{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T23:48:20Z","timestamp":1768261700383,"version":"3.49.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T00:00:00Z","timestamp":1671580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","pediatr-neonatol.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics & Neonatology"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.pedneo.2022.09.015","type":"journal-article","created":{"date-parts":[[2023,1,2]],"date-time":"2023-01-02T11:18:29Z","timestamp":1672658309000},"page":"398-404","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Predictors of a non-response to prophylactic indomethacin for patent ductus arteriosus in preterm infants"],"prefix":"10.1016","volume":"64","author":[{"given":"Masafumi","family":"Utsumi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriko","family":"Motoki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saori","family":"Yokota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Honami","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoko","family":"Yamazaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukihide","family":"Miyosawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pedneo.2022.09.015_bib1","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/chd.12708","article-title":"PDA: to treat or not to treat","volume":"14","author":"Sankar","year":"2019","journal-title":"Congenit Heart Dis"},{"key":"10.1016\/j.pedneo.2022.09.015_bib2","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jpeds.2016.06.046","article-title":"Mandatory closure versus nonintervention for patent ductus arteriosus in very preterm infants","volume":"177","author":"Sung","year":"2016","journal-title":"J Pediatr"},{"key":"10.1016\/j.pedneo.2022.09.015_bib3","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1203\/00006450-199112000-00026","article-title":"Patent ductus arteriosus increases lung fluid filtration in preterm lambs","volume":"30","author":"Alpan","year":"1991","journal-title":"Pediatr Res"},{"key":"10.1016\/j.pedneo.2022.09.015_bib4","doi-asserted-by":"crossref","first-page":"F424","DOI":"10.1136\/adc.2007.118117","article-title":"Towards rational management of the patent ductus arteriosus: the need for disease staging","volume":"92","author":"McNamara","year":"2007","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.pedneo.2022.09.015_bib5","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/s13019-020-01191-2","article-title":"Surgical ligation of patent ductus arteriosus in preterm neonates weighing less than 1500g: a 9-year single center experience","volume":"15","author":"Lee","year":"2020","journal-title":"J Cardiothorac Surg"},{"key":"10.1016\/j.pedneo.2022.09.015_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2020.590578","article-title":"Management of patent ductus arteriosus in premature infants in 2020","volume":"8","author":"Parkerson","year":"2021","journal-title":"Front Pediatr"},{"key":"10.1016\/j.pedneo.2022.09.015_bib7","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1055\/s-0037-1608792","article-title":"Predictors of PDA treatment in preterm neonates who had received prophylactic indomethacin","volume":"35","author":"Louis","year":"2018","journal-title":"Am J Perinatol"},{"key":"10.1016\/j.pedneo.2022.09.015_bib8","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s00246-018-1831-x","article-title":"Prediction of therapeutic response to cyclooxygenase inhibitors in preterm infants with patent ductus arteriosus","volume":"39","author":"Hu","year":"2018","journal-title":"Pediatr Cardiol"},{"key":"10.1016\/j.pedneo.2022.09.015_bib9","first-page":"CD000174","article-title":"Prophylactic intravenous indomethacin for preventing mortality and morbidity in preterm infants","volume":"7","author":"Fowlie","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.pedneo.2022.09.015_bib10","series-title":"Clinical practice guideline for the management of patent ductus arteriosus in preterm or low birth weight infants, 2010","first-page":"508","year":"2010"},{"key":"10.1016\/j.pedneo.2022.09.015_bib11","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/S0002-9378(13)90462-2","article-title":"Maternal and umbilical cord serum interleukin levels in preterm labor with clinical chorioamnionitis","volume":"170","author":"Lencki","year":"1994","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.pedneo.2022.09.015_bib12","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1111\/jog.13430","article-title":"Significance of pathological examination of the placenta, with a focus on intrauterine infection and fetal growth restriction","volume":"43","author":"Nakayama","year":"2017","journal-title":"J Obstet Gynaecol Res"},{"key":"10.1016\/j.pedneo.2022.09.015_bib13","article-title":"Practice bulletin No.172: premature rupture of membranes","volume":"128","year":"2016","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.pedneo.2022.09.015_bib14","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1542\/peds.82.4.527","article-title":"Abnormal pulmonary outcomes in premature infants: prediction from oxygen requirement in the neonatal period","volume":"82","author":"Shennan","year":"1988","journal-title":"Pediatrics"},{"key":"10.1016\/j.pedneo.2022.09.015_bib15","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1164\/ajrccm.163.7.2011060","article-title":"Bronchopulmonary dysplasia","volume":"163","author":"Jobe","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pedneo.2022.09.015_bib16","doi-asserted-by":"crossref","first-page":"R291","DOI":"10.1152\/ajpregu.2001.281.1.R291","article-title":"Factors that increase the contractile tone of the ductus arteriosus also regulate its anatomic remodeling","volume":"281","author":"Kajino","year":"2001","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.pedneo.2022.09.015_bib17","doi-asserted-by":"crossref","first-page":"H2342","DOI":"10.1152\/ajpheart.2001.280.5.H2342","article-title":"Characterization of PGE2 receptors in fetal and newborn lamb ductus arteriosus","volume":"280","author":"Bouayad","year":"2001","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.pedneo.2022.09.015_bib18","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0378-3782(92)90059-P","article-title":"The placenta, PGE2 and parturition","volume":"29","author":"Thorburn","year":"1992","journal-title":"Early Hum Dev"},{"key":"10.1016\/j.pedneo.2022.09.015_bib19","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1111\/ped.12769","article-title":"Prostaglandin E-mediated molecular mechanisms driving remodeling of the ductus arteriosus","volume":"57","author":"Yokoyama","year":"2015","journal-title":"Pediatr Int"},{"key":"10.1016\/j.pedneo.2022.09.015_bib20","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1540\/jsmr.46.77","article-title":"Regulation of vascular tone and remodeling of the ductus arteriosus","volume":"46","author":"Yokoyama","year":"2010","journal-title":"J Smooth Muscle Res"},{"key":"10.1016\/j.pedneo.2022.09.015_bib21","doi-asserted-by":"crossref","first-page":"R1496","DOI":"10.1152\/ajpregu.2000.278.6.R1496","article-title":"Cyclooxygenase-2 inhibitors constrict the fetal lamb ductus arteriosus both in vitro and in vivo","volume":"278","author":"Takahashi","year":"2000","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.pedneo.2022.09.015_bib22","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1056\/NEJM200106283442602","article-title":"Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants","volume":"344","author":"Schmidt","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.pedneo.2022.09.015_bib23","first-page":"23","article-title":"Human ductus arteriosus. A histological study on the relation between ductal maturation and gestational age","volume":"35","author":"Tada","year":"1985","journal-title":"Acta Pathol Jpn"},{"key":"10.1016\/j.pedneo.2022.09.015_bib24","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1530\/jrf.0.0970513","article-title":"Early hypophysectomy of sheep fetuses: effects on growth, placental steroidogenesis and prostaglandin production","volume":"97","author":"Deayton","year":"1993","journal-title":"J Reprod Fertil"},{"key":"10.1016\/j.pedneo.2022.09.015_bib25","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1161\/CIRCULATIONAHA.113.004726","article-title":"Prostaglandin E2 inhibits elastogenesis in the ductus arteriosus via EP4 signaling","volume":"129","author":"Yokoyama","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.pedneo.2022.09.015_bib26","doi-asserted-by":"crossref","first-page":"28702","DOI":"10.1074\/jbc.M804223200","article-title":"Prostaglandin E2-activated Epac promotes neointimal formation of the rat ductus arteriosus by a process distinct from that of cAMP-dependent protein kinase","volume":"283","author":"Yokoyama","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pedneo.2022.09.015_bib27","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1161\/CIRCRESAHA.109.214924","article-title":"Differential regulation of vascular tone and remodeling via stimulation of type 2 and type 6 adenylyl cyclases in the ductus arteriosus","volume":"106","author":"Yokoyama","year":"2010","journal-title":"Circ Res"},{"key":"10.1016\/j.pedneo.2022.09.015_bib28","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/S0022-3476(96)70356-6","article-title":"Influence of infection on patent ductus arteriosus and chronic lung disease in premature infants weighing 1000 grams or less","volume":"128","author":"Gonzalez","year":"1996","journal-title":"J Pediatr"},{"key":"10.1016\/j.pedneo.2022.09.015_bib29","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1111\/j.1651-2227.2008.00871.x","article-title":"The fate of ductus arteriosus in infants at 23-27 weeks of gestation: from spontaneous closure to ibuprofen resistance","volume":"97","author":"Dani","year":"2008","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.pedneo.2022.09.015_bib30","first-page":"42","article-title":"The association between patent ductus arteriosus and perinatal infection in a group of low birth weight preterm infants","volume":"24","author":"Pistulli","year":"2014","journal-title":"Iran J Pediatr"},{"key":"10.1016\/j.pedneo.2022.09.015_bib31","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1055\/s-0030-1247597","article-title":"Outcomes and milestone achievement differences for very low-birth-weight multiples compared with singleton infants","volume":"27","author":"Kirkby","year":"2010","journal-title":"Am J Perinatol"},{"key":"10.1016\/j.pedneo.2022.09.015_bib32","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/S0002-9378(97)70160-1","article-title":"Neonatal outcome of very premature infants from multiple and singleton gestations","volume":"177","author":"Nielsen","year":"1997","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.pedneo.2022.09.015_bib33","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1159\/000454798","article-title":"Patent ductus arteriosus treatment in very preterm infants: a European population-based cohort study (EPICE) on variation and outcomes","volume":"111","author":"Edstedt Bonamy","year":"2017","journal-title":"Neonatology"},{"key":"10.1016\/j.pedneo.2022.09.015_bib34","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1007\/s12576-017-0565-5","article-title":"Attenuation of ductus arteriosus intimal thickening in preterm sheep twins compared with singletons","volume":"67","author":"Ito","year":"2017","journal-title":"J Physiol Sci"},{"key":"10.1016\/j.pedneo.2022.09.015_bib35","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0378-3782(92)90059-P","article-title":"The placenta, PGE2 and parturition","volume":"29","author":"Thorburn","year":"1992","journal-title":"Early Hum Dev"},{"key":"10.1016\/j.pedneo.2022.09.015_bib36","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1210\/endo.136.3.7867577","article-title":"Prostaglandin E2 administered to fetal sheep increases the plasma concentration of adrenocorticotropin (ACTH) and the proportion of ACTH in low molecular weight forms","volume":"136","author":"Hollingworth","year":"1995","journal-title":"Endocrinology"},{"key":"10.1016\/j.pedneo.2022.09.015_bib37","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1095\/biolreprod66.5.1562","article-title":"Impact of maternal undernutrition during the periconceptional period, fetal number, and fetal sex on the development of the hypothalamo-pituitary adrenal axis in sheep during late gestation","volume":"66","author":"Edwards","year":"2002","journal-title":"Biol Reprod"},{"key":"10.1016\/j.pedneo.2022.09.015_bib38","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1113\/jphysiol.2004.061796","article-title":"Adrenocortical responsiveness is blunted in twin relative to singleton ovine fetuses","volume":"557","author":"Gardner","year":"2004","journal-title":"J Physiol"},{"key":"10.1016\/j.pedneo.2022.09.015_bib39","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s12519-008-0017-7","article-title":"Factors affecting successful closure of hemodynamically significant patent ductus arteriosus with indomethacin in extremely low birth weight infants","volume":"4","author":"Yang","year":"2008","journal-title":"World J Pediatr"},{"key":"10.1016\/j.pedneo.2022.09.015_bib40","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/jp.2015.33","article-title":"Predictors of successful closure of patent ductus arteriosus with indomethacin","volume":"35","author":"Ahamed","year":"2015","journal-title":"J Perinatol"},{"key":"10.1016\/j.pedneo.2022.09.015_bib41","first-page":"CD000503","article-title":"Restricted versus liberal water intake for preventing morbidity and mortality in preterm infants","volume":"2014","author":"Bell","year":"2014","journal-title":"Cochrane Database Syst Rev"}],"container-title":["Pediatrics & Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1875957222002704?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1875957222002704?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T14:56:29Z","timestamp":1761749789000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1875957222002704"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["S1875957222002704"],"URL":"https:\/\/doi.org\/10.1016\/j.pedneo.2022.09.015","relation":{},"ISSN":["1875-9572"],"issn-type":[{"value":"1875-9572","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Predictors of a non-response to prophylactic indomethacin for patent ductus arteriosus in preterm infants","name":"articletitle","label":"Article Title"},{"value":"Pediatrics & Neonatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pedneo.2022.09.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Taiwan Pediatric Association. Published by Elsevier Taiwan LLC.","name":"copyright","label":"Copyright"}]}}