{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T03:12:30Z","timestamp":1790478750190,"version":"4.1.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,20]],"date-time":"2018-09-20T00:00:00Z","timestamp":1537401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Yuanta Foundation"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","pediatr-neonatol.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics & Neonatology"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.pedneo.2018.09.006","type":"journal-article","created":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T12:59:26Z","timestamp":1537793966000},"page":"389-395","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Prognostic parameters of pediatric acute liver failure and the role of plasma exchange"],"prefix":"10.1016","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0988-4012","authenticated-orcid":false,"given":"Mu-Ming","family":"Chien","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Hwei","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-Chi","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang-Ting","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Chun","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huey-Ling","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen-Hsuan","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5720-4835","authenticated-orcid":false,"given":"Hong-Yuan","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Feng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pedneo.2018.09.006_bib1","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1067\/mpd.2001.119989","article-title":"Acute liver failure in infancy: a 14-year experience of a pediatric liver transplantation center","volume":"139","author":"Durand","year":"2001","journal-title":"J Pediatr"},{"key":"10.1016\/j.pedneo.2018.09.006_bib2","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/S1665-2681(19)30767-7","article-title":"Etiology, outcome and prognostic factors of childhood acute liver failure in a German single center","volume":"14","author":"Kathemann","year":"2015","journal-title":"Ann Hepatol"},{"key":"10.1016\/j.pedneo.2018.09.006_bib3","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1097\/01.MPG.0000158524.30294.E2","article-title":"Etiology, outcome and prognostic indicators of childhood fulminant hepatic failure in the United Kingdom","volume":"40","author":"Lee","year":"2005","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.pedneo.2018.09.006_bib4","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.jpeds.2005.12.051","article-title":"Acute liver failure in children: the first 348 patients in the pediatric acute liver failure study group","volume":"148","author":"Squires","year":"2006","journal-title":"J Pediatr"},{"key":"10.1016\/j.pedneo.2018.09.006_bib5","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1111\/petr.12083","article-title":"Pediatric acute liver failure: etiology, outcomes, and the role of serial pediatric end-stage liver disease scores","volume":"17","author":"Rajanayagam","year":"2013","journal-title":"Pediatr Transplant"},{"key":"10.1016\/j.pedneo.2018.09.006_bib6","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1111\/j.1440-1746.2005.03923.x","article-title":"Factors affecting the mortality of pediatric fulminant hepatic failure in relation to hepatitis B virus infection","volume":"20","author":"Chan","year":"2005","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.pedneo.2018.09.006_bib7","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.4254\/wjh.v7.i11.1509","article-title":"Current developments in pediatric liver transplantation","volume":"7","author":"Hackl","year":"2015","journal-title":"World J Hepatol"},{"key":"10.1016\/j.pedneo.2018.09.006_bib8","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1016\/j.cgh.2008.05.013","article-title":"Evaluation of a scoring system for assessing prognosis in pediatric acute liver failure","volume":"6","author":"Lu","year":"2008","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.pedneo.2018.09.006_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpeds.2012.11.021","article-title":"Evaluation of the liver injury unit scoring system to predict survival in a multinational study of pediatric acute liver failure","volume":"162","author":"Lu","year":"2013","journal-title":"J Pediatr"},{"key":"10.1016\/j.pedneo.2018.09.006_bib10","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.jhep.2005.06.021","article-title":"Characterization of acute liver failure and development of a continuous risk of death staging system in children","volume":"44","author":"Liu","year":"2006","journal-title":"J Hepatol"},{"key":"10.1016\/j.pedneo.2018.09.006_bib11","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1097\/MPG.0b013e3182349a04","article-title":"Pediatric end-stage liver disease score in acute liver failure to assess poor prognosis","volume":"54","author":"Sanchez","year":"2012","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.pedneo.2018.09.006_bib12","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1097\/00000658-200109000-00015","article-title":"Role of plasmapheresis in the management of acute hepatic failure in children","volume":"234","author":"Singer","year":"2001","journal-title":"Ann Surg"},{"key":"10.1016\/j.pedneo.2018.09.006_bib13","doi-asserted-by":"crossref","first-page":"e268","DOI":"10.1097\/PCC.0000000000000511","article-title":"Continuous veno-venous hemodiafiltration and plasma exchange in infantile acute liver failure","volume":"16","author":"Ide","year":"2015","journal-title":"Pediatr Crit Care Med"},{"key":"10.1016\/j.pedneo.2018.09.006_bib14","doi-asserted-by":"crossref","DOI":"10.1097\/PCC.0000000000000172","article-title":"High-volume hemofiltration in children with acute liver failure*","volume":"15","author":"Chevret","year":"2014","journal-title":"Pediatr Crit Care Med"},{"key":"10.1016\/j.pedneo.2018.09.006_bib15","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jhep.2015.08.018","article-title":"High-volume plasma exchange in patients with acute liver failure: an open randomised controlled trial","volume":"64","author":"Larsen","year":"2016","journal-title":"J Hepatol"},{"key":"10.1016\/j.pedneo.2018.09.006_bib16","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/00007890-200207270-00006","article-title":"Principal Investigators and Institutions of the studies of pediatric liver transplantation (SPLIT) research Group. Development of a pediatric end-stage liver disease score to predict poor outcome in children awaiting liver transplantation","volume":"74","author":"McDiarmid","year":"2002","journal-title":"Transplantation"},{"key":"10.1016\/j.pedneo.2018.09.006_bib17","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/00005176-198901000-00005","article-title":"Serum alpha-fetoprotein levels in normal infants: a reappraisal of regression analysis and sex difference","volume":"8","author":"Lee","year":"1989","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.pedneo.2018.09.006_bib18","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1002\/lt.24037","article-title":"Experience with molecular adsorbent recirculating system treatment in 20 children listed for high-urgency liver transplantation","volume":"21","author":"Lexmond","year":"2015","journal-title":"Liver Transpl"},{"key":"10.1016\/j.pedneo.2018.09.006_bib19","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1097\/PCC.0b013e3181f35fa2","article-title":"Continuous veno-venous single-pass albumin hemodiafiltration in children with acute liver failure","volume":"12","author":"Ringe","year":"2011","journal-title":"Pediatr Crit Care Med"},{"key":"10.1016\/j.pedneo.2018.09.006_bib20","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1097\/MPG.0b013e3182a853a3","article-title":"Effect of molecular adsorbents recirculating system treatment in children with acute liver failure caused by Wilson disease","volume":"58","author":"Rustom","year":"2014","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.pedneo.2018.09.006_bib21","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1007\/s00467-013-2691-5","article-title":"Molecular absorbent recirculating system therapy (MARS\u00ae)\u00a0in pediatric acute liver failure: a single center experience","volume":"29","author":"Bourgoin","year":"2014","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.pedneo.2018.09.006_bib22","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1016\/j.transproceed.2008.05.075","article-title":"Pediatric acute liver failure with molecular adsorbent recirculating system treatment","volume":"40","author":"Novelli","year":"2008","journal-title":"Transplant Proc"},{"key":"10.1016\/j.pedneo.2018.09.006_bib23","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1111\/j.1432-2277.2007.00474.x","article-title":"Paediatric acute liver failure and transplantation: the University of Essen experience","volume":"20","author":"Nadalin","year":"2007","journal-title":"Transpl Int"},{"key":"10.1016\/j.pedneo.2018.09.006_bib24","series-title":"Case numbers of liver and kidney transplantation with living donor from 2009 to 2015","year":"2016"},{"key":"10.1016\/j.pedneo.2018.09.006_bib25","series-title":"The number of organ procurement and post-transplantation survival rate of each hospital from 2006 to 2010","year":"2011"},{"key":"10.1016\/j.pedneo.2018.09.006_bib26","doi-asserted-by":"crossref","first-page":"522","DOI":"10.7326\/0003-4819-159-8-201310150-00005","article-title":"Albumin dialysis with a noncell artificial liver support device in patients with acute liver failure: a randomized, controlled trial","volume":"159","author":"Saliba","year":"2013","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.pedneo.2018.09.006_bib27","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1002\/lt.20886","article-title":"Alpha-fetoprotein and prognosis in acute liver failure","volume":"12","author":"Schi\u00f8dt","year":"2006","journal-title":"Liver Transpl"},{"key":"10.1016\/j.pedneo.2018.09.006_bib28","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/hep.20511","article-title":"Alpha-fetoprotein is a predictor of outcome in acetaminophen-induced liver injury","volume":"41","author":"Schmidt","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.pedneo.2018.09.006_bib29","doi-asserted-by":"crossref","first-page":"E12","DOI":"10.1111\/hepr.12448","article-title":"Alpha-fetoprotein: a biomarker for the recruitment of progenitor cells in the liver in patients with acute liver injury or failure","volume":"45","author":"Kakisaka","year":"2015","journal-title":"Hepatol Res"},{"key":"10.1016\/j.pedneo.2018.09.006_bib30","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1097\/00005176-199007000-00005","article-title":"Prognostic implications of serum alpha-fetoprotein levels in neonatal hepatitis","volume":"11","author":"Lee","year":"1990","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.pedneo.2018.09.006_bib31","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1373\/clinchem.2014.229799","article-title":"Pediatric population reference value distributions for cancer biomarkers and covariate-stratified reference intervals in the CALIPER cohort","volume":"60","author":"Bevilacqua","year":"2014","journal-title":"Clin Chem"},{"key":"10.1016\/j.pedneo.2018.09.006_bib32","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1053\/j.gastro.2009.09.018","article-title":"Serum levels of interleukin-10 and interleukin-12 predict early, spontaneous hepatitis B virus e antigen seroconversion","volume":"138","author":"Wu","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pedneo.2018.09.006_bib33","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.cld.2018.01.006","article-title":"Nonacetaminophen drug-induced acute liver failure","volume":"22","author":"Thomas","year":"2018","journal-title":"Clin Liver Dis"},{"key":"10.1016\/j.pedneo.2018.09.006_bib34","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1093\/infdis\/jis420","article-title":"Toll-like receptor and hepatitis B virus clearance in chronic infected patients: a long-term prospective cohort study in Taiwan","volume":"206","author":"Wu","year":"2012","journal-title":"J Infect Dis"},{"key":"10.1016\/j.pedneo.2018.09.006_bib35","doi-asserted-by":"crossref","first-page":"e111825","DOI":"10.1371\/journal.pone.0111825","article-title":"Infantile hepatitis B in immunized children: risk for fulminant hepatitis and long-term outcomes","volume":"9","author":"Tseng","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.pedneo.2018.09.006_bib36","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s13312-013-0147-4","article-title":"Management of acute liver failure in infants and children: consensus statement of the pediatric gastroenterology chapter, Indian academy of pediatrics","volume":"50","author":"Bhatia","year":"2013","journal-title":"Indian Pediatr"}],"container-title":["Pediatrics & Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1875957218301633?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1875957218301633?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T23:09:31Z","timestamp":1565305771000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1875957218301633"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["S1875957218301633"],"URL":"https:\/\/doi.org\/10.1016\/j.pedneo.2018.09.006","relation":{},"ISSN":["1875-9572"],"issn-type":[{"value":"1875-9572","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prognostic parameters of pediatric acute liver failure and the role of plasma exchange","name":"articletitle","label":"Article Title"},{"value":"Pediatrics & Neonatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pedneo.2018.09.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Taiwan Pediatric Association. Published by Elsevier Taiwan LLC.","name":"copyright","label":"Copyright"}]}}