{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T13:09:23Z","timestamp":1772888963646,"version":"3.50.1"},"reference-count":25,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,1,27]],"date-time":"2016-01-27T00:00:00Z","timestamp":1453852800000},"content-version":"vor","delay-in-days":1518,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"Catholic Cardinal Tien Hospital","award":["92-1-2B04"],"award-info":[{"award-number":["92-1-2B04"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics &amp; Neonatology"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1016\/j.pedneo.2011.08.005","type":"journal-article","created":{"date-parts":[[2011,11,12]],"date-time":"2011-11-12T04:24:58Z","timestamp":1321071898000},"page":"327-331","source":"Crossref","is-referenced-by-count":11,"title":["The Immunoregulatory Effects of Caffeic Acid Phenethyl Ester on the Cytokine Secretion of Peripheral Blood Mononuclear Cells From Asthmatic Children"],"prefix":"10.1016","volume":"52","author":[{"given":"Leticia Bautista","family":"Sy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-King","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiau-Juno","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Mein","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pedneo.2011.08.005_bib1","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1002\/ptr.1029","article-title":"Recent progress in pharmacological research of propolis","volume":"15","author":"Banskota","year":"2001","journal-title":"Phytother Res"},{"key":"10.1016\/j.pedneo.2011.08.005_bib2","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1093\/carcin\/17.4.761","article-title":"Inhibitory effects of caffeic acid phenethyl ester (CAPE) on 2-O-tetradecanoylphorbol-13-acetate-induced tumor promotion in mouse skin and the synthesis of DNA, RNA and protein in HeLa cells","volume":"17","author":"Huang","year":"1996","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.pedneo.2011.08.005_bib3","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1207\/s15327914nc4702_8","article-title":"Inhibitory effect of water-soluble derivative of propolis and its polyphenolic compounds on tumor growth and metastasizing ability: a possible mode of antitumor action","volume":"47","author":"Orsoli\u0107","year":"2003","journal-title":"Nutr Cancer"},{"key":"10.1016\/j.pedneo.2011.08.005_bib4","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1096\/fj.04-2126com","article-title":"Novel and therapeutic effect of caffeic acid and caffeic acid phenethyl ester on hepatocarcinoma cells: complete regression of hepatoma growth and metastasis by dual mechanism","volume":"18","author":"Chung","year":"2004","journal-title":"FASEB J"},{"key":"10.1016\/j.pedneo.2011.08.005_bib5","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.canlet.2005.03.046","article-title":"Inhibitory effect of caffeic acid phenethyl ester on the growth of C6 glioma cells in\u00a0vitro and in\u00a0vivo","volume":"234","author":"Kuo","year":"2006","journal-title":"Cancer Lett"},{"key":"10.1016\/j.pedneo.2011.08.005_bib6","first-page":"3576","article-title":"Apoptosis and altered redox state induced by caffeic acid phenethyl ester (CAPE) in transformed rat fibroblast cells","volume":"55","author":"Chiao","year":"1995","journal-title":"Cancer Res"},{"key":"10.1016\/j.pedneo.2011.08.005_bib7","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0952-3278(96)90129-5","article-title":"The effect of propolis and its components on eicosanoid production during the inflammatory response","volume":"55","author":"Mirzoeva","year":"1996","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"10.1016\/j.pedneo.2011.08.005_bib8","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/S0022-3565(24)29210-7","article-title":"Caffeic acid phenethyl ester, an inhibitor of nuclear factor-kappaB, attenuates bacterial peptidoglycan polysaccharide- induced colitis in rats","volume":"299","author":"Fitzpatrick","year":"2001","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pedneo.2011.08.005_bib9","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0014-5793(93)80184-V","article-title":"Caffeic acid phenethyl ester as a lipoxygenease inhibitor with antioxidant properties","volume":"329","author":"Sud\u2019ina","year":"1993","journal-title":"FEBS Lett"},{"key":"10.1016\/j.pedneo.2011.08.005_bib10","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cccn.2004.03.035","article-title":"Caffeic acid phenethyl ester as a protective agent against doxorubicin nephrotoxicity in rats","volume":"348","author":"Yagmurca","year":"2004","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.pedneo.2011.08.005_bib11","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.jep.2004.11.019","article-title":"Caffeic acid phenethyl ester protects kidneys against carbon tetrachloride toxicity in rats","volume":"97","author":"Ogeturk","year":"2005","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.pedneo.2011.08.005_bib12","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1097\/01.shk.0000168525.97716.28","article-title":"Myocardial ischemia\/reperfusion-induced oxidative renal damage in rats: protection by caffeic acid phenethyl ester (CAPE)","volume":"24","author":"Ozer","year":"2005","journal-title":"Shock"},{"key":"10.1016\/j.pedneo.2011.08.005_bib13","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1515\/znc-2003-7-823","article-title":"Propolis and some of its constituents down-regulate DNA synthesis and inflammatory cytokine production but induce TGF-beta1 production of human immune cells","volume":"58","author":"Ansorge","year":"2003","journal-title":"Z Naturforsch C"},{"key":"10.1016\/j.pedneo.2011.08.005_bib14","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1124\/jpet.103.060673","article-title":"Caffeic acid phenethyl ester inhibits T-cell activation by targeting both NFAT and NF- kappa B transcription factors","volume":"308","author":"Marquez","year":"2004","journal-title":"J\u00a0Pharmacol Exp Ther"},{"key":"10.1016\/j.pedneo.2011.08.005_bib15","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.intimp.2004.01.013","article-title":"Immunomodulatory effect of caffeic acid phenethyl ester in Balb\/c mice","volume":"4","author":"Park","year":"2004","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.pedneo.2011.08.005_bib16","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1056\/NEJM200101043440106","article-title":"Allergy and allergic diseases. First of two parts","volume":"344","author":"Kay","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.pedneo.2011.08.005_bib17","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1002\/ppul.20591","article-title":"Anti-inflammatory pharmacotherapy for wheezing in preschool children","volume":"42","author":"Kaditis","year":"2007","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.pedneo.2011.08.005_bib18","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1001\/jama.1955.02960060017005","article-title":"Major undesirable side-effects resulting from prednisolone and prednisone","volume":"158","author":"Bollet","year":"1955","journal-title":"J Am Med Asssoc"},{"key":"10.1016\/j.pedneo.2011.08.005_bib19","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/0091-6749(92)90106-C","article-title":"Effects of inhaled budesonide on serum markers of bone metabolism in children with asthma","volume":"90","author":"Sorva","year":"1992","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.pedneo.2011.08.005_bib20","doi-asserted-by":"crossref","first-page":"4996","DOI":"10.3748\/wjg.v12.i31.4996","article-title":"Caffeic acid phenethyl ester modifies the TH1\/TH2 balance in ileal mucosa after gamma-irradiation in the rat by modulating the cytokine pattern","volume":"12","author":"Gremy","year":"2006","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.pedneo.2011.08.005_bib21","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/S1081-1206(10)63297-8","article-title":"Evaluation of Th1\/Th2 ratio and cytokine production profile during acute exacerbation and convalescence in asthmatic children","volume":"86","author":"Kuo","year":"2001","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.pedneo.2011.08.005_bib22","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.4049\/jimmunol.136.7.2348","article-title":"Two types of murine helper T-cell clone: I-definition according to profiles of lymphokine activities and secreted proteins","volume":"136","author":"Mosmann","year":"1986","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.pedneo.2011.08.005_bib23","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1034\/j.1600-065X.2001.1820105.x","article-title":"Type 1 T regulatory cells","volume":"182","author":"Roncarolo","year":"2001","journal-title":"Immunol Rev"},{"key":"10.1016\/j.pedneo.2011.08.005_bib24","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1084\/jem.193.11.1295","article-title":"Human CD4+ CD25+ T regulatory cells suppress na\u00efve and memory T-cell proliferation and can be expanded in\u00a0vitro without loss of function","volume":"193","author":"Levings","year":"2001","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.pedneo.2011.08.005_bib25","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1378\/chest.06-2434","article-title":"Regulatory T cells in allergy and asthma","volume":"132","author":"Larch\u00e9","year":"2007","journal-title":"Chest"}],"container-title":["Pediatrics &amp; Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1875957211001215?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1875957211001215?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T00:44:17Z","timestamp":1741913057000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1875957211001215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["S1875957211001215"],"URL":"https:\/\/doi.org\/10.1016\/j.pedneo.2011.08.005","relation":{},"ISSN":["1875-9572"],"issn-type":[{"value":"1875-9572","type":"print"}],"subject":[],"published":{"date-parts":[[2011,12]]}}}