{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:33:47Z","timestamp":1760146427839,"version":"build-2065373602"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","pediatricnursing.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pediatric Nursing"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.pedn.2021.06.012","type":"journal-article","created":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T20:12:21Z","timestamp":1626293541000},"page":"215-222","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["A Quality Improvement Project to Reduce Antibiotic Utilization and Ancillary Laboratory Tests in the Appraisal of Early-Onset Sepsis in the NICU"],"prefix":"10.1016","volume":"60","author":[{"suffix":"Jr","given":"C. Martin","family":"Begnaud","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Lemoine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Broussard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger","family":"Rholdon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harshit","family":"Doshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pedn.2021.06.012_bb0005","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1007\/s00431-018-3113-2","article-title":"Sepsis calculator implementation reduces empiric antibiotics for suspected early- onset sepsis","volume":"177","author":"Achten","year":"2018","journal-title":"European Journal of Pediatrics"},{"issue":"1","key":"10.1016\/j.pedn.2021.06.012_bb0010","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1001\/jamapediatrics.2019.2825","article-title":"Associate of use of the neonatal early onset sepsis calculator with reduction in antibiotic therapy and safety: A systemic review and meta-analysis","volume":"173","author":"Achten","year":"2019","journal-title":"JAMA Pediatrics"},{"issue":"3","key":"10.1016\/j.pedn.2021.06.012_bb0015","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.jpeds.2011.02.035","article-title":"Antibiotic exposure in the newborn intensive care unit and the risk of necrotizing enterocolitis","volume":"159","author":"Alexander","year":"2011","journal-title":"The Journal of Pediatrics"},{"author":"American Society for Microbiology","key":"10.1016\/j.pedn.2021.06.012_bb0020"},{"issue":"10","key":"10.1016\/j.pedn.2021.06.012_bb0025","doi-asserted-by":"crossref","first-page":"e51","DOI":"10.1093\/cid\/ciw118","article-title":"Implementing an antibiotic stewardship program: Guidelines by the infectious disease Society of America and the Society for Healthcare Epidemiology of America","volume":"62","author":"Barlam","year":"2016","journal-title":"Clinical Infectious Diseases"},{"issue":"4","key":"10.1016\/j.pedn.2021.06.012_bb9052","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/s41372-018-0041-y","article-title":"Reducing antibiotic utilization rate in preterm infants: A quality improvement initiative","volume":"38","author":"Bhat","year":"2018","journal-title":"Journal of Perinatology"},{"issue":"4","key":"10.1016\/j.pedn.2021.06.012_bb0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1542\/peds.2017-0044","article-title":"Ending the culture of culture-negative sepsis in the neonatal icu","volume":"140","author":"Cantey","year":"2017","journal-title":"Pediatrics"},{"issue":"10","key":"10.1016\/j.pedn.2021.06.012_bb0035","first-page":"1178","article-title":"Reducing unnecessary antibiotic use in the neonatal intensive care unit (scout): A prospective interrupted time- series study","volume":"16","author":"Cantey","year":"2016","journal-title":"The Lancet: Infectious Disease"},{"author":"Centers for Disease Control and Prevention","key":"10.1016\/j.pedn.2021.06.012_bb0040"},{"issue":"118","key":"10.1016\/j.pedn.2021.06.012_bb9050","first-page":"1","article-title":"Prevalence of early-onset neonatal infection among newborns of mothers with bacterial infection or colonization: A systemic review and meta-analysis","volume":"15","author":"Chan","year":"2015","journal-title":"BMC Infectious Diseases"},{"issue":"1","key":"10.1016\/j.pedn.2021.06.012_bb9049","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1542\/peds.2005-0179","article-title":"Empiric use of ampicillin and cefotaxime, compared with ampicillin and gentamicin, for neonates at risk for sepsis is associated with an increased risk of neonatal death","volume":"117","author":"Clark","year":"2006","journal-title":"Pediatrics"},{"issue":"1","key":"10.1016\/j.pedn.2021.06.012_bb0050","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.clp.2014.10.007","article-title":"Antibiotic stewardship: Reassessment of guidelines for management of neonatal sepsis","volume":"42","author":"Cotten","year":"2015","journal-title":"Clinics in Perinatology"},{"issue":"2","key":"10.1016\/j.pedn.2021.06.012_bb0055","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1542\/peds.2005-2677","article-title":"The association of third-generation cephalosporin use and invasive candidiasis in extremely-low--birth-weight infants","volume":"118","author":"Cotten","year":"2006","journal-title":"Pediatrics"},{"issue":"1","key":"10.1016\/j.pedn.2021.06.012_bb0060","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1542\/peds.2007-3423","article-title":"Prolonged duration of initial empirical antibiotic treatment is associated with increased rates of necrotizing enterocolitis and death for extremely low- birth-weight infants","volume":"123","author":"Cotten","year":"2009","journal-title":"Pediatrics"},{"issue":"5","key":"10.1016\/j.pedn.2021.06.012_bb0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1542\/hpeds.2017-0180","article-title":"Implementation of the sepsis risk calculator at an academic birth hospital","volume":"8","author":"Dhudasia","year":"2018","journal-title":"Hospital Pediatrics"},{"issue":"3","key":"10.1016\/j.pedn.2021.06.012_bb0075","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2015-0312","article-title":"Evidence, quality and waste: Solving the value in neonatology","volume":"137","author":"Dukhovny","year":"2016","journal-title":"Pediatrics"},{"issue":"1","key":"10.1016\/j.pedn.2021.06.012_bb0080","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1542\/peds.2013-1689","article-title":"Stratification of risk of early-onset sepsis in newborns \u2265 34 weeks\u2019 gestation","volume":"133","author":"Escobar","year":"2014","journal-title":"Pediatrics"},{"issue":"3","key":"10.1016\/j.pedn.2021.06.012_bb0085","doi-asserted-by":"crossref","first-page":"s120","DOI":"10.1097\/01.PCC.0000161583.34305.A0","article-title":"Physicians\u2019 ability to diagnose sepsis in newborns and critically ill children","volume":"6","author":"Fischer","year":"2005","journal-title":"Pediatric Critical Care Medicine"},{"issue":"1","key":"10.1016\/j.pedn.2021.06.012_bb0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/INF.0000000000000906","article-title":"Early-onset sepsis and antibiotic exposure in term infants: A nationwide population-based study in Norway","volume":"35","author":"Fjalstad","year":"2016","journal-title":"Pediatric Infectious Disease Journal"},{"issue":"2","key":"10.1016\/j.pedn.2021.06.012_bb0095","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.idc.2016.02.012","article-title":"The evolving role of antimicrobial stewardship in management of multidrug resistant infections","volume":"30","author":"Goff","year":"2016","journal-title":"Infectious Disease Clinics of North America"},{"issue":"1","key":"10.1016\/j.pedn.2021.06.012_bb0100","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jpeds.2014.01.010","article-title":"Early empiric antibiotic use in preterm infants is associated with lower bacterial diversity and higher relative abundance of enterobacter","volume":"165","author":"Greenwood","year":"2014","journal-title":"Journal of Pediatrics"},{"issue":"50","key":"10.1016\/j.pedn.2021.06.012_bb0105","first-page":"1","article-title":"Knowledge translation of research findings","volume":"7","author":"Grimshaw","year":"2012","journal-title":"Implementation Science"},{"issue":"2","key":"10.1016\/j.pedn.2021.06.012_bb0110","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1542\/peds.2015-0737","article-title":"Choosing wisely in newborn medicine; five opportunities to increase value","volume":"136","author":"Ho","year":"2015","journal-title":"Pediatrics"},{"issue":"2","key":"10.1016\/j.pedn.2021.06.012_bb0115","doi-asserted-by":"crossref","first-page":"s69","DOI":"10.1016\/S0378-3782(12)70019-1","article-title":"Early and late onset sepsis in very-low-birth-weight infants from a large group of neonatal intensive care units","volume":"88","author":"Hornik","year":"2012","journal-title":"Early Human Development"},{"issue":"23","key":"10.1016\/j.pedn.2021.06.012_bb0120","doi-asserted-by":"crossref","first-page":"3860","DOI":"10.3109\/14767058.2016.1149563","article-title":"Application of sepsis calculator in newborns with suspected infection","volume":"29","author":"Kerste","year":"2016","journal-title":"The Journal of Maternal-Fetal and Neonatal Medicine"},{"issue":"3","key":"10.1016\/j.pedn.2021.06.012_bb0125","first-page":"356","article-title":"Measuring advance practice nursing outcomes","volume":"10","author":"Kleinpell-Novell","year":"1999","journal-title":"American Association of Critical Care Nurses Clinical Issues"},{"issue":"1","key":"10.1016\/j.pedn.2021.06.012_bb0130","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1177\/1062860617741437","article-title":"Improved newborn care: Evidence-based protocol for the evaluation and management of early-onset-sepsis","volume":"33","author":"Klingman","year":"2018","journal-title":"American Journal of Medical Quality"},{"issue":"5","key":"10.1016\/j.pedn.2021.06.012_bb0135","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.jpeds.2011.05.033","article-title":"Prolonged initial empirical antibiotic treatment is associated with adverse outcomes in premature infants","volume":"159","author":"Kuppala","year":"2011","journal-title":"Journal of Pediatrics"},{"author":"Lamorte","key":"10.1016\/j.pedn.2021.06.012_bb0140"},{"key":"10.1016\/j.pedn.2021.06.012_bb9053","doi-asserted-by":"crossref","DOI":"10.1136\/bmjoq-2017-000285","article-title":"Managing antiobiotics wisely: A quality improvement programme in a tertiary neonatal unit in the UK","volume":"7","author":"Makri","year":"2018","journal-title":"BMJ Open Quality"},{"year":"2017","series-title":"Antibiotic days with negative cultures [Clinical Data Warehouse file]","author":"Mednax PSO, LLC","key":"10.1016\/j.pedn.2021.06.012_bb1000"},{"author":"Mednax PSO, LLC","key":"10.1016\/j.pedn.2021.06.012_bb0145"},{"author":"Mednax PSO, LLC","key":"10.1016\/j.pedn.2021.06.012_bb0150"},{"author":"National Institute for Health and Care Excellence","key":"10.1016\/j.pedn.2021.06.012_bb0160"},{"issue":"7","key":"10.1016\/j.pedn.2021.06.012_bb0165","first-page":"640","article-title":"Patterns of empiric antibiotic administration for presumed early-onset neonatal sepsis in neonatal intensive care units in the United States","volume":"34","author":"Oliver","year":"2017","journal-title":"American Journal of Perinatology"},{"key":"10.1016\/j.pedn.2021.06.012_bb0170","series-title":"Hot Topics in Neonatology. Symposium Conducted at the Meeting of the American Academy of Pediatrics in Washington, D. C","article-title":"An evidence-based approach to early-onset sepsis: Finding a needle in a haystack","author":"Polin","year":"2017"},{"issue":"5","key":"10.1016\/j.pedn.2021.06.012_bb0175","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1542\/peds.2012-0541","article-title":"Management of neonates with suspected or proven early-onset bacterial sepsis","volume":"129","author":"Polin","year":"2012","journal-title":"Pediatrics"},{"key":"10.1016\/j.pedn.2021.06.012_bb0180","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1542\/peds.2014-0360","article-title":"The conundrum of early onset sepsis","volume":"133","author":"Polin","year":"2014","journal-title":"Pediatrics"},{"issue":"6","key":"10.1016\/j.pedn.2021.06.012_bb0185","first-page":"1","article-title":"Management of neonates born at 35 0\/7 weeks\u2019 gestation with suspected or proven early- onset bacterial sepsis","volume":"142","author":"Puopolo","year":"2018","journal-title":"Pediatrics"},{"issue":"2","key":"10.1016\/j.pedn.2021.06.012_bb0190","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1542\/peds.2019-1881","article-title":"Management of infants at risk for group b streptococcus disease","volume":"144","author":"Puopolo","year":"2019","journal-title":"Pediatrics"},{"issue":"5","key":"10.1016\/j.pedn.2021.06.012_bb0195","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.siny.2017.07.001","article-title":"Antibiotic stewardship in perinatal and neonatal care","volume":"22","author":"Ramasethu","year":"2017","journal-title":"Seminars in Fetal and Neonatal Medicine"},{"year":"1983","series-title":"Diffusion of innovations","author":"Rogers","key":"10.1016\/j.pedn.2021.06.012_bb0200"},{"issue":"6","key":"10.1016\/j.pedn.2021.06.012_bb0210","first-page":"s55","article-title":"Diffusion of innovation theory for clinical change","volume":"180","author":"Sanson-Fisher","year":"2004","journal-title":"The Medical Journal of Australia"},{"issue":"6","key":"10.1016\/j.pedn.2021.06.012_bb0215","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1542\/peds.2016-2013","article-title":"Epidemiology of invasive early-onset neonatal sepsis, 2005-2014","volume":"138","author":"Schrag","year":"2016","journal-title":"Pediatrics"},{"issue":"5","key":"10.1016\/j.pedn.2021.06.012_bb0220","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1542\/peds.2014-3409","article-title":"Neonatal intensive care unit antibiotic use","volume":"135","author":"Schulman","year":"2015","journal-title":"Pediatrics"},{"author":"Setiawan","key":"10.1016\/j.pedn.2021.06.012_bb0225"},{"issue":"1","key":"10.1016\/j.pedn.2021.06.012_bb0230","first-page":"1","article-title":"Neonatal sepsis calculator in reduction of antibiotics use in eos (early onset sepsis)","volume":"142","author":"Simpson","year":"2018","journal-title":"Pediatrics"},{"issue":"3","key":"10.1016\/j.pedn.2021.06.012_bb0235","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1542\/peds.2009-2959","article-title":"Neonatal outcomes of extremely preterm infants from the nichd neonatal research network","volume":"126","author":"Stoll","year":"2010","journal-title":"Pediatrics"},{"issue":"5","key":"10.1016\/j.pedn.2021.06.012_bb0240","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1542\/peds.2010-2217","article-title":"Early onset neonatal sepsis: The burden of group b streptococcal and e. coli disease continues","volume":"125","author":"Stoll","year":"2011","journal-title":"Pediatrics"},{"issue":"2","key":"10.1016\/j.pedn.2021.06.012_bb0245","first-page":"105","article-title":"Implementation of an automatic stop order and initial antibiotic exposure in very low birth weight infants","volume":"34","author":"Tolia","year":"2017","journal-title":"American Journal of Perinatology"},{"issue":"1","key":"10.1016\/j.pedn.2021.06.012_bb0250","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.clp.2011.12.003","article-title":"Antibiotic use and misuse in the neonatal intensive care unit","volume":"39","author":"Tripathi","year":"2012","journal-title":"Clinics in Perinatology"},{"issue":"11","key":"10.1016\/j.pedn.2021.06.012_bb0260","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1097\/INF.0b013e318223bad2","article-title":"The burden of invasive early-onset neonatal sepsis in the United States, 20052008","volume":"10","author":"Weston","year":"2011","journal-title":"Pediatric Infectious Disease Journal"},{"issue":"6","key":"10.1016\/j.pedn.2021.06.012_bb0265","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1097\/PCC.0000000000000157","article-title":"Time for a neonatal-specific consensus definition for sepsis","volume":"15","author":"Wynn","year":"2014","journal-title":"Pediatric Critical Care Medicine"}],"container-title":["Journal of Pediatric Nursing"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882596321001834?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882596321001834?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:25:17Z","timestamp":1760113517000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882596321001834"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":53,"alternative-id":["S0882596321001834"],"URL":"https:\/\/doi.org\/10.1016\/j.pedn.2021.06.012","relation":{},"ISSN":["0882-5963"],"issn-type":[{"type":"print","value":"0882-5963"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Quality Improvement Project to Reduce Antibiotic Utilization and Ancillary Laboratory Tests in the Appraisal of Early-Onset Sepsis in the NICU","name":"articletitle","label":"Article Title"},{"value":"Journal of Pediatric Nursing","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pedn.2021.06.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}