{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T12:36:47Z","timestamp":1793018207824,"version":"4.5.0"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Photodiagnosis and Photodynamic Therapy"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.pdpdt.2026.105502","type":"journal-article","created":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T15:20:53Z","timestamp":1777735253000},"page":"105502","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Efficacy and safety of sonidegib combined with photodynamic therapy in basal cell carcinoma: A retrospective case series of 7 patients"],"prefix":"10.1016","volume":"59","author":[{"given":"Jiaxi","family":"Lai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaixin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyuan","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiyan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoshuang","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwen","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renliang","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqin","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongfeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongyi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pdpdt.2026.105502_bib0001","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ejca.2019.06.003","article-title":"Diagnosis and treatment of basal cell carcinoma: european consensus-based interdisciplinary guidelines","volume":"118","author":"Peris","year":"2019","journal-title":"Eur. J. Cancer Oxf. Engl."},{"key":"10.1016\/j.pdpdt.2026.105502_bib0002","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.jaad.2022.03.023","article-title":"Advanced basal cell carcinoma: what dermatologists need to know about diagnosis","volume":"86","author":"Krakowski","year":"2022","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.pdpdt.2026.105502_bib0003","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1111\/ddg.14580","article-title":"Known and new facts on basal cell carcinoma","volume":"19","author":"Seidl-Philipp","year":"2021","journal-title":"J. Dtsch. Dermatol. Ges."},{"key":"10.1016\/j.pdpdt.2026.105502_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.216821","article-title":"Treatments on the horizon for locally advanced basal cell carcinoma","volume":"589","author":"Idriss","year":"2024","journal-title":"Cancer Lett."},{"key":"10.1016\/j.pdpdt.2026.105502_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.esmoop.2023.102037","article-title":"Guidelines for the diagnosis and treatment of basal cell carcinoma: a GRADE approach for evidence evaluation and recommendations by the Italian Association of Medical Oncology","volume":"8","author":"Queirolo","year":"2023","journal-title":"ESMo Open."},{"key":"10.1016\/j.pdpdt.2026.105502_bib0006","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ejca.2022.09.013","article-title":"Safety and efficacy of nivolumab, an anti-PD1 immunotherapy, in patients with advanced basal cell carcinoma, after failure or intolerance to sonic Hedgehog inhibitors: UNICANCER AcS\u00e9 NIVOLUMAB trial","volume":"177","author":"V\u00e9ron","year":"2022","journal-title":"Eur. J. Cancer Oxf. Engl."},{"key":"10.1016\/j.pdpdt.2026.105502_bib0007","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.6004\/jnccn.2023.0056","article-title":"Basal Cell Skin Cancer, Version 2.2024, NCCN Clinical Practice Guidelines in oncology","volume":"21","author":"Schmults","year":"2023","journal-title":"J. Natl. Compr. Cancer Netw. JNCCN"},{"key":"10.1016\/j.pdpdt.2026.105502_bib0008","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.ijrobp.2024.09.034","article-title":"Definitive radiation therapy is a viable treatment for locally advanced basal cell carcinoma otherwise requiring radical or disfiguring resection","volume":"121","author":"Su","year":"2025","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.pdpdt.2026.105502_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2021.100844","article-title":"Vismodegib in neoadjuvant treatment of locally advanced basal cell carcinoma: first results of a multicenter, open-label, phase 2 trial (VISMONEO study): neoadjuvant Vismodegib in locally advanced basal cell carcinoma","volume":"35","author":"Bertrand","year":"2021","journal-title":"EClinicalMedicine"},{"key":"10.1016\/j.pdpdt.2026.105502_bib0010","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/s41416-021-01506-7","article-title":"Machine-learning algorithm to predict multidisciplinary team treatment recommendations in the management of basal cell carcinoma","volume":"126","author":"Andrew","year":"2022","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.pdpdt.2026.105502_bib0011","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1111\/jdv.18070","article-title":"Analysis of efficacy and safety of vismodegib therapy in patients with advanced basal cell carcinoma \u2013 real world multicenter cohort study","volume":"36","author":"S\u0142owi\u0144ska","year":"2022","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"10.1016\/j.pdpdt.2026.105502_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.critrevonc.2023.104066","article-title":"Long-term strategies for management of advanced basal cell carcinoma with hedgehog inhibitors","volume":"189","author":"Bossi","year":"2023","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.pdpdt.2026.105502_bib0013","article-title":"Photodynamic therapy: overview and mechanism of action","author":"Austin","year":"2025","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.pdpdt.2026.105502_bib0014","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1476228","article-title":"Applications and challenges of photodynamic therapy in the treatment of skin malignancies","volume":"15","author":"Hua","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.pdpdt.2026.105502_bib0015","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s40257-023-00829-w","article-title":"Photodynamic therapy in treating a subset of basal cell carcinoma: strengths, shortcomings, comparisons with surgical modalities, and potential role as adjunctive therapy","volume":"25","author":"Chen","year":"2024","journal-title":"Am. J. Clin. Dermatol."},{"key":"10.1016\/j.pdpdt.2026.105502_bib0016","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1016\/j.jaad.2025.08.031","article-title":"Red light photodynamic therapy with 10% aminolevulinic acid gel showed efficacy for treatment of superficial basal cell carcinoma in a randomized, vehicle controlled, double-blind, multicenter phase III study","volume":"93","author":"Schlesinger","year":"2025","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.pdpdt.2026.105502_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2025.104959","article-title":"Exploration of non-surgical treatments for basal cell carcinoma: clinical application of sonidegib in combination with photodynamic therapy","volume":"56","author":"Chen","year":"2025","journal-title":"Photodiagnosis. Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2026.105502_bib0018","unstructured":"S.Ting Zhang, Response evaluation criteria practice for skin cancer by RECIST 1.1, or modified World Health Organization (WHO) criteria or composite criteria. (Paper SA-142) PharmaSUG China, 2023. https:\/\/www.pharmasug.com.cn\/resources\/2023\/2023-08\/Pharmasug-China-2023-SA142.pdf."},{"key":"10.1016\/j.pdpdt.2026.105502_bib0019","unstructured":"U.S. Department of Health and Human Services, National Institutes of Health, National Cancer Institute. Common Terminology Criteria for Adverse Events (CTCAE) version 5.0. Bethesda, MD; 2017. https:\/\/ctep.cancer.gov\/protocoldevelopment\/electronic_applications\/docs\/CTCAE_v5_Quick_Reference_8.5x11.pdf (accessed 7 May 2026)."},{"key":"10.1016\/j.pdpdt.2026.105502_bib0020","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s40257-023-00763-x","article-title":"Efficacy and safety of Sonic hedgehog inhibitors in basal cell carcinomas: an updated systematic review and meta-analysis (2009-2022)","volume":"24","author":"Nguyen","year":"2023","journal-title":"Am. J. Clin. Dermatol."},{"key":"10.1016\/j.pdpdt.2026.105502_bib0021","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1111\/jdv.16017","article-title":"European dermatology forum guidelines on topical photodynamic therapy 2019 part 1: treatment delivery and established indications \u2013 actinic keratoses, bowen\u2019s disease and basal cell carcinomas","volume":"33","author":"Morton","year":"2019","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"10.1016\/j.pdpdt.2026.105502_bib0022","doi-asserted-by":"crossref","first-page":"147","DOI":"10.4103\/ijd.IJD_165_17","article-title":"Conventional versus giant basal cell carcinoma, a review of 57 cases: histologic differences contributing to excessive growth","volume":"63","author":"Purnell","year":"2018","journal-title":"Indian J. Dermatol."},{"key":"10.1016\/j.pdpdt.2026.105502_bib0023","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1111\/jdv.19806","article-title":"Dynamic optical coherence tomography evaluation in locally advanced basal cell carcinoma during sonidegib treatment","volume":"38","author":"Cantisani","year":"2024","journal-title":"J. Eur. Acad. Dermatol. Venereol. JEADV"},{"key":"10.1016\/j.pdpdt.2026.105502_bib0024","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.pdpdt.2017.10.028","article-title":"Combination vismodegib and photodynamic therapy for multiple basal cell carcinomas","volume":"21","author":"Rizzo","year":"2018","journal-title":"Photodiagnosis. Photodyn. Ther."},{"key":"10.1016\/j.pdpdt.2026.105502_bib0025","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/lsm.20860","article-title":"Fractional CO(2) laser-assisted drug delivery","volume":"42","author":"Haedersdal","year":"2010","journal-title":"Lasers. Surg. Med."},{"key":"10.1016\/j.pdpdt.2026.105502_bib0026","first-page":"1202","article-title":"Fractional carbon dioxide laser improves nodular basal cell carcinoma treatment with photodynamic therapy with methyl 5-aminolevulinate","volume":"39","author":"Lippert","year":"2013","journal-title":"Dermatol. Surg. Off. Publ. Am. Soc. Dermato.l Surg. Al."},{"key":"10.1016\/j.pdpdt.2026.105502_bib0027","doi-asserted-by":"crossref","first-page":"156","DOI":"10.36849\/JDD.5657","article-title":"A review of hedgehog inhibitors sonidegib and vismodegib for treatment of advanced basal cell carcinoma","volume":"20","author":"Migden","year":"2021","journal-title":"J. Drugs Dermatol. JDD"},{"key":"10.1016\/j.pdpdt.2026.105502_bib0028","article-title":"Disproportionality analysis comparing safety profiles of sonidegib and vismodegib based on the FAERS database","volume":"15","author":"Zheng","year":"2025","journal-title":"Sci. Rep."}],"container-title":["Photodiagnosis and Photodynamic Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100026001699?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1572100026001699?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T12:19:14Z","timestamp":1793017154000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1572100026001699"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":28,"alternative-id":["S1572100026001699"],"URL":"https:\/\/doi.org\/10.1016\/j.pdpdt.2026.105502","relation":{},"ISSN":["1572-1000"],"issn-type":[{"value":"1572-1000","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy and safety of sonidegib combined with photodynamic therapy in basal cell carcinoma: A retrospective case series of 7 patients","name":"articletitle","label":"Article Title"},{"value":"Photodiagnosis and Photodynamic Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pdpdt.2026.105502","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"105502"}}