{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T12:25:21Z","timestamp":1773923121900,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,3,31]],"date-time":"2016-03-31T00:00:00Z","timestamp":1459382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","pediatr-neonatol.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics & Neonatology"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.pedneo.2015.11.004","type":"journal-article","created":{"date-parts":[[2016,4,3]],"date-time":"2016-04-03T14:57:14Z","timestamp":1459695434000},"page":"488-495","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Myocardial Injury Biomarkers in Newborns with Congenital Heart Disease"],"prefix":"10.1016","volume":"57","author":[{"given":"Ana Luisa","family":"Neves","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Cabral","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adelino","family":"Leite-Moreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Monterroso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Ramalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herc\u00edlia","family":"Guimar\u00e3es","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrique","family":"Barros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o T.","family":"Guimar\u00e3es","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiago","family":"Henriques-Coelho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 C.","family":"Areias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pedneo.2015.11.004_bib1","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1161\/CIRCULATIONAHA.111.023697","article-title":"How to interpret elevated cardiac troponin levels","volume":"124","author":"Mahajan","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.pedneo.2015.11.004_bib2","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1093\/clinchem\/45.7.1104","article-title":"National Academy of Clinical Biochemistry Standards of Laboratory Practice: recommendations for the use of cardiac markers in coronary artery diseases","volume":"45","author":"Wu","year":"1999","journal-title":"Clin Chem"},{"key":"10.1016\/j.pedneo.2015.11.004_bib3","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/j.clinbiochem.2004.08.003","article-title":"Reference values for cardiac troponins T and I in healthy neonates","volume":"37","author":"Baum","year":"2004","journal-title":"Clin Biochem"},{"key":"10.1016\/j.pedneo.2015.11.004_bib4","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.cca.2006.02.018","article-title":"Cardiac troponin I serum concentrations in newborns: a study and review of the literature","volume":"371","author":"Bader","year":"2006","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.pedneo.2015.11.004_bib5","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1111\/j.1651-2227.2003.tb00832.x","article-title":"Cardiac troponin I, cardiac troponin T and creatine kinase MB concentrations in umbilical cord blood of healthy term neonates","volume":"92","author":"Trevisanuto","year":"2003","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.pedneo.2015.11.004_bib6","doi-asserted-by":"crossref","first-page":"273.e1","DOI":"10.1016\/j.ajog.2008.10.009","article-title":"Biochemical tissue-specific injury markers of the heart and brain in postpartum cord blood","volume":"200","author":"Kocylowski","year":"2009","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.pedneo.2015.11.004_bib7","first-page":"980","article-title":"Serum creatine kinase and creatine kinase-MB isoenzyme activities in perinatally asphyxiated newborns","volume":"12","author":"Omokhodion","year":"1991","journal-title":"Eur Heart J"},{"key":"10.1016\/j.pedneo.2015.11.004_bib8","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1093\/clinchem\/41.9.1266","article-title":"Equivalent early sensitivities of myoglobin, creatine kinase MB mass, creatine kinase isoform ratios, and cardiac troponins I and T for acute myocardial infarction","volume":"41","author":"Mair","year":"1995","journal-title":"Clin Chem"},{"key":"10.1016\/j.pedneo.2015.11.004_bib9","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1056\/NEJM199610313351802","article-title":"Cardiac-specific troponin I levels to predict the risk of mortality in patients with acute coronary syndromes","volume":"335","author":"Antman","year":"1996","journal-title":"New Engl J Med"},{"key":"10.1016\/j.pedneo.2015.11.004_bib10","doi-asserted-by":"crossref","first-page":"F464","DOI":"10.1136\/adc.2008.145987","article-title":"Cardiac troponin I at birth is of fetal\u2013neonatal origin","volume":"94","author":"Trevisanuto","year":"2009","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.pedneo.2015.11.004_bib11","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1159\/000079068","article-title":"Cord blood cardiac troponin I as an early predictor of short-term outcome in perinatal hypoxia","volume":"86","author":"T\u00fcrker","year":"2004","journal-title":"Biol Neonate"},{"key":"10.1016\/j.pedneo.2015.11.004_bib12","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/1824-7288-38-39","article-title":"Abd El-Aziz L. Cardiac troponin I levels and its relation to echocardiographic findings in infants of diabetic mothers","volume":"38","author":"Korraa","year":"2012","journal-title":"Ital J Pediatr"},{"key":"10.1016\/j.pedneo.2015.11.004_bib13","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1253\/circj.CJ-10-1211","article-title":"Volume overload and pressure overload due to left-to-right shunt-induced myocardial injury. Evaluation using a highly sensitive cardiac Troponin-I assay in children with congenital heart disease","volume":"75","author":"Sugimoto","year":"2011","journal-title":"Circ J"},{"key":"10.1016\/j.pedneo.2015.11.004_bib14","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1253\/circj.CJ-11-0772","article-title":"Highly sensitive cardiac troponin-I in congenital heart disease","volume":"75","author":"Kogaki","year":"2011","journal-title":"Circ J"},{"key":"10.1016\/j.pedneo.2015.11.004_bib15","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/pr.2012.88","article-title":"Use of cardiac biomarkers in neonatology","volume":"72","author":"Vijlbrief","year":"2012","journal-title":"Pediatr Res"},{"key":"10.1016\/j.pedneo.2015.11.004_bib16","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1159\/000080890","article-title":"Cardiac troponin I should be interpreted with caution in paediatric neonatal patients. Concerning Turker et\u00a0al. Cord blood cardiac troponin I as an early predictor of short-term outcome in perinatal hypoxia","volume":"87","author":"Gaze","year":"2005","journal-title":"Biol Neonate"},{"key":"10.1016\/j.pedneo.2015.11.004_bib17","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/j.echo.2013.08.019","article-title":"Validation study of the accuracy of echocardiographic measurements of systemic blood flow volume in newborn infants","volume":"26","author":"Ficial","year":"2013","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.pedneo.2015.11.004_bib18","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1203\/00006450-199404000-00024","article-title":"Doppler echocardiographic evaluation of left ventricular output and left ventricular diastolic filling changes in the first day of life","volume":"35","author":"Harada","year":"1994","journal-title":"Pediatr Res"},{"key":"10.1016\/j.pedneo.2015.11.004_bib19","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1093\/ejechocard\/jer181","article-title":"Targeted neonatal echocardiography in the neonatal intensive care unit: practice guidelines and recommendations for training","volume":"12","author":"Mertens","year":"2011","journal-title":"Eur J Echocardiogr"},{"key":"10.1016\/j.pedneo.2015.11.004_bib20","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/j.echo.2007.02.023","article-title":"Annular and septal Doppler tissue imaging in children: normal z-score tables and effects of age, heart rate, and body surface area","volume":"20","author":"Roberson","year":"2007","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.pedneo.2015.11.004_bib21","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.amjcard.2011.03.085","article-title":"Postnatal left ventricular diastolic function after fetal aortic valvuloplasty","volume":"108","author":"Friedman","year":"2011","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.pedneo.2015.11.004_bib22","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1016\/j.transproceed.2011.03.085","article-title":"Preoperative echocardiographic indices associated with elevated brain natriuretic peptide in liver transplant recipients","volume":"43","author":"Kim","year":"2011","journal-title":"Transplant Proc"},{"key":"10.1016\/j.pedneo.2015.11.004_bib23","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.amjcard.2011.10.049","article-title":"Usefulness of B-type natriuretic peptide and N-terminal pro-B-type natriuretic peptide as biomarkers for heart failure in young children with single ventricle congenital heart disease","volume":"109","author":"Lowenthal","year":"2012","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.pedneo.2015.11.004_bib24","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.amjcard.2012.03.020","article-title":"Use and misuse of serum troponin assays in pediatric practice","volume":"110","author":"Liesemer","year":"2012","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.pedneo.2015.11.004_bib25","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.ejcts.2006.05.001","article-title":"Early and long-term prognostic value of troponin-I after cardiac surgery in newborns and children","volume":"30","author":"Bottio","year":"2006","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.pedneo.2015.11.004_bib26","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1016\/j.jtcvs.2012.05.034","article-title":"Early elevation of cardiac troponin I is predictive of short-term outcome in neonates and infants with coronary anomalies or reduced ventricular mass undergoing cardiac surgery","volume":"144","author":"Bojan","year":"2012","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.pedneo.2015.11.004_bib27","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.earlhumdev.2013.04.017","article-title":"Serial change in myocardial tissue Doppler imaging from fetus to neonate","volume":"89","author":"Iwashima","year":"2013","journal-title":"Early Hum Dev"},{"key":"10.1016\/j.pedneo.2015.11.004_bib28","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s00246-014-1033-0","article-title":"Speckle tracking and myocardial tissue imaging in infant of diabetic mother with gestational and pregestational diabetes","volume":"36","author":"Al-Biltagi","year":"2015","journal-title":"Pediatr Cardiol"},{"key":"10.1016\/j.pedneo.2015.11.004_bib29","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1111\/echo.12552","article-title":"Associations of tissue Doppler imaging with NT-proBNP and hs-TnT: a pilot study in end-stage renal disease","volume":"31","author":"Dubin","year":"2014","journal-title":"Echocardiography"},{"key":"10.1016\/j.pedneo.2015.11.004_bib30","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s00431-005-0001-3","article-title":"Sequential cardiac troponin T following delivery and its relationship with myocardial performance in neonates with respiratory distress syndrome","volume":"165","author":"Clark","year":"2006","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.pedneo.2015.11.004_bib31","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1159\/000339117","article-title":"Cardiac biomarkers as indicators of hemodynamic adaptation during postasphyxial hypothermia treatment","volume":"102","author":"Vijlbrief","year":"2012","journal-title":"Neonatology"},{"key":"10.1016\/j.pedneo.2015.11.004_bib32","doi-asserted-by":"crossref","first-page":"682538","DOI":"10.1100\/2012\/682538","article-title":"The evaluation of diagnostic role of cardiac troponin T (cTnT) in newborns with heart defects","volume":"2012","author":"Tarkowska","year":"2012","journal-title":"Scientific World Journal"},{"key":"10.1016\/j.pedneo.2015.11.004_bib33","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1542\/peds.36.5.752","article-title":"Hemodynamic adaptations in the newborn infant","volume":"36","author":"Gessner","year":"1965","journal-title":"Pediatrics"},{"key":"10.1016\/j.pedneo.2015.11.004_bib34","doi-asserted-by":"crossref","first-page":"H17","DOI":"10.1152\/ajpheart.00684.2005","article-title":"Cardiac endocrine function is an essential component of the homeostatic regulation network: physiological and clinical implications","volume":"290","author":"Clerico","year":"2006","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.pedneo.2015.11.004_bib35","first-page":"106","article-title":"The transition from fetal to neonatal circulation: normal responses and implications for infants with heart disease","volume":"17","author":"Friedman","year":"1993","journal-title":"Semin Perinatol"},{"key":"10.1016\/j.pedneo.2015.11.004_bib36","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1002\/pd.1062","article-title":"The fetal circulation","volume":"24","author":"Kiserud","year":"2004","journal-title":"Prenat Diagn"}],"container-title":["Pediatrics & Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1875957216300195?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1875957216300195?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T23:56:21Z","timestamp":1655423781000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1875957216300195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["S1875957216300195"],"URL":"https:\/\/doi.org\/10.1016\/j.pedneo.2015.11.004","relation":{},"ISSN":["1875-9572"],"issn-type":[{"value":"1875-9572","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Myocardial Injury Biomarkers in Newborns with Congenital Heart Disease","name":"articletitle","label":"Article Title"},{"value":"Pediatrics & Neonatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pedneo.2015.11.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016, Taiwan Pediatric Association. Published by Elsevier Taiwan LLC.","name":"copyright","label":"Copyright"}]}}