j.pdpdt.2025.104766_bib0005","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ajo.2020.02.017","article-title":"Keratoconus screening using values derived from auto-keratometer measurements: a multicenter study","volume":"215","author":"Kojima","year":"2020","journal-title":"Am. J. Ophthalmol."},{"issue":"7","key":"10.1016\/j.pdpdt.2025.104766_bib0006","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1016\/S0161-6420(00)00159-7","article-title":"Changes in anterior and posterior corneal curvatures in keratoconus","volume":"107","author":"Tomidokoro","year":"2000","journal-title":"Ophthalmology"},{"issue":"11","key":"10.1016\/j.pdpdt.2025.104766_bib0007","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.3390\/diagnostics11112120","article-title":"Screening of keratoconus using autokeratometer and keratometer keratoconus index","volume":"11","author":"Kojima","year":"2021","journal-title":"Diagnostics."},{"issue":"3","key":"10.1016\/j.pdpdt.2025.104766_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.clae.2021.101559","article-title":"Keratoconus: an updated review","volume":"45","author":"Santodomingo-Rubido","year":"2022","journal-title":"Cont. Lens. Anterior. Eye"},{"issue":"1","key":"10.1016\/j.pdpdt.2025.104766_bib0009","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1097\/IAE.0b013e3180986299","article-title":"Central serous chorioretinopathy in patients with keratoconus","volume":"28","author":"Eandi","year":"2008","journal-title":"Retina"},{"issue":"3","key":"10.1016\/j.pdpdt.2025.104766_bib0010","doi-asserted-by":"crossref","first-page":"313","DOI":"10.22336\/rjo.2020.52","article-title":"Association of retinitis pigmentosa and advanced keratoconus in siblings","volume":"64","author":"Zemba","year":"2020","journal-title":"Rom. J. Ophthalmol."},{"issue":"3","key":"10.1016\/j.pdpdt.2025.104766_bib0011","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1167\/tvst.7.3.15","article-title":"Macular choroidal thickening in keratoconus patients: swept-source optical coherence tomography study","volume":"7","author":"Gutierrez-Bonet","year":"2018","journal-title":"Transl. Vis. Sci. Technol."},{"key":"10.1016\/j.pdpdt.2025.104766_bib0012","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/2453931","article-title":"Increased choroidal thickness in Keratoconus patients: perspectives in the disease pathophysiology","volume":"2019","author":"Pinheiro-Costa","year":"2019","journal-title":"J. Ophthalmol."},{"key":"10.1016\/j.pdpdt.2025.104766_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2024.104390","article-title":"Metrics of retinal vasculature detected on OCTA in carotid artery stenosis: a systematic review and meta-analysis","volume":"50","author":"Ji","year":"2024","journal-title":"Photodiagnosis. Photodyn. Ther."},{"issue":"1","key":"10.1016\/j.pdpdt.2025.104766_bib0014","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1177\/11206721221127770","article-title":"Evaluation of the optic nerve head and macular vessel density in keratoconus patients using optical coherence tomography angiography- a cross-sectional study","volume":"33","author":"Z\u0131rt\u0131lo\u011flu","year":"2023","journal-title":"Eur. J. Ophthalmol."},{"key":"10.1016\/j.pdpdt.2025.104766_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2022.103218","article-title":"Optic disc and retinal vessel densities assessment by optical coherence tomography angiography in patients with keratoconus","volume":"41","author":"Dogan","year":"2023","journal-title":"Photodiagnosis Photodyn Ther."},{"key":"10.1016\/j.pdpdt.2025.104766_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijsu.2021.105906","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"88","author":"Page","year":"2021","journal-title":"Int. J. Surg."},{"issue":"9","key":"10.1016\/j.pdpdt.2025.104766_bib0017","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s10654-010-9491-z","article-title":"Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses","volume":"25","author":"Stang","year":"2010","journal-title":"Eur. J. Epidemiol."},{"key":"10.1016\/j.pdpdt.2025.104766_bib0018","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/1471-2288-14-135","article-title":"Estimating the sample mean and standard deviation from the sample size, median, range and\/or interquartile range","volume":"14","author":"Wan","year":"2014","journal-title":"BMC Med. Res. Methodol."},{"issue":"6","key":"10.1016\/j.pdpdt.2025.104766_bib0019","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1177\/0962280216669183","article-title":"Optimally estimating the sample mean from the sample size, median, mid-range, and\/or mid-quartile range","volume":"27","author":"Luo","year":"2018","journal-title":"Stat. Methods Med. Res."},{"issue":"1","key":"10.1016\/j.pdpdt.2025.104766_bib0020","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-76464-0","article-title":"Retinal neurovascular assessment and choroidal vascularity index in patients with keratoconus","volume":"14","author":"Sadeghi","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.pdpdt.2025.104766_bib0021","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.ajo.2022.10.012","article-title":"New findings in early-stage keratoconus: lamina cribrosa curvature, retinal nerve Fiber layer thickness, and vascular perfusion","volume":"246","author":"Pierro","year":"2023","journal-title":"Am. J. Ophthalmol."},{"issue":"7","key":"10.1016\/j.pdpdt.2025.104766_bib0022","doi-asserted-by":"crossref","first-page":"707","DOI":"10.3390\/diagnostics14070707","article-title":"Reduced retinal blood vessel densities measured by optical coherence tomography angiography in keratoconus patients are negatively correlated with keratoconus severity","volume":"14","author":"Leclaire","year":"2024","journal-title":"Diagnostics."},{"issue":"17","key":"10.1016\/j.pdpdt.2025.104766_bib0023","doi-asserted-by":"crossref","first-page":"5111","DOI":"10.3390\/jcm13175111","article-title":"Assessment of OCT and angio-OCT parameters in keratoconus patients with and without penetrating keratoplasty","volume":"13","author":"Gadamer","year":"2024","journal-title":"J. Clin. Med."},{"issue":"10","key":"10.1016\/j.pdpdt.2025.104766_bib0024","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1136\/bjophthalmol-2017-311391","article-title":"Prevalence of keratoconus in paediatric patients in Riyadh, Saudi Arabia","volume":"102","author":"Torres Netto","year":"2018","journal-title":"Br. J. Ophthalmol."},{"issue":"4","key":"10.1016\/j.pdpdt.2025.104766_bib0025","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.jcjo.2020.03.011","article-title":"Thresholding strategies to measure vessel density by optical coherence tomography angiography","volume":"55","author":"Corvi","year":"2020","journal-title":"Can. J. Ophthalmol."},{"issue":"10","key":"10.1016\/j.pdpdt.2025.104766_bib0026","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.21037\/qims-20-340","article-title":"Evaluation of the different thresholding strategies for quantifying choriocapillaris using optical coherence tomography angiography","volume":"10","author":"Laiginhas","year":"2020","journal-title":"Quant. ImAging Med. Surg."},{"issue":"6","key":"10.1016\/j.pdpdt.2025.104766_bib0027","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1007\/s00417-020-04945-9","article-title":"A quantitative comparison of four optical coherence tomography angiography devices in healthy eyes","volume":"259","author":"Lu","year":"2021","journal-title":"Graefes. Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.pdpdt.2025.104766_bib0028","doi-asserted-by":"crossref","first-page":"93","DOI":"10.2147\/OPTH.S284872","article-title":"Repeatability of vascular density measurement of the three retinal plexus layers using OCT angiography in pathologic eyes (OCTA Vascular Density Repeatability of Three Plexus Layers)","volume":"15","author":"Mukkamala","year":"2021","journal-title":"Clin. Ophthalmol."},{"issue":"2","key":"10.1016\/j.pdpdt.2025.104766_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2025.e42099","article-title":"Retinal thickness and vascular density changes in Keratoconus: a systematic review and meta-analysis","volume":"11","author":"Vahedi","year":"2025","journal-title":"Heliyon."},{"issue":"4","key":"10.1016\/j.pdpdt.2025.104766_bib0030","doi-asserted-by":"crossref","first-page":"e303","DOI":"10.1111\/j.1755-3768.2011.02369.x","article-title":"Proteases, proteolysis and inflammatory molecules in the tears of people with keratoconus","volume":"90","author":"Balasubramanian","year":"2012","journal-title":"Acta Ophthalmol."},{"issue":"1","key":"10.1016\/j.pdpdt.2025.104766_bib0031","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1177\/11206721211000644","article-title":"Evaluation of inflammatory biomarkers in patients with keratoconus","volume":"32","author":"Oltulu","year":"2022","journal-title":"Eur. J. Ophthalmol."},{"issue":"6","key":"10.1016\/j.pdpdt.2025.104766_bib0032","doi-asserted-by":"crossref","first-page":"e777","DOI":"10.1111\/aos.14714","article-title":"Oxidative and antioxidative stress markers in keratoconus: a systematic review and meta-analysis","volume":"99","author":"Navel","year":"2021","journal-title":"Acta Ophthalmol."},{"issue":"6","key":"10.1016\/j.pdpdt.2025.104766_bib0033","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1046\/j.1442-9071.2001.d01-16.x","article-title":"The genetics of keratoconus","volume":"29","author":"Edwards","year":"2001","journal-title":"Clin. Exp. Ophthalmol."},{"issue":"8","key":"10.1016\/j.pdpdt.2025.104766_bib0034","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1080\/02713683.2022.2066698","article-title":"Microvascular retinal changes in patients with Marfan syndrome","volume":"47","author":"Rezar-Dreindl","year":"2022","journal-title":"Curr. Eye. Res."},{"key":"10.1016\/j.pdpdt.2025.104766_bib0035","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jprot.2013.05.023","article-title":"The keratoconus corneal proteome: loss of epithelial integrity and stromal degeneration","volume":"87","author":"Chaerkady","year":"2013","journal-title":"J. Proteom."},{"issue":"11","key":"10.1016\/j.pdpdt.2025.104766_bib0036","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1016\/j.bbadis.2014.07.008","article-title":"Vascular wall extracellular matrix proteins and vascular diseases","volume":"1842","author":"Xu","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"issue":"1","key":"10.1016\/j.pdpdt.2025.104766_bib0037","doi-asserted-by":"crossref","first-page":"26","DOI":"10.18240\/ijo.2021.01.04","article-title":"Changes of matrix metalloproteinases in the stroma after corneal cross-linking in rabbits","volume":"14","author":"Jia","year":"2021","journal-title":"Int. J. Ophthalmol."},{"issue":"12","key":"10.1016\/j.pdpdt.2025.104766_bib0038","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.18240\/ijo.2019.12.16","article-title":"Combined corneal CXL and photorefractive keratectomy for treatment of keratoconus: a review","volume":"12","author":"Al-Mohaimeed","year":"2019","journal-title":"Int. J. Ophthalmol."}],"container-title":["Photodiagnosis and Photodynamic Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100025002984?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100025002984?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T22:18:10Z","timestamp":1762553890000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1572100025002984"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":38,"alternative-id":["S1572100025002984"],"URL":"https:\/\/doi.org\/10.1016\/j.pdpdt.2025.104766","relation":{},"ISSN":["1572-1000"],"issn-type":[{"value":"1572-1000","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quantitative analysis of microvasculature in macular and optic disc regions in keratoconus patients: A systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Photodiagnosis and Photodynamic Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pdpdt.2025.104766","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104766"}}