{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T15:13:15Z","timestamp":1792249995967,"version":"4.4.0"},"reference-count":21,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,6,8]],"date-time":"2016-06-08T00:00:00Z","timestamp":1465344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","pediatr-neonatol.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics &amp; Neonatology"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.pedneo.2016.01.009","type":"journal-article","created":{"date-parts":[[2016,6,27]],"date-time":"2016-06-27T19:09:23Z","timestamp":1467054563000},"page":"158-164","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Fetal Valproate Syndrome"],"prefix":"10.1016","volume":"58","author":[{"given":"Hatice","family":"Mutlu-Albayrak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cahide","family":"Bulut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00fcseyin","family":"\u00c7aksen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pedneo.2016.01.009_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.reprotox.2009.02.014","article-title":"Valproic acid in pregnancy: how much are we endangering the embryo and fetus?","volume":"28","author":"Ornoy","year":"2009","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.pedneo.2016.01.009_bib2","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/S1474-4422(11)70107-7","article-title":"Dose-dependent risk of malformations with antiepileptic drugs: an analysis of data from the EURAP epilepsy and pregnancy registry","volume":"10","author":"Tomson","year":"2011","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.pedneo.2016.01.009_bib3","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/1096-8628(20010115)98:2<168::AID-AJMG1026>3.0.CO;2-O","article-title":"Valproic acid embryopathy: report of two siblings with further expansion of the phenotypic abnormalities and a review of the literature","volume":"98","author":"Kozma","year":"2001","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.pedneo.2016.01.009_bib4","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1002\/ajmg.1320190308","article-title":"The fetal valproate syndrome","volume":"19","author":"DiLiberti","year":"1984","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.pedneo.2016.01.009_bib5","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/ajmg.1320290123","article-title":"Verification of the fetal valproate syndrome phenotype","volume":"29","author":"Ardinger","year":"1988","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.pedneo.2016.01.009_bib6","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1056\/NEJMoa0907328","article-title":"Valproic acid monotherapy in pregnancy and major congenital malformations","volume":"362","author":"Jentink","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.pedneo.2016.01.009_bib7","doi-asserted-by":"crossref","first-page":"21","DOI":"10.2147\/tcrm.1.1.21.53605","article-title":"Should valproate be taken during pregnancy?","volume":"1","author":"Eadie","year":"2005","journal-title":"Ther Clin Risk Manag"},{"key":"10.1016\/j.pedneo.2016.01.009_bib8","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0920-1211(98)00084-9","article-title":"Congenital malformations due to antiepileptic drugs","volume":"33","author":"Kaneko","year":"1999","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.pedneo.2016.01.009_bib9","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.jocn.2004.05.003","article-title":"Critical relationship between sodium valproate dose and human teratogenicity: results of the Australian register of anti-epileptic drugs in pregnancy","volume":"11","author":"Vajda","year":"2004","journal-title":"J Clin Neurosci"},{"key":"10.1016\/j.pedneo.2016.01.009_bib10","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/ajmg.10781","article-title":"Teratogen-induced limb defects","volume":"112","author":"Holmes","year":"2002","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.pedneo.2016.01.009_bib11","first-page":"99","article-title":"Stage-dependent skeletal malformations induced by valproic acid in rat","volume":"42","author":"Menegola","year":"1998","journal-title":"Int J Dev Biol"},{"key":"10.1016\/j.pedneo.2016.01.009_bib12","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1002\/(SICI)1096-8628(20000228)90:5<376::AID-AJMG6>3.0.CO;2-V","article-title":"Prenatal exposure to valproic acid during pregnancy and limb deficiencies: a case-control study","volume":"90","author":"Rodr\u00edguez-Pinilla","year":"2000","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.pedneo.2016.01.009_bib13","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/tera.1420340305","article-title":"Teratogenesis of calcium valproate in rabbits","volume":"34","author":"Petrere","year":"1986","journal-title":"Teratology"},{"key":"10.1016\/j.pedneo.2016.01.009_bib14","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/S0890-6238(02)00056-4","article-title":"Comparative study of sodium valproate-induced skeletal malformations using single or double staining methods","volume":"16","author":"Menegola","year":"2002","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.pedneo.2016.01.009_bib15","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1002\/ajmg.a.30494","article-title":"Valproate embryopathy: clinical and cognitive profile in 5 siblings","volume":"133A","author":"Schorry","year":"2005","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.pedneo.2016.01.009_bib16","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1136\/jmg.24.11.692","article-title":"Fetal valproate syndrome: is there a recognisable phenotype?","volume":"24","author":"Winter","year":"1987","journal-title":"J Med Genet"},{"key":"10.1016\/j.pedneo.2016.01.009_bib17","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1136\/jnnp.2003.029132","article-title":"The longer term outcome of children born to mothers with epilepsy","volume":"75","author":"Adab","year":"2004","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.pedneo.2016.01.009_bib18","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.eplepsyres.2005.06.001","article-title":"Children exposed to valproate in utero\u2014population based evaluation of risks and confounding factors for long-term neurocognitive development","volume":"65","author":"Eriksson","year":"2005","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.pedneo.2016.01.009_bib19","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1203\/PDR.0b013e3180a02e50","article-title":"Antiepileptic medication during pregnancy: does fetal genotype affect outcome?","volume":"62","author":"Atkinson","year":"2007","journal-title":"Pediatr Res"},{"key":"10.1016\/j.pedneo.2016.01.009_bib20","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.taap.2010.08.001","article-title":"Epigenetic modifications in valproic acid-induced teratogenesis","volume":"248","author":"Tung","year":"2010","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.pedneo.2016.01.009_bib21","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1212\/WNL.59.4.630","article-title":"Valproate embryopathy in three sets of siblings: further proof of hereditary susceptibility","volume":"59","author":"Malm","year":"2002","journal-title":"Neurology"}],"container-title":["Pediatrics &amp; Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1875957216300729?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1875957216300729?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T22:58:23Z","timestamp":1536620303000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1875957216300729"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["S1875957216300729"],"URL":"https:\/\/doi.org\/10.1016\/j.pedneo.2016.01.009","relation":{},"ISSN":["1875-9572"],"issn-type":[{"value":"1875-9572","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fetal Valproate Syndrome","name":"articletitle","label":"Article Title"},{"value":"Pediatrics & Neonatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pedneo.2016.01.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016, Taiwan Pediatric Association. Published by Elsevier Taiwan LLC.","name":"copyright","label":"Copyright"}]}}