{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T03:18:04Z","timestamp":1778037484200,"version":"3.51.4"},"reference-count":30,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,1,27]],"date-time":"2016-01-27T00:00:00Z","timestamp":1453852800000},"content-version":"vor","delay-in-days":666,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004699","name":"Chung Shan Medical University Hospital, Taiwan","doi-asserted-by":"crossref","award":["CSH 2009-A-011"],"award-info":[{"award-number":["CSH 2009-A-011"]}],"id":[{"id":"10.13039\/501100004699","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","pediatr-neonatol.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics & Neonatology"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1016\/j.pedneo.2013.05.008","type":"journal-article","created":{"date-parts":[[2013,7,27]],"date-time":"2013-07-27T13:30:49Z","timestamp":1374931849000},"page":"120-126","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["The Significance of Serum and Fecal Levels of Interleukin-6 and Interleukin-8 in Hospitalized Children with Acute Rotavirus and Norovirus Gastroenteritis"],"prefix":"10.1016","volume":"55","author":[{"given":"Shan-Ming","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching-Pin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeng-Dau","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Hua","family":"Chao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Nan","family":"Sheu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pedneo.2013.05.008_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/000992289903800101","article-title":"Acute gastroenteritis","volume":"38","author":"Gasta\u00f1aduy","year":"1999","journal-title":"Clin Pediatr (Phila)"},{"key":"10.1016\/j.pedneo.2013.05.008_bib2","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1136\/bmj.39036.406169.80","article-title":"Acute gastroenteritis in children","volume":"334","author":"Elliott","year":"2007","journal-title":"BMJ"},{"key":"10.1016\/j.pedneo.2013.05.008_bib3","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1097\/QCO.0b013e328330662f","article-title":"Viruses causing childhood diarrhoea in the developing world","volume":"22","author":"Ramani","year":"2009","journal-title":"Curr Opin Infect Dis"},{"key":"10.1016\/j.pedneo.2013.05.008_bib4","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1097\/INF.0b013e3182059102","article-title":"Viral gastroenteritis in children","volume":"30","author":"Dennehy","year":"2011","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.pedneo.2013.05.008_bib5","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1097\/MOG.0b013e328333f8ee","article-title":"New and candidate vaccines for gastrointestinal infections","volume":"26","author":"Simon","year":"2010","journal-title":"Curr Opin Gastroenterol"},{"key":"10.1016\/j.pedneo.2013.05.008_bib6","series-title":"Nelson textbook of pediatrics","first-page":"1605","article-title":"Acute gastroenteritis in children","author":"Bhutta","year":"2007"},{"key":"10.1016\/j.pedneo.2013.05.008_bib7","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/j.pcl.2009.09.004","article-title":"Acute and persistent diarrhea","volume":"56","author":"Grimwood","year":"2009","journal-title":"Pediatr Clin North Am"},{"key":"10.1016\/j.pedneo.2013.05.008_bib8","doi-asserted-by":"crossref","first-page":"S50","DOI":"10.1097\/INF.0b013e3181967bee","article-title":"Rotavirus overview","volume":"28","author":"Bernstein","year":"2009","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.pedneo.2013.05.008_bib9","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1097\/01.mpg.0000235764.30743.5b","article-title":"The diagnostic value of serum interleukins 6 and 8 in children with acute gastroenteritis","volume":"43","author":"Lin","year":"2006","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.pedneo.2013.05.008_bib10","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/S1043-4666(03)00177-7","article-title":"The involvement of IL-6 and IL-8 in acute invasive gastroenteritis of children","volume":"22","author":"Vaisman","year":"2003","journal-title":"Cytokine"},{"key":"10.1016\/j.pedneo.2013.05.008_bib11","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1097\/00044067-200401000-00002","article-title":"Biological mediators of acute inflammation","volume":"15","author":"Rankin","year":"2004","journal-title":"AACN Clin Issues"},{"key":"10.1016\/j.pedneo.2013.05.008_bib12","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/S1286-4579(01)01479-4","article-title":"Cytokines in host defense against Salmonella","volume":"3","author":"Eckmann","year":"2001","journal-title":"Microbes Infect"},{"key":"10.1016\/j.pedneo.2013.05.008_bib13","doi-asserted-by":"crossref","first-page":"S463","DOI":"10.1097\/01.CCM.0000186784.62662.A1","article-title":"Interleukin-6","volume":"33","author":"Song","year":"2005","journal-title":"Crit Care Med"},{"key":"10.1016\/j.pedneo.2013.05.008_bib14","doi-asserted-by":"crossref","first-page":"d12","DOI":"10.2741\/A171","article-title":"Cytokines in acute and chronic inflammation","volume":"2","author":"Feghali","year":"1997","journal-title":"Front Biosci"},{"key":"10.1016\/j.pedneo.2013.05.008_bib15","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S1369-5274(99)80017-4","article-title":"Cytokine responses during mucosal infections: role in disease pathogenesis and host defence","volume":"2","author":"Svanborg","year":"1999","journal-title":"Curr Opin Microbiol"},{"key":"10.1016\/j.pedneo.2013.05.008_bib16","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1128\/CDLI.10.6.995-1001.2003","article-title":"Cytokines as mediators for or effectors against rotavirus disease in children","volume":"10","author":"Jiang","year":"2003","journal-title":"Clin Diagn Lab Immunol"},{"key":"10.1016\/j.pedneo.2013.05.008_bib17","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1111\/j.1651-2227.1999.tb00004.x","article-title":"Interferon-alpha in viral and bacterial gastroenteritis: a comparison with C-reactive protein and interleukin-6","volume":"88","author":"Mangiarotti","year":"1999","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.pedneo.2013.05.008_bib18","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/S0929-6646(09)60280-1","article-title":"Microbial etiology of acute gastroenteritis in hospitalized children in Taiwan","volume":"105","author":"Chen","year":"2006","journal-title":"J Formos Med Assoc"},{"key":"10.1016\/j.pedneo.2013.05.008_bib19","doi-asserted-by":"crossref","first-page":"259","DOI":"10.3109\/00365549009027046","article-title":"Rotavirus disease in Finnish children: use of numerical scores for clinical severity of diarrhoeal episodes","volume":"22","author":"Ruuska","year":"1990","journal-title":"Scand J Infect Dis"},{"key":"10.1016\/j.pedneo.2013.05.008_bib20","doi-asserted-by":"crossref","first-page":"5798","DOI":"10.1016\/j.vaccine.2008.08.030","article-title":"Comparison between two severity scoring scales commonly used in the evaluation of rotavirus gastroenteritis in children","volume":"26","author":"Givon-Lavi","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.pedneo.2013.05.008_bib21","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1136\/gut.38.3.328","article-title":"Local entrapment of interferon gamma in the recovery from Shigella dysenteriae type 1 infection","volume":"38","author":"Raqib","year":"1996","journal-title":"Gut"},{"key":"10.1016\/j.pedneo.2013.05.008_bib22","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1080\/00365529850171891","article-title":"Detection of pro- and anti-inflammatory cytokines in stools of patients with inflammatory bowel disease","volume":"33","author":"Saiki","year":"1998","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.pedneo.2013.05.008_bib23","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1002\/jmv.20630","article-title":"Fecal cytokines and markers of intestinal inflammation in international travelers with diarrhea due to noroviruses","volume":"78","author":"Ko","year":"2006","journal-title":"J Med Virol"},{"key":"10.1016\/j.pedneo.2013.05.008_bib24","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1006\/viro.1996.0374","article-title":"Rotavirus stimulates IL-8 secretion from cultured epithelial cells","volume":"221","author":"Sheth","year":"1996","journal-title":"Virology"},{"key":"10.1016\/j.pedneo.2013.05.008_bib25","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.cyto.2012.04.034","article-title":"Diagnostic performance of serum interleukin-6 and interleukin-10 levels and clinical predictors in children with rotavirus and norovirus gastroenteritis","volume":"59","author":"Chen","year":"2012","journal-title":"Cytokine"},{"key":"10.1016\/j.pedneo.2013.05.008_bib26","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1086\/652403","article-title":"Reduction in acute gastroenteritis hospitalizations among US children after introduction of rotavirus vaccine: analysis of hospital discharge data from 18 US states","volume":"201","author":"Curns","year":"2010","journal-title":"J Infect Dis"},{"key":"10.1016\/j.pedneo.2013.05.008_bib27","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1086\/597256","article-title":"Norovirus infection as a cause of diarrhea-associated benign infantile seizures","volume":"48","author":"Chen","year":"2009","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.pedneo.2013.05.008_bib28","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/j.1440-1754.2010.01986.x","article-title":"Norovirus as cause of benign convulsion associated with gastro-enteritis","volume":"47","author":"Chan","year":"2011","journal-title":"J Paediatr Child Health"},{"key":"10.1016\/j.pedneo.2013.05.008_bib29","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1128\/CVI.00214-07","article-title":"European multicenter evaluation of commercial enzyme immunoassays for detecting norovirus antigen in fecal samples","volume":"14","author":"Gray","year":"2007","journal-title":"Clin Vaccine Immunol"},{"key":"10.1016\/j.pedneo.2013.05.008_bib30","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.diagmicrobio.2011.08.023","article-title":"Evaluation of third-generation RIDASCREEN enzyme immunoassay for the detection of norovirus antigens in stool samples of hospitalized children in Bel\u00e9m, Par\u00e1","volume":"71","author":"Siqueira","year":"2011","journal-title":"Diagn Microbiol Infect Dis"}],"container-title":["Pediatrics & Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1875957213001101?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1875957213001101?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T22:34:37Z","timestamp":1596234877000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1875957213001101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["S1875957213001101"],"URL":"https:\/\/doi.org\/10.1016\/j.pedneo.2013.05.008","relation":{},"ISSN":["1875-9572"],"issn-type":[{"value":"1875-9572","type":"print"}],"subject":[],"published":{"date-parts":[[2014,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Significance of Serum and Fecal Levels of Interleukin-6 and Interleukin-8 in Hospitalized Children with Acute Rotavirus and Norovirus Gastroenteritis","name":"articletitle","label":"Article Title"},{"value":"Pediatrics & Neonatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pedneo.2013.05.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}