{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T08:03:29Z","timestamp":1789632209731,"version":"build-2803163510"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515110487"],"award-info":[{"award-number":["2023A1515110487"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515110981"],"award-info":[{"award-number":["2023A1515110981"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515010095"],"award-info":[{"award-number":["2023A1515010095"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Photodiagnosis and Photodynamic Therapy"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.pdpdt.2026.105405","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T16:43:52Z","timestamp":1771519432000},"page":"105405","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["All-trans retinoic acid enhances the anti-angiogenic effects of hemoporfin-mediated photodynamic therapy via the ATM\u2013SerRS\u2013VEGFA axis in endothelial cells"],"prefix":"10.1016","volume":"58","author":[{"given":"Zhaohui","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhangsong","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liuping","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changxing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0369-7582","authenticated-orcid":false,"given":"Hongyan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.pdpdt.2026.105405_bib0001","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1002\/lsm.20788","article-title":"Port wine stain progression: a potential consequence of delayed and inadequate treatment?","volume":"41","author":"Minkis","year":"2009","journal-title":"Lasers Surg. Med."},{"issue":"8","key":"10.1016\/j.pdpdt.2026.105405_bib0002","doi-asserted-by":"crossref","DOI":"10.2340\/00015555-3883","article-title":"Influence of port-wine stains on quality of life of children and their parents [J]","volume":"101","author":"Jiang","year":"2021","journal-title":"Acta Derm. Venereol."},{"issue":"2","key":"10.1016\/j.pdpdt.2026.105405_bib0003","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.jaad.2015.09.063","article-title":"The somatic GNAQ mutation (R183Q) is primarily located within the blood vessels of port wine stains [J]","volume":"74","author":"Tan","year":"2016","journal-title":"J. Am. Acad. Dermatol."},{"issue":"1","key":"10.1016\/j.pdpdt.2026.105405_bib0004","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/bjd.15068","article-title":"Pathological alterations involve the entire skin physiological milieu in infantile and early-childhood port-wine stain [J]","volume":"177","author":"Tan","year":"2017","journal-title":"Br. J. Dermatol."},{"issue":"4","key":"10.1016\/j.pdpdt.2026.105405_bib0005","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.otohns.2008.07.015","article-title":"The expression of vascular endothelial growth factor and its receptors in port-wine stains [J]","volume":"139","author":"Vural","year":"2008","journal-title":"Otolaryngol. Head. Neck. Surg."},{"issue":"5","key":"10.1016\/j.pdpdt.2026.105405_bib0006","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1111\/bjd.12204","article-title":"Pulsed dye laser-resistant port-wine stains: mechanisms of resistance and implications for treatment [J]","volume":"168","author":"Savas","year":"2013","journal-title":"Br. J. Dermatol."},{"issue":"4","key":"10.1016\/j.pdpdt.2026.105405_bib0007","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1111\/1346-8138.15238","article-title":"Retrospective study of photodynamic therapy for pulsed dye laser-resistant port-wine stains [J]","volume":"47","author":"Han","year":"2020","journal-title":"J. Dermatol."},{"key":"10.1016\/j.pdpdt.2026.105405_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2021.102568","article-title":"Efficacy and safety of hemoporfin photodynamic therapy for port-wine stains in paediatric patients: A retrospective study of 439 cases at a single centre [J]","volume":"36","author":"Chun-Hua","year":"2021","journal-title":"Photodiagnosis. Photodyn. Ther."},{"issue":"1","key":"10.1016\/j.pdpdt.2026.105405_bib0009","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s10103-018-2649-8","article-title":"Effect of 410 nm photodynamic therapy with hemoporfin on the expression of vascular endothelial growth factor (VEGF) in cultured human vascular endothelial cells [J]","volume":"34","author":"Ma","year":"2019","journal-title":"Lasers. Med. Sci."},{"key":"10.1016\/j.pdpdt.2026.105405_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2020.101793","article-title":"Effect of 532 nm photodynamic therapy with hemoporfin on the expression of vascular endothelial growth factor in cultured human vascular endothelial cells [J]","volume":"30","author":"Dong","year":"2020","journal-title":"Photodiagnosis. Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2026.105405_bib0011","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.02349","article-title":"tRNA synthetase counteracts c-myc to develop functional vasculature [J]","volume":"3","author":"Shi","year":"2014","journal-title":"Elife"},{"key":"10.1016\/j.pdpdt.2026.105405_bib0012","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/s41392-019-0078-1","article-title":"Seryl tRNA synthetase cooperates with POT1 to regulate telomere length and cellular senescence [J]","volume":"4","author":"Li","year":"2019","journal-title":"Signal. Transduct. Target. Ther."},{"issue":"12","key":"10.1016\/j.pdpdt.2026.105405_bib0013","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3000991","article-title":"Phosphorylation of seryl-tRNA synthetase by ATM\/ATR is essential for hypoxia-induced angiogenesis [J]","volume":"18","author":"Shi","year":"2020","journal-title":"PLoS. Biol."},{"issue":"15","key":"10.1016\/j.pdpdt.2026.105405_bib0014","doi-asserted-by":"crossref","first-page":"6839","DOI":"10.7150\/thno.43622","article-title":"Herb-sourced emodin inhibits angiogenesis of breast cancer by targeting VEGFA transcription [J]","volume":"10","author":"Zou","year":"2020","journal-title":"Theranostics."},{"issue":"12","key":"10.1016\/j.pdpdt.2026.105405_bib0015","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.3390\/cancers11121847","article-title":"Targeting angiogenesis by blocking the ATM-SerRS-VEGFA pathway for UV-induced skin photodamage and melanoma growth [J]","volume":"11","author":"Song","year":"2019","journal-title":"Cancers. (Basel)"},{"issue":"47","key":"10.1016\/j.pdpdt.2026.105405_bib0016","doi-asserted-by":"crossref","first-page":"7305","DOI":"10.1038\/sj.onc.1206936","article-title":"Retinoids in cancer therapy and chemoprevention: promise meets resistance [J]","volume":"22","author":"Freemantle","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.pdpdt.2026.105405_bib0017","doi-asserted-by":"crossref","DOI":"10.1038\/celldisc.2017.36","article-title":"Retinoic acid induces white adipose tissue browning by increasing adipose vascularity and inducing beige adipogenesis of pdgfr\u03b1+ adipose progenitors [J]","volume":"3","author":"Wang","year":"2017","journal-title":"Cell Discov."},{"issue":"4","key":"10.1016\/j.pdpdt.2026.105405_bib0018","article-title":"All-trans retinoic acid suppresses the angiopoietin-Tie2 pathway and inhibits angiogenesis and metastasis in esophageal squamous cell carcinoma [J]","volume":"12","author":"Li","year":"2017","journal-title":"PLoS. One"},{"key":"10.1016\/j.pdpdt.2026.105405_bib0019","article-title":"Recent advances of anti-angiogenic inhibitors targeting VEGF\/VEGFR axis","volume":"14","author":"Zhang","year":"2023","journal-title":"Front. Pharmacol."},{"issue":"4","key":"10.1016\/j.pdpdt.2026.105405_bib0020","first-page":"250","article-title":"Photodynamic therapy of cancer: an update [J]","volume":"61","author":"Agostinis","year":"2011","journal-title":"CA Cancer J. Clin."},{"issue":"9","key":"10.1016\/j.pdpdt.2026.105405_bib0021","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.3390\/pharmaceutics13091332","article-title":"Photodynamic Therapy review: principles, photosensitizers, applications, and future directions [J]","volume":"13","author":"Correia","year":"2021","journal-title":"Pharmaceutics."},{"key":"10.1016\/j.pdpdt.2026.105405_bib0022","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jphotobiol.2019.03.012","article-title":"5-aminolevulinic acid photodynamic therapy reduces HPV viral load via autophagy and apoptosis by modulating Ras\/raf\/MEK\/ERK and PI3K\/AKT pathways in HeLa cells [J]","volume":"194","author":"Xie","year":"2019","journal-title":"J. Photochem. Photobiol. B"},{"issue":"1","key":"10.1016\/j.pdpdt.2026.105405_bib0023","first-page":"53","article-title":"Angiogenesis inhibition for the improvement of photodynamic therapy: the revival of a promising idea [J]","volume":"1826","author":"Weiss","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.pdpdt.2026.105405_bib0024","article-title":"Hemoporfin-mediated photodynamic therapy for port-wine stains: multivariate analysis of clinical efficacy and optical coherence tomography appearance","volume":"9","author":"Lin","year":"2022","journal-title":"Front. Med. (Lausanne)"},{"key":"10.1016\/j.pdpdt.2026.105405_bib0025","article-title":"Real-world cohort] Hemoporfin-mediated photodynamic therapy for the treatment of port-wine stains: a real-life efficacy and safety study","year":"2023","journal-title":"Photodiagnosis. Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2026.105405_bib0026","article-title":"Lin-type study on extremity lesions: hemoporfin-mediated photodynamic therapy for port-wine stains on the extremities: efficacy and safety analysis","year":"2023","journal-title":"Dermatol. Ther. (Heidelb)"},{"issue":"1","key":"10.1016\/j.pdpdt.2026.105405_bib0027","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.intimp.2015.05.025","article-title":"Low dose photodynamic-therapy induce immune escape of tumor cells in a HIF-1\u03b1 dependent manner through PI3K\/Akt pathway [J]","volume":"28","author":"Wan","year":"2015","journal-title":"Int. Immunopharmacol."},{"issue":"5","key":"10.1016\/j.pdpdt.2026.105405_bib0028","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.apsb.2015.05.007","article-title":"HIF-1\u03b1 pathway: role, regulation and intervention for cancer therapy [J]","volume":"5","author":"Masoud","year":"2015","journal-title":"Acta Pharm. Sin. B"},{"issue":"1","key":"10.1016\/j.pdpdt.2026.105405_bib0029","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nrc3183","article-title":"HIF1\u03b1 and HIF2\u03b1: sibling rivalry in hypoxic tumour growth and progression [J]","volume":"12","author":"Keith","year":"2011","journal-title":"Nat. Rev. Cancer"},{"issue":"21","key":"10.1016\/j.pdpdt.2026.105405_bib0030","doi-asserted-by":"crossref","first-page":"7381","DOI":"10.1128\/MCB.00440-07","article-title":"Hypoxia-inducible factor 1 and dysregulated c-myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1 [J]","volume":"27","author":"Kim","year":"2007","journal-title":"Mol. Cell Biol."},{"issue":"3","key":"10.1016\/j.pdpdt.2026.105405_bib0031","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1074\/jbc.M112.401554","article-title":"Hypoxia-inducible Factor-1 (HIF-1)-independent hypoxia response of the small heat shock protein hsp-16.1 gene regulated by chromatin remodeling factors in the nematode Caenorhabditis elegans [J]","volume":"288","author":"Lee","year":"2013","journal-title":"J. Biol. Chem."},{"issue":"20","key":"10.1016\/j.pdpdt.2026.105405_bib0032","doi-asserted-by":"crossref","first-page":"13957","DOI":"10.1074\/jbc.M511763200","article-title":"Hypoxic regulation of vascular endothelial growth factor through the induction of phosphatidylinositol 3-kinase\/Rho\/ROCK and c-Myc [J]","volume":"281","author":"Mizukami","year":"2006","journal-title":"J. Biol. Chem."}],"container-title":["Photodiagnosis and Photodynamic Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100026000724?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100026000724?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T07:16:20Z","timestamp":1789629380000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1572100026000724"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":32,"alternative-id":["S1572100026000724"],"URL":"https:\/\/doi.org\/10.1016\/j.pdpdt.2026.105405","relation":{},"ISSN":["1572-1000"],"issn-type":[{"value":"1572-1000","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"All-trans retinoic acid enhances the anti-angiogenic effects of hemoporfin-mediated photodynamic therapy via the ATM\u2013SerRS\u2013VEGFA axis in endothelial cells","name":"articletitle","label":"Article Title"},{"value":"Photodiagnosis and Photodynamic Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pdpdt.2026.105405","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"105405"}}