{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T23:08:01Z","timestamp":1788822481847,"version":"build-2803163510"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","pediatricnursing.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pediatric Nursing"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.pedn.2026.07.022","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T20:49:34Z","timestamp":1784666974000},"page":"627-640","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["The impact of different types of play interventions on anxiety and depressive symptoms in children with cancer: A systematic review and meta-analysis"],"prefix":"10.1016","volume":"90","author":[{"given":"Ying","family":"Xiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengfeng","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuyue","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiting","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaorong","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.pedn.2026.07.022_bb0005","first-page":"1388","article-title":"Impact of incentive-based game therapy and transporting children on toy vehicle to operation theatre on reducing anxiety prior to induction of anesthesia","volume":"73","author":"Akhtar","year":"2023","journal-title":"Journal of the Pakistan Medical Association"},{"key":"10.1016\/j.pedn.2026.07.022_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejon.2025.103037","article-title":"The effects of digital games on pain, fear, anxiety, and physiological responses in children during port catheter needle insertion: A randomized controlled study","volume":"80","author":"Azak","year":"2026","journal-title":"European Journal of Oncology Nursing"},{"issue":"2","key":"10.1016\/j.pedn.2026.07.022_bb0015","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.appdev.2012.11.004","article-title":"What do children and adolescents say they do during video game play?","volume":"34","author":"Blumberg","year":"2013","journal-title":"Journal of Applied Developmental Psychology"},{"key":"10.1016\/j.pedn.2026.07.022_bb0020","doi-asserted-by":"crossref","first-page":"301","DOI":"10.4097\/kja.25001","article-title":"Heterogeneity in meta-analyses: An unavoidable challenge worth exploring","volume":"78","author":"Choi","year":"2025","journal-title":"Korean Journal of Anesthesiology"},{"key":"10.1016\/j.pedn.2026.07.022_bb0025","series-title":"Statistical power analysis for the behavioral sciences","article-title":"Statistical power analysis for the behavioral sciences","author":"Cohen","year":"1988"},{"key":"10.1016\/j.pedn.2026.07.022_bb0030","article-title":"Effects of child-centered play therapy on quality of life, depression and anxiety in children with cancer","volume":"9","author":"Co\u015fkun","year":"2025","journal-title":"International Journal of Modern Education Studies"},{"issue":"24","key":"10.1016\/j.pedn.2026.07.022_bb0035","doi-asserted-by":"crossref","first-page":"4251","DOI":"10.1002\/cncr.34479","article-title":"Annual report to the nation on the status of cancer, part 1: National cancer statistics","volume":"128","author":"Cronin","year":"2022","journal-title":"Cancer"},{"issue":"10","key":"10.1016\/j.pedn.2026.07.022_bb0040","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.31557\/APJCP.2019.20.10.2935","article-title":"The effect of filial therapy on depressive symptoms of children with Cancer and their mother's depression, anxiety, and stress: A randomized controlled trial","volume":"20","author":"Ebrahimi","year":"2019","journal-title":"Asian Pacific Journal of Cancer Prevention"},{"key":"10.1016\/j.pedn.2026.07.022_bb0045","doi-asserted-by":"crossref","DOI":"10.1177\/15347354231168984","article-title":"The impact of virtual reality (VR) on psychological and physiological variables in children receiving chemotherapy: A pilot cross-over study","volume":"22","author":"Erd\u0151s","year":"2023","journal-title":"Integrative Cancer Therapies"},{"key":"10.1016\/j.pedn.2026.07.022_bb0050","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3390\/jintelligence10040077","article-title":"Developing children's creativity and social-emotional competencies through play: Summary of twenty years of findings of the evidence-based interventions \u201cgame program\u201d","volume":"10","author":"Garaigordobil","year":"2022","journal-title":"Journal of Intelligence"},{"issue":"5","key":"10.1016\/j.pedn.2026.07.022_bb0055","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1089\/g4h.2015.0014","article-title":"Clinical and neurobiological perspectives of empowering pediatric Cancer patients using videogames","volume":"4","author":"Govender","year":"2015","journal-title":"Games for Health Journal"},{"issue":"23","key":"10.1016\/j.pedn.2026.07.022_bb0060","first-page":"190","article-title":"Effect of game counseling in nursing care of pediatric oncology patients","volume":"31","author":"Hanwen","year":"2021","journal-title":"Chinese Health Care and Nutrition Journal"},{"key":"10.1016\/j.pedn.2026.07.022_bb0065","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.chb.2016.05.062","article-title":"Video games as virtual teachers: Prosocial video game use by children and adolescents from different socioeconomic groups is associated with increased empathy and prosocial behaviour","volume":"63","author":"Harrington","year":"2016","journal-title":"Computers in Human Behavior"},{"issue":"3","key":"10.1016\/j.pedn.2026.07.022_bb0070","first-page":"17","article-title":"Application of medical game counselling in PICC catheter in children patients with tumor","volume":"25","author":"Hua","year":"2019","journal-title":"Journal of Qilu Nursing"},{"issue":"10","key":"10.1016\/j.pedn.2026.07.022_bb0075","first-page":"1270","article-title":"Gamified interventions for physical activity in pediatric cancer survivors:A scoping review","volume":"60","author":"Hua","year":"2025","journal-title":"Chinese Journal of Nursing"},{"key":"10.1016\/j.pedn.2026.07.022_bb0080","doi-asserted-by":"crossref","first-page":"e195","DOI":"10.1016\/j.pedn.2024.04.029","article-title":"The effect of therapeutic play on fear, anxiety, and satisfaction levels of pediatric oncology patients receiving chemotherapy","volume":"77","author":"H\u00fczmeli","year":"2024","journal-title":"Journal of Pediatric Nursing"},{"key":"10.1016\/j.pedn.2026.07.022_bb0085","first-page":"10","article-title":"Effect of group play intervention on psychological and social functions in school-age children with leukemia","volume":"16","author":"Jianjun","year":"2022","journal-title":"Maternal and Child Health Journal"},{"issue":"7","key":"10.1016\/j.pedn.2026.07.022_bb0090","first-page":"77","article-title":"Effect of video game intervention on depressive mood in children with leukemia","volume":"35","author":"Jiasi","year":"2020","journal-title":"Journal of Nursing Science"},{"issue":"3","key":"10.1016\/j.pedn.2026.07.022_bb0095","first-page":"408","article-title":"Effect of group game coaching nursing on negative mood and treatment compliance in school-age leukemia children","volume":"20","author":"Jingjing","year":"2023","journal-title":"Nursing Practice and Research"},{"issue":"06","key":"10.1016\/j.pedn.2026.07.022_bb0100","first-page":"152","article-title":"Effect of pediatric medical counseling games on social anxiety in children with acute leukemia","volume":"37","author":"Jingjing","year":"2019","journal-title":"Health Vocational Education"},{"key":"10.1016\/j.pedn.2026.07.022_bb0105","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1111\/j.1365-2702.2011.03733.x","article-title":"The effectiveness of therapeutic play, using virtual reality computer games, in promoting the psychological well-being of children hospitalised with cancer","volume":"20","author":"Li","year":"2011","journal-title":"Journal of Clinical Nursing"},{"issue":"04","key":"10.1016\/j.pedn.2026.07.022_bb0110","first-page":"190","article-title":"Research progress on influencing factors and non-pharmacological interventions of cancer-related fatigue in children with cancer","volume":"20","author":"Li","year":"2023","journal-title":"Practical Journal of Clinical Medicine"},{"issue":"2","key":"10.1016\/j.pedn.2026.07.022_bb0115","article-title":"Effect of medical counseling games in radiotherapy for pediatric patients with neuroblastoma","volume":"22","author":"Liping","year":"2024","journal-title":"Contemporary Medical and Pharmaceutical Journal"},{"key":"10.1016\/j.pedn.2026.07.022_bb0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12916-025-04287-5","article-title":"Preliminary effectiveness and feasibility of an integrated hope techniques and narrative-based card game intervention for pediatric cancer patients in China: A randomized controlled trial","volume":"23","author":"Liu","year":"2025","journal-title":"BMC Medicine"},{"key":"10.1016\/j.pedn.2026.07.022_bb0125","series-title":"Construction and application of early warning and intervention model for psychological crisis in adolescents with Cancer","author":"Lu","year":"2023"},{"issue":"21","key":"10.1016\/j.pedn.2026.07.022_bb0130","first-page":"2915","article-title":"Application effect of medical counseling games in PICC catheterization for children with acute leukemia","volume":"19","author":"Minhua","year":"2021","journal-title":"Chinese General Practice Nursing"},{"key":"10.1016\/j.pedn.2026.07.022_bb0135","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jclinepi.2021.09.021","article-title":"Reliability of the revised Cochrane risk-of-bias tool for randomised trials (RoB2) improved with the use of implementation instruction","volume":"141","author":"Minozzi","year":"2022","journal-title":"Journal of Clinical Epidemiology"},{"key":"10.1016\/j.pedn.2026.07.022_bb0140","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1177\/0308022620987125","article-title":"The effect of play-based occupational therapy on symptoms and participation in daily life activities in children with cancer: A randomized controlled trial","volume":"84","author":"Mohammadi","year":"2021","journal-title":"British Journal of Occupational Therapy"},{"key":"10.1016\/j.pedn.2026.07.022_bb0145","series-title":"Pediatric core frequently asked questions","author":"National Institutes of Health","year":"2026"},{"issue":"2","key":"10.1016\/j.pedn.2026.07.022_bb0150","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1007\/s00520-024-09144-4","article-title":"The effectiveness of play therapy on depression and anxiety in hospitalized children with cancer: A systematic review [review]","volume":"33","author":"Nazari","year":"2025","journal-title":"Supportive Care in Cancer"},{"key":"10.1016\/j.pedn.2026.07.022_bb0155","doi-asserted-by":"crossref","first-page":"29","DOI":"10.48286\/aro.2024.81","article-title":"The effects of virtual reality on pain and anxiety in pediatric oncology patients","volume":"04","author":"Nerini","year":"2024","journal-title":"Annals of Research in Oncology"},{"issue":"4","key":"10.1016\/j.pedn.2026.07.022_bb0160","first-page":"25","article-title":"Effects of hospital clowning on anxiety and fatigue in children with cancer undergoing chemotherapy","volume":"10","author":"Nikkhah-Beydokhti","year":"2021","journal-title":"Evidence Based Care Journal"},{"key":"10.1016\/j.pedn.2026.07.022_bb0165","series-title":"The effects of pre-intervention training provided through therapeutic play on the anxiety of pediatric oncology patients during peripheral catheterization","first-page":"1533","author":"Orhan","year":"2017"},{"issue":"2","key":"10.1016\/j.pedn.2026.07.022_bb0170","doi-asserted-by":"crossref","DOI":"10.1111\/nhs.70156","article-title":"Effectiveness of psychosocial interventions on stress, anxiety, depression, and quality of life in parents of children, adolescents, and young adults with Cancer: A Meta-analysis of RCTs","volume":"27","author":"Ozturk","year":"2025","journal-title":"Nursing & Health Sciences"},{"key":"10.1016\/j.pedn.2026.07.022_bb0175","author":"Ping"},{"issue":"9","key":"10.1016\/j.pedn.2026.07.022_bb0180","first-page":"963","article-title":"Effect of video game intervention combined with palliative care on symptom perception in pediatric patients with neuroblastic lymphoma","volume":"30","author":"Qingqing","year":"2021","journal-title":"Chinese Journal of Convalescent Medicine"},{"issue":"1","key":"10.1016\/j.pedn.2026.07.022_bb0185","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1097\/NCC.0000000000001369","article-title":"The relationship between digital game addiction and levels of anxiety and depression in adolescents receiving Cancer treatment","volume":"48","author":"Sarvan","year":"2025","journal-title":"Cancer Nursing"},{"key":"10.1016\/j.pedn.2026.07.022_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejon.2024.102621","article-title":"The effect of a biofeedback-based virtual reality game on pain, fear and anxiety levels during port catheter needle insertion in pediatric oncology patients: A randomized controlled study","volume":"70","author":"Sava\u015f","year":"2024","journal-title":"European Journal of Oncology Nursing"},{"issue":"2025","key":"10.1016\/j.pedn.2026.07.022_bb0195","article-title":"How physical activity protects against smartphone addiction: Examining the mediating pathways of resilience and subjective wellbeing in Chinese university students [original research]","volume":"16","author":"Shi","year":"2026","journal-title":"Frontiers in Psychology"},{"issue":"13","key":"10.1016\/j.pedn.2026.07.022_bb0200","doi-asserted-by":"crossref","first-page":"4575","DOI":"10.1002\/cam4.4014","article-title":"Patterns and trends of cancer incidence in children and adolescents in China, 2011-2015: A population-based cancer registry study","volume":"10","author":"Sun","year":"2021","journal-title":"Cancer Medicine"},{"key":"10.1016\/j.pedn.2026.07.022_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejon.2025.103049","article-title":"The effect of therapeutic play on anxiety and fear levels in 6-12-year old children undergoing central venous catheter insertion in a pediatric hematology-oncology unit: A randomized controlled trial","volume":"80","author":"Ta\u015fpinar","year":"2026","journal-title":"European Journal of Oncology Nursing"},{"issue":"13","key":"10.1016\/j.pedn.2026.07.022_bb0210","first-page":"2477","article-title":"Analysis of quality of life influencing factors among HIV\/HCV co-infected individuals in Yunnan using structural equation modeling","volume":"52","author":"Ting","year":"2025","journal-title":"Modern Preventive Medicine"},{"key":"10.1016\/j.pedn.2026.07.022_bb0215","author":"Wang"},{"key":"10.1016\/j.pedn.2026.07.022_bb0220","article-title":"The impact of sports participation on subjective wellbeing among Chinese young adults: Exploring the chain mediation effect of perceived social support and psychological resilience [original research]","volume":"14","author":"Wang","year":"2026","journal-title":"Frontiers in Public Health"},{"issue":"3","key":"10.1016\/j.pedn.2026.07.022_bb0225","first-page":"344","article-title":"WHO launches new tools to help countries build effective childhood cancer programmes","volume":"42","author":"WHO","year":"2021","journal-title":"Saudi Medical Journal"},{"issue":"S1","key":"10.1016\/j.pedn.2026.07.022_bb0230","first-page":"227","article-title":"Effect of play therapy based on holistic nursing care philosophy on improving hospital adaptation in pediatric patients with hematological oncology complicated by tuberculosis","volume":"46","author":"Xiaoxia","year":"2024","journal-title":"Chinese Journal of Antituberculosis"},{"key":"10.1016\/j.pedn.2026.07.022_bb0235","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.pedn.2026.01.050","article-title":"Effectiveness of exercise interventions for adolescent idiopathic scoliosis: An umbrella review","volume":"88","author":"Xinchun","year":"2026","journal-title":"Journal of Pediatric Nursing"},{"issue":"3","key":"10.1016\/j.pedn.2026.07.022_bb0240","doi-asserted-by":"crossref","DOI":"10.2196\/37079","article-title":"Development of a therapeutic video game with the MDA framework to decrease anxiety in preschool-aged children with acute lymphoblastic leukemia: Mixed methods approach","volume":"10","author":"Yang","year":"2022","journal-title":"JMIR Serious Games"},{"issue":"19","key":"10.1016\/j.pedn.2026.07.022_bb0245","first-page":"166","article-title":"Effects of health education based on family-hospital joint concept combined with sandplay on resistance emotion and behavioral problems in school-age children with bronchiolitis","volume":"9","author":"Yanni","year":"2024","journal-title":"Clinical Research and Practice"},{"issue":"12","key":"10.1016\/j.pedn.2026.07.022_bb0250","first-page":"2295","article-title":"Effects of interest induction combined with situational game intervention on subcutaneous injection compliance in children with severe pneumonia","volume":"34","author":"Yanyan","year":"2025","journal-title":"Henan Medical Research"},{"key":"10.1016\/j.pedn.2026.07.022_bb0255","first-page":"36","article-title":"The effect of shyness and social apathy on peer play behavior in preschool children aged 3\u223c6 years: Mediating and moderating role of play","volume":"09","author":"Yaoyang","year":"2023","journal-title":"Studies in early Childhood Education"},{"issue":"16","key":"10.1016\/j.pedn.2026.07.022_bb0260","doi-asserted-by":"crossref","first-page":"5653","DOI":"10.1002\/cam4.4100","article-title":"Trajectories and risk factors for anxiety and depression in children and adolescents with cancer: A 1-year follow-up","volume":"10","author":"Yardeni","year":"2021","journal-title":"Cancer Medicine"},{"issue":"23","key":"10.1016\/j.pedn.2026.07.022_bb0265","first-page":"236","article-title":"Research progress on negative emotions in childhood cancer patients","volume":"19","author":"Yaxin","year":"2024","journal-title":"Psychology Monthly"},{"issue":"4","key":"10.1016\/j.pedn.2026.07.022_bb0270","first-page":"65","article-title":"Application study on parent-child interactive medical game intervention in pediatric patients with leukemia undergoing chemotherapy","volume":"32","author":"Youzhen","year":"2025","journal-title":"Modern Nurse"},{"key":"10.1016\/j.pedn.2026.07.022_bb0275","series-title":"Exploring emotional processing in individuals at HighRisk in internet gaming disorder and PotentialIntervention via oxytocin","author":"Yu","year":"2023"},{"issue":"8","key":"10.1016\/j.pedn.2026.07.022_bb0280","first-page":"1219","article-title":"Effect of intimacy enhancement therapycombined with medical auxiliarygameson psychological status of children with leukemia","volume":"32","author":"Yuping","year":"2024","journal-title":"China Journal of Health Psychology"},{"issue":"6","key":"10.1016\/j.pedn.2026.07.022_bb0285","first-page":"397","article-title":"Effect of game and shared reading group counseling on psychological and behavioral problems in pediatric patients with malignant tumors","volume":"29","author":"Yuqian","year":"2014","journal-title":"Chinese Journal of Rehabilitation Medicine"},{"key":"10.1016\/j.pedn.2026.07.022_bb0290","article-title":"Social-media-based mental health interventions: Meta-analysis of randomized controlled trials","volume":"27","author":"Zhang","year":"2025","journal-title":"Journal of Medical Internet Research"}],"container-title":["Journal of Pediatric Nursing"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882596326003246?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882596326003246?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T22:26:59Z","timestamp":1788820019000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882596326003246"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":58,"alternative-id":["S0882596326003246"],"URL":"https:\/\/doi.org\/10.1016\/j.pedn.2026.07.022","relation":{},"ISSN":["0882-5963"],"issn-type":[{"value":"0882-5963","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The impact of different types of play interventions on anxiety and depressive symptoms in children with cancer: A systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Journal of Pediatric Nursing","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pedn.2026.07.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}