{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T14:26:15Z","timestamp":1773411975561,"version":"3.50.1"},"reference-count":19,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T00:00:00Z","timestamp":1610496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","pediatr-neonatol.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics & Neonatology"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.pedneo.2021.01.002","type":"journal-article","created":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T11:40:22Z","timestamp":1611056422000},"page":"249-257","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Role of primary prophylaxis in preventing variceal bleeding in children with gastroesophageal varices"],"prefix":"10.1016","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9163-2828","authenticated-orcid":false,"given":"Way Seah","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3910-9241","authenticated-orcid":false,"given":"Zhi Liang","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun Min","family":"Em","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9259-6993","authenticated-orcid":false,"given":"Kee Seang","family":"Chew","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1656-5797","authenticated-orcid":false,"given":"Ruey Terng","family":"Ng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pedneo.2021.01.002_bib1","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.cld.2018.06.007","article-title":"Cirrhosis and portal hypertension in the pediatric population","volume":"22","author":"Chapin","year":"2018","journal-title":"Clin Liver Dis"},{"key":"10.1016\/j.pedneo.2021.01.002_bib2","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1586\/17474124.2015.993610","article-title":"Advances in the management of childhood portal hypertension","volume":"9","author":"McKiernan","year":"2015","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.pedneo.2021.01.002_bib3","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1056\/NEJMra0901512","article-title":"Management of varices and variceal hemorrhage in cirrhosis","volume":"362","author":"Garcia-Tsao","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.pedneo.2021.01.002_bib4","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1097\/MPG.0b013e31826eb0cf","article-title":"Portal hypertension in children and young adults with biliary atresia","volume":"55","author":"Shneider","year":"2012","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.pedneo.2021.01.002_bib5","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1053\/j.gastro.2013.06.022","article-title":"Experience with endoscopic management of high-risk gastroesophageal varices, with and without bleeding, in children with biliary atresia","volume":"145","author":"Duch\u00e9","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pedneo.2021.01.002_bib6","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.jhep.2016.09.006","article-title":"Portal hypertension in children: high-risk varices, primary prophylaxis and consequences of bleeding","volume":"66","author":"Duch\u00e9","year":"2017","journal-title":"J Hepatol"},{"key":"10.1016\/j.pedneo.2021.01.002_bib7","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1097\/MPG.0000000000001160","article-title":"Endoscopic evaluation in children with end-stage liver disease-associated portal hypertension awaiting liver transplant","volume":"63","author":"Ng","year":"2016","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.pedneo.2021.01.002_bib8","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1002\/hep.28153","article-title":"Primary prophylaxis of variceal bleeding in children and the role of MesoRex bypass: summary of the Baveno VI Pediatric Satellite Symposium","volume":"63","author":"Shneider","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.pedneo.2021.01.002_bib9","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1097\/MPG.0b013e3182a1cd7f","article-title":"Management of portal hypertension in children with portal vein thrombosis","volume":"57","author":"Giouleme","year":"2013","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.pedneo.2021.01.002_bib10","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1111\/j.1399-3046.2012.01652.x","article-title":"Portal hypertension in children: expert pediatric opinion on the report of the Baveno V Consensus workshop on methodology of diagnosis and therapy in portal hypertension","volume":"16","author":"Shneider","year":"2012","journal-title":"Pediatr Transplant"},{"key":"10.1016\/j.pedneo.2021.01.002_bib11","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1053\/j.gastro.2013.08.026","article-title":"Preventing variceal bleeding in infants and children: is less more?","volume":"145","author":"Molleston","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pedneo.2021.01.002_bib12","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1097\/MPG.0000000000000710","article-title":"Progression of high-risk gastroesophageal varices in children with biliary atresia with low-risk signs at first endoscopy","volume":"60","author":"Duch\u00e9","year":"2015","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.pedneo.2021.01.002_bib13","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1590\/s0004-2803.2017v54n1-04","article-title":"Evaluation of endoscopic secondary prophylaxis in children and adolescents with esophageal varices","volume":"54","author":"Pimenta","year":"2017","journal-title":"Arq Gastroenterol"},{"key":"10.1016\/j.pedneo.2021.01.002_bib14","doi-asserted-by":"crossref","first-page":"7776","DOI":"10.3748\/wjg.v23.i43.7776","article-title":"Chronic liver disease is universal in children with biliary atresia living with native liver","volume":"23","author":"Lee","year":"2017","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.pedneo.2021.01.002_bib15","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0016-5085(90)91305-P","article-title":"Gastroesophageal endoscopic features in cirrhosis. Observer variability, interassociations, and relationship to hepatic dysfunction","volume":"98","author":"Cal\u00e8s","year":"1990","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pedneo.2021.01.002_bib16","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1097\/MPG.0b013e318213be81","article-title":"Variation in care for children with esophageal varices: a study of physicians', patients', and families' approaches and attitudes","volume":"52","author":"Gana","year":"2011","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.pedneo.2021.01.002_bib17","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0022-3468(00)90203-3","article-title":"Prophylactic sclerotherapy in children with esophageal varices: long-term results of a controlled prospective randomized trial","volume":"35","author":"Gon\u00e7alves","year":"2000","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.pedneo.2021.01.002_bib18","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/S0022-3468(03)00181-7","article-title":"Endoscopic ligation of esophageal varices for prophylaxis of first bleeding in children and adolescents with portal hypertension: preliminary results of a prospective study","volume":"38","author":"Celi\u0144ska-Cedro","year":"2003","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.pedneo.2021.01.002_bib19","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1016\/j.jpedsurg.2006.08.022","article-title":"Pediatric gastroesophageal varices: treatment strategy and long-term results","volume":"41","author":"Mitsunaga","year":"2006","journal-title":"J Pediatr Surg"}],"container-title":["Pediatrics & Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1875957221000024?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1875957221000024?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T14:55:14Z","timestamp":1761749714000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1875957221000024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["S1875957221000024"],"URL":"https:\/\/doi.org\/10.1016\/j.pedneo.2021.01.002","relation":{},"ISSN":["1875-9572"],"issn-type":[{"value":"1875-9572","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of primary prophylaxis in preventing variceal bleeding in children with gastroesophageal varices","name":"articletitle","label":"Article Title"},{"value":"Pediatrics & Neonatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pedneo.2021.01.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Taiwan Pediatric Association. Published by Elsevier Taiwan LLC.","name":"copyright","label":"Copyright"}]}}