{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T08:39:46Z","timestamp":1789634386691,"version":"build-2803163510"},"reference-count":34,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,1,27]],"date-time":"2016-01-27T00:00:00Z","timestamp":1453852800000},"content-version":"vor","delay-in-days":1152,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics &amp; Neonatology"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1016\/j.pedneo.2012.08.011","type":"journal-article","created":{"date-parts":[[2012,9,28]],"date-time":"2012-09-28T23:04:32Z","timestamp":1348873472000},"page":"346-353","source":"Crossref","is-referenced-by-count":12,"title":["Oral Ibuprofen versus Intravenous Indomethacin for Closure of Patent Ductus Arteriosus in Very Low Birth Weight Infants"],"prefix":"10.1016","volume":"53","author":[{"given":"Cheng Han","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiao-Neng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long-Yen","family":"Tsao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Chou","family":"Hsiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Luen","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pedneo.2012.08.011_bib1","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1542\/peds.107.1.e1","article-title":"Very low birth weight outcomes of the National Institute of Child health and human development neonatal research network, January 1995 through December 1996. NICHD Neonatal Research Network","volume":"107","author":"Lemons","year":"2001","journal-title":"Pediatrics"},{"key":"10.1016\/j.pedneo.2012.08.011_bib2","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1007\/s004310051125","article-title":"A patent ductus arteriosus is associated with reduced middle cerebral artery blood flow velocity","volume":"158","author":"Weir","year":"1999","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.pedneo.2012.08.011_bib3","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/S0022-3476(83)80022-5","article-title":"Effects of indomethacin in premature infants with patent ductus arteriosus: results of a national collaborative study","volume":"102","author":"Gersony","year":"1983","journal-title":"J Pediatr"},{"key":"10.1016\/j.pedneo.2012.08.011_bib4","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/sj.jp.7211465","article-title":"Patent ductus arteriosus: pathophysiology and management","volume":"26","author":"Hermes-DeSantis","year":"2006","journal-title":"J Perinatol"},{"key":"10.1016\/j.pedneo.2012.08.011_bib5","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.siny.2004.10.003","article-title":"The pharmacologic closure of the patent ductus arteriosus","volume":"10","author":"Van Overmeire","year":"2005","journal-title":"Semin Fetal Neonatal Med"},{"key":"10.1016\/j.pedneo.2012.08.011_bib6","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1056\/NEJM200009073431001","article-title":"A comparison of ibuprofen and indomethacin for closure of patent ductus arteriosus","volume":"343","author":"Van Overmeire","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.pedneo.2012.08.011_bib7","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/S0022-3476(05)83391-8","article-title":"Indomethacin induced changes in renal blood flow velocity waveform in premature infants investigated with color Doppler imaging","volume":"118","author":"Van Bel","year":"1991","journal-title":"J Pediatr"},{"key":"10.1016\/j.pedneo.2012.08.011_bib8","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S0022-3476(05)81860-8","article-title":"Controlled study of the effects of indomethacin on cerebral blood flow velocities in newborn infants","volume":"118","author":"Mardoum","year":"1991","journal-title":"J Pediatr"},{"key":"10.1016\/j.pedneo.2012.08.011_bib9","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1136\/adc.65.10_Spec_No.1067","article-title":"Gut blood flow velocities in newborn: effects of patent ductus arteriosus and parenteral indomethacin","volume":"65","author":"Coombs","year":"1990","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.pedneo.2012.08.011_bib10","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1001\/jama.1996.03530310045031","article-title":"Early ibuprofen administration to prevent patent ductus arteriosus in premature infants","volume":"275","author":"Varvarigou","year":"1996","journal-title":"JAMA"},{"key":"10.1016\/j.pedneo.2012.08.011_bib11","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0022-3476(97)70060-X","article-title":"Comparative evaluation of the effects of indomethacin and ibuprofen on cerebral perfusion and oxygenation in preterm infants with patent ductus arteriosus","volume":"131","author":"Mosca","year":"1997","journal-title":"J Pediatr"},{"key":"10.1016\/j.pedneo.2012.08.011_bib12","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1007\/s00431-002-0915-y","article-title":"Safety and efficacy of ibuprofen versus indomethacin in preterm infants treated for patent ductus arteriosus: a randomised controlled trial","volume":"161","author":"Lago","year":"2002","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.pedneo.2012.08.011_bib13","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1080\/08998280.2007.11928244","article-title":"Ibuprofen lysine (NeoProfen) for the treatment of patent ductus arteriosus","volume":"20","author":"Poon","year":"2007","journal-title":"Proc (Bayl Univ Med Cent)"},{"key":"10.1016\/j.pedneo.2012.08.011_bib14","first-page":"99","article-title":"Oral ibuprofen for closure of hemodinamically significant PDA in premature neonates","volume":"39","author":"Hariprasad","year":"2002","journal-title":"Indian Pediatr"},{"key":"10.1016\/j.pedneo.2012.08.011_bib15","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1542\/peds.2008-1780","article-title":"Randomized pilot study comparing oral ibuprofen with intravenous ibuprofen in very low birth weight infants with patent ductus arteriosus","volume":"122","author":"Cherif","year":"2008","journal-title":"Pediatrics"},{"key":"10.1016\/j.pedneo.2012.08.011_bib16","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1542\/peds.2009-0003","article-title":"Oral versus intravenous ibuprofen: which is better in closure of patent ductus arteriosus?","volume":"123","author":"Erdeve","year":"2009","journal-title":"Pediatrics"},{"key":"10.1016\/j.pedneo.2012.08.011_bib17","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1055\/s-2007-981853","article-title":"Oral ibuprofen in early curative closure of patent ductus arteriosus in very premature infants","volume":"24","author":"Cherif","year":"2007","journal-title":"Am J Perinatol"},{"key":"10.1016\/j.pedneo.2012.08.011_bib18","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1055\/s-2007-976550","article-title":"Oral ibuprofen and ductus arteriosus in premature infants: a randomized pilot study","volume":"24","author":"Aly","year":"2007","journal-title":"Am J Perinatol"},{"key":"10.1016\/j.pedneo.2012.08.011_bib19","first-page":"399","article-title":"Comparison of oral ibuprofen and indomethacin therapy for patent ductus arteriosus in preterm infants","volume":"9","author":"Fakhraee","year":"2007","journal-title":"Zhongguo Dang Dai Er Ke Za Zhi"},{"key":"10.1016\/j.pedneo.2012.08.011_bib20","first-page":"563","article-title":"A comparison of oral ibuprofen and intravenous indomethacin for closure of patent ductus arteriosus in preterm infants","volume":"86","author":"Chotigeat","year":"2003","journal-title":"J Med Assoc Thai"},{"key":"10.1016\/j.pedneo.2012.08.011_bib21","first-page":"1252","article-title":"Oral ibuprofen and indomethacin for treatment of patent ductus arteriosus in premature infants: a randomised trial at Ramathibodi Hospital","volume":"85","author":"Supapannachart","year":"2002","journal-title":"J Med Assoc Thai"},{"key":"10.1016\/j.pedneo.2012.08.011_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpeds.2010.10.008","article-title":"Efficacy and safety of oral versus intravenous ibuprofen in very low birth weight preterm infants with patent ductus arteriosus","volume":"158","author":"Gokmen","year":"2011","journal-title":"J Pediatr"},{"key":"10.1016\/j.pedneo.2012.08.011_bib23","doi-asserted-by":"crossref","first-page":"F45","DOI":"10.1136\/adc.2009.168682","article-title":"Network meta-analysis of indomethacin versus ibuprofen versus placebo for PDA in preterm infants","volume":"96","author":"Jones","year":"2011","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.pedneo.2012.08.011_bib24","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1053\/j.semperi.2006.04.003","article-title":"Systematic review: ibuprofen in preterm newborns","volume":"30","author":"Aranda","year":"2006","journal-title":"Semin Perinatol"},{"key":"10.1016\/j.pedneo.2012.08.011_bib25","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S1695-4033(07)70648-3","article-title":"Ibuprofen versus indomethacin in the preterm persistent patent ductus arteriosus therapy: review and meta-analysis","volume":"67","author":"Gimeno Navarro","year":"2007","journal-title":"An Pediatr (Barc)"},{"issue":"4","key":"10.1016\/j.pedneo.2012.08.011_bib26","first-page":"CD003481","article-title":"Ibuprofen for the treatment of patent ductus arteriosus in preterm and\/or low birth weight infants","volume":"14","author":"Ohlsson","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.pedneo.2012.08.011_bib27","doi-asserted-by":"crossref","first-page":"e354","DOI":"10.1542\/peds.112.5.e354","article-title":"Closure of patent ductus arteriosus with oral ibuprofen suspension in premature newborns: a pilot study","volume":"112","author":"Heyman","year":"2003","journal-title":"Pediatrics"},{"key":"10.1016\/j.pedneo.2012.08.011_bib28","first-page":"314","article-title":"Oral ibuprofen prophylaxis for symptomatic patent ductus arteriosus of prematurity","volume":"89","author":"Sangtawesin","year":"2006","journal-title":"J Med Assoc Thai"},{"key":"10.1016\/j.pedneo.2012.08.011_bib29","doi-asserted-by":"crossref","first-page":"e1256","DOI":"10.1542\/peds.2008-1780","article-title":"Randomized pilot study comparing oral ibuprofen with intravenous ibuprofen in very low birth weight infants with patent ductus arteriosus","volume":"122","author":"Cherif","year":"2008","journal-title":"Pediatrics"},{"key":"10.1016\/j.pedneo.2012.08.011_bib30","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1007\/s003830000515","article-title":"Surgical closure of patent ductus arteriosus in very-low-birth-weight infants","volume":"17","author":"Niinikoski","year":"2001","journal-title":"Pediatr Surg Int"},{"key":"10.1016\/j.pedneo.2012.08.011_bib31","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1016\/j.athoracsur.2008.12.101","article-title":"Is there an optimal timing for surgical ligation of patent ductus arteriosus in preterm infants?","volume":"87","author":"Vida","year":"2009","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.pedneo.2012.08.011_bib32","first-page":"54","article-title":"Acute renal impairment after oral ibuprofen for medical Closure of patent ductus arteriosus","volume":"44","author":"Tiker","year":"2007","journal-title":"Indian Pediatr"},{"issue":"9","key":"10.1016\/j.pedneo.2012.08.011_bib33","doi-asserted-by":"crossref","first-page":"956","DOI":"10.3345\/kjp.2008.51.9.956","article-title":"The pharmacological treatment of patent ductus arteriosus in premature infants with respiratory distress syndrome: oral ibuprofen vs. indomethacin","volume":"51","author":"Lee","year":"2008","journal-title":"Korean J Pediatr"},{"issue":"10","key":"10.1016\/j.pedneo.2012.08.011_bib34","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1016\/j.clinthera.2010.08.011","article-title":"Efficacy and tolerability of enteral formulations of ibuprofen in the treatment of patent ductus arteriosus in preterm infants","volume":"32","author":"Gouyon","year":"2010","journal-title":"Clin Ther"}],"container-title":["Pediatrics &amp; Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1875957212001428?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1875957212001428?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T04:32:05Z","timestamp":1562214725000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1875957212001428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["S1875957212001428"],"URL":"https:\/\/doi.org\/10.1016\/j.pedneo.2012.08.011","relation":{},"ISSN":["1875-9572"],"issn-type":[{"value":"1875-9572","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12]]}}}