{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T08:39:47Z","timestamp":1789634387891,"version":"build-2803163510"},"reference-count":29,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,4,26]],"date-time":"2016-04-26T00:00:00Z","timestamp":1461628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","pediatr-neonatol.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics &amp; Neonatology"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.pedneo.2015.04.017","type":"journal-article","created":{"date-parts":[[2016,4,30]],"date-time":"2016-04-30T07:20:44Z","timestamp":1462000844000},"page":"29-35","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Repeated Courses of Oral Ibuprofen in Premature Infants with Patent Ductus Arteriosus: Efficacy and Safety"],"prefix":"10.1016","volume":"58","author":[{"given":"Ha\u015fim","family":"Olgun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2911-6483","authenticated-orcid":false,"given":"Naci","family":"Ceviz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130brahim","family":"Kartal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130brahim","family":"Caner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Karacan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayhan","family":"Ta\u015ftekin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Necip","family":"Becit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pedneo.2015.04.017_bib1","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1056\/NEJM200009073431001","article-title":"A comparison of ibuprofen and indomethacin for closure of patent ductus arteriosus","volume":"343","author":"Van Overmeire","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.pedneo.2015.04.017_bib2","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1007\/s00431-002-0915-y","article-title":"Safety and efficacy of ibuprofen versus indomethacin in preterm infants treated for patent ductus arteriosus: a randomised controlled trial","volume":"161","author":"Lago","year":"2002","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.pedneo.2015.04.017_bib3","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1055\/s-0032-1332800","article-title":"Effectiveness and safety of indomethacin versus ibuprofen for the treatment of patent ductus arteriosus in preterm infants","volume":"30","author":"Sivanandan","year":"2013","journal-title":"Am J Perinatol"},{"key":"10.1016\/j.pedneo.2015.04.017_bib4","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.jpeds.2006.11.039","article-title":"Neurosensory impairment after surgical closure of patent ductus arteriosus in extremely low birth weight infants: results from the Trial of Indomethacin Prophylaxis in Preterms","volume":"150","author":"Kabra","year":"2007","journal-title":"J Pediatr"},{"key":"10.1016\/j.pedneo.2015.04.017_bib5","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1542\/peds.2006-3124","article-title":"Patent ductus arteriosus and its treatment as risk factors for neonatal and neurodevelopmental morbidity","volume":"119","author":"Chorne","year":"2007","journal-title":"Pediatrics"},{"key":"10.1016\/j.pedneo.2015.04.017_bib6","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1007\/s00246-007-9166-z","article-title":"Multiple courses of indomethacin and neonatal outcomes in premature infants","volume":"29","author":"Sangem","year":"2008","journal-title":"Pediatr Cardiol"},{"key":"10.1016\/j.pedneo.2015.04.017_bib7","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1542\/peds.112.3.583","article-title":"Persistent Doppler flow predicts lack of response to multiple courses of indomethacin in premature infants with recurrent patent ductus arteriosus","volume":"112","author":"Keller","year":"2003","journal-title":"Pediatrics"},{"key":"10.1016\/j.pedneo.2015.04.017_bib8","doi-asserted-by":"crossref","first-page":"e287","DOI":"10.1542\/peds.2008-2232","article-title":"A second course of ibuprofen is effective in the closure of a clinically significant PDA in ELBW infants","volume":"124","author":"Richards","year":"2009","journal-title":"Pediatrics"},{"key":"10.1016\/j.pedneo.2015.04.017_bib9","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1007\/s00431-012-1805-6","article-title":"Repeated courses of ibuprofen are effective in closure of a patent ductus arteriosus","volume":"171","author":"van der Lugt","year":"2012","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.pedneo.2015.04.017_bib10","doi-asserted-by":"crossref","first-page":"e354","DOI":"10.1542\/peds.112.5.e354","article-title":"Closure of patent ductus arteriosus with oral ibuprofen suspension in premature newborns: a pilot study","volume":"112","author":"Heyman","year":"2003","journal-title":"Pediatrics"},{"key":"10.1016\/j.pedneo.2015.04.017_bib11","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1016\/j.clinthera.2010.08.011","article-title":"Efficacy and tolerability of enteral formulations of ibuprofen in the treatment of patent ductus arteriosus in preterm infants","volume":"32","author":"Gouyon","year":"2010","journal-title":"Clin Ther"},{"key":"10.1016\/j.pedneo.2015.04.017_bib12","doi-asserted-by":"crossref","first-page":"F279","DOI":"10.1136\/archdischild-2011-300532","article-title":"Oral versus intravenous ibuprofen for patent ductus arteriosus closure: a randomised controlled trial in extremely low birthweight infants","volume":"97","author":"Erdeve","year":"2012","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.pedneo.2015.04.017_bib13","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.jpeds.2010.10.008","article-title":"Efficacy and safety of oral versus intravenous ibuprofen in very low birth weight preterm infants with patent ductus arteriosus","volume":"158","author":"Gokmen","year":"2011","journal-title":"J Pediatr"},{"key":"10.1016\/j.pedneo.2015.04.017_bib14","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.pedneo.2012.08.011","article-title":"Oral ibuprofen versus intravenous indomethacin for closure of patent ductus arteriosus in very low birth weight infants","volume":"53","author":"Lee","year":"2012","journal-title":"Pediatr Neonatol"},{"key":"10.1016\/j.pedneo.2015.04.017_bib15","first-page":"99","article-title":"Oral ibuprofen for closure of hemodynamically significant PDA in premature neonates","volume":"39","author":"Hariprasad","year":"2002","journal-title":"Indian Pediatr"},{"key":"10.1016\/j.pedneo.2015.04.017_bib16","first-page":"S1252","article-title":"Oral ibuprofen and indomethacin for treatment of patent ductus arteriosus in premature infants: a randomized trial at Ramathibodi Hospital","volume":"85","author":"Supapannachart","year":"2002","journal-title":"J Med Assoc Thai"},{"key":"10.1016\/j.pedneo.2015.04.017_bib17","doi-asserted-by":"crossref","first-page":"e1256","DOI":"10.1542\/peds.2008-1780","article-title":"Randomized pilot study comparing oral ibuprofen with intravenous ibuprofen in very low birth weight infants with patent ductus arteriosus","volume":"122","author":"Cherif","year":"2008","journal-title":"Pediatrics"},{"key":"10.1016\/j.pedneo.2015.04.017_bib18","doi-asserted-by":"crossref","first-page":"F116","DOI":"10.1136\/adc.2011.215160","article-title":"Pharmacokinetics of oral ibuprofen for patent ductus arteriosus closure in preterm infants","volume":"97","author":"Barzilay","year":"2012","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.pedneo.2015.04.017_bib19","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1055\/s-0029-1243315","article-title":"Treatment of patent ductus arteriosus: indomethacin or ibuprofen?","volume":"27","author":"Linder","year":"2010","journal-title":"Am J Perinatol"},{"key":"10.1016\/j.pedneo.2015.04.017_bib20","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1600-0773.1996.tb00012.x","article-title":"Does ibuprofen affect bilirubin\u2013albumin binding in newborn infant serum?","volume":"79","author":"Cooper-Peel","year":"1996","journal-title":"Pharmacol Toxicol"},{"key":"10.1016\/j.pedneo.2015.04.017_bib21","doi-asserted-by":"crossref","first-page":"F179","DOI":"10.1136\/fn.76.3.F179","article-title":"Treatment of patent ductus arteriosus with ibuprofen","volume":"76","author":"Van Overmeire","year":"1997","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.pedneo.2015.04.017_bib22","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1203\/00006450-200001000-00009","article-title":"Randomized double-blind controlled trial comparing the effects of ibuprofen with indomethacin on cerebral hemodynamics in preterm infants with patent ductus arteriosus","volume":"47","author":"Patel","year":"2000","journal-title":"Pediatr Res"},{"key":"10.1016\/j.pedneo.2015.04.017_bib23","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1203\/00006450-200011000-00008","article-title":"The renal hemodynamic effects of ibuprofen in the newborn rabbit","volume":"48","author":"Chamaa","year":"2000","journal-title":"Pediatr Res"},{"key":"10.1016\/j.pedneo.2015.04.017_bib24","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1016\/S0140-6736(02)08424-6","article-title":"Pulmonary hypertension after ibuprofen prophylaxis in very preterm infants","volume":"359","author":"Gournay","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.pedneo.2015.04.017_bib25","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.jpeds.2003.11.027","article-title":"Effect of ibuprofen on bilirubin-albumin binding","volume":"144","author":"Ahlfors","year":"2004","journal-title":"J Pediatr"},{"key":"10.1016\/j.pedneo.2015.04.017_bib26","doi-asserted-by":"crossref","first-page":"F514","DOI":"10.1136\/adc.2004.060434","article-title":"Potential risk factors for the development of acute renal failure in preterm newborn infants: a case-control study","volume":"90","author":"Cataldi","year":"2005","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.pedneo.2015.04.017_bib27","doi-asserted-by":"crossref","first-page":"S154","DOI":"10.1016\/j.earlhumdev.2008.09.400","article-title":"Study of efficacy of oral ibuprofen in preterm neonates with PDA and impact on short term clinical variables","volume":"84","author":"Manjunath","year":"2008","journal-title":"Early Hum Dev"},{"key":"10.1016\/j.pedneo.2015.04.017_bib28","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1055\/s-0028-1090594","article-title":"The ductus arteriosus rarely requires treatment in infants >1000 grams","volume":"25","author":"Nemerofsky","year":"2008","journal-title":"Am J Perinatol"},{"key":"10.1016\/j.pedneo.2015.04.017_bib29","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1007\/s00467-008-0867-1","article-title":"Determination of reference values for plasma cystatin C and comparison with creatinine in premature infants","volume":"23","author":"Armangil","year":"2008","journal-title":"Pediatr Nephrol"}],"container-title":["Pediatrics &amp; Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1875957216300389?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1875957216300389?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,12]],"date-time":"2018-09-12T13:51:48Z","timestamp":1536760308000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1875957216300389"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["S1875957216300389"],"URL":"https:\/\/doi.org\/10.1016\/j.pedneo.2015.04.017","relation":{},"ISSN":["1875-9572"],"issn-type":[{"value":"1875-9572","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Repeated Courses of Oral Ibuprofen in Premature Infants with Patent Ductus Arteriosus: Efficacy and Safety","name":"articletitle","label":"Article Title"},{"value":"Pediatrics & Neonatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pedneo.2015.04.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016, Taiwan Pediatric Association. Published by Elsevier Taiwan LLC.","name":"copyright","label":"Copyright"}]}}