{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T08:06:11Z","timestamp":1790409971435,"version":"4.1.0"},"reference-count":21,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,2,19]],"date-time":"2020-02-19T00:00:00Z","timestamp":1582070400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006280","name":"Ministerio de Ciencia y Tecnolog\u00c3\u00ada","doi-asserted-by":"publisher","award":["105-3011-F-182A-001"],"award-info":[{"award-number":["105-3011-F-182A-001"]}],"id":[{"id":"10.13039\/501100006280","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPG3G1971"],"award-info":[{"award-number":["CMRPG3G1971"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPG3F1143"],"award-info":[{"award-number":["CMRPG3F1143"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPG3F0083"],"award-info":[{"award-number":["CMRPG3F0083"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPG3H0041"],"award-info":[{"award-number":["CMRPG3H0041"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPG370551"],"award-info":[{"award-number":["CMRPG370551"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","pediatr-neonatol.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics &amp; Neonatology"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.pedneo.2020.02.005","type":"journal-article","created":{"date-parts":[[2020,2,22]],"date-time":"2020-02-22T11:15:25Z","timestamp":1582370125000},"page":"338-342","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Thomsen-Friedenreich antigen activation as a predictor for clinical outcome of pediatric patients with invasive pneumococcal disease"],"prefix":"10.1016","volume":"61","author":[{"given":"Yi-Ching","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin-Hang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4331-0925","authenticated-orcid":false,"given":"Rajendra-Prasad","family":"Janapatla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1461-6271","authenticated-orcid":false,"given":"Anna","family":"Dudek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Hua","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4591-0924","authenticated-orcid":false,"given":"Chyi-Liang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Hsun","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pedneo.2020.02.005_bib1","doi-asserted-by":"crossref","first-page":"e1528","DOI":"10.1542\/peds.2013-4177","article-title":"Sinusitis and pneumonia hospitalization after introduction of pneumococcal conjugate vaccine","volume":"134","author":"Lindstrand","year":"2014","journal-title":"Pediatrics"},{"key":"10.1016\/j.pedneo.2020.02.005_bib2","doi-asserted-by":"crossref","first-page":"e23","DOI":"10.1086\/600045","article-title":"Invasive pneumococcal disease among adults: associations among serotypes, disease characteristics, and outcome","volume":"49","author":"Jansen","year":"2009","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.pedneo.2020.02.005_bib3","doi-asserted-by":"crossref","first-page":"121","DOI":"10.7774\/cevr.2015.4.2.121","article-title":"Pneumococcal disease and use of pneumococcal vaccines in Taiwan","volume":"4","author":"Wei","year":"2015","journal-title":"Clin Exp Vaccine Res"},{"key":"10.1016\/j.pedneo.2020.02.005_bib4","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1093\/cid\/ciu524","article-title":"Impact of 13-valent pneumococcal conjugate vaccination in invasive pneumococcal disease incidence and mortality","volume":"59","author":"Harboe","year":"2014","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.pedneo.2020.02.005_bib5","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S1473-3099(15)70044-7","article-title":"Effect of the 13-valent pneumococcal conjugate vaccine on invasive pneumococcal disease in England and Wales 4 years after its introduction: an observational cohort study","volume":"15","author":"Waight","year":"2015","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.pedneo.2020.02.005_bib6","doi-asserted-by":"crossref","first-page":"e71","DOI":"10.1097\/INF.0000000000000565","article-title":"Pediatric invasive pneumococcal disease in Taiwan following a national catch-up program with the 13-valent pneumococcal conjugate vaccine","volume":"34","author":"Wei","year":"2015","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.pedneo.2020.02.005_bib7","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1097\/INF.0b013e31829ee872","article-title":"Diagnosis of Streptococcus pneumoniae-associated hemolytic uremic syndrome","volume":"32","author":"Loupiac","year":"2013","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.pedneo.2020.02.005_bib8","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1097\/01.inf.0000223494.83542.ad","article-title":"T-antigen activation for prediction of pneumococcus-induced hemolytic uremic syndrome and hemolytic anemia","volume":"25","author":"Huang","year":"2006","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.pedneo.2020.02.005_bib9","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1111\/j.1469-0691.2012.03894.x","article-title":"Necrotizing pneumonia caused by nanC-carrying serotypes is associated with pneumococcal haemolytic uraemic syndrome in children","volume":"19","author":"Janapatla","year":"2013","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.pedneo.2020.02.005_bib10","doi-asserted-by":"crossref","first-page":"e3221","DOI":"10.1097\/MD.0000000000003221","article-title":"Low serum fetuin-A as a biomarker to predict pneumococcal necrotizing pneumonia and hemolytic uremic syndrome in children","volume":"95","author":"Janapatla","year":"2016","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.pedneo.2020.02.005_bib11","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1099\/jmm.0.000724","article-title":"Immunization with pneumococcal neuraminidases NanA, NanB and NanC to generate neutralizing antibodies and to increase survival in mice","volume":"67","author":"Janapatla","year":"2018","journal-title":"J Med Microbiol"},{"key":"10.1016\/j.pedneo.2020.02.005_bib12","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1128\/JCM.44.1.124-131.2006","article-title":"Sequential multiplex PCR approach for determining capsular serotypes of Streptococcus pneumoniae isolates","volume":"44","author":"Pai","year":"2006","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.pedneo.2020.02.005_bib13","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1086\/606118","article-title":"First report of putative Streptococcus pneumoniae serotype 6D among nasopharyngeal isolates from Fijian children","volume":"200","author":"Jin","year":"2009","journal-title":"J Infect Dis"},{"key":"10.1016\/j.pedneo.2020.02.005_bib14","doi-asserted-by":"crossref","first-page":"971","DOI":"10.3346\/jkms.2011.26.8.971","article-title":"Streptococcus pneumoniae type determination by multiplex polymerase chain reaction","volume":"26","author":"Yun","year":"2011","journal-title":"J Korean Med Sci"},{"key":"10.1016\/j.pedneo.2020.02.005_bib15","first-page":"154","article-title":"Glomerular and arteriolar thrombosis in pneumococcal septicemia","volume":"89","author":"Schenk","year":"1970","journal-title":"Arch Pathol"},{"key":"10.1016\/j.pedneo.2020.02.005_bib16","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1007\/s00431-005-0041-8","article-title":"Hemolytic uremic syndrome associated with pneumococcal pneumonia in Taiwan","volume":"165","author":"Huang","year":"2006","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.pedneo.2020.02.005_bib17","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.mehy.2013.05.030","article-title":"Does dysregulated complement activation contribute to haemolytic uraemic syndrome secondary to Streptococcus pneumoniae?","volume":"81","author":"Gilbert","year":"2013","journal-title":"Med Hypotheses"},{"key":"10.1016\/j.pedneo.2020.02.005_bib18","doi-asserted-by":"crossref","first-page":"e174","DOI":"10.1542\/peds.2007-2017","article-title":"Streptococcus pneumoniae-associated hemolytic uremic syndrome: classification and the emergence of serotype 19A","volume":"125","author":"Copelovitch","year":"2010","journal-title":"Pediatrics"},{"key":"10.1016\/j.pedneo.2020.02.005_bib19","doi-asserted-by":"crossref","first-page":"F192","DOI":"10.1136\/fn.80.3.F192","article-title":"T and Tk antigen activation in necrotising enterocolitis: manifestations, severity of illness and effectiveness of testing","volume":"80","author":"Osborn","year":"1999","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.pedneo.2020.02.005_bib20","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1111\/trf.12981","article-title":"Red blood cell Thomsen-Friedenreich antigen expression and galectin-3 plasma concentrations in Streptococcus pneumoniae\u2013associated hemolytic uremic syndrome and hemolytic anemia","volume":"55","author":"Burin des Roziers","year":"2015","journal-title":"Transfusion"},{"key":"10.1016\/j.pedneo.2020.02.005_bib21","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1056\/NEJMra0902814","article-title":"Atypical hemolytic uremic syndrome","volume":"361","author":"Noris","year":"2009","journal-title":"N Engl J Med"}],"container-title":["Pediatrics &amp; Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1875957220300231?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1875957220300231?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T14:54:43Z","timestamp":1761749683000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1875957220300231"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["S1875957220300231"],"URL":"https:\/\/doi.org\/10.1016\/j.pedneo.2020.02.005","relation":{},"ISSN":["1875-9572"],"issn-type":[{"value":"1875-9572","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Thomsen-Friedenreich antigen activation as a predictor for clinical outcome of pediatric patients with invasive pneumococcal disease","name":"articletitle","label":"Article Title"},{"value":"Pediatrics & Neonatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pedneo.2020.02.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Taiwan Pediatric Association. Published by Elsevier Taiwan LLC.","name":"copyright","label":"Copyright"}]}}