{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:22:32Z","timestamp":1788870152281,"version":"build-2803163510"},"reference-count":34,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,1,27]],"date-time":"2016-01-27T00:00:00Z","timestamp":1453852800000},"content-version":"vor","delay-in-days":1031,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"crossref","award":["CMRPG890192"],"award-info":[{"award-number":["CMRPG890192"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"crossref","award":["CMRPG890202"],"award-info":[{"award-number":["CMRPG890202"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics & Neonatology"],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.1016\/j.pedneo.2012.11.008","type":"journal-article","created":{"date-parts":[[2013,1,8]],"date-time":"2013-01-08T17:33:02Z","timestamp":1357666382000},"page":"95-101","source":"Crossref","is-referenced-by-count":14,"title":["Sex Differences of Oxidative Stress to Cholestatic Liver and Kidney Injury in Young Rats"],"prefix":"10.1016","volume":"54","author":[{"given":"Kow-Aung","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I-Chun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiunn-Ming","family":"Sheen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Chieh","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Cheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You-Lin","family":"Tain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Sung","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Tung","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pedneo.2012.11.008_bib1","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/S1665-2681(19)32126-X","article-title":"Cholestasis: human disease and experimental animal models","volume":"2","author":"Rodriguez-Garay","year":"2003","journal-title":"Ann Hepatol"},{"key":"10.1016\/j.pedneo.2012.11.008_bib2","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0168-8278(02)00413-0","article-title":"A comparison of fibrosis progression in chronic liver diseases","volume":"38","author":"Poynard","year":"2003","journal-title":"J. Hepatol"},{"key":"10.1016\/j.pedneo.2012.11.008_bib3","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1001\/archinte.1977.03630190041012","article-title":"Morbidity in alcoholics. Evidence for accelerated development of physical disease in women","volume":"137","author":"Ashley","year":"1997","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.pedneo.2012.11.008_bib4","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1007\/BF02256052","article-title":"Oxidative-stress-related changes in the livers of bile-duct-ligated rats","volume":"10","author":"Huang","year":"2003","journal-title":"J Biomed Sci"},{"key":"10.1016\/j.pedneo.2012.11.008_bib5","first-page":"147","article-title":"The differences in selected biochemical markers and histological findings after bile duct ligation in male and female rats","volume":"5","author":"Zivna","year":"2001","journal-title":"Adv Clin Path"},{"key":"10.1016\/j.pedneo.2012.11.008_bib6","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1016\/j.freeradbiomed.2007.01.039","article-title":"Parallel intestinal and liver injury during early cholestasis in the rat: modulation by bile salts and antioxidants","volume":"42","author":"Portincasa","year":"2007","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.pedneo.2012.11.008_bib7","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1136\/gut.47.5.710","article-title":"Evidence of a systemic phenomenon for oxidative stress in cholestatic liver disease","volume":"47","author":"Ljubuncic","year":"2000","journal-title":"Gut"},{"key":"10.1016\/j.pedneo.2012.11.008_bib8","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1253\/circj.CJ-08-1102","article-title":"Endothelial function and oxidative stress in cardiovascular diseases","volume":"73","author":"Higashi","year":"2009","journal-title":"Circ J"},{"key":"10.1016\/j.pedneo.2012.11.008_bib9","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S1567-5688(03)00033-3","article-title":"ADMA and oxidative stress","volume":"4","author":"Sydow","year":"2003","journal-title":"Atheroscler Suppl"},{"key":"10.1016\/j.pedneo.2012.11.008_bib10","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1002\/hep.20968","article-title":"A role for asymmetric dimethylarginine in the pathophysiology of portal hypertension in rats with biliary cirrhosis","volume":"42","author":"Laleman","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.pedneo.2012.11.008_bib11","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1016\/j.jpedsurg.2009.12.019","article-title":"Bile duct ligation in developing rats: temporal progression of liver, kidney, and brain damage","volume":"45","author":"Sheen","year":"2010","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.pedneo.2012.11.008_bib12","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/S0929-6646(11)60012-0","article-title":"Asymmetric dimethylarginine: clinical applications in pediatric medicine","volume":"110","author":"Tain","year":"2011","journal-title":"J Formos Med Assoc"},{"key":"10.1016\/j.pedneo.2012.11.008_bib13","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1203\/PDR.0b013e31818d5bc7","article-title":"Melatonin ameliorates bile duct ligation-induced systemic oxidative stress and spatial memory deficits in developing rats","volume":"65","author":"Huang","year":"2009","journal-title":"Pediatr Res"},{"key":"10.1016\/j.pedneo.2012.11.008_bib14","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/j.1600-079X.2010.00745.x","article-title":"Melatonin prevents increased asymmetric dimethylarginine in young rats with bile duct ligation","volume":"48","author":"Tain","year":"2010","journal-title":"J Pineal Res"},{"key":"10.1016\/j.pedneo.2012.11.008_bib15","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/hep.1840010511","article-title":"Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis","volume":"1","author":"Knodell","year":"1981","journal-title":"Hepatology"},{"key":"10.1016\/j.pedneo.2012.11.008_bib16","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1161\/01.HYP.33.4.1013","article-title":"Salt-sensitive hypertension develops after short-term exposure to angiotensin II","volume":"33","author":"Lombardi","year":"1999","journal-title":"Hypertension"},{"key":"10.1016\/j.pedneo.2012.11.008_bib17","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1111\/j.1600-079X.2010.00806.x","article-title":"Melatonin prevents hypertension and increased asymmetric dimethylarginine in young spontaneous hypertensive rats","volume":"49","author":"Tain","year":"2010","journal-title":"J Pineal Res"},{"key":"10.1016\/j.pedneo.2012.11.008_bib18","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.niox.2010.03.005","article-title":"Effects of maternal L-citrulline supplementation on renal function and blood pressure in offspring exposed to maternal caloric restriction: the impact of nitric oxide pathway","volume":"23","author":"Tain","year":"2010","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.pedneo.2012.11.008_bib19","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jss.2005.04.017","article-title":"Current understanding of gender dimorphism in hepatic pathophysiology","volume":"128","author":"Yokoyama","year":"2005","journal-title":"J Surg Res"},{"key":"10.1016\/j.pedneo.2012.11.008_bib20","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.ijdevneu.2009.11.006","article-title":"The interaction between high ammonia diet and bile duct ligation in developing rats: assessment by spatial memory and asymmetric dimethylarginine","volume":"28","author":"Huang","year":"2010","journal-title":"Int J Dev Neurosci"},{"key":"10.1016\/j.pedneo.2012.11.008_bib21","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1177\/153537020623100108","article-title":"Accumulation of symmetric dimethylarginine in hepatorenal syndrome","volume":"231","author":"Lluch","year":"2006","journal-title":"Exp Biol Med (Maywood)"},{"key":"10.1016\/j.pedneo.2012.11.008_bib22","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1203\/01.PDR.0000110524.88784.DD","article-title":"Estrogen receptor-alpha, sexual dimorphism and reduced-size liver ischemia and reperfusion injury in mice","volume":"55","author":"Harada","year":"2004","journal-title":"Pediatr Res"},{"key":"10.1016\/j.pedneo.2012.11.008_bib23","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/ncpneph0143","article-title":"Arginine, arginine analogs and nitric oxide production in chronic kidney disease","volume":"2","author":"Baylis","year":"2006","journal-title":"Nat Clin Pract Nephrol"},{"key":"10.1016\/j.pedneo.2012.11.008_bib24","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0735-1097(01)01380-8","article-title":"Endothelium-dependent vasodilation is independent of the plasma L-arginine\/ADMA ratio in men with stable angina: lack of effect of oral L-arginine on endothelial function, oxidative stress and exercise performance","volume":"38","author":"Walker","year":"2001","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.pedneo.2012.11.008_bib25","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/S0168-8278(01)00055-1","article-title":"Progression of fibrosis in chronic liver diseases: time to tally the score","volume":"34","author":"Pinzani","year":"2001","journal-title":"J Hepatol"},{"key":"10.1016\/j.pedneo.2012.11.008_bib26","doi-asserted-by":"crossref","first-page":"883","DOI":"10.3748\/wjg.v8.i5.883","article-title":"Estrogen reduces CCL4- induced liver fibrosis in rats","volume":"8","author":"Xu","year":"2002","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.pedneo.2012.11.008_bib27","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.bbrc.2011.05.023","article-title":"The antifibrotic effects of TGF-beta1 siRNA on hepatic fibrosis in rats","volume":"409","author":"Lang","year":"2011","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.pedneo.2012.11.008_bib28","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1213\/ane.0b013e318178ca42","article-title":"Renal ischemia: does sex matter?","volume":"107","author":"Hutchens","year":"2008","journal-title":"Anesth Analg"},{"key":"10.1016\/j.pedneo.2012.11.008_bib29","first-page":"1","article-title":"Production of sexual steroids in rats during pre- and early postnatal life","volume":"88","author":"Csernus","year":"1986","journal-title":"Exp Clin Endocrinol"},{"key":"10.1016\/j.pedneo.2012.11.008_bib30","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1111\/j.1523-1755.2002.kid590.x","article-title":"Sexual dimorphism in renal ischemia-reperfusion injury in rats: possible role of endothelin","volume":"62","author":"Muller","year":"2002","journal-title":"Kidney Int"},{"key":"10.1016\/j.pedneo.2012.11.008_bib31","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1139\/y05-012","article-title":"Sexual dimorphism in angiotensin II-induced hypertension and vascular alterations","volume":"83","author":"Tatchum-Talom","year":"2005","journal-title":"Can J Physiol Pharmacol"},{"key":"10.1016\/j.pedneo.2012.11.008_bib32","doi-asserted-by":"crossref","first-page":"E1039","DOI":"10.1152\/ajpendo.00059.2004","article-title":"Effects of gender and GH secretory pattern on sterol regulatory element-binding protein-1c and its target genes in rat liver","volume":"287","author":"Ameen","year":"2004","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.pedneo.2012.11.008_bib33","doi-asserted-by":"crossref","first-page":"C1302","DOI":"10.1152\/ajpcell.00203.2007","article-title":"Sexual dimorphism in liver mitochondrial oxidative capacity is conserved under caloric restriction conditions","volume":"293","author":"Valle","year":"2007","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.pedneo.2012.11.008_bib34","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1210\/me.2007-0549","article-title":"Sex-specific early growth hormone response genes in rat liver","volume":"22","author":"Wauthier","year":"2008","journal-title":"Mol Endocrinol"}],"container-title":["Pediatrics & Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1875957212001830?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1875957212001830?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T03:19:53Z","timestamp":1588821593000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1875957212001830"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["S1875957212001830"],"URL":"https:\/\/doi.org\/10.1016\/j.pedneo.2012.11.008","relation":{},"ISSN":["1875-9572"],"issn-type":[{"value":"1875-9572","type":"print"}],"subject":[],"published":{"date-parts":[[2013,4]]}}}