{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:25:09Z","timestamp":1790814309645,"version":"4.1.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,7,18]],"date-time":"2020-07-18T00:00:00Z","timestamp":1595030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","pediatr-neonatol.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics &amp; Neonatology"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.pedneo.2020.07.014","type":"journal-article","created":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T12:14:18Z","timestamp":1595506458000},"page":"629-636","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Evolution of congenital hypothyroidism in a cohort of preterm born children"],"prefix":"10.1016","volume":"61","author":[{"given":"Maria","family":"Scavone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Giancotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Anastasio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Licia","family":"Pensabene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Sestito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1223-7358","authenticated-orcid":false,"given":"Daniela","family":"Concolino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pedneo.2020.07.014_bib1","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1001\/archpedi.1949.02030050840001","article-title":"End results in treatment of congenital hypothyroidism; follow-up study of physical, mental and behavioral development","volume":"78","author":"Radwin","year":"1949","journal-title":"Am J Dis Child"},{"key":"10.1016\/j.pedneo.2020.07.014_bib2","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1210\/jcem-72-3-523","article-title":"Clinical review 19: Management of congenital hypothyroidism","volume":"72","author":"Fisher","year":"1991","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.pedneo.2020.07.014_bib3","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nrendo.2011.160","article-title":"Detection and treatment of congenital hypothyroidism","volume":"8","author":"Gr\u00fcters","year":"2012","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.pedneo.2020.07.014_bib4","first-page":"195","article-title":"The Italian screening program for primary congenital hypothyroidism: actions to improve screening, diagnosis, follow-up, and surveillance","volume":"36","author":"Cassio","year":"2013","journal-title":"J Endocrinol Invest"},{"key":"10.1016\/j.pedneo.2020.07.014_bib5","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1210\/jc.2013-1891","article-title":"European Society for Paediatric Endocrinology Consensus guidelines on screening, diagnosis, and management of congenital hypothyroidism","volume":"99","author":"L\u00e9ger","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.pedneo.2020.07.014_bib6","first-page":"E88","article-title":"Syndromes of thyroid hormone resistance","volume":"243","author":"Refetoff","year":"1982","journal-title":"Am J Physiol"},{"key":"10.1016\/j.pedneo.2020.07.014_bib7","first-page":"191","article-title":"Resistance to thyroid hormone due to a novel THR-\u03b2 mutation in a patient with thyroid agenesis","volume":"13","author":"Scavone","year":"2018","journal-title":"EMBJ"},{"key":"10.1016\/j.pedneo.2020.07.014_bib8","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1750-1172-5-17","article-title":"Congenital hypothyroidism","volume":"5","author":"Rastogi","year":"2010","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.pedneo.2020.07.014_bib9","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1111\/j.1365-2265.2009.03568.x","article-title":"A 7-year experience with low blood TSH cutoff levels for neonatal screening reveals an unsuspected frequency of congenital hypothyroidism","volume":"71","author":"Corbetta","year":"2009","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.pedneo.2020.07.014_bib10","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1111\/j.1365-2265.2011.04128.x","article-title":"The increased incidence of congenital hypothyroidism: fact or fancy?","volume":"75","author":"Mitchell","year":"2011","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.pedneo.2020.07.014_bib11","doi-asserted-by":"crossref","first-page":"4283","DOI":"10.1210\/jc.2010-0057","article-title":"Screening for congenital hypothyroidism: the significance of threshold limit in false-negative results","volume":"95","author":"Mengreli","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.pedneo.2020.07.014_bib12","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1097\/MED.0000000000000181","article-title":"Congenital hypothyroidism: recent advances","volume":"22","author":"Wassner","year":"2015","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"10.1016\/j.pedneo.2020.07.014_bib13","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.beem.2013.05.008","article-title":"Screening for congenital hypothyroidism: a worldwide view of strategies","volume":"28","author":"Ford","year":"2014","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"10.1016\/j.pedneo.2020.07.014_bib14","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S1084-2756(03)00114-3","article-title":"Hypothyroxinaemia and thyroid function after preterm birth","volume":"9","author":"van Wassenaer","year":"2004","journal-title":"Semin Neonatol"},{"key":"10.1016\/j.pedneo.2020.07.014_bib15","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1515\/JPEM.2008.21.3.237","article-title":"Thyroid function in 76 sick preterm infants 30\u201336 weeks: results from a longitudinal study","volume":"21","author":"Carrascosa","year":"2008","journal-title":"J Pediatr Endocrinol Metab"},{"key":"10.1016\/j.pedneo.2020.07.014_bib16","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1016\/j.jpeds.2013.12.048","article-title":"Evolution of thyroid function in preterm infants detected by screening for congenital hypothyroidism","volume":"164","author":"Vigone","year":"2014","journal-title":"J Pediatr"},{"key":"10.1016\/j.pedneo.2020.07.014_bib17","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.ymgme.2007.03.012","article-title":"Increase in congenital hypothyroidism in New York State and in the United States","volume":"91","author":"Harris","year":"2007","journal-title":"Mol Genet Metab"},{"key":"10.1016\/j.pedneo.2020.07.014_bib18","doi-asserted-by":"crossref","first-page":"S37","DOI":"10.1542\/peds.2009-1975D","article-title":"Trends in incidence rates of congenital hypothyroidism related to select demographic factors: data from the United States, California, Massachusetts, New York, and Texas","volume":"125","author":"Hinton","year":"2010","journal-title":"Pediatrics"},{"key":"10.1016\/j.pedneo.2020.07.014_bib19","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1159\/000369394","article-title":"Multiple factors influencing the incidence of congenital hypothyroidism detected by neonatal screening","volume":"83","author":"Olivieri","year":"2015","journal-title":"Horm Res Paediatr"},{"key":"10.1016\/j.pedneo.2020.07.014_bib20","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.annepidem.2015.11.005","article-title":"Increased incidence of congenital hypothyroidism in France from 1982 to 2012: a nationwide multicenter analysis","volume":"26","author":"Barry","year":"2016","journal-title":"Ann Epidemiol"},{"key":"10.1016\/j.pedneo.2020.07.014_bib21","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1159\/000488288","article-title":"Permanent decompensated congenital hypothyroidism in newborns with whole-blood thyroid-stimulating hormone concentrations between 8 and 10 mU\/L: the case for lowering the threshold","volume":"89","author":"McGrath","year":"2018","journal-title":"Horm Res Paediatr"},{"key":"10.1016\/j.pedneo.2020.07.014_bib22","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/j.jpeds.2014.02.031","article-title":"Screening preterm infants for congenital hypothyroidism: better the second time around","volume":"164","author":"LaFranchi","year":"2014","journal-title":"J Pediatr"},{"key":"10.1016\/j.pedneo.2020.07.014_bib23","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1056\/NEJM199102213240805","article-title":"Maturation of the secretion of thyroid hormone and thyroid-stimulating hormone in the fetus","volume":"324","author":"Thorpe-Beeston","year":"1991","journal-title":"N Engl J Med"},{"key":"10.1016\/j.pedneo.2020.07.014_bib24","doi-asserted-by":"crossref","first-page":"5314","DOI":"10.1210\/jc.2004-0869","article-title":"Developmental trends in cord and postpartum serum thyroid hormones in preterm infants","volume":"89","author":"Williams","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.pedneo.2020.07.014_bib25","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.jpeds.2010.10.018","article-title":"Congenital hypothyroidism with a delayed thyroid-stimulating hormone elevation in very premature infants: incidence and growth and developmental outcomes","volume":"158","author":"Woo","year":"2011","journal-title":"J Pediatr"},{"key":"10.1016\/j.pedneo.2020.07.014_bib26","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1067\/S0022-3476(03)00332-9","article-title":"Risk factors associated with delayed thyrotropin elevations in congenital hypothyroidism","volume":"143","author":"Larson","year":"2003","journal-title":"J Pediatr"},{"key":"10.1016\/j.pedneo.2020.07.014_bib27","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.jpeds.2018.11.044","article-title":"Increased congenital hypothyroidism detection in preterm infants with serial newborn screening","volume":"207","author":"Kaluarachchi","year":"2019","journal-title":"J Pediatr"},{"key":"10.1016\/j.pedneo.2020.07.014_bib28","doi-asserted-by":"crossref","first-page":"3050","DOI":"10.1210\/jc.2017-00701","article-title":"Risk factors for the development of delayed TSH elevation in neonatal intensive care unit newborns","volume":"102","author":"Zung","year":"2017","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.pedneo.2020.07.014_bib29","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1159\/000448658","article-title":"Transient versus permanent congenital hypothyroidism after the age of 3 years in infants detected on the first versus second newborn screening test in Oregon, USA","volume":"86","author":"Ford","year":"2016","journal-title":"Horm Res Paediatr"},{"key":"10.1016\/j.pedneo.2020.07.014_bib30","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1530\/EC-17-0332","article-title":"Diagnostic re-evaluation of congenital hypothyroidism in Macedonia: predictors for transient or permanent hypothyroidism","volume":"7","author":"Zdraveska","year":"2018","journal-title":"Endocr Connect"},{"key":"10.1016\/j.pedneo.2020.07.014_bib31","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1007\/s12020-015-0574-1","article-title":"Levothyroxine requirement in congenital hypothyroidism: a 12-year longitudinal study","volume":"50","author":"Delvecchio","year":"2015","journal-title":"Endocrine"},{"key":"10.1016\/j.pedneo.2020.07.014_bib32","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1515\/jpem-2019-0054","article-title":"Congenital hypothyroidism in preterm infants: a 3- to 8-year longitudinal study in southern Thailand","volume":"32","author":"Jaruratanasirikul","year":"2019","journal-title":"J Pediatr Endocrinol Metab"},{"key":"10.1016\/j.pedneo.2020.07.014_bib33","doi-asserted-by":"crossref","first-page":"4499","DOI":"10.1210\/jc.2013-2175","article-title":"Cognitive development in congenital hypothyroidism: is overtreatment a greater threat than undertreatment?","volume":"98","author":"Bongers-Schokking","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.pedneo.2020.07.014_bib34","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.pedneo.2017.01.002","article-title":"Three-year follow-up of children with abnormal newborn screening results for congenital hypothyroidism","volume":"58","author":"Kang","year":"2017","journal-title":"Pediatr Neonatol"},{"key":"10.1016\/j.pedneo.2020.07.014_bib35","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1159\/000435811","article-title":"Early discrimination between transient and permanent congenital hypothyroidism in children with eutopic gland","volume":"84","author":"Messina","year":"2015","journal-title":"Horm Res Paediatr"},{"key":"10.1016\/j.pedneo.2020.07.014_bib36","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1186\/s12887-019-1833-8","article-title":"Factors associated with permanent hypothyroidism in infants with congenital hypothyroidism","volume":"19","author":"Park","year":"2019","journal-title":"BMC Pediatr"}],"container-title":["Pediatrics &amp; Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1875957220301133?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1875957220301133?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T14:54:01Z","timestamp":1761749641000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1875957220301133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["S1875957220301133"],"URL":"https:\/\/doi.org\/10.1016\/j.pedneo.2020.07.014","relation":{},"ISSN":["1875-9572"],"issn-type":[{"value":"1875-9572","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evolution of congenital hypothyroidism in a cohort of preterm born children","name":"articletitle","label":"Article Title"},{"value":"Pediatrics & Neonatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pedneo.2020.07.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Taiwan Pediatric Association. Published by Elsevier Taiwan LLC.","name":"copyright","label":"Copyright"}]}}